NO20024421L - Polyglutaminsyre-camptothecin-konjugater og fremgangsmÕte for fremstilling av disse - Google Patents

Polyglutaminsyre-camptothecin-konjugater og fremgangsmÕte for fremstilling av disse Download PDF

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Publication number
NO20024421L
NO20024421L NO20024421A NO20024421A NO20024421L NO 20024421 L NO20024421 L NO 20024421L NO 20024421 A NO20024421 A NO 20024421A NO 20024421 A NO20024421 A NO 20024421A NO 20024421 L NO20024421 L NO 20024421L
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NO
Norway
Prior art keywords
camptothecin
approx
polyglutamic acid
conjugate
weight
Prior art date
Application number
NO20024421A
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English (en)
Norwegian (no)
Other versions
NO20024421D0 (no
Inventor
Rama Bhatt
Peter De Vries
Peter J Klein
Robert A Lewis
Jack W Singer
John Tulinsky
Original Assignee
Cell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of NO20024421D0 publication Critical patent/NO20024421D0/no
Publication of NO20024421L publication Critical patent/NO20024421L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
NO20024421A 2000-03-17 2002-09-16 Polyglutaminsyre-camptothecin-konjugater og fremgangsmÕte for fremstilling av disse NO20024421L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19042900P 2000-03-17 2000-03-17
PCT/US2001/008553 WO2001070275A2 (en) 2000-03-17 2001-03-19 Polyglutamic acid-camptothecin conjugates and methods of preparation

Publications (2)

Publication Number Publication Date
NO20024421D0 NO20024421D0 (no) 2002-09-16
NO20024421L true NO20024421L (no) 2002-11-15

Family

ID=22701317

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024421A NO20024421L (no) 2000-03-17 2002-09-16 Polyglutaminsyre-camptothecin-konjugater og fremgangsmÕte for fremstilling av disse

Country Status (20)

Country Link
US (1) US20020016285A1 (zh)
EP (1) EP1267939A2 (zh)
JP (1) JP2003527443A (zh)
KR (1) KR20020082888A (zh)
CN (1) CN1429121A (zh)
AU (1) AU2001247513A1 (zh)
BR (1) BR0109272A (zh)
CA (1) CA2402643A1 (zh)
CZ (1) CZ20023330A3 (zh)
HU (1) HUP0204562A2 (zh)
IL (1) IL151685A0 (zh)
MX (1) MXPA02009082A (zh)
NO (1) NO20024421L (zh)
PL (1) PL358335A1 (zh)
RU (1) RU2002128610A (zh)
SI (1) SI21172A (zh)
SK (1) SK14822002A3 (zh)
TR (1) TR200202194T2 (zh)
WO (1) WO2001070275A2 (zh)
ZA (1) ZA200207423B (zh)

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Also Published As

Publication number Publication date
WO2001070275A3 (en) 2002-01-03
AU2001247513A1 (en) 2001-10-03
HUP0204562A2 (hu) 2003-04-28
CZ20023330A3 (cs) 2003-02-12
ZA200207423B (en) 2003-12-17
MXPA02009082A (es) 2003-12-11
SK14822002A3 (sk) 2003-05-02
CN1429121A (zh) 2003-07-09
JP2003527443A (ja) 2003-09-16
IL151685A0 (en) 2003-04-10
SI21172A (sl) 2003-10-31
KR20020082888A (ko) 2002-10-31
NO20024421D0 (no) 2002-09-16
US20020016285A1 (en) 2002-02-07
BR0109272A (pt) 2004-06-29
EP1267939A2 (en) 2003-01-02
TR200202194T2 (tr) 2003-01-21
WO2001070275A2 (en) 2001-09-27
CA2402643A1 (en) 2001-09-27
PL358335A1 (en) 2004-08-09
RU2002128610A (ru) 2004-03-27

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