NO20082748L - Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater - Google Patents
Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivaterInfo
- Publication number
- NO20082748L NO20082748L NO20082748A NO20082748A NO20082748L NO 20082748 L NO20082748 L NO 20082748L NO 20082748 A NO20082748 A NO 20082748A NO 20082748 A NO20082748 A NO 20082748A NO 20082748 L NO20082748 L NO 20082748L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- hydrogen
- aryl
- isoxazol
- imidazo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår aryl-isoksazol-4-yl-imidazo[1,5-a]pyridinderivater med formel (I): hvor R1 er hydrogen, halogen, hydroksy, lavere alkyl, benzyloksy eller 5- eller 6-leddet -O-(CH2)-(CO)-heteroaryl eventuelt substituert med aryl og lavere alkyl; R2 er hydrogen, lavere alkyl eller -(CO)-Ra; R3 er hydrogen, halogen, cyano, lavere alkyl eller -(CO)-Ra; Ra er hydroksy, lavere alkoksy, NR'R'', hvor R' og R'' hver, uavhengig, er hydrogen, cykloalkyl, 5- eller 6-leddet heterocykloalkyl eller lavere alkyl eventuelt substituert med cykloalkyl, cyano, 5- eller 6-leddet heterocykloalkyl eller 5- eller 6-leddet heteroaryl; så vel som farmasøytisk akseptable syreaddisjonssalter derav. Det er funnet at denne klasse forbindelser viser høy affinitet til, og selektivitet overfor, GABA A ?5-reseptor-bindingsseter, og kan være anvendelige som kognitiv forbedrer eller for behandling av kognitive lidelser som Alzheimers sykdom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05112988 | 2005-12-27 | ||
PCT/EP2006/069792 WO2007074089A1 (en) | 2005-12-27 | 2006-12-18 | Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20082748L true NO20082748L (no) | 2008-09-24 |
Family
ID=37909303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082748A NO20082748L (no) | 2005-12-27 | 2008-06-13 | Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater |
Country Status (17)
Country | Link |
---|---|
US (1) | US7399769B2 (no) |
EP (1) | EP1968977B1 (no) |
JP (1) | JP4864982B2 (no) |
KR (1) | KR101033719B1 (no) |
CN (1) | CN101346377B (no) |
AR (1) | AR058728A1 (no) |
AT (1) | ATE537171T1 (no) |
AU (1) | AU2006331363B2 (no) |
BR (1) | BRPI0620760A2 (no) |
CA (1) | CA2633536A1 (no) |
ES (1) | ES2376357T3 (no) |
IL (1) | IL192236A0 (no) |
NO (1) | NO20082748L (no) |
RU (1) | RU2420527C2 (no) |
TW (1) | TWI324156B (no) |
WO (1) | WO2007074089A1 (no) |
ZA (1) | ZA200805354B (no) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE527255T1 (de) * | 2005-12-27 | 2011-10-15 | Hoffmann La Roche | Aryl-isoxazol-4-yl-imidazol-derivate |
KR101228194B1 (ko) * | 2007-06-22 | 2013-01-30 | 에프. 호프만-라 로슈 아게 | 아이속사졸-이미다졸 유도체 |
JP5301557B2 (ja) | 2007-12-04 | 2013-09-25 | エフ.ホフマン−ラ ロシュ アーゲー | イソオキサゾロ−ピリジン誘導体 |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
WO2014001279A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
WO2014001280A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
AU2013283488A1 (en) | 2012-06-26 | 2015-01-15 | Saniona Aps | A phenyl triazole derivative and its use for modulating the GABAA receptor complex |
WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
