NO2017015I1 - Kombinasjon avNεB29-Nα-(HOOC(CH2)14CO)-γ-Glu)des(B30)-humant insulin og Arg34Lys26(Nε-(γ-glutamyl(Nα-heksadekanoyl)))-GLP-1(7-37) - Google Patents
Kombinasjon avNεB29-Nα-(HOOC(CH2)14CO)-γ-Glu)des(B30)-humant insulin og Arg34Lys26(Nε-(γ-glutamyl(Nα-heksadekanoyl)))-GLP-1(7-37)Info
- Publication number
- NO2017015I1 NO2017015I1 NO2017015C NO2017015C NO2017015I1 NO 2017015 I1 NO2017015 I1 NO 2017015I1 NO 2017015 C NO2017015 C NO 2017015C NO 2017015 C NO2017015 C NO 2017015C NO 2017015 I1 NO2017015 I1 NO 2017015I1
- Authority
- NO
- Norway
- Prior art keywords
- nεb29
- arg34lys26
- hexadecanoyl
- hooc
- glutamyl
- Prior art date
Links
- 101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 title 1
- 125000002642 gamma-glutamyl group Chemical group 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07120880 | 2007-11-16 | ||
| PCT/EP2008/065601 WO2009063072A2 (en) | 2007-11-16 | 2008-11-14 | Pharmaceutical compositions containing insulin and an insulinotropic peptide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO2017015I2 NO2017015I2 (no) | 2017-04-21 |
| NO2017015I1 true NO2017015I1 (no) | 2017-04-21 |
Family
ID=40639234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2017015C NO2017015I1 (no) | 2007-11-16 | 2017-04-21 | Kombinasjon avNεB29-Nα-(HOOC(CH2)14CO)-γ-Glu)des(B30)-humant insulin og Arg34Lys26(Nε-(γ-glutamyl(Nα-heksadekanoyl)))-GLP-1(7-37) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8937042B2 (OSRAM) |
| EP (2) | EP2209800B1 (OSRAM) |
| JP (2) | JP5241849B2 (OSRAM) |
| CN (3) | CN107412742B (OSRAM) |
| BR (1) | BRPI0820535B8 (OSRAM) |
| CA (1) | CA2705821A1 (OSRAM) |
| DK (1) | DK2597103T3 (OSRAM) |
| ES (2) | ES2612736T3 (OSRAM) |
| HU (2) | HUE030383T2 (OSRAM) |
| MX (1) | MX2010005245A (OSRAM) |
| NO (1) | NO2017015I1 (OSRAM) |
| PL (2) | PL2209800T3 (OSRAM) |
| PT (1) | PT2597103T (OSRAM) |
| WO (1) | WO2009063072A2 (OSRAM) |
| ZA (1) | ZA201003019B (OSRAM) |
Families Citing this family (99)
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| EP2107069B1 (en) * | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Novel insulin derivatives |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2505593A1 (en) * | 2005-12-28 | 2012-10-03 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| DE602007009496D1 (de) | 2006-02-27 | 2010-11-11 | Novo Nordisk As | Insulinderivate |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| EA030606B1 (ru) | 2006-05-04 | 2018-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Способы приготовления лекарственного средства, содержащего полиморфы |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| CN101677947B (zh) | 2007-06-13 | 2013-07-17 | 诺沃-诺迪斯克有限公司 | 包含胰岛素衍生物的药物制剂 |
| PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
| PT2910570T (pt) | 2008-03-18 | 2017-01-24 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
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| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
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| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| DK3228320T3 (da) | 2008-10-17 | 2020-03-09 | Sanofi Aventis Deutschland | Kombination af et insulin og en glp-1-agonist |
