NO20053242L - 4-substituerte benzimidazoler og deres anvendelse som inhibitorer av gastrisk sekresjon - Google Patents

4-substituerte benzimidazoler og deres anvendelse som inhibitorer av gastrisk sekresjon

Info

Publication number
NO20053242L
NO20053242L NO20053242A NO20053242A NO20053242L NO 20053242 L NO20053242 L NO 20053242L NO 20053242 A NO20053242 A NO 20053242A NO 20053242 A NO20053242 A NO 20053242A NO 20053242 L NO20053242 L NO 20053242L
Authority
NO
Norway
Prior art keywords
inhibitors
substituted benzimidazoles
gastric secretion
gastric
benzimidazoles
Prior art date
Application number
NO20053242A
Other languages
English (en)
Other versions
NO20053242D0 (no
Inventor
Gerhard Grundler
Jorg Senn-Bilfinger
Stefan Postius
Wolfgang-Alexander Simon
Wolfgang Kromer
M Vittoria Chiesa
Andreas Palmer
Christof Brehm
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of NO20053242D0 publication Critical patent/NO20053242D0/no
Publication of NO20053242L publication Critical patent/NO20053242L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen vedrører 6-substituerte benzimidazoler med formel 1, hvori substituentene og symbolene har betydningene indikert i beskrivelsen. Forbindelsene har gastrisk sekresjonshemmende og utmerkede gastriske og intestinale beskyttende virkningsegenskaper.
NO20053242A 2002-12-13 2005-07-01 4-substituerte benzimidazoler og deres anvendelse som inhibitorer av gastrisk sekresjon NO20053242L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02027874 2002-12-13
EP03021348 2003-09-20
PCT/EP2003/014069 WO2004054984A1 (en) 2002-12-13 2003-12-11 4-substituted benzimidazoles and their use as inhibitors of gastric secretion

Publications (2)

Publication Number Publication Date
NO20053242D0 NO20053242D0 (no) 2005-07-01
NO20053242L true NO20053242L (no) 2005-07-01

Family

ID=32598782

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053242A NO20053242L (no) 2002-12-13 2005-07-01 4-substituerte benzimidazoler og deres anvendelse som inhibitorer av gastrisk sekresjon

Country Status (19)

Country Link
US (1) US20060194969A1 (no)
EP (1) EP1575924A1 (no)
JP (1) JP2006511600A (no)
KR (1) KR20050084170A (no)
AR (1) AR043063A1 (no)
AU (1) AU2003294831A1 (no)
BR (1) BR0317041A (no)
CA (1) CA2508838A1 (no)
CO (1) CO5580786A2 (no)
EA (1) EA008779B1 (no)
HR (1) HRP20050612A2 (no)
IS (1) IS7926A (no)
MX (1) MXPA05006052A (no)
NO (1) NO20053242L (no)
NZ (1) NZ540862A (no)
PL (1) PL375820A1 (no)
RS (1) RS20050435A (no)
TW (1) TW200504031A (no)
WO (1) WO2004054984A1 (no)

