NO20082956L - Aryl-isoksazol-4-yl-imidazo[1,2-A]pyridin anvendbar for behandling av Alzheimers sykdom via GABA-reseptorer - Google Patents

Aryl-isoksazol-4-yl-imidazo[1,2-A]pyridin anvendbar for behandling av Alzheimers sykdom via GABA-reseptorer

Info

Publication number
NO20082956L
NO20082956L NO20082956A NO20082956A NO20082956L NO 20082956 L NO20082956 L NO 20082956L NO 20082956 A NO20082956 A NO 20082956A NO 20082956 A NO20082956 A NO 20082956A NO 20082956 L NO20082956 L NO 20082956L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
aryl
membered heteroaryl
isoxazol
Prior art date
Application number
NO20082956A
Other languages
English (en)
Inventor
Bernd Buettelmann
Henner Knust
Andrew Thomas
Bo Han
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37965110&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20082956(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20082956L publication Critical patent/NO20082956L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Foreliggende oppfinnelse angår aryl-isoksazol-4-yl-imidazo[1,2-a]pyridinderivater med formel I: hvor R1 er hydrogen, halogen, hydroksy, lavere alkyl, benzyloksy eller -O-(CH2)-(CO)-5- eller 6-leddet heteroaryl eventuelt substituert med aryl eller med lavere alkyl; R2 er hydrogen, halogen, lavere alkyl, lavere alkynyl, amino, -NHC(O)-Ra eller -(CO)-Ra; R3 er hydrogen, halogen, cyano, lavere alkyl, lavere alkynyl, amino, -NHC(O)-Ra, -(CO)-Ra, -5 eller 6-leddet heterocykloalkyl i 1-stilling, eventuelt substituert med =O eller er en -5 eller 6-leddet heteroaryl i 1-stilling; R4 er hydrogen eller -5 eller 6-leddet heteroaryl; R5 er lavere alkyl eller cykloalkyl; Ra er lavere alkoksy eller NR'R'' , hvor R' og R'' hver er uavhengig hydrogen, lavere alkyl eventuelt substituert med hydroksy, lavere alkynyl, -(CH2)n-cykloalkyl, -(CH2)n-5 eller 6-leddet heterocykloalkyl eller -(CH2)n-5 eller 6-leddet heteroaryl; n er 0 til 3; så vel som farmasøyt isk akseptable syreaddisjonssalter derav. Det er funnet at denne klassen forbindelser viser høy affinitet og selektivitet for GABA A ?5 reseptor-bindingsseter og kan være anvendelige som kognitive forsterkere eller for behandling av kognitive lidelser slik som Alzheimers sykdom. 1
NO20082956A 2006-01-17 2008-07-03 Aryl-isoksazol-4-yl-imidazo[1,2-A]pyridin anvendbar for behandling av Alzheimers sykdom via GABA-reseptorer NO20082956L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100426 2006-01-17
PCT/EP2007/050137 WO2007082806A1 (en) 2006-01-17 2007-01-08 Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine useful for the treatment of alzheimer’s disease via gaba receptors

Publications (1)

Publication Number Publication Date
NO20082956L true NO20082956L (no) 2008-08-06

Family

ID=37965110

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082956A NO20082956L (no) 2006-01-17 2008-07-03 Aryl-isoksazol-4-yl-imidazo[1,2-A]pyridin anvendbar for behandling av Alzheimers sykdom via GABA-reseptorer

Country Status (15)

Country Link
US (1) US7585874B2 (no)
EP (1) EP1979350A1 (no)
JP (1) JP4913157B2 (no)
KR (1) KR101062583B1 (no)
CN (1) CN101370807B (no)
AR (1) AR059016A4 (no)
AU (1) AU2007207053B2 (no)
BR (1) BRPI0706560A2 (no)
CA (1) CA2636112A1 (no)
IL (1) IL192636A0 (no)
NO (1) NO20082956L (no)
RU (1) RU2426732C2 (no)
TW (1) TWI338691B (no)
WO (1) WO2007082806A1 (no)
ZA (1) ZA200805839B (no)