AU2013283487C1 (en) | 2012-06-26 | 2018-01-18 | Saniona Aps | A phenyl triazole derivative and its use for modulating the GABAA receptor complex |
HUE046273T2 (hu) | 2014-02-13 | 2020-02-28 | Incyte Corp | Ciklopropilaminok mint LSD1 inhibitorok |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
CR20200362A (es) | 2014-02-13 | 2020-10-26 | Incyte Corp | CICLOPROPILAMINA COMO INHIBIDORES DE LA LSD1 (Divisional 2016-0395) |
US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
US9695168B2 (en) * | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
US9944647B2 (en) | 2015-04-03 | 2018-04-17 | Incyte Corporation | Heterocyclic compounds as LSD1 inhibitors |
JP7427363B2 (ja) | 2015-08-12 | 2024-02-05 | インサイト・ホールディングス・コーポレイション | Lsd1阻害剤の塩 |
BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02004735A (es) * | 1999-11-12 | 2003-01-28 | Orive Javier Uhthoff | Compuestos heteroaromaticos, biciclicos y triciclicos. |
EP1448561B1 (en) * | 2001-11-20 | 2008-02-20 | Eli Lilly And Company | Beta 3 adrenergic agonists |
-
2006
- 2006-12-18 ES ES06841391T patent/ES2376357T3/es active Active
- 2006-12-18 WO PCT/EP2006/069792 patent/WO2007074089A1/en active Application Filing
- 2006-12-18 KR KR1020087015509A patent/KR101033719B1/ko not_active IP Right Cessation
- 2006-12-18 AU AU2006331363A patent/AU2006331363B2/en not_active Ceased
- 2006-12-18 BR BRPI0620760-0A patent/BRPI0620760A2/pt not_active IP Right Cessation
- 2006-12-18 US US11/640,768 patent/US7399769B2/en not_active Expired - Fee Related
- 2006-12-18 JP JP2008547940A patent/JP4864982B2/ja not_active Expired - Fee Related
- 2006-12-18 EP EP06841391A patent/EP1968977B1/en not_active Not-in-force
- 2006-12-18 CA CA002633536A patent/CA2633536A1/en not_active Abandoned
- 2006-12-18 AT AT06841391T patent/ATE537171T1/de active
- 2006-12-18 RU RU2008125040/04A patent/RU2420527C2/ru not_active IP Right Cessation
- 2006-12-18 CN CN2006800491806A patent/CN101346377B/zh not_active Expired - Fee Related
- 2006-12-25 TW TW095148805A patent/TWI324156B/zh not_active IP Right Cessation
- 2006-12-26 AR ARP060105770A patent/AR058728A1/es not_active Application Discontinuation
-
2008
- 2008-06-13 NO NO20082748A patent/NO20082748L/no not_active Application Discontinuation
- 2008-06-16 IL IL192236A patent/IL192236A0/en unknown
- 2008-06-19 ZA ZA200805354A patent/ZA200805354B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US7399769B2 (en) | 2008-07-15 |
WO2007074089A1 (en) | 2007-07-05 |
AU2006331363A1 (en) | 2007-07-05 |
IL192236A0 (en) | 2008-12-29 |
TW200734328A (en) | 2007-09-16 |
RU2420527C2 (ru) | 2011-06-10 |
TWI324156B (en) | 2010-05-01 |
CN101346377B (zh) | 2011-05-11 |
BRPI0620760A2 (pt) | 2011-11-22 |
KR101033719B1 (ko) | 2011-05-09 |
ES2376357T3 (es) | 2012-03-13 |
ZA200805354B (en) | 2009-10-28 |
CA2633536A1 (en) | 2007-07-05 |
JP4864982B2 (ja) | 2012-02-01 |
EP1968977B1 (en) | 2011-12-14 |
JP2009521517A (ja) | 2009-06-04 |
KR20080072072A (ko) | 2008-08-05 |
US20070191421A1 (en) | 2007-08-16 |
CN101346377A (zh) | 2009-01-14 |
RU2008125040A (ru) | 2010-02-10 |
AU2006331363B2 (en) | 2012-07-05 |
EP1968977A1 (en) | 2008-09-17 |
AR058728A1 (es) | 2008-02-20 |
ATE537171T1 (de) | 2011-12-15 |
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