ES2147810T3 - Derivados de acido benzoico orto-substituidos. - Google Patents

Derivados de acido benzoico orto-substituidos.

Info

Publication number
ES2147810T3
ES2147810T3 ES95112998T ES95112998T ES2147810T3 ES 2147810 T3 ES2147810 T3 ES 2147810T3 ES 95112998 T ES95112998 T ES 95112998T ES 95112998 T ES95112998 T ES 95112998T ES 2147810 T3 ES2147810 T3 ES 2147810T3
Authority
ES
Spain
Prior art keywords
benzoic acid
halogen
orto
derivatives
substituted benzoic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95112998T
Other languages
English (en)
Inventor
Manfred Dr Baumgarth
Rolf Dr Gericke
Dieter Dr Dorsch
Klaus-Otto Dr Minck
Norbert Dr Beier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2147810T3 publication Critical patent/ES2147810T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVADOS DE ACIDO BENZOICO ORTO SUSTITUIDOS DE LA FORMULA I DONDE R{SUP, 1} SIGNIFICA A, CF{SUB, 3}, CH{SUB, 2}F, CGF{SUB, 2} C{SUB, 2}F{SUB, 5}, CN, NO{SUB, 2} HAL, C = CH O - X R{SUP, 4}, R{SUP, 2} SIGNIFICA CF{SUB, 3}, - SO {SUB, N} - R{SUP, 6} O OS{SUB, 2}NR{SUP, 4}R{SUP, 5}, R{SUP, 3} ES CN, HAL, COA, CHO, CSNR{SUP, 7}R{SUP, 8} O CONR{SUP, 7}R{SUP, 8}, Q ES - N = C(NH{SUB, 2}){SUB, 2}, CL, BR, OA, O - CO - A, O - CO PH, OH O UN OTRO GRUPO OH ESTERIFICADO CON CAPACIDAD DE REACCION O GRUPO DE SALIDA SUSTITUIBLE DE FORMA SENCILLA NUCLEOFILA, R{SUP, 4} ES H, A, CICLOALQUILO CON 5 HASTA 7 ATOMOS DE C, CICLOALQUILMETILO CON 6 HASTA 8 ATOMOS DE C, CF{SUB, 3}, CH{SUB, 2}F, CHF{SUB, 2}, CH{SUB, 2}CF{SUB, 3}, PH O - CH{SUB, 2} - PH, R{SUP, 5} SIGNIFICA H O A O R{SUP, 4} Y R{SUP, 5} CONJUNTAMENTE PUEDEN SIGNIFICAR TAMBIEN ALQUILENO CON 4 HASTA 5 ATOMOS DE C, DONDE UN GRUPO CH{SUB, 2} PUEDE SER TAMBIEN SUSTITUIDO POR O, S, NH, N - A O N - CH{SUB, 2} - PH, R{SUP, 6} ES A O PH, R{SUP, 7} Y R{SUP, 8} DE FORMA INDEPENDIENTE UNO DE OTRO SIGNIFICAN H, A O AC, A ES ALQUILO CON 1 HASTA 6 ATOMOS DE C X ES O, S O NR{SUP, 5}, PH ES FENILO INSUSTITUIDO O SUSTITUIDO 1, 2 O 3 VECES POR A, OA, NR{SUP, 4}R{SUP, 5}, F, CL, BR, I O CF{SUB, 3}, AC ES ALCANOILO CON 1 HASTA 10 ATOMOS DE C O AROILO CON 7 HASTA 11 ATOMOS DE C Y N ES 1 O 2 ASI COMO LAS SALES TOLERABLES FARMACEUTICAMENTE, QUE SE CARACTERIZAN POR PROPIEDADES ANTIARRITMICAS Y ACTUAN COMO INHIBIDORES DEL ANTIPORTADOR NA+/H+ CELULAR. ADEMAS LO COMPUESTOS DE LA FORMULA I, DONDE R{SUP, 1} HASTA R{SUP, 3} ASI COMO Q TIENEN LOS SIGNIFICADOS DADOS, SON APROPIADOS COMO PRODUCTOS INTERMEDIOS VALIOSOS PARA LA ELABORACION DE MEDICAMENTOS, EN PARTICULAR DE INHIBIDORES DEL ANTIPORTADOR NA+/H+ CELULAR.
ES95112998T 1994-08-28 1995-08-18 Derivados de acido benzoico orto-substituidos. Expired - Lifetime ES2147810T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4430212A DE4430212A1 (de) 1994-08-28 1994-08-28 Ortho-substituierte Benzoesäure-Derivate

Publications (1)

Publication Number Publication Date
ES2147810T3 true ES2147810T3 (es) 2000-10-01

Family

ID=6526569

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95112998T Expired - Lifetime ES2147810T3 (es) 1994-08-28 1995-08-18 Derivados de acido benzoico orto-substituidos.