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ZA200904477B (en) 2006-11-27 2010-09-29 Lundbeck & Co As H Heteroaryl amide derivatives
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
WO2009000662A1 (en) * 2007-06-22 2008-12-31 F. Hoffmann-La Roche Ag Isoxazole-imidazole derivatives
CN101889010B (zh) 2007-12-04 2012-12-05 弗·哈夫曼-拉罗切有限公司 异*唑-吡啶衍生物
RU2502737C2 (ru) 2009-09-24 2013-12-27 Ф. Хоффманн-Ля Рош Аг Производные имидазопиридина или имидазопиримидина в качестве ингибиторов фосфодиэстеразы 10а
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
PT2571503E (pt) 2010-05-14 2015-04-29 Dana Farber Cancer Inst Inc Composições e a sua utilização no tratamento de neoplasia, doença inflamatória e outros distúrbios
EP2571875A4 (en) 2010-05-14 2013-10-30 Dana Farber Cancer Inst Inc CONTRACEPTIVE COMPOSITIONS FOR MEN AND METHODS OF USE THEREOF
BR112012029057A2 (pt) 2010-05-14 2020-10-13 Dana-Farber Cancer Institute, Inc. composições e métodos de tratamento de leucemia
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2884956A1 (en) 2012-11-29 2014-06-05 F. Hoffmann-La Roche Ag Imidazopyridine derivatives
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
DK2991983T3 (en) * 2013-04-29 2017-05-08 Hoffmann La Roche 2-PHENYL OR 2-HETARYLIMIDAZOLE [1,2-a] PYRIDINE DERIVATIVES
RU2016105108A (ru) * 2013-07-25 2017-08-30 Дана-Фарбер Кэнсер Инститьют, Инк. Ингибиторы факторов транскрипции и их применение
JP6637884B2 (ja) 2013-11-08 2020-01-29 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ブロモドメインおよびエクストラターミナル（ｂｅｔ）タンパク質インヒビターを使用するがんのための併用療法
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
BR112016017045A2 (pt) 2014-01-31 2017-08-08 Dana Farber Cancer Inst Inc Derivados de diazepano e usos dos mesmos
WO2015117053A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
CN106456653A (zh) 2014-02-28 2017-02-22 腾沙治疗公司 高胰岛素血症相关病症的治疗
MX2017001757A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
KR20170032473A (ko) 2014-08-08 2017-03-22 다나-파버 캔서 인스티튜트 인크. 디아제판 유도체 및 그의 용도
AU2015339511B2 (en) 2014-10-27 2020-05-14 Tensha Therapeutics, Inc. Bromodomain inhibitors
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
WO2017044792A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazoldiazepines and uses thereof
WO2017044849A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
SG11201803210YA (en) 2015-11-25 2018-05-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
CN111225915B (zh) * 2017-10-18 2023-03-07 朱比兰特埃皮帕德有限公司 作为pad抑制剂的咪唑并吡啶化合物

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IT1314191B1 (it) 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
WO2002002557A2 (en) * 2000-06-30 2002-01-10 Neurogen Corporation 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
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Also Published As

Publication number Publication date
EP1979350A1 (en) 2008-10-15
TW200736257A (en) 2007-10-01
RU2008126807A (ru) 2010-02-27
IL192636A0 (en) 2009-02-11
KR101062583B1 (ko) 2011-09-06
KR20080075924A (ko) 2008-08-19
US20070179178A1 (en) 2007-08-02
JP4913157B2 (ja) 2012-04-11
RU2426732C2 (ru) 2011-08-20
AU2007207053B2 (en) 2012-05-24
CA2636112A1 (en) 2007-07-26
WO2007082806A1 (en) 2007-07-26
US7585874B2 (en) 2009-09-08
BRPI0706560A2 (pt) 2011-03-29
CN101370807A (zh) 2009-02-18
AR059016A4 (es) 2008-03-05
JP2009523752A (ja) 2009-06-25
ZA200805839B (en) 2009-09-30
AU2007207053A1 (en) 2007-07-26
CN101370807B (zh) 2011-08-31
TWI338691B (en) 2011-03-11

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