NO20080187L - Aspartylproteaseinhibitorer - Google Patents
AspartylproteaseinhibitorerInfo
- Publication number
- NO20080187L NO20080187L NO20080187A NO20080187A NO20080187L NO 20080187 L NO20080187 L NO 20080187L NO 20080187 A NO20080187 A NO 20080187A NO 20080187 A NO20080187 A NO 20080187A NO 20080187 L NO20080187 L NO 20080187L
- Authority
- NO
- Norway
- Prior art keywords
- cognitive
- compounds
- formula
- disclosed
- neurodegenerative diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69053705P | 2005-06-14 | 2005-06-14 | |
PCT/US2006/022918 WO2006138264A2 (fr) | 2005-06-14 | 2006-06-12 | Inhibiteurs d'aspartyl protease |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20080187L true NO20080187L (no) | 2008-03-14 |
Family
ID=37114557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20080187A NO20080187L (no) | 2005-06-14 | 2008-01-11 | Aspartylproteaseinhibitorer |
Country Status (18)
Country | Link |
---|---|
US (1) | US7868000B2 (fr) |
EP (1) | EP1896478B1 (fr) |
JP (2) | JP2008543849A (fr) |
KR (1) | KR20080029965A (fr) |
CN (1) | CN101228163A (fr) |
AR (1) | AR054617A1 (fr) |
AU (1) | AU2006259572A1 (fr) |
BR (1) | BRPI0612072A2 (fr) |
CA (1) | CA2609582A1 (fr) |
EC (1) | ECSP078003A (fr) |
IL (1) | IL187814A0 (fr) |
MX (1) | MX2007016180A (fr) |
NO (1) | NO20080187L (fr) |
PE (1) | PE20070135A1 (fr) |
RU (1) | RU2008100165A (fr) |
SG (1) | SG162790A1 (fr) |
TW (2) | TW201004961A (fr) |
WO (1) | WO2006138264A2 (fr) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0220581D0 (en) * | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
AR049401A1 (es) * | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
TW201004961A (en) | 2005-06-14 | 2010-02-01 | Schering Corp | Aspartyl protease inhibitors |
AR054620A1 (es) | 2005-06-14 | 2007-07-04 | Schering Corp | Inhibidores de aspartil proteasas |
AU2006259573A1 (en) | 2005-06-14 | 2006-12-28 | Pharmacopeia, Inc. | Heterocyclic aspartyl protease inhibitors, preparation and use thereof |
GB0521508D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
AR057983A1 (es) | 2005-10-27 | 2008-01-09 | Schering Corp | Inhibidores hterociclicos de aspartil proteasas |
GB0525672D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
US8168641B2 (en) * | 2006-06-12 | 2012-05-01 | Schering Corporation | Aspartyl protease inhibitors |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
WO2008073370A1 (fr) * | 2006-12-12 | 2008-06-19 | Schering Corporation | Inhibiteurs de la protéase aspartyle contenant un système de noyau tricyclique |
EP2064191B1 (fr) | 2006-12-12 | 2014-06-25 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase d'aspartyle |
TW200902499A (en) | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
JP2010538068A (ja) | 2007-09-06 | 2010-12-09 | シェーリング コーポレイション | ガンマセクレターゼモジュレーター |
MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
JP2011506461A (ja) | 2007-12-11 | 2011-03-03 | シェーリング コーポレイション | γ−セクレターゼモジュレーター |
WO2009131974A1 (fr) * | 2008-04-22 | 2009-10-29 | Schering Corporation | Composes de 2-imino-3-methyl-pyrrolo pyrimidinone substitues par thiophenyle utilises en tant qu’inhibiteurs bace-1, compositions et utilisation associees |
AU2009314049B2 (en) | 2008-11-13 | 2015-03-05 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
CA2747744A1 (fr) | 2008-12-22 | 2010-07-01 | Theodros Asberom | Modulateurs de gamma secretase |
EP2379566A2 (fr) | 2008-12-22 | 2011-10-26 | Schering Corporation | Modulateurs de gamma secretase |
