UY27811A1 - 3-aminopirazoles n-sustituidos como inhibidores para el tratamiento de los desórdenes proliferativos de las células. - Google Patents

3-aminopirazoles n-sustituidos como inhibidores para el tratamiento de los desórdenes proliferativos de las células.

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Publication number
UY27811A1
UY27811A1 UY27811A UY27811A UY27811A1 UY 27811 A1 UY27811 A1 UY 27811A1 UY 27811 A UY27811 A UY 27811A UY 27811 A UY27811 A UY 27811A UY 27811 A1 UY27811 A1 UY 27811A1
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UY
Uruguay
Prior art keywords
inhibitors
substituted
aminopirazols
cells
treatment
Prior art date
Application number
UY27811A
Other languages
English (en)
Inventor
Chih Yung Ho
Bengt Anders Brunmark
Stuart Emanuel
Robert A Galemmo Jr
Dana I Hohnson
Donald W Ludovici
Umar Maharoof
Jay M Mei
Jam I Sechler
Eric D Strobel
Robert W Tuman
Hwa Kwo Yen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY27811A1 publication Critical patent/UY27811A1/es

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/04—Ortho-condensed systems

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Abstract

La invención está dirigida a derivados 3Aaminipirazol tricíclicos N-sustituídos, que son utilizados como inhibidores de la quinasa de receptor del factor de crecimiento derivado de plaquetas (PDGF-R), y los métodos para la preparación de dichos derivados. La presente invención está dirigida además a las composiciones farmacéuticas que comprenden los compuestos de la presente invención y a los métodos para tratar las afecciones tales como tumores y otros desórdenes proliferativos de células.
UY27811A 2002-05-15 2003-05-15 3-aminopirazoles n-sustituidos como inhibidores para el tratamiento de los desórdenes proliferativos de las células. UY27811A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38073502P 2002-05-15 2002-05-15

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UY27811A1 true UY27811A1 (es) 2003-10-31

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UY27811A UY27811A1 (es) 2002-05-15 2003-05-15 3-aminopirazoles n-sustituidos como inhibidores para el tratamiento de los desórdenes proliferativos de las células.

Country Status (29)

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US (2) US7196110B2 (es)
EP (1) EP1506175B1 (es)
JP (1) JP2006502097A (es)
KR (1) KR20040106554A (es)
CN (1) CN100396670C (es)
AR (1) AR040079A1 (es)
AT (1) ATE427301T1 (es)
AU (1) AU2003234567A1 (es)
BR (1) BRPI0311179A2 (es)
CA (1) CA2486097A1 (es)
CR (1) CR7574A (es)
DE (1) DE60326950D1 (es)
EA (1) EA008770B1 (es)
ES (1) ES2323952T3 (es)
HR (1) HRP20041188A2 (es)
IL (1) IL165197A0 (es)
MX (1) MXPA04011320A (es)
MY (1) MY138268A (es)
NO (1) NO20045451L (es)
NZ (1) NZ548796A (es)
PE (1) PE20040758A1 (es)
PL (1) PL374062A1 (es)
RS (1) RS98804A (es)
SA (1) SA03240431A (es)
TW (1) TW200407311A (es)
UA (1) UA80820C2 (es)
UY (1) UY27811A1 (es)
WO (1) WO2003097609A1 (es)
ZA (1) ZA200410108B (es)

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AR040079A1 (es) 2005-03-16
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