NO20023567L - Alkynylsubstituerte propionsyrederivater og deres anvendelse mot sukkersyke og fedme - Google Patents

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Publication number

NO20023567L

NO20023567L NO20023567A NO20023567A NO20023567L NO 20023567 L NO20023567 L NO 20023567L NO 20023567 A NO20023567 A NO 20023567A NO 20023567 A NO20023567 A NO 20023567A NO 20023567 L NO20023567 L NO 20023567L

Authority

NO

Norway

Prior art keywords

ynyloxy

ethoxypropionic acid

pent

phenyl

methylpent

Prior art date

2000-01-28

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• 208000008589 Obesity Diseases 0.000 title claims description 21
• 235000020824 obesity Nutrition 0.000 title claims description 21
• 206010012601 diabetes mellitus Diseases 0.000 title claims description 6
• 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 title 1
• 150000005599 propionic acid derivatives Chemical class 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 273
• -1 C 1 -6 -alkyl Chemical group 0.000 claims description 107
• 229910052739 hydrogen Inorganic materials 0.000 claims description 88
• 229910052736 halogen Inorganic materials 0.000 claims description 76
• 150000002367 halogens Chemical class 0.000 claims description 76
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 75
• 125000003118 aryl group Chemical group 0.000 claims description 73
• 239000000203 mixture Substances 0.000 claims description 71
• 239000001257 hydrogen Substances 0.000 claims description 69
• 125000001424 substituent group Chemical group 0.000 claims description 60
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 56
• 150000003839 salts Chemical class 0.000 claims description 55
• 125000001072 heteroaryl group Chemical group 0.000 claims description 54
• 238000000034 method Methods 0.000 claims description 53
• 125000004475 heteroaralkyl group Chemical group 0.000 claims description 52
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 43
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 43
• 150000002431 hydrogen Chemical class 0.000 claims description 36
• 238000011282 treatment Methods 0.000 claims description 35
• 125000003545 alkoxy group Chemical group 0.000 claims description 32
• 125000000217 alkyl group Chemical group 0.000 claims description 29
• 125000000623 heterocyclic group Chemical group 0.000 claims description 27
• WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 27
• 238000002360 preparation method Methods 0.000 claims description 26
• YMWUJEATGCHHMB-UHFFFAOYSA-N dichloromethane Substances ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 25
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 24
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 22
• 238000011321 prophylaxis Methods 0.000 claims description 22
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 21
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 19
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 19
• 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims description 19
• 125000004104 aryloxy group Chemical group 0.000 claims description 19
• 239000003085 diluting agent Substances 0.000 claims description 19
• 239000012453 solvate Substances 0.000 claims description 19
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
• SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 18
• 206010022489 Insulin Resistance Diseases 0.000 claims description 18
• 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims description 18
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 18
• KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 18
• 239000002253 acid Substances 0.000 claims description 18
• 239000003937 drug carrier Substances 0.000 claims description 18
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 17
• 125000005110 aryl thio group Chemical group 0.000 claims description 17
• 125000005553 heteroaryloxy group Chemical group 0.000 claims description 17
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
• 239000000825 pharmaceutical preparation Substances 0.000 claims description 16