FR2944011B1 (fr) * | 2009-04-03 | 2011-05-20 | Pf Medicament | Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. |
WO2010147969A2 (fr) | 2009-06-16 | 2010-12-23 | Schering Corporation | Modulateurs de gamma sécrétase |
WO2010147975A1 (fr) | 2009-06-16 | 2010-12-23 | Schering Corporation | Modulateurs de gamma sécrétase |
US20120232108A1 (en) | 2009-06-16 | 2012-09-13 | Xianhai Huang | Gamma secretase modulators |
GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
GB0912777D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
EP2281824A1 (fr) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Dérivés de furan-imidazolone pour le traitement de maladies ou de troubles cognitifs, neurodégénératifs ou neuronaux |
US8557826B2 (en) | 2009-10-08 | 2013-10-15 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use |
US8569310B2 (en) | 2009-10-08 | 2013-10-29 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use |
EP2485591B1 (fr) | 2009-10-08 | 2016-03-23 | Merck Sharp & Dohme Corp. | Composés de type dioxyde d'imino-thiadiazine utilisés en tant qu'inhibiteurs de bace, compositions en contenant et leur utilisation |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
US20120245155A1 (en) * | 2009-12-11 | 2012-09-27 | Shionogi & Co., Ltd. | Fused heterocyclic compound having amino group |
JP2013542973A (ja) | 2010-11-22 | 2013-11-28 | ノスシラ、ソシエダッド、アノニマ | 神経変性疾患または神経変性状態を治療するためのビピリジンスルホンアミド誘導体 |
US8415483B2 (en) | 2010-12-22 | 2013-04-09 | Astrazeneca Ab | Compounds and their use as BACE inhibitors |
GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
WO2012100179A1 (fr) | 2011-01-21 | 2012-07-26 | Eisai R&D Management Co., Ltd. | Procédés et composés utiles dans la synthèse de dérivés fusionnés d'aminodihydrothiazine |
GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
WO2012138590A1 (fr) * | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Composés de dioxyde de thiadiazine fusionnée à la pyrrolidine en tant qu'inhibiteurs de bace, compositions et leur utilisation |
US9221839B2 (en) | 2011-04-07 | 2015-12-29 | Merck Sharp & Dohme Corp. | C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
AU2012298983A1 (en) | 2011-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as BACE inhibitors, compositions and their use |
WO2013054108A1 (fr) | 2011-10-10 | 2013-04-18 | Astrazeneca Ab | Inhibiteurs de mono fluoro-bêta-secretase |
WO2013142370A1 (fr) | 2012-03-19 | 2013-09-26 | Varghese John | Inhibiteurs de bace spécifiques de l'app (asbi) et leurs utilisations |
JO3143B1 (ar) | 2012-04-03 | 2017-09-20 | Lilly Co Eli | مركبات تتراهيدرو بيرولو ثيازين |
JPWO2013180265A1 (ja) | 2012-06-01 | 2016-01-21 | 武田薬品工業株式会社 | 複素環化合物 |
US9000183B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors |
US9000184B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors |
US9000185B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | Cycloalkyl ether compounds and their use as BACE inhibitors |
US9000182B2 (en) | 2012-06-20 | 2015-04-07 | Astrazeneca Ab | 2H-imidazol-4-amine compounds and their use as BACE inhibitors |
US10548882B2 (en) | 2012-06-21 | 2020-02-04 | Astrazeneca Ab | Camsylate salt |
WO2014062549A1 (fr) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Composés de dioxyde de thiadiazine substitués tricycliques en tant qu'inhibiteurs de bace, compositions et leur utilisation |
US9416129B2 (en) | 2012-10-17 | 2016-08-16 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use |
LT2912041T (lt) | 2012-10-26 | 2017-03-10 | Eli Lilly And Company | Tetrahidropiroltiazino dariniai kaip bace slopikliai |
