NO20045451L - N-substituerte tricykliske 3-aminopyrazoler som PDGF receptorinibitorer - Google Patents
N-substituerte tricykliske 3-aminopyrazoler som PDGF receptorinibitorerInfo
- Publication number
- NO20045451L NO20045451L NO20045451A NO20045451A NO20045451L NO 20045451 L NO20045451 L NO 20045451L NO 20045451 A NO20045451 A NO 20045451A NO 20045451 A NO20045451 A NO 20045451A NO 20045451 L NO20045451 L NO 20045451L
- Authority
- NO
- Norway
- Prior art keywords
- aminopyrazoles
- substituted tricyclic
- receptor inhibitors
- pdgf receptor
- compounds
- Prior art date
Links
- 108091008606 PDGF receptors Proteins 0.000 title abstract 3
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 title abstract 3
- JVVRJMXHNUAPHW-UHFFFAOYSA-N 1h-pyrazol-5-amine Chemical class NC=1C=CNN=1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38073502P | 2002-05-15 | 2002-05-15 | |
PCT/US2003/015193 WO2003097609A1 (en) | 2002-05-15 | 2003-05-13 | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20045451L true NO20045451L (no) | 2005-02-09 |
Family
ID=29550005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20045451A NO20045451L (no) | 2002-05-15 | 2004-12-14 | N-substituerte tricykliske 3-aminopyrazoler som PDGF receptorinibitorer |
Country Status (29)
Country | Link |
---|---|
US (2) | US7196110B2 (es) |
EP (1) | EP1506175B1 (es) |
JP (1) | JP2006502097A (es) |
KR (1) | KR20040106554A (es) |
CN (1) | CN100396670C (es) |
AR (1) | AR040079A1 (es) |
AT (1) | ATE427301T1 (es) |
AU (1) | AU2003234567A1 (es) |
BR (1) | BRPI0311179A2 (es) |
CA (1) | CA2486097A1 (es) |
CR (1) | CR7574A (es) |
DE (1) | DE60326950D1 (es) |
EA (1) | EA008770B1 (es) |
ES (1) | ES2323952T3 (es) |
HR (1) | HRP20041188A2 (es) |
IL (1) | IL165197A0 (es) |
MX (1) | MXPA04011320A (es) |
MY (1) | MY138268A (es) |
NO (1) | NO20045451L (es) |
NZ (1) | NZ548796A (es) |
PE (1) | PE20040758A1 (es) |
PL (1) | PL374062A1 (es) |
RS (1) | RS98804A (es) |
SA (1) | SA03240431A (es) |
TW (1) | TW200407311A (es) |
UA (1) | UA80820C2 (es) |
UY (1) | UY27811A1 (es) |
WO (1) | WO2003097609A1 (es) |
ZA (1) | ZA200410108B (es) |
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PL374062A1 (en) * | 2002-05-15 | 2005-09-19 | Janssen Pharmaceutica N.V. | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors |
CN1914179A (zh) * | 2003-11-13 | 2007-02-14 | 詹森药业有限公司 | 用于生物分子靶标识别的固定的n-取代的三环3-氨基吡唑类 |
EP1711825A4 (en) * | 2004-01-07 | 2008-01-23 | Ambit Biosciences Corp | SMALL MOLECULES CONJUGATED |
WO2005123048A2 (en) * | 2004-06-21 | 2005-12-29 | Proteome Sciences Plc | Screening methods using c-abl, fyn and syk in combination with tau protein |
CA2573190A1 (en) * | 2004-07-09 | 2006-01-26 | Medisyn Technologies, Inc. | Mt477 and related compounds for the treatment of various cancers |
CA2583177A1 (en) * | 2004-10-13 | 2006-04-27 | Ptc Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
JP2006321724A (ja) * | 2005-05-17 | 2006-11-30 | Tokyo Univ Of Science | 抗腫瘍剤 |
EP2037954A4 (en) * | 2006-06-20 | 2011-09-14 | Janssen Pharmaceutica Nv | METHOD FOR MODULATING PHARMACOKINETICS AND METABOLISM OF THERAPEUTIC USE |