Country Status (23)

Country Link
US (1) US5849796A (es)
EP (1) EP0704431B1 (es)
JP (1) JPH0859602A (es)
KR (1) KR100406686B1 (es)
CN (1) CN1068587C (es)
AT (1) ATE193282T1 (es)
AU (1) AU703633B2 (es)
BR (1) BR9503817A (es)
CA (1) CA2156959A1 (es)
CZ (1) CZ289492B6 (es)
DE (2) DE4430212A1 (es)
DK (1) DK0704431T3 (es)
ES (1) ES2147810T3 (es)
GR (1) GR3033989T3 (es)
HU (1) HUT74946A (es)
NO (1) NO305794B1 (es)
PL (1) PL181183B1 (es)
PT (1) PT704431E (es)
RU (1) RU2125981C1 (es)
SK (1) SK282202B6 (es)
TW (1) TW406067B (es)
UA (1) UA44238C2 (es)
ZA (1) ZA957161B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713427A1 (de) * 1997-04-01 1998-10-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19919349A1 (de) * 1999-04-28 2000-11-02 Merck Patent Gmbh Verfahren zur Herstellung eines Benzoylguanidinderivates
AU2001293555A1 (en) * 2000-09-21 2002-04-02 Novation Pharmaceuticals Inc. Benzoic acid derivatives and uses thereof
JP4529119B2 (ja) * 2001-08-09 2010-08-25 小野薬品工業株式会社 カルボン酸誘導体化合物およびその化合物を有効成分として含有する薬剤
SI2438913T1 (sl) * 2002-03-20 2020-10-30 University Of Maryland, Baltimore Neselektivni kationski kanal v nevralnih celicah in spojine, ki blokirajo kanal, za uporabo pri zdravljenju otekanja možganov
US8980952B2 (en) * 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
WO2006036278A2 (en) * 2004-09-18 2006-04-06 University Of Maryland, Baltimore THERAPEUTIC AGENTS TARGETING THE NCCa-ATP CHANNEL AND METHODS OF USE THEREOF
ATE487484T1 (de) 2004-09-18 2010-11-15 Univ Maryland Therapeutische mittel zum targeting des nc ca-atp-kanals und verwendungsverfahren dafür
NZ565255A (en) * 2005-06-22 2010-04-30 Plexxikon Inc Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors
EP3103451A1 (en) 2007-01-12 2016-12-14 University of Maryland, Baltimore Targetting ncca-atp channel for organ protection following ischemic episode
US20100092469A1 (en) * 2007-02-09 2010-04-15 Simard J Marc Antagonists of a non-selective cation channel in neural cells
CA2974689C (en) 2007-06-22 2020-02-25 The United States Of America As Represented By The Department Of Veters Affairs Inhibitors of ncca-atp channels for therapy
LT6401B (lt) * 2015-07-28 2017-06-12 Vilniaus Universitetas Karboanhidrazės selektyvūs inhibitoriai
CN105732357A (zh) * 2016-03-23 2016-07-06 叶芳 2-氯-4氟苯甲酸及其制备方法
CN106892852B (zh) * 2017-03-21 2019-07-09 重庆医科大学 具有抗流感病毒活性的胍基类似物及其制备方法
CN111116395B (zh) * 2019-12-27 2023-04-07 湖北工业大学 多碘代芳香酸类化合物及其在抗腺病毒7型中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
ATE158278T1 (de) * 1992-02-15 1997-10-15 Hoechst Ag Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
DK0556674T3 (da) * 1992-02-15 1996-10-14 Hoechst Ag 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation
ATE144248T1 (de) * 1992-07-01 1996-11-15 Hoechst Ag 3,4,5-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
EP0589336B1 (de) * 1992-09-22 1997-01-08 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
TW250479B (es) * 1992-12-15 1995-07-01 Hoechst Ag
DE4404183A1 (de) * 1994-02-10 1995-08-17 Merck Patent Gmbh 4-Amino-1-piperidylbenzoylguanidine
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
KR960007539A (ko) 1996-03-22
PL310192A1 (en) 1996-03-04
ATE193282T1 (de) 2000-06-15
SK282202B6 (sk) 2001-12-03
EP0704431A3 (de) 1997-01-29
TW406067B (en) 2000-09-21
HUT74946A (en) 1997-03-28
UA44238C2 (uk) 2002-02-15
CN1068587C (zh) 2001-07-18
CA2156959A1 (en) 1996-03-01
EP0704431B1 (de) 2000-05-24
JPH0859602A (ja) 1996-03-05
CN1125722A (zh) 1996-07-03
EP0704431A2 (de) 1996-04-03
RU2125981C1 (ru) 1999-02-10
NO953352L (no) 1996-02-29
AU3014595A (en) 1996-03-14
CZ289492B6 (cs) 2002-02-13
ZA957161B (en) 1996-04-17
SK105495A3 (en) 1996-03-06
AU703633B2 (en) 1999-03-25
HU9502500D0 (en) 1995-10-30
GR3033989T3 (en) 2000-11-30
NO953352D0 (no) 1995-08-25
NO305794B1 (no) 1999-07-26
KR100406686B1 (ko) 2004-07-19
PT704431E (pt) 2000-10-31
US5849796A (en) 1998-12-15
DE59508383D1 (de) 2000-06-29
DK0704431T3 (da) 2000-09-11
BR9503817A (pt) 1996-04-16
CZ218195A3 (en) 1996-03-13
DE4430212A1 (de) 1996-02-29
PL181183B1 (pl) 2001-06-29

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