• 208000002705 Glucose Intolerance Diseases 0.000 claims description 15
• 201000009104 prediabetes syndrome Diseases 0.000 claims description 15
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 14
• 238000006243 chemical reaction Methods 0.000 claims description 13
• IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims description 12
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 12
• 239000003112 inhibitor Substances 0.000 claims description 12
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 11
• 125000005907 alkyl ester group Chemical group 0.000 claims description 11
• 210000004027 cell Anatomy 0.000 claims description 11
• 239000003814 drug Substances 0.000 claims description 11
• 125000002252 acyl group Chemical group 0.000 claims description 10
• 239000003795 chemical substances by application Substances 0.000 claims description 10
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 9
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 9
• PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims description 9
• RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims description 9
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 9
• 239000002904 solvent Substances 0.000 claims description 9
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 9
• UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims description 8
• 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims description 8
• 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims description 8
• 125000000732 arylene group Chemical group 0.000 claims description 8
• SHHBDKPKMFQHAH-ARHOYUFESA-N ethyl (2s)-2-ethoxy-3-[4-[(e)-3-methyl-5-phenylpent-2-en-4-ynoxy]phenyl]propanoate Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(/C)C#CC1=CC=CC=C1 SHHBDKPKMFQHAH-ARHOYUFESA-N 0.000 claims description 8
• 230000001404 mediated effect Effects 0.000 claims description 8
• LTZUJPUCWXJTSU-VPVJOJIASA-N (2s)-2-ethoxy-3-[4-[(e)-5-phenylpent-2-en-4-ynoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC=CC=C1 LTZUJPUCWXJTSU-VPVJOJIASA-N 0.000 claims description 7
• HEYBIHPGXJXPHD-RKMMBKDRSA-N C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(\C)C#CC1=CC(Cl)=CC(Cl)=C1 Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(\C)C#CC1=CC(Cl)=CC(Cl)=C1 HEYBIHPGXJXPHD-RKMMBKDRSA-N 0.000 claims description 7
• 239000004480 active ingredient Substances 0.000 claims description 7
• 239000003153 chemical reaction reagent Substances 0.000 claims description 7
• XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 7
• 229960003105 metformin Drugs 0.000 claims description 7
• RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims description 7
• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 6
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
• FAEKWTJYAYMJKF-QHCPKHFHSA-N GlucoNorm Chemical compound C1=C(C(O)=O)C(OCC)=CC(CC(=O)N[C@@H](CC(C)C)C=2C(=CC=CC=2)N2CCCCC2)=C1 FAEKWTJYAYMJKF-QHCPKHFHSA-N 0.000 claims description 6
• 108020005497 Nuclear hormone receptor Proteins 0.000 claims description 6
• 239000000460 chlorine Substances 0.000 claims description 6
• 229910052801 chlorine Inorganic materials 0.000 claims description 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
• 125000005549 heteroarylene group Chemical group 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
• 125000001624 naphthyl group Chemical group 0.000 claims description 6
• 102000006255 nuclear receptors Human genes 0.000 claims description 6
• 108020004017 nuclear receptors Proteins 0.000 claims description 6
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
• NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 6
• 229960002354 repaglinide Drugs 0.000 claims description 6
• SWLAMJPTOQZTAE-UHFFFAOYSA-N 4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]benzoic acid Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C(O)=O)C=C1 SWLAMJPTOQZTAE-UHFFFAOYSA-N 0.000 claims description 5
• 229940123208 Biguanide Drugs 0.000 claims description 5
• 125000003342 alkenyl group Chemical group 0.000 claims description 5
• 208000035475 disorder Diseases 0.000 claims description 5