US20080031866A1 (en) * | 2006-06-20 | 2008-02-07 | Eichenbaum Gary M | Method for modulating the pharmacokinetics and metabolism of a therapeutic agent |
EP2128138A1 (en) | 2007-01-29 | 2009-12-02 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
US7816390B2 (en) | 2007-01-31 | 2010-10-19 | Janssen Pharmaceutica Nv | N-substituted tricyclic 3-aminopyrazoles as anti-mitotic tubulin polymerization inhibitors |
US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
US9220837B2 (en) | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
CN104069567A (zh) | 2007-03-19 | 2014-10-01 | 茵苏莱恩医药有限公司 | 药物输送设备 |
US8409133B2 (en) | 2007-12-18 | 2013-04-02 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
RU2532893C2 (ru) | 2008-11-07 | 2014-11-10 | Инсьюлин Медикал Лтд. | Устройство и способ доставки лекарственных средств |
WO2011059784A1 (en) * | 2009-10-29 | 2011-05-19 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
JPWO2012121168A1 (ja) * | 2011-03-04 | 2014-07-17 | 国立大学法人京都大学 | キナーゼ阻害剤 |
TWI553010B (zh) * | 2012-04-12 | 2016-10-11 | 財團法人生物技術開發中心 | 雜環吡唑化合物,其製備方法及用途 |
CN107383009B (zh) | 2012-06-13 | 2020-06-09 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9475816B2 (en) | 2012-09-07 | 2016-10-25 | Takeda Pharmaceutical Company Limited | Substituted-1,4-dihydropyrazolo[4,3-b]indoles |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
SG11201507255QA (en) * | 2013-03-14 | 2015-10-29 | Newlink Genetics Corp | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
SG11201508328PA (en) | 2013-04-19 | 2015-11-27 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
CN105884828A (zh) * | 2015-02-16 | 2016-08-24 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
CN107438607B (zh) | 2015-02-20 | 2021-02-05 | 因赛特公司 | 作为fgfr抑制剂的双环杂环 |
US10633354B2 (en) | 2016-09-02 | 2020-04-28 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
WO2019032631A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | OXIME ETHER COMPOUNDS |
CA3099116A1 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Salts of an fgfr inhibitor |
AU2019262195B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
JP2022552324A (ja) | 2019-10-14 | 2022-12-15 | インサイト・コーポレイション | Fgfr阻害剤としての二環式複素環 |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
JP2024522189A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Fgfr阻害剤としての三環式ヘテロ環 |
IL312506A (en) | 2021-11-08 | 2024-07-01 | Progentos Therapeutics Inc | Platelet-based alpha inhibitors and their uses |
CN114890987B (zh) * | 2022-04-13 | 2023-12-19 | 万华化学集团股份有限公司 | 一种硫酚-噻吩配体及其制备方法、烯烃聚合催化剂及其制备方法、应用 |
CN114686427B (zh) * | 2022-05-23 | 2022-07-29 | 中国人民解放军总医院第一医学中心 | 一种脾脏调节型b淋巴细胞及其制备方法与应用 |
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US4140785A (en) * | 1978-05-08 | 1979-02-20 | E. I. Du Pont De Nemours And Company | N-(benzothienopyrazol)amide antirhinoviral agents |
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-
2003
- 2003-05-13 PL PL03374062A patent/PL374062A1/xx not_active Application Discontinuation
- 2003-05-13 ES ES03728909T patent/ES2323952T3/es not_active Expired - Lifetime
- 2003-05-13 AT AT03728909T patent/ATE427301T1/de not_active IP Right Cessation
- 2003-05-13 RS YU98804A patent/RS98804A/sr unknown
