ES2095891T3 - Procedimiento enzimatico para la conversion de preproinsulinas en insulinas. - Google Patents

Procedimiento enzimatico para la conversion de preproinsulinas en insulinas.

Info

Publication number
ES2095891T3
ES2095891T3 ES91114934T ES91114934T ES2095891T3 ES 2095891 T3 ES2095891 T3 ES 2095891T3 ES 91114934 T ES91114934 T ES 91114934T ES 91114934 T ES91114934 T ES 91114934T ES 2095891 T3 ES2095891 T3 ES 2095891T3
Authority
ES
Spain
Prior art keywords
preproinsulins
insulins
conversion
enzymatic procedure
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91114934T
Other languages
English (en)
Inventor
Michael Dr Dorschug
Klaus-Peter Dr Koller
Rudiger Dr Marquardt
Johannes Dr Meiwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2095891T3 publication Critical patent/ES2095891T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE DESCRIBE UN METODO PARA LA HIDROLISIS ESPECIFICA DE UNA CADENA DE ACIDO DE AMINO DE PREPOINSULINA EN LOS INTERMEDIARIOS CORRESPONDIENTES CON AYUDA DE CLOSTRIPAIN Y ESTOS INTERMEDIARIOS PUEDEN TRANSFORMARSE EN LAS CORRESPONDIENTES INSULINAS CON CARBOXIPEPTIDASE DE B.
ES91114934T 1990-09-05 1991-09-04 Procedimiento enzimatico para la conversion de preproinsulinas en insulinas. Expired - Lifetime ES2095891T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028118 1990-09-05

Publications (1)

Publication Number Publication Date
ES2095891T3 true ES2095891T3 (es) 1997-03-01

Family

ID=6413629

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91114934T Expired - Lifetime ES2095891T3 (es) 1990-09-05 1991-09-04 Procedimiento enzimatico para la conversion de preproinsulinas en insulinas.

Country Status (26)

Country Link
US (1) US5728543A (es)
EP (1) EP0474212B1 (es)
JP (1) JP3005335B2 (es)
KR (1) KR100188800B1 (es)
AT (1) ATE145922T1 (es)
AU (1) AU637254B2 (es)
CA (1) CA2050606C (es)
CZ (1) CZ283234B6 (es)
DE (1) DE59108392D1 (es)
DK (1) DK0474212T3 (es)
ES (1) ES2095891T3 (es)
FI (1) FI103805B (es)
GR (1) GR3021909T3 (es)
HR (1) HRP940766A2 (es)
HU (1) HU214676B (es)
IE (1) IE75723B1 (es)
IL (1) IL99383A (es)
LT (1) LT3328B (es)
LV (1) LV10508B (es)
NO (1) NO300980B1 (es)
NZ (1) NZ239652A (es)
PL (1) PL167810B1 (es)
RU (1) RU2062301C1 (es)
SK (1) SK279686B6 (es)
YU (1) YU147491A (es)
ZA (1) ZA917008B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461834B1 (en) 1998-11-06 2002-10-08 Bionebraska, Inc. Clostripain catalyzed amidation of peptides
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
AU2003239863A1 (en) * 2002-05-24 2003-12-12 Restoragen Inc. Method for enzymatic production of glp-1 (7-36) amide peptides
EP1513945A4 (en) * 2002-05-24 2008-12-24 Restoragen Inc PROCESS FOR UNIVERSAL ENZYMATIC PRODUCTION OF BIOACTIVE PEPTIDES
WO2003099854A2 (en) * 2002-05-24 2003-12-04 Nps Allelix Corp. Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
ME01366B (me) * 2003-11-21 2013-12-20 Nps Allelix Corp POSTUPAK ZA PROIZVODNJU PEPTIDA 2 NALIK NA GLUKAGON l NJIHOVIH ANALOGA
WO2013015697A1 (en) * 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
KR102646845B1 (ko) 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU81606A1 (de) 1979-08-14 1981-03-24 Arbed Verfahren und einrichtung zur wiederverwertung von kohlenstoffreichen abfallprodukten
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
JPS59500910A (ja) 1982-05-27 1984-05-24 ネマン・ソシエテ・アノニム シリンダ錠、特に自動車のかじ取ハンドル錠
JPS60217894A (ja) * 1984-04-14 1985-10-31 Suntory Ltd 新規プロテア−ゼ及びその製造方法
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
ZA877505B (en) 1986-10-14 1989-05-30 Lilly Co Eli Process for transforming a human insulin precursor to human insulin
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3919852A1 (de) * 1988-06-23 1989-12-28 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung
DE58906966D1 (de) 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
EP0367163B1 (de) 1988-11-03 1996-01-03 Hoechst Aktiengesellschaft Verfahren zur Herstellung eines Insulin-Vorprodukts in Streptomyceten
US5617606A (en) 1996-02-29 1997-04-08 Baracuda International Corp. Fluted swimming pool cleaner discs