• 229950004994 meglitinide Drugs 0.000 claims description 5
• OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 claims description 5
• 229960000698 nateglinide Drugs 0.000 claims description 5
• 235000019260 propionic acid Nutrition 0.000 claims description 5
• ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 5
• LDMAWMWSTCNZPV-RSAMLISRSA-N (2s)-3-[4-[(z)-5-(3,5-dichlorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(Cl)=CC(Cl)=C1 LDMAWMWSTCNZPV-RSAMLISRSA-N 0.000 claims description 4
• CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims description 4
• 125000006017 1-propenyl group Chemical group 0.000 claims description 4
• 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 claims description 4
• XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 4
• 125000000304 alkynyl group Chemical group 0.000 claims description 4
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
• 229940079593 drug Drugs 0.000 claims description 4
• SHHBDKPKMFQHAH-QLWWLHSCSA-N ethyl (2s)-2-ethoxy-3-[4-[(z)-3-methyl-5-phenylpent-2-en-4-ynoxy]phenyl]propanoate Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(\C)C#CC1=CC=CC=C1 SHHBDKPKMFQHAH-QLWWLHSCSA-N 0.000 claims description 4
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
• OQJBFFCUFALWQL-UHFFFAOYSA-N n-(piperidine-1-carbonylimino)piperidine-1-carboxamide Chemical compound C1CCCCN1C(=O)N=NC(=O)N1CCCCC1 OQJBFFCUFALWQL-UHFFFAOYSA-N 0.000 claims description 4
• 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 4
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 4
• TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 claims description 4
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 4
• 229920002554 vinyl polymer Polymers 0.000 claims description 4
• MFQIQMISMHBYLM-LXKWBGADSA-N (2s)-2-ethoxy-3-[4-[(e)-3-methyl-5-phenylpent-2-en-4-ynoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC=CC=C1 MFQIQMISMHBYLM-LXKWBGADSA-N 0.000 claims description 3
• CFOPQWHPAUUUQY-NJQMWTHNSA-N C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(\C)C#CC1=CC=CC2=CC=CC=C12 Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(\C)C#CC1=CC=CC2=CC=CC=C12 CFOPQWHPAUUUQY-NJQMWTHNSA-N 0.000 claims description 3
• UCOOXEBUANDZQS-BVBLWJPBSA-N C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C\C#CC1=CC(Cl)=CC(Cl)=C1 Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C\C#CC1=CC(Cl)=CC(Cl)=C1 UCOOXEBUANDZQS-BVBLWJPBSA-N 0.000 claims description 3
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
• 125000005354 acylalkyl group Chemical group 0.000 claims description 3
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 3
• 125000000131 cyclopropyloxy group Chemical group C1(CC1)O* 0.000 claims description 3
• FAMRKDQNMBBFBR-BQYQJAHWSA-N diethyl azodicarboxylate Substances CCOC(=O)\N=N\C(=O)OCC FAMRKDQNMBBFBR-BQYQJAHWSA-N 0.000 claims description 3
• 239000002552 dosage form Substances 0.000 claims description 3
• GXBVRHRUODRNJN-KOZCBZIKSA-N ethyl (2s)-2-ethoxy-3-[4-[(e)-3-methyl-5-[3-(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]phenyl]propanoate Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(/C)C#CC1=CC=CC(C(F)(F)F)=C1 GXBVRHRUODRNJN-KOZCBZIKSA-N 0.000 claims description 3
• DZSYJXNOEAYDFC-LNLBBOMNSA-N ethyl (2s)-2-ethoxy-3-[4-[(e)-5-phenylpent-2-en-4-ynoxy]phenyl]propanoate Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C\C#CC1=CC=CC=C1 DZSYJXNOEAYDFC-LNLBBOMNSA-N 0.000 claims description 3
• DZSYJXNOEAYDFC-ZJZKVMBWSA-N ethyl (2s)-2-ethoxy-3-[4-[(z)-5-phenylpent-2-en-4-ynoxy]phenyl]propanoate Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C/C#CC1=CC=CC=C1 DZSYJXNOEAYDFC-ZJZKVMBWSA-N 0.000 claims description 3
• HEYBIHPGXJXPHD-VHFIJRQBSA-N ethyl (2s)-3-[4-[(e)-5-(3,5-dichlorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoate Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(/C)C#CC1=CC(Cl)=CC(Cl)=C1 HEYBIHPGXJXPHD-VHFIJRQBSA-N 0.000 claims description 3
• FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 claims description 3
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 3