- 2003-05-13 CA CA002486097A patent/CA2486097A1/en not_active Abandoned
- 2003-05-13 EP EP03728909A patent/EP1506175B1/en not_active Expired - Lifetime
- 2003-05-13 EA EA200401378A patent/EA008770B1/ru not_active IP Right Cessation
- 2003-05-13 CN CNB038164884A patent/CN100396670C/zh not_active Expired - Fee Related
- 2003-05-13 DE DE60326950T patent/DE60326950D1/de not_active Expired - Fee Related
- 2003-05-13 JP JP2004505342A patent/JP2006502097A/ja not_active Withdrawn
- 2003-05-13 BR BRPI0311179A patent/BRPI0311179A2/pt not_active IP Right Cessation
- 2003-05-13 WO PCT/US2003/015193 patent/WO2003097609A1/en active Application Filing
- 2003-05-13 NZ NZ548796A patent/NZ548796A/en unknown
- 2003-05-13 MY MYPI20031800A patent/MY138268A/en unknown
- 2003-05-13 AU AU2003234567A patent/AU2003234567A1/en not_active Abandoned
- 2003-05-13 MX MXPA04011320A patent/MXPA04011320A/es active IP Right Grant
- 2003-05-13 UA UA20041109391A patent/UA80820C2/uk unknown
- 2003-05-13 KR KR10-2004-7018454A patent/KR20040106554A/ko not_active Application Discontinuation
- 2003-05-14 US US10/438,152 patent/US7196110B2/en not_active Expired - Lifetime
- 2003-05-14 TW TW092113012A patent/TW200407311A/zh unknown
- 2003-05-15 PE PE2003000466A patent/PE20040758A1/es not_active Application Discontinuation
- 2003-05-15 UY UY27811A patent/UY27811A1/es not_active Application Discontinuation
- 2003-05-15 AR ARP030101696A patent/AR040079A1/es not_active Application Discontinuation
- 2003-12-07 SA SA03240431A patent/SA03240431A/ar unknown
-
2004
- 2004-11-14 IL IL16519704A patent/IL165197A0/xx unknown
- 2004-11-15 CR CR7574A patent/CR7574A/es not_active Application Discontinuation
- 2004-12-14 ZA ZA200410108A patent/ZA200410108B/en unknown
- 2004-12-14 HR HR20041188A patent/HRP20041188A2/xx not_active Application Discontinuation
- 2004-12-14 NO NO20045451A patent/NO20045451L/no unknown
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2007
- 2007-01-25 US US11/657,912 patent/US7795440B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CR7574A (es) | 2008-09-10 |
EP1506175A1 (en) | 2005-02-16 |
UY27811A1 (es) | 2003-10-31 |
AU2003234567A1 (en) | 2003-12-02 |
TW200407311A (en) | 2004-05-16 |
DE60326950D1 (de) | 2009-05-14 |
HRP20041188A2 (en) | 2007-03-31 |
AR040079A1 (es) | 2005-03-16 |
MXPA04011320A (es) | 2005-08-16 |
US20040082639A1 (en) | 2004-04-29 |
US7196110B2 (en) | 2007-03-27 |
CN1668601A (zh) | 2005-09-14 |
EP1506175B1 (en) | 2009-04-01 |
WO2003097609A1 (en) | 2003-11-27 |
CA2486097A1 (en) | 2003-11-27 |
RS98804A (en) | 2006-10-27 |
MY138268A (en) | 2009-05-29 |
IL165197A0 (en) | 2005-12-18 |
BRPI0311179A2 (pt) | 2016-06-21 |
PL374062A1 (en) | 2005-09-19 |
ES2323952T3 (es) | 2009-07-28 |
US7795440B2 (en) | 2010-09-14 |
JP2006502097A (ja) | 2006-01-19 |
ATE427301T1 (de) | 2009-04-15 |
US20070142305A1 (en) | 2007-06-21 |
UA80820C2 (en) | 2007-11-12 |
KR20040106554A (ko) | 2004-12-17 |
SA03240431A (ar) | 2005-12-03 |
ZA200410108B (en) | 2006-05-31 |
CN100396670C (zh) | 2008-06-25 |
NZ548796A (en) | 2008-01-31 |
EA200401378A1 (ru) | 2005-06-30 |
EA008770B1 (ru) | 2007-08-31 |
PE20040758A1 (es) | 2005-01-01 |
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