| AU2009309623B9 (en) | 2008-10-30 | 2014-10-02 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| CN102256976A (zh) | 2008-12-23 | 2011-11-23 | 贝林格尔.英格海姆国际有限公司 | 有机化合物的盐形式 |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| LT2395983T (lt) | 2009-02-13 | 2020-07-10 | Boehringer Ingelheim International Gmbh | Farmacinė kompozicija, apimanti sglt2 inhibitorių, dpp-iv inhibitorių ir, pasirinktinai, papildomą priešdiabetinį agentą, bei jos panaudojimas |
| PL3417871T3 (pl) | 2009-11-13 | 2021-06-14 | Sanofi-Aventis Deutschland Gmbh | Kompozycja farmaceutyczna zawierająca agonistę GLP-1, insulinę i metioninę |
| CN102711804B (zh) | 2009-11-13 | 2015-09-16 | 赛诺菲-安万特德国有限公司 | 包含glp-1激动剂和甲硫氨酸的药物组合物 |
| EA034869B1 (ru) | 2009-11-27 | 2020-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин |
| KR101819609B1 (ko) | 2010-05-05 | 2018-01-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
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2008
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- 2008-11-14 ES ES13155712.6T patent/ES2612736T3/es active Active
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- 2008-11-14 PL PL08849536T patent/PL2209800T3/pl unknown
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- 2008-11-14 BR BRPI0820535A patent/BRPI0820535B8/pt active IP Right Grant
- 2008-11-14 DK DK13155712.6T patent/DK2597103T3/en active
- 2008-11-14 PT PT131557126T patent/PT2597103T/pt unknown
- 2008-11-14 CN CN201611159339.1A patent/CN107115523A/zh active Pending
- 2008-11-14 HU HUE13155712A patent/HUE030383T2/en unknown
- 2008-11-14 ES ES08849536T patent/ES2430042T3/es active Active
- 2008-11-14 CN CN200880116227A patent/CN101861333A/zh not_active Withdrawn
- 2008-11-14 EP EP08849536.1A patent/EP2209800B1/en active Active
- 2008-11-14 PL PL13155712T patent/PL2597103T3/pl unknown
- 2008-11-14 WO PCT/EP2008/065601 patent/WO2009063072A2/en not_active Ceased
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- 2010-04-30 ZA ZA2010/03019A patent/ZA201003019B/en unknown
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- 2012-05-29 JP JP2012122502A patent/JP5757530B2/ja active Active
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- 2017-04-21 NO NO2017015C patent/NO2017015I1/no unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| PL2597103T3 (pl) | 2017-04-28 |
| BRPI0820535B8 (pt) | 2021-05-25 |
| JP2012229214A (ja) | 2012-11-22 |
| BRPI0820535B1 (pt) | 2020-09-29 |
| ES2612736T3 (es) | 2017-05-18 |
| JP2011503152A (ja) | 2011-01-27 |
| CA2705821A1 (en) | 2009-05-22 |
| PL2209800T3 (pl) | 2013-12-31 |
| CN107412742B (zh) | 2022-03-15 |
| HUE030383T2 (en) | 2017-05-29 |
| JP5757530B2 (ja) | 2015-07-29 |
| ZA201003019B (en) | 2011-06-29 |
| NO2017015I2 (no) | 2017-04-21 |
| CN101861333A (zh) | 2010-10-13 |
| EP2209800B1 (en) | 2013-07-24 |
| EP2209800A2 (en) | 2010-07-28 |
| WO2009063072A3 (en) | 2010-01-07 |
| MX2010005245A (es) | 2010-06-01 |
| US20110152185A1 (en) | 2011-06-23 |
| BRPI0820535A2 (pt) | 2016-06-21 |
| EP2597103B1 (en) | 2016-11-02 |
| ES2430042T3 (es) | 2013-11-18 |
| HUS1700016I1 (hu) | 2017-05-29 |
| DK2597103T3 (en) | 2017-02-13 |
| JP5241849B2 (ja) | 2013-07-17 |
| CN107412742A (zh) | 2017-12-01 |
| EP2597103A1 (en) | 2013-05-29 |
| US8937042B2 (en) | 2015-01-20 |
| CN107115523A (zh) | 2017-09-01 |
| BRPI0820535A8 (pt) | 2016-10-18 |
| WO2009063072A2 (en) | 2009-05-22 |
| PT2597103T (pt) | 2017-02-08 |
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