NO20050841L - Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer - Google Patents
Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorerInfo
- Publication number
- NO20050841L NO20050841L NO20050841A NO20050841A NO20050841L NO 20050841 L NO20050841 L NO 20050841L NO 20050841 A NO20050841 A NO 20050841A NO 20050841 A NO20050841 A NO 20050841A NO 20050841 L NO20050841 L NO 20050841L
- Authority
- NO
- Norway
- Prior art keywords
- sub
- sup
- optionally substituted
- formula
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0221455A GB0221455D0 (en) | 2002-09-16 | 2002-09-16 | Compounds |
GBGB0230045.7A GB0230045D0 (en) | 2002-12-23 | 2002-12-23 | Compounds |
GB0306595A GB0306595D0 (en) | 2003-03-21 | 2003-03-21 | Compounds |
GB0308017A GB0308017D0 (en) | 2003-04-07 | 2003-04-07 | Compounds |
GB0319708A GB0319708D0 (en) | 2003-08-21 | 2003-08-21 | Compounds |
GB0321074A GB0321074D0 (en) | 2003-09-09 | 2003-09-09 | Compounds |
PCT/EP2003/011814 WO2004024728A2 (en) | 2002-09-16 | 2003-09-12 | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20050841L true NO20050841L (no) | 2005-06-15 |
Family
ID=31999797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20050841A NO20050841L (no) | 2002-09-16 | 2005-02-16 | Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer |
Country Status (23)
Country | Link |
---|---|
US (2) | US20060089375A1 (pl) |
EP (1) | EP1539753B1 (pl) |
JP (1) | JP2006503108A (pl) |
KR (1) | KR20050052501A (pl) |
CN (1) | CN100387598C (pl) |
AT (1) | ATE442367T1 (pl) |
AU (1) | AU2010201417A1 (pl) |
BR (1) | BR0314392A (pl) |
CA (1) | CA2497550A1 (pl) |
CY (1) | CY1109619T1 (pl) |
DE (1) | DE60329193D1 (pl) |
DK (1) | DK1539753T3 (pl) |
ES (1) | ES2331119T3 (pl) |
IL (1) | IL166898A (pl) |
IS (1) | IS7709A (pl) |
MA (1) | MA27475A1 (pl) |
MX (1) | MXPA05002887A (pl) |
NO (1) | NO20050841L (pl) |
NZ (1) | NZ538515A (pl) |
PL (1) | PL375993A1 (pl) |
PT (1) | PT1539753E (pl) |
SI (1) | SI1539753T1 (pl) |
WO (1) | WO2004024728A2 (pl) |
Families Citing this family (90)
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PL375993A1 (pl) * | 2002-09-16 | 2005-12-12 | Glaxo Group Limited | Związki pirazolo[3,4-b]pirydynowe i ich zastosowanie jako inhibitorów fosfodiesterazy |
GB0230045D0 (en) | 2002-12-23 | 2003-01-29 | Glaxo Group Ltd | Compounds |
EP1608652A1 (en) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
CN1809351A (zh) | 2003-04-24 | 2006-07-26 | 麦克公司 | Akt活性抑制剂 |
GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
US20070111995A1 (en) * | 2003-12-19 | 2007-05-17 | Allen David G | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors |
GB0405933D0 (en) * | 2004-03-16 | 2004-04-21 | Glaxo Group Ltd | Compounds |
EP1740590A1 (en) * | 2004-03-16 | 2007-01-10 | Glaxo Group Limited | PYRAZOLO [3,4- b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS |
AU2005227733A1 (en) | 2004-04-02 | 2005-10-13 | Glaxo Group Limited | Chemical process and new crystalline form |
PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
EP1763528B1 (en) * | 2004-07-05 | 2008-11-26 | Astellas Pharma Inc. | Pyrazolopyridine derivatives |
GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
WO2006072599A2 (en) | 2005-01-10 | 2006-07-13 | Glaxo Group Limited | Androstane 17-alpha carbonate derivatives for use in the treatment of allergic and inflammatory conditions |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
US20090131431A1 (en) * | 2005-09-29 | 2009-05-21 | Christopher David Edlin | Pyrazolo[3,4-b]pyridine compounds, and their use as a PDE4 inhibitors |
AR058109A1 (es) | 2005-12-20 | 2008-01-23 | Glaxo Group Ltd | Acido 3 - (4 - {[4 -(4 -{[3 - (3, 3 - dimetil - 1 - piperidinil)propil]oxi}fenil) - 1 - piperidinil]carbonil} - 1 - naftalenil)propanoico como antagonistas de los receptotres de histamina h1/h3, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamie |
US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
US7829713B2 (en) * | 2006-02-28 | 2010-11-09 | Helicon Therapeutics, Inc. | Therapeutic piperazines |
MX2008011220A (es) | 2006-03-07 | 2008-09-11 | Array Biopharma Inc | Compuestos de pirazol heterobiciclicos y metodos de uso. |
ES2388351T3 (es) | 2006-04-20 | 2012-10-11 | Glaxo Group Limited | Compuestos novedosos |
GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
TW200817006A (en) | 2006-06-23 | 2008-04-16 | Smithkline Beecham Corp | IL-8 receptor antagonist |
US20090325952A1 (en) | 2006-08-01 | 2009-12-31 | Glaxo Group Limited | Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
WO2009041591A1 (ja) * | 2007-09-28 | 2009-04-02 | Kyowa Hakko Kirin Co., Ltd. | 縮環ピリジン誘導体 |
EP2070929A1 (en) * | 2007-12-11 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
PE20091553A1 (es) * | 2008-02-06 | 2009-10-30 | Glaxo Group Ltd | Farmacoforos duales - antagonistas muscarinicos de pde4 |