• 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
• 230000008569 process Effects 0.000 claims description 3
• 230000002685 pulmonary effect Effects 0.000 claims description 3
• VPQCGJCAUTVEKV-OEHGHSTBSA-N (2s)-2-ethoxy-3-[4-[(e)-3-methyl-5-[3-(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC=CC(C(F)(F)F)=C1 VPQCGJCAUTVEKV-OEHGHSTBSA-N 0.000 claims description 2
• QDLLZQHWSYAJFO-XNQHKPBGSA-N (2s)-2-ethoxy-3-[4-[(z)-3-methyl-5-naphthalen-1-ylpent-2-en-4-ynoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC=CC2=CC=CC=C12 QDLLZQHWSYAJFO-XNQHKPBGSA-N 0.000 claims description 2
• LTZUJPUCWXJTSU-DJHHFUNSSA-N (2s)-2-ethoxy-3-[4-[(z)-5-phenylpent-2-en-4-ynoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC=CC=C1 LTZUJPUCWXJTSU-DJHHFUNSSA-N 0.000 claims description 2
• ONJVXORHVJQLQD-ZGAQRXBASA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(Br)C=CC=C(Br)C1 ONJVXORHVJQLQD-ZGAQRXBASA-N 0.000 claims description 2
• OGJPIWNJCGRJOF-PFHJWNERSA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(Br)C=CC=C(Br)C1 OGJPIWNJCGRJOF-PFHJWNERSA-N 0.000 claims description 2
• DGOYVQWFGJAWQW-RBKRILAMSA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC)C=CC=C(OCC)C1 DGOYVQWFGJAWQW-RBKRILAMSA-N 0.000 claims description 2
• MRYVXNUOPZTRGZ-VNBDLNNKSA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OCC)C=CC=C(OCC)C1 MRYVXNUOPZTRGZ-VNBDLNNKSA-N 0.000 claims description 2
• AOJRHHPRMFYFNS-ZGAQRXBASA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(F)C=CC=C(F)C1 AOJRHHPRMFYFNS-ZGAQRXBASA-N 0.000 claims description 2
• ZMTVKSNBCVBVIN-PFHJWNERSA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(F)C=CC=C(F)C1 ZMTVKSNBCVBVIN-PFHJWNERSA-N 0.000 claims description 2
• IFMDEEQRFXBUIF-ZGAQRXBASA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(I)C=CC=C(I)C1 IFMDEEQRFXBUIF-ZGAQRXBASA-N 0.000 claims description 2
• HPBVODKRMRPCQR-PFHJWNERSA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(I)C=CC=C(I)C1 HPBVODKRMRPCQR-PFHJWNERSA-N 0.000 claims description 2
• IOWUICTWJLJBCA-HPGPFDCKSA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxybutanoic acid Chemical compound BrC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 IOWUICTWJLJBCA-HPGPFDCKSA-N 0.000 claims description 2
• OPJJBBMEOQYQFT-VDGVVHNXSA-N (2s)-3-[3-bromo-4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 OPJJBBMEOQYQFT-VDGVVHNXSA-N 0.000 claims description 2
• PVMFUMQREFSQLD-BODNZJIQSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(Br)=CC(Br)=C1 PVMFUMQREFSQLD-BODNZJIQSA-N 0.000 claims description 2
• ZMFBAPJZOBVSLZ-GUWAZMKPSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-dibromophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(Br)=CC(Br)=C1 ZMFBAPJZOBVSLZ-GUWAZMKPSA-N 0.000 claims description 2
• IRBSHGOBVJCHJV-CTSWPSOHSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC)=CC(OCC)=C1 IRBSHGOBVJCHJV-CTSWPSOHSA-N 0.000 claims description 2
• ZMKQUCYAPRDAFO-PMDNVAFQSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-diethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC)=CC(OCC)=C1 ZMKQUCYAPRDAFO-PMDNVAFQSA-N 0.000 claims description 2
• QKEOMYLLGRAUSN-BODNZJIQSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-difluorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(F)=CC(F)=C1 QKEOMYLLGRAUSN-BODNZJIQSA-N 0.000 claims description 2
• HERZKCUJSABYCV-GUWAZMKPSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(F)=CC(F)=C1 HERZKCUJSABYCV-GUWAZMKPSA-N 0.000 claims description 2
• GBVPHJXRKMMDEP-BODNZJIQSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-diiodophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(I)=CC(I)=C1 GBVPHJXRKMMDEP-BODNZJIQSA-N 0.000 claims description 2
• PJYUAHIPEVQXSN-GUWAZMKPSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-diiodophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(I)=CC(I)=C1 PJYUAHIPEVQXSN-GUWAZMKPSA-N 0.000 claims description 2
• ARSPGEHXNVAVEK-GOOYREHVSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OC)=CC(OC)=C1 ARSPGEHXNVAVEK-GOOYREHVSA-N 0.000 claims description 2
• ZQILGBSOCSLLQE-BVBLWJPBSA-N (2s)-3-[3-bromo-4-[(e)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OC)=CC(OC)=C1 ZQILGBSOCSLLQE-BVBLWJPBSA-N 0.000 claims description 2
