NO300980B1 - Fremgangsmåte for hydrolyse av aminosyrekjeden til preproinsulin - Google Patents

Fremgangsmåte for hydrolyse av aminosyrekjeden til preproinsulin

Info

Publication number
NO300980B1
NO300980B1 NO913474A NO913474A NO300980B1 NO 300980 B1 NO300980 B1 NO 300980B1 NO 913474 A NO913474 A NO 913474A NO 913474 A NO913474 A NO 913474A NO 300980 B1 NO300980 B1 NO 300980B1
Authority
NO
Norway
Prior art keywords
amino acid
clostripain
preproinsulin
carboxypeptidase
insulin
Prior art date
Application number
NO913474A
Other languages
English (en)
Norwegian (no)
Other versions
NO913474L (no
NO913474D0 (no
Inventor
Michael Doerschug
Klaus-Peter Koller
Ruediger Marquardt
Johannes Meiwes
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO913474D0 publication Critical patent/NO913474D0/no
Publication of NO913474L publication Critical patent/NO913474L/no
Publication of NO300980B1 publication Critical patent/NO300980B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO913474A 1990-09-05 1991-09-04 Fremgangsmåte for hydrolyse av aminosyrekjeden til preproinsulin NO300980B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028118 1990-09-05

Publications (3)

Publication Number Publication Date
NO913474D0 NO913474D0 (no) 1991-09-04
NO913474L NO913474L (no) 1992-03-06
NO300980B1 true NO300980B1 (no) 1997-08-25

Family

ID=6413629

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913474A NO300980B1 (no) 1990-09-05 1991-09-04 Fremgangsmåte for hydrolyse av aminosyrekjeden til preproinsulin

Country Status (26)

Country Link
US (1) US5728543A (cs)
EP (1) EP0474212B1 (cs)
JP (1) JP3005335B2 (cs)
KR (1) KR100188800B1 (cs)
AT (1) ATE145922T1 (cs)
AU (1) AU637254B2 (cs)
CA (1) CA2050606C (cs)
CZ (1) CZ283234B6 (cs)
DE (1) DE59108392D1 (cs)
DK (1) DK0474212T3 (cs)
ES (1) ES2095891T3 (cs)
FI (1) FI103805B1 (cs)
GR (1) GR3021909T3 (cs)
HR (1) HRP940766A2 (cs)
HU (1) HU214676B (cs)
IE (1) IE75723B1 (cs)
IL (1) IL99383A (cs)
LT (1) LT3328B (cs)
LV (1) LV10508B (cs)
NO (1) NO300980B1 (cs)
NZ (1) NZ239652A (cs)
PL (1) PL167810B1 (cs)
RU (1) RU2062301C1 (cs)
SK (1) SK279686B6 (cs)
YU (1) YU147491A (cs)
ZA (1) ZA917008B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2122549C1 (ru) * 1997-12-29 1998-11-27 Закрытое акционерное общество "Фосфосорб" Способ хроматографического выделения и очистки белков, пептидов и их комплексов
RU2238951C2 (ru) * 1998-03-31 2004-10-27 Тонгхуа Гэнтеч Биотекнолоджи Лтд. Химерный белок, обеспечивающий образование биоактивной конформации, способ получения белка с инсулиновой активностью, способ идентификации пептидильного фрагмента
US6461834B1 (en) * 1998-11-06 2002-10-08 Bionebraska, Inc. Clostripain catalyzed amidation of peptides
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
AU2003243316A1 (en) * 2002-05-24 2003-12-12 Nps Allelix Corp. Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
CA2485695A1 (en) * 2002-05-24 2003-12-04 Fred W. Wagner Method for universal enzymatic production of bioactive peptides
WO2003099847A2 (en) * 2002-05-24 2003-12-04 Restoragen, Inc. Method for enzymatic production of glp-1 (7-36) amide peptides
PL1704234T3 (pl) * 2003-11-21 2012-06-29 Nps Pharma Inc Wytwarzanie glukagonopodobnego peptydu 2 i analogów
WO2013015697A1 (en) * 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
KR102646845B1 (ko) 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU81606A1 (de) 1979-08-14 1981-03-24 Arbed Verfahren und einrichtung zur wiederverwertung von kohlenstoffreichen abfallprodukten
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
JPS59500910A (ja) 1982-05-27 1984-05-24 ネマン・ソシエテ・アノニム シリンダ錠、特に自動車のかじ取ハンドル錠
JPS60217894A (ja) * 1984-04-14 1985-10-31 Suntory Ltd 新規プロテア−ゼ及びその製造方法
DE3440988A1 (de) * 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
ZA877505B (en) 1986-10-14 1989-05-30 Lilly Co Eli Process for transforming a human insulin precursor to human insulin
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3919852A1 (de) * 1988-06-23 1989-12-28 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung
EP0347781B1 (de) 1988-06-23 1994-02-16 Hoechst Aktiengesellschaft Mini-Proinsulin, seine Herstellung und Verwendung
ATE132531T1 (de) 1988-11-03 1996-01-15 Hoechst Ag Verfahren zur herstellung eines insulin- vorprodukts in streptomyceten
US5617606A (en) 1996-02-29 1997-04-08 Baracuda International Corp. Fluted swimming pool cleaner discs

Also Published As

Publication number Publication date
LV10508B (en) 1996-02-20
CA2050606C (en) 2002-08-13
AU637254B2 (en) 1993-05-20
FI914151A0 (fi) 1991-09-03
JPH04258296A (ja) 1992-09-14
LT3328B (en) 1995-07-25
NO913474L (no) 1992-03-06
IE913117A1 (en) 1992-03-11
KR100188800B1 (ko) 1999-06-01
GR3021909T3 (en) 1997-03-31
CS271191A3 (en) 1992-03-18
HUT58823A (en) 1992-03-30
IE75723B1 (en) 1997-09-24
IL99383A0 (en) 1992-08-18
KR920006504A (ko) 1992-04-27
CA2050606A1 (en) 1992-03-06
FI103805B (fi) 1999-09-30
HU912875D0 (en) 1992-01-28
PL291617A1 (en) 1992-03-09
YU147491A (sh) 1995-10-24
EP0474212A2 (de) 1992-03-11
EP0474212B1 (de) 1996-12-04
ATE145922T1 (de) 1996-12-15
DK0474212T3 (da) 1997-05-12
NZ239652A (en) 1992-09-25
AU8356791A (en) 1992-03-12
US5728543A (en) 1998-03-17
ES2095891T3 (es) 1997-03-01
EP0474212A3 (de) 1992-04-08
HRP940766A2 (en) 1997-08-31
LTIP712A (en) 1995-01-31
IL99383A (en) 1996-01-31
PL167810B1 (pl) 1995-11-30
SK279686B6 (sk) 1999-02-11
LV10508A (lv) 1995-02-20
NO913474D0 (no) 1991-09-04
JP3005335B2 (ja) 2000-01-31
FI914151L (fi) 1992-03-06
DE59108392D1 (de) 1997-01-16
FI103805B1 (fi) 1999-09-30
RU2062301C1 (ru) 1996-06-20
ZA917008B (en) 1992-04-29
HU214676B (hu) 1998-04-28
CZ283234B6 (cs) 1998-02-18

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Legal Events

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