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* Cited by examiner, † Cited by third party
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AR043962A1 (es) 2003-04-04 2005-08-17 Altana Pharma Ag Compuestos derivados de bencimidazol, medicamentos que los contienen y su uso para preparar dichos medicamentos.
AR049168A1 (es) * 2004-05-18 2006-07-05 Altana Pharma Ag Derivados de benzimidazol
WO2006061380A2 (en) * 2004-12-09 2006-06-15 Altana Pharma Ag SUBSTITUTED IMIDAZO[4,5-b]PYRIDINES AS INHIBITORS OF GASTRIC ACID SECRETION
WO2006100254A1 (en) * 2005-03-24 2006-09-28 Nycomed Gmbh 6-thioamide substituted benzimidazoles
US7718809B2 (en) 2005-06-14 2010-05-18 Raqualia Pharma Inc. Chromane substituted benzimidazole derivatives as acid pump antagonists
AR057061A1 (es) * 2005-06-16 2007-11-14 Altana Pharma Ag Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos
AU2006283876A1 (en) * 2005-08-22 2007-03-01 Nycomed Gmbh Isotopically substituted benzimidazole derivatives
WO2007031860A1 (en) * 2005-09-15 2007-03-22 Pfizer Japan Inc. Indane substituted benzimidazoles and their use as acid pump inhibitors
BRPI0620081B8 (pt) * 2005-12-19 2021-05-25 Pfizer composto e composição farmacêutica.
WO2007072142A2 (en) * 2005-12-19 2007-06-28 Pfizer Japan Inc. Benzimidazole-5-carboxamide derivatives
WO2008017466A1 (en) * 2006-08-08 2008-02-14 Nycomed Gmbh Pharmaceutically active tetrahydroisoquinoline-substituted benzimidazole derivatives
BRPI0717102A2 (pt) 2006-09-21 2013-10-29 Raqualia Pharma Inc Derivados de benzimidazol como inibidores seletivos de bomba de ácido
WO2008071765A1 (en) * 2006-12-14 2008-06-19 Nycomed Gmbh Pharmaceutically active spiro-substituted benzimidazole derivatives
WO2008084067A2 (en) * 2007-01-12 2008-07-17 Nycomed Gmbh Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives
WO2008151927A2 (en) * 2007-06-15 2008-12-18 Nycomed Gmbh 6-n-substituted benz imidazole derivatives as acid pump antagonists
EP2182805B1 (en) * 2007-08-27 2013-06-26 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
WO2010081670A2 (en) * 2009-01-14 2010-07-22 Lonza Ltd Process for the preparation of benzimidazoles
WO2011004882A1 (ja) 2009-07-09 2011-01-13 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
WO2012081036A2 (en) * 2010-12-13 2012-06-21 Sequent Scientific Limited A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione)
RU2506259C1 (ru) * 2012-12-04 2014-02-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный университет им. П.Г. Демидова" Способ получения 4-{4-амино-2-хлоро-5-[(5-хлоро-2-метил-1н-бензимидазол-6-ил)амино]фенокси}бензойной кислоты
WO2014124458A1 (en) 2013-02-11 2014-08-14 The Regents Of The University Of California Compositions and methods for treating neurodegenerative diseases
PL3010503T3 (pl) 2013-06-21 2020-08-24 Zenith Epigenetics Ltd. Nowe bicykliczne inhibitory bromodomen
WO2015004534A2 (en) * 2013-06-21 2015-01-15 Zenith Epigenetics Corp. Novel substituted bicyclic compounds as bromodomain inhibitors
KR101472686B1 (ko) 2013-07-09 2014-12-16 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 제조방법
CN105593224B (zh) 2013-07-31 2021-05-25 恒元生物医药科技(苏州)有限公司 作为溴结构域抑制剂的新型喹唑啉酮类化合物
US10710992B2 (en) 2014-12-01 2020-07-14 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
US10292968B2 (en) 2014-12-11 2019-05-21 Zenith Epigenetics Ltd. Substituted heterocycles as bromodomain inhibitors
CN107406438B (zh) 2014-12-17 2021-05-14 恒翼生物医药科技(上海)有限公司 溴结构域的抑制剂
KR101684053B1 (ko) 2015-01-20 2016-12-08 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법
DK3305291T3 (da) * 2015-06-08 2021-06-28 Hk Inno N Corp Anvendelser af benzimidazolderivat mod natligt syregennembrud
AU2018290225A1 (en) * 2017-06-21 2020-01-23 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
CN113527272B (zh) * 2021-08-06 2023-07-21 西安淳甄新材料有限公司 一种特戈拉赞的合成方法
KR20230099093A (ko) 2021-12-27 2023-07-04 에이치케이이노엔 주식회사 벤즈이미다졸 유도체의 제조방법

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SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
IL108520A (en) * 1993-02-15 1997-09-30 Byk Gulden Lomberg Chem Fab 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
SE9602286D0 (sv) * 1996-06-10 1996-06-10 Astra Ab New compounds

Also Published As

Publication number Publication date
MXPA05006052A (es) 2005-08-18
KR20050084170A (ko) 2005-08-26
HRP20050612A2 (en) 2006-08-31
RS20050435A (en) 2007-08-03
CA2508838A1 (en) 2004-07-01
EA200500895A1 (ru) 2005-12-29
AU2003294831A1 (en) 2004-07-09
US20060194969A1 (en) 2006-08-31
CO5580786A2 (es) 2005-11-30
EP1575924A1 (en) 2005-09-21
JP2006511600A (ja) 2006-04-06
NZ540862A (en) 2008-07-31
IS7926A (is) 2005-07-01
TW200504031A (en) 2005-02-01
NO20053242D0 (no) 2005-07-01
EA008779B1 (ru) 2007-08-31
WO2004054984A1 (en) 2004-07-01
PL375820A1 (en) 2005-12-12
AR043063A1 (es) 2005-07-13
BR0317041A (pt) 2005-10-25

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