LTIP712A - Process for the preparation of insulin - Google Patents

Process for the preparation of insulin

Info

Publication number
LTIP712A
LTIP712A LTIP712A LTIP712A LTIP712A LT IP712 A LTIP712 A LT IP712A LT IP712 A LTIP712 A LT IP712A LT IP712 A LTIP712 A LT IP712A LT IP712 A LTIP712 A LT IP712A
Authority
LT
Lithuania
Prior art keywords
insulin
preparation
intermediates
preproinsulins
clostripain
Prior art date
Application number
LTIP712A
Inventor
Michael Doerschug
Klaus Peter Koller
Ruediger Marquardt
Johannes Meiwes
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of LTIP712A publication Critical patent/LTIP712A/en
Publication of LT3328B publication Critical patent/LT3328B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A process for the specific hydrolysis of the amino-acid chain of preproinsulins to give the corresponding intermediates with the aid of clostripain is described, and these intermediates can be converted where appropriate with carboxypeptidase B into the corresponding insulins.
LTIP712A 1990-09-05 1993-06-25 Process for the preparation of insulin LT3328B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028118 1990-09-05

Publications (2)

Publication Number Publication Date
LTIP712A true LTIP712A (en) 1995-01-31
LT3328B LT3328B (en) 1995-07-25

Family

ID=6413629

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP712A LT3328B (en) 1990-09-05 1993-06-25 Process for the preparation of insulin

Country Status (26)

Country Link
US (1) US5728543A (en)
EP (1) EP0474212B1 (en)
JP (1) JP3005335B2 (en)
KR (1) KR100188800B1 (en)
AT (1) ATE145922T1 (en)
AU (1) AU637254B2 (en)
CA (1) CA2050606C (en)
CZ (1) CZ283234B6 (en)
DE (1) DE59108392D1 (en)
DK (1) DK0474212T3 (en)
ES (1) ES2095891T3 (en)
FI (1) FI103805B (en)
GR (1) GR3021909T3 (en)
HR (1) HRP940766A2 (en)
HU (1) HU214676B (en)
IE (1) IE75723B1 (en)
IL (1) IL99383A (en)
LT (1) LT3328B (en)
LV (1) LV10508B (en)
NO (1) NO300980B1 (en)
NZ (1) NZ239652A (en)
PL (1) PL167810B1 (en)
RU (1) RU2062301C1 (en)
SK (1) SK279686B6 (en)
YU (1) YU147491A (en)
ZA (1) ZA917008B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2122549C1 (en) * 1997-12-29 1998-11-27 Закрытое акционерное общество "Фосфосорб" Chromatography method of isolation and purification of proteins, peptides and their complexes
RU2238951C2 (en) * 1998-03-31 2004-10-27 Тонгхуа Гэнтеч Биотекнолоджи Лтд. Chimeric protein providing formation of bioactive conformation, method for preparing protein with insulin activity, method for identification of peptidyl fragment
US6461834B1 (en) * 1998-11-06 2002-10-08 Bionebraska, Inc. Clostripain catalyzed amidation of peptides
DE19915938A1 (en) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Production of pancreatic procarboxypeptidase B, isoforms and muteins thereof and their use
CA2485703A1 (en) * 2002-05-24 2003-12-04 Fred W. Wagner Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
CA2485701A1 (en) * 2002-05-24 2003-12-04 Fred W. Wagner Method for enzymatic production of glp-1 (7-36) amide peptides
AU2003239865A1 (en) * 2002-05-24 2003-12-12 Restoragen Inc. Method for universal enzymatic production of bioactive peptides
SI1704234T1 (en) * 2003-11-21 2012-08-31 Nps Pharma Inc Production of glucagon like peptide 2 and analogs
WO2013015697A1 (en) * 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
KR102646845B1 (en) * 2018-08-08 2024-03-14 주식회사 대웅제약 A Method for Producing Long-acting Insulin Analog Derivatives as an Active Form Using Clostripain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU81606A1 (en) 1979-08-14 1981-03-24 Arbed METHOD AND DEVICE FOR THE RECYCLING OF CARBON-RICH WASTE PRODUCTS
DE3209184A1 (en) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt METHOD FOR CONVERTING PRAEPROINSULIN ANALOGS TO INSULINES
EP0109420A1 (en) 1982-05-27 1984-05-30 Neiman S.A. Cylindrical lock, particularly steering bolt for motor vehicle
JPS60217894A (en) * 1984-04-14 1985-10-31 Suntory Ltd Novel protease and production thereof
DE3440988A1 (en) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt METHOD FOR CLEAVING PEPTIDES AND PROTEINS ON THE METHIONYL BOND
DK129385A (en) * 1985-03-22 1986-09-23 Novo Industri As PEPTIDES AND PREPARATION THEREOF
CA1339955C (en) 1986-10-14 1998-07-14 Richard Eugene Heiney Process for transforming a human insulin precursor to human insulin
DE4012818A1 (en) * 1990-04-21 1991-10-24 Hoechst Ag METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES
DE3919852A1 (en) * 1988-06-23 1989-12-28 Hoechst Ag Mini-proinsulin, its preparation and use
EP0347781B1 (en) 1988-06-23 1994-02-16 Hoechst Aktiengesellschaft Mini-proinsulin, its oroduction and use
ES2081826T3 (en) 1988-11-03 1996-03-16 Hoechst Ag PROCEDURE FOR THE PREPARATION OF A PREVIOUS PRODUCT OF INSULIN IN STREPTOMICETS.
US5617606A (en) 1996-02-29 1997-04-08 Baracuda International Corp. Fluted swimming pool cleaner discs

