NO20076185L - 2-amido-6-amino-8-oksopurinderivater som "Toll-like receptor" modulatorer for behandling av cancer og virale infeksjoner slik som hepatitt C - Google Patents
2-amido-6-amino-8-oksopurinderivater som "Toll-like receptor" modulatorer for behandling av cancer og virale infeksjoner slik som hepatitt CInfo
- Publication number
- NO20076185L NO20076185L NO20076185A NO20076185A NO20076185L NO 20076185 L NO20076185 L NO 20076185L NO 20076185 A NO20076185 A NO 20076185A NO 20076185 A NO20076185 A NO 20076185A NO 20076185 L NO20076185 L NO 20076185L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- viral infections
- toll
- hepatitis
- cancer
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Foreliggende oppfinnelse angår purinderivater, fremgangsmåter for deres fremstilling, sammensetninger som inneholder dem og deres anvendelse. Foreliggende oppfinnelse tilveiebringer forbindelser med formel (1), hvori R1, R2, R3, R9, R9a og Y er definert i beskrivelsen. Mer spesielt angår foreliggende oppfinnelse anvendelse av purinderivater ved behandling av et antall virale infeksjoner og immun og inflammatoriske forstyrrelser, som inkluderer de hvori modulering, særlig agonisme, av Toll-lignende reseptorer (TLRer) er implisert. Følgelig er forbindelsene ifølge oppfinnelsen anvendelige ved behandling av infeksjonssykdommer slik som hepatitt (for eksempel HCV, HBV), genetisk relaterte virale infeksjoner, inflammatoriske sykdommer slik som astma og artritt og kreft.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67805405P | 2005-05-04 | 2005-05-04 | |
PCT/IB2006/001181 WO2006117670A1 (en) | 2005-05-04 | 2006-04-24 | 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20076185L true NO20076185L (no) | 2008-02-01 |
Family
ID=36698805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20076185A NO20076185L (no) | 2005-05-04 | 2007-11-30 | 2-amido-6-amino-8-oksopurinderivater som "Toll-like receptor" modulatorer for behandling av cancer og virale infeksjoner slik som hepatitt C |
Country Status (23)
Country | Link |
---|---|
US (1) | US7642350B2 (no) |
EP (1) | EP1888587A1 (no) |
JP (1) | JP2008540396A (no) |
KR (1) | KR20080006004A (no) |
CN (1) | CN101203519A (no) |
AR (1) | AR054269A1 (no) |
AU (1) | AU2006242920A1 (no) |
BR (1) | BRPI0611435A2 (no) |
CA (1) | CA2607780A1 (no) |
DO (1) | DOP2006000102A (no) |
EA (1) | EA200702235A1 (no) |
GT (1) | GT200600184A (no) |
IL (1) | IL187135A0 (no) |
MA (1) | MA29533B1 (no) |
MX (1) | MX2007013780A (no) |
NL (1) | NL1031741C2 (no) |
NO (1) | NO20076185L (no) |
PE (1) | PE20061439A1 (no) |
TN (1) | TNSN07411A1 (no) |
TW (1) | TW200716125A (no) |
UY (1) | UY29516A1 (no) |
WO (1) | WO2006117670A1 (no) |
ZA (1) | ZA200709591B (no) |
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US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
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US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
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2006
- 2006-04-24 EA EA200702235A patent/EA200702235A1/ru unknown
- 2006-04-24 EP EP06727586A patent/EP1888587A1/en not_active Withdrawn
- 2006-04-24 JP JP2008509532A patent/JP2008540396A/ja not_active Withdrawn
- 2006-04-24 CA CA002607780A patent/CA2607780A1/en not_active Abandoned
- 2006-04-24 CN CNA2006800222871A patent/CN101203519A/zh active Pending
- 2006-04-24 WO PCT/IB2006/001181 patent/WO2006117670A1/en active Application Filing
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- 2006-05-02 PE PE2006000461A patent/PE20061439A1/es not_active Application Discontinuation
- 2006-05-03 US US11/417,982 patent/US7642350B2/en not_active Expired - Fee Related
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Also Published As
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KR20080006004A (ko) | 2008-01-15 |
GT200600184A (es) | 2006-11-28 |
JP2008540396A (ja) | 2008-11-20 |
EP1888587A1 (en) | 2008-02-20 |
PE20061439A1 (es) | 2007-02-03 |
DOP2006000102A (es) | 2006-11-15 |
EA200702235A1 (ru) | 2008-04-28 |
TW200716125A (en) | 2007-05-01 |
TNSN07411A1 (fr) | 2009-03-17 |
MA29533B1 (fr) | 2008-06-02 |
AU2006242920A1 (en) | 2006-11-09 |
AR054269A1 (es) | 2007-06-13 |
CA2607780A1 (en) | 2006-11-09 |
US20060264448A1 (en) | 2006-11-23 |
NL1031741C2 (nl) | 2007-07-10 |
US7642350B2 (en) | 2010-01-05 |
NL1031741A1 (nl) | 2006-11-07 |
WO2006117670A1 (en) | 2006-11-09 |
ZA200709591B (en) | 2010-01-27 |
MX2007013780A (es) | 2008-02-05 |
IL187135A0 (en) | 2008-02-09 |
UY29516A1 (es) | 2006-11-30 |
CN101203519A (zh) | 2008-06-18 |
BRPI0611435A2 (pt) | 2010-09-08 |
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