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JP5502858B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | Pi3キナーゼの阻害剤として有用な4−カルボキサミドインダゾール誘導体 |
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JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ikk2阻害剤としてのインドール誘導体 |
US20120058984A1 (en) | 2009-03-17 | 2012-03-08 | Catherine Mary Alder | Pyrimidine derivatives used as itk inhibitors |
US20120016011A1 (en) | 2009-03-19 | 2012-01-19 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
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WO2010107957A2 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GATA BINDING PROTEIN 3 (GATA3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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US20100273744A1 (en) | 2009-04-24 | 2010-10-28 | Paul Martin Gore | Compounds |
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US3840546A (en) * | 1972-11-15 | 1974-10-08 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine carboxamides |
US3979399A (en) * | 1972-11-15 | 1976-09-07 | E. R. Squibb & Sons, Inc. | Amino derivatives of pyrazolopyridine carboxamides |
US3833598A (en) * | 1972-12-29 | 1974-09-03 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine-6-carboxylic acids and esters |
US4115394A (en) * | 1974-05-06 | 1978-09-19 | E. R. Squibb & Sons, Inc. | Amino derivatives of 6-phenylpyrazolo[3,4-b]pyridines |
US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
US6326379B1 (en) * | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
JP2002020386A (ja) * | 2000-07-07 | 2002-01-23 | Ono Pharmaceut Co Ltd | ピラゾロピリジン誘導体 |
US20050043319A1 (en) * | 2001-08-14 | 2005-02-24 | Exonhit Therapeutics Sa | Molecular target of neurotoxicity |
GB0230045D0 (en) * | 2002-12-23 | 2003-01-29 | Glaxo Group Ltd | Compounds |
PL375993A1 (pl) * | 2002-09-16 | 2005-12-12 | Glaxo Group Limited | Związki pirazolo[3,4-b]pirydynowe i ich zastosowanie jako inhibitorów fosfodiesterazy |
US20070111995A1 (en) * | 2003-12-19 | 2007-05-17 | Allen David G | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors |
-
2003
- 2003-09-12 PL PL03375993A patent/PL375993A1/pl not_active Application Discontinuation
- 2003-09-12 NZ NZ538515A patent/NZ538515A/en unknown
- 2003-09-12 KR KR1020057004514A patent/KR20050052501A/ko not_active Application Discontinuation
- 2003-09-12 PT PT03778283T patent/PT1539753E/pt unknown
- 2003-09-12 WO PCT/EP2003/011814 patent/WO2004024728A2/en active Application Filing
- 2003-09-12 SI SI200331680T patent/SI1539753T1/sl unknown
- 2003-09-12 CA CA002497550A patent/CA2497550A1/en not_active Abandoned
- 2003-09-12 DK DK03778283T patent/DK1539753T3/da active
- 2003-09-12 EP EP03778283A patent/EP1539753B1/en not_active Expired - Lifetime
- 2003-09-12 AT AT03778283T patent/ATE442367T1/de active
- 2003-09-12 BR BR0314392-9A patent/BR0314392A/pt not_active IP Right Cessation
- 2003-09-12 CN CNB038250438A patent/CN100387598C/zh not_active Expired - Fee Related
- 2003-09-12 DE DE60329193T patent/DE60329193D1/de not_active Expired - Lifetime
- 2003-09-12 MX MXPA05002887A patent/MXPA05002887A/es active IP Right Grant
- 2003-09-12 ES ES03778283T patent/ES2331119T3/es not_active Expired - Lifetime
- 2003-09-12 US US10/527,866 patent/US20060089375A1/en not_active Abandoned
- 2003-09-12 JP JP2004571743A patent/JP2006503108A/ja active Pending
-
2005
- 2005-02-15 IL IL166898A patent/IL166898A/en not_active IP Right Cessation
- 2005-02-16 NO NO20050841A patent/NO20050841L/no unknown
- 2005-02-24 IS IS7709A patent/IS7709A/is unknown
- 2005-04-15 MA MA28224A patent/MA27475A1/fr unknown
-
2008
- 2008-01-14 US US12/013,529 patent/US20080175914A1/en not_active Abandoned
-
2009
- 2009-11-24 CY CY20091101212T patent/CY1109619T1/el unknown
-
2010
- 2010-04-08 AU AU2010201417A patent/AU2010201417A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003285300A1 (en) | 2004-04-30 |
MA27475A1 (fr) | 2005-08-01 |
MXPA05002887A (es) | 2005-05-27 |
CN100387598C (zh) | 2008-05-14 |
JP2006503108A (ja) | 2006-01-26 |
DE60329193D1 (de) | 2009-10-22 |
PT1539753E (pt) | 2009-12-10 |
DK1539753T3 (da) | 2010-01-04 |
BR0314392A (pt) | 2005-07-12 |
EP1539753B1 (en) | 2009-09-09 |
CY1109619T1 (el) | 2014-08-13 |
ES2331119T3 (es) | 2009-12-22 |
PL375993A1 (pl) | 2005-12-12 |
KR20050052501A (ko) | 2005-06-02 |
AU2010201417A1 (en) | 2010-04-29 |
EP1539753A2 (en) | 2005-06-15 |
US20060089375A1 (en) | 2006-04-27 |
WO2004024728A2 (en) | 2004-03-25 |
US20080175914A1 (en) | 2008-07-24 |
IS7709A (is) | 2005-02-24 |
CN1694882A (zh) | 2005-11-09 |
IL166898A (en) | 2010-06-30 |
CA2497550A1 (en) | 2004-03-25 |
SI1539753T1 (sl) | 2009-12-31 |
NZ538515A (en) | 2007-04-27 |
WO2004024728A3 (en) | 2004-10-21 |
ATE442367T1 (de) | 2009-09-15 |
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