Also Published As

Publication number Publication date
ES2095891T3 (en) 1997-03-01
HU214676B (en) 1998-04-28
HRP940766A2 (en) 1997-08-31
FI103805B1 (en) 1999-09-30
YU147491A (en) 1995-10-24
LV10508A (en) 1995-02-20
IE913117A1 (en) 1992-03-11
ATE145922T1 (en) 1996-12-15
HU912875D0 (en) 1992-01-28
GR3021909T3 (en) 1997-03-31
IL99383A0 (en) 1992-08-18
CS271191A3 (en) 1992-03-18
IL99383A (en) 1996-01-31
RU2062301C1 (en) 1996-06-20
PL291617A1 (en) 1992-03-09
KR100188800B1 (en) 1999-06-01
CZ283234B6 (en) 1998-02-18
AU637254B2 (en) 1993-05-20
FI103805B (en) 1999-09-30
DK0474212T3 (en) 1997-05-12
IE75723B1 (en) 1997-09-24
SK279686B6 (en) 1999-02-11
CA2050606A1 (en) 1992-03-06
LV10508B (en) 1996-02-20
KR920006504A (en) 1992-04-27
PL167810B1 (en) 1995-11-30
EP0474212A2 (en) 1992-03-11
EP0474212B1 (en) 1996-12-04
NZ239652A (en) 1992-09-25
FI914151L (en) 1992-03-06
HUT58823A (en) 1992-03-30
FI914151A0 (en) 1991-09-03
NO913474L (en) 1992-03-06
JPH04258296A (en) 1992-09-14
LT3328B (en) 1995-07-25
NO300980B1 (en) 1997-08-25
US5728543A (en) 1998-03-17
AU8356791A (en) 1992-03-12
EP0474212A3 (en) 1992-04-08
CA2050606C (en) 2002-08-13
ZA917008B (en) 1992-04-29
JP3005335B2 (en) 2000-01-31
DE59108392D1 (en) 1997-01-16
NO913474D0 (en) 1991-09-04

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Legal Events

Date Code Title Description
PC9A Transfer of patents

Free format text: 20020812 * AVENTIS PHARMA DEUTSCHLAND GMBH,DE

MK9A Expiry of a patent

Effective date: 20130625