WO2014099788A1 (fr) | 2012-12-21 | 2014-06-26 | Merck Sharp & Dohme Corp. | Dioxydes d'iminothiadiazine spiro c5 utilisés en tant qu'inhibiteurs de bace |
US20140371283A1 (en) | 2013-02-12 | 2014-12-18 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
TWI593692B (zh) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
JO3318B1 (ar) | 2013-06-18 | 2019-03-13 | Lilly Co Eli | مثبطات bace |
US9745324B2 (en) | 2013-12-18 | 2017-08-29 | Merck Sharp & Dohme Corp. | Iminothiadiazepane dioxide compounds as BACE inhibitors, compositions, and their use |
AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
CN104761557B (zh) * | 2015-04-08 | 2017-02-22 | 河南师范大学 | 六氢‑1H‑吡咯并[3,4‑d]嘧啶类化合物及其制备方法 |
AR104241A1 (es) | 2015-04-29 | 2017-07-05 | Lilly Co Eli | Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos |
EP3414253B1 (fr) | 2016-02-11 | 2021-07-21 | Merck Sharp & Dohme Corp. | Composés de dioxyde d'iminothiazine condensé oxacylique en c5 a c6 portant un lieur éther en tant qu'inhibiteurs de bace, compositions et leur utilisation |
CN107892697B (zh) * | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用,药物组合物 |
BR112020016784A2 (pt) | 2018-02-28 | 2021-01-12 | Japan Tobacco Inc. | Composto de di-hidropirimidinona ou di-hidropirimidinona condensado ao anel saturado e uso farmacêutico do mesmo |
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2006
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- 2006-06-12 EP EP06784807.7A patent/EP1896478B1/fr active Active
- 2006-06-12 TW TW095120854A patent/TWI332005B/zh active
- 2006-06-12 AR ARP060102461A patent/AR054617A1/es not_active Application Discontinuation
- 2006-06-12 RU RU2008100165/04A patent/RU2008100165A/ru not_active Application Discontinuation
- 2006-06-12 PE PE2006000655A patent/PE20070135A1/es not_active Application Discontinuation
- 2006-06-12 US US11/451,541 patent/US7868000B2/en active Active
- 2006-06-12 JP JP2008516997A patent/JP2008543849A/ja active Pending
- 2006-06-12 CA CA002609582A patent/CA2609582A1/fr not_active Abandoned
- 2006-06-12 SG SG201004170-5A patent/SG162790A1/en unknown
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- 2006-06-12 BR BRPI0612072-5A patent/BRPI0612072A2/pt not_active IP Right Cessation
- 2006-06-12 WO PCT/US2006/022918 patent/WO2006138264A2/fr active Application Filing
- 2006-06-12 AU AU2006259572A patent/AU2006259572A1/en not_active Abandoned
- 2006-06-12 CN CNA2006800215030A patent/CN101228163A/zh active Pending
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Also Published As
Publication number | Publication date |
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TW200716642A (en) | 2007-05-01 |
SG162790A1 (en) | 2010-07-29 |
JP2008201784A (ja) | 2008-09-04 |
WO2006138264A2 (fr) | 2006-12-28 |
CA2609582A1 (fr) | 2006-12-28 |
AR054617A1 (es) | 2007-07-04 |
ECSP078003A (es) | 2008-01-23 |
EP1896478B1 (fr) | 2014-05-21 |
EP1896478A2 (fr) | 2008-03-12 |
TWI332005B (en) | 2010-10-21 |
CN101228163A (zh) | 2008-07-23 |
KR20080029965A (ko) | 2008-04-03 |
JP2008543849A (ja) | 2008-12-04 |
PE20070135A1 (es) | 2007-03-09 |
IL187814A0 (en) | 2008-08-07 |
TW201004961A (en) | 2010-02-01 |
BRPI0612072A2 (pt) | 2010-10-19 |
MX2007016180A (es) | 2008-03-07 |
RU2008100165A (ru) | 2009-07-20 |
WO2006138264A3 (fr) | 2007-03-01 |
AU2006259572A1 (en) | 2006-12-28 |
US20070060575A1 (en) | 2007-03-15 |
US7868000B2 (en) | 2011-01-11 |
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