Also Published As

Publication number Publication date
SK279686B6 (sk) 1999-02-11
NZ239652A (en) 1992-09-25
NO913474L (no) 1992-03-06
DE59108392D1 (de) 1997-01-16
PL167810B1 (pl) 1995-11-30
DK0474212T3 (da) 1997-05-12
CA2050606C (en) 2002-08-13
FI103805B1 (fi) 1999-09-30
HU912875D0 (en) 1992-01-28
GR3021909T3 (en) 1997-03-31
EP0474212A2 (de) 1992-03-11
KR920006504A (ko) 1992-04-27
CA2050606A1 (en) 1992-03-06
YU147491A (sh) 1995-10-24
RU2062301C1 (ru) 1996-06-20
IE75723B1 (en) 1997-09-24
AU8356791A (en) 1992-03-12
HRP940766A2 (en) 1997-08-31
IL99383A0 (en) 1992-08-18
HUT58823A (en) 1992-03-30
ATE145922T1 (de) 1996-12-15
JP3005335B2 (ja) 2000-01-31
KR100188800B1 (ko) 1999-06-01
LV10508B (en) 1996-02-20
NO913474D0 (no) 1991-09-04
FI914151A (fi) 1992-03-06
EP0474212B1 (de) 1996-12-04
ZA917008B (en) 1992-04-29
CZ283234B6 (cs) 1998-02-18
IE913117A1 (en) 1992-03-11
EP0474212A3 (de) 1992-04-08
CS271191A3 (en) 1992-03-18
JPH04258296A (ja) 1992-09-14
IL99383A (en) 1996-01-31
PL291617A1 (en) 1992-03-09
US5728543A (en) 1998-03-17
LTIP712A (en) 1995-01-31
LV10508A (lv) 1995-02-20
AU637254B2 (en) 1993-05-20
LT3328B (en) 1995-07-25
FI103805B (fi) 1999-09-30
FI914151A0 (fi) 1991-09-03
HU214676B (hu) 1998-04-28
NO300980B1 (no) 1997-08-25

Similar Documents

Publication Publication Date Title
AU638133B2 (en) Ribosome inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
DE58907431D1 (de) Neue Transaminase, ihre Herstellung und ihre Verwendung.
PT90939A (pt) Processo para a preparacao de mini-proinsulina
ES2095891T3 (es) Procedimiento enzimatico para la conversion de preproinsulinas en insulinas.
DK459989D0 (da) Gaeringsproces
DE3685764D1 (de) Antibiotikum hergestellt von lysobacter sp. sc 14,067.
ATE104265T1 (de) Herstellung von 1,1,1-2-tetrafluorethan.
ES2159296T3 (es) Procedimiento para preparar 2,2-difluorocetena silil acetales y esteres de acido alfa,alfa-difluoro-beta-sililoxi-1,3-dioxolano-4-propanoico.
PT86552A (de) Gama-glutamyl-transpeptidase deren herstellung und deren verwendung
GR3006794T3 (es)
FR2583060B1 (fr) Production de butanol et d'acetone par fermentation avec recyclage de la biomasse par ultrafiltration
ATE52258T1 (de) Verfahren zur herstellung von 2-beta-dribofuranosylselenazol-4-carboxamid.
AU563288B2 (en) Preparing high-dextrose starch hydrolysates
ES2038601T3 (es) Procedimiento para preparar 4-androsten-3,17-diona y 1,4-androstadien-3,17-diona.
BR8706611A (pt) Processo para queimar clinquer e usina com forno alimentado a carvao
EP0243496A4 (en) PROCESS FOR PRODUCING L-THREONINE BY FERMENTATION.
JPS62139169U (es)

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 474212

Country of ref document: ES