• ONJVXORHVJQLQD-SYMXCSSMSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(Br)C=CC=C(Br)C1 ONJVXORHVJQLQD-SYMXCSSMSA-N 0.000 claims description 2
• OGJPIWNJCGRJOF-OPQGSUJVSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(Br)C=CC=C(Br)C1 OGJPIWNJCGRJOF-OPQGSUJVSA-N 0.000 claims description 2
• DGOYVQWFGJAWQW-KGSFJYNRSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC)C=CC=C(OCC)C1 DGOYVQWFGJAWQW-KGSFJYNRSA-N 0.000 claims description 2
• MRYVXNUOPZTRGZ-YLRTXIDLSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC)C=CC=C(OCC)C1 MRYVXNUOPZTRGZ-YLRTXIDLSA-N 0.000 claims description 2
• AOJRHHPRMFYFNS-SYMXCSSMSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(F)C=CC=C(F)C1 AOJRHHPRMFYFNS-SYMXCSSMSA-N 0.000 claims description 2
• ZMTVKSNBCVBVIN-OPQGSUJVSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(F)C=CC=C(F)C1 ZMTVKSNBCVBVIN-OPQGSUJVSA-N 0.000 claims description 2
• IFMDEEQRFXBUIF-SYMXCSSMSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(I)C=CC=C(I)C1 IFMDEEQRFXBUIF-SYMXCSSMSA-N 0.000 claims description 2
• OPJJBBMEOQYQFT-RENKASEKSA-N (2s)-3-[3-bromo-4-[(z)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 OPJJBBMEOQYQFT-RENKASEKSA-N 0.000 claims description 2
• PVMFUMQREFSQLD-YDBYVANFSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(Br)=CC(Br)=C1 PVMFUMQREFSQLD-YDBYVANFSA-N 0.000 claims description 2
• ZMFBAPJZOBVSLZ-OMUFJYGLSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-dibromophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(Br)=CC(Br)=C1 ZMFBAPJZOBVSLZ-OMUFJYGLSA-N 0.000 claims description 2
• IRBSHGOBVJCHJV-WLYOPYGYSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC)=CC(OCC)=C1 IRBSHGOBVJCHJV-WLYOPYGYSA-N 0.000 claims description 2
• ZMKQUCYAPRDAFO-NAFJXCGOSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-diethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OCC)=CC(OCC)=C1 ZMKQUCYAPRDAFO-NAFJXCGOSA-N 0.000 claims description 2
• QKEOMYLLGRAUSN-YDBYVANFSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-difluorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(F)=CC(F)=C1 QKEOMYLLGRAUSN-YDBYVANFSA-N 0.000 claims description 2
• HERZKCUJSABYCV-OMUFJYGLSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(F)=CC(F)=C1 HERZKCUJSABYCV-OMUFJYGLSA-N 0.000 claims description 2
• GBVPHJXRKMMDEP-YDBYVANFSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-diiodophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(I)=CC(I)=C1 GBVPHJXRKMMDEP-YDBYVANFSA-N 0.000 claims description 2
• PJYUAHIPEVQXSN-OMUFJYGLSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-diiodophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(I)=CC(I)=C1 PJYUAHIPEVQXSN-OMUFJYGLSA-N 0.000 claims description 2
• ARSPGEHXNVAVEK-VVVJUMKJSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OC)=CC(OC)=C1 ARSPGEHXNVAVEK-VVVJUMKJSA-N 0.000 claims description 2
• ZQILGBSOCSLLQE-DADDIACRSA-N (2s)-3-[3-bromo-4-[(z)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OC)=CC(OC)=C1 ZQILGBSOCSLLQE-DADDIACRSA-N 0.000 claims description 2
• LKZVHOBYGKSNSE-ZGAQRXBASA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(Br)C=CC=C(Br)C1 LKZVHOBYGKSNSE-ZGAQRXBASA-N 0.000 claims description 2
• HSIJYOPGZHLXFC-PFHJWNERSA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(Br)C=CC=C(Br)C1 HSIJYOPGZHLXFC-PFHJWNERSA-N 0.000 claims description 2
• CGIUMSLPDNNCQT-RBKRILAMSA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC)C=CC=C(OCC)C1 CGIUMSLPDNNCQT-RBKRILAMSA-N 0.000 claims description 2
• SQVQSWJKCDCBPU-VNBDLNNKSA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OCC)C=CC=C(OCC)C1 SQVQSWJKCDCBPU-VNBDLNNKSA-N 0.000 claims description 2
• UUTLGJVQZBTOTD-ZGAQRXBASA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(F)C=CC=C(F)C1 UUTLGJVQZBTOTD-ZGAQRXBASA-N 0.000 claims description 2
• HWWUQADUTHDFHA-PFHJWNERSA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(F)C=CC=C(F)C1 HWWUQADUTHDFHA-PFHJWNERSA-N 0.000 claims description 2
• PQCVXAHYKDZYKO-ZGAQRXBASA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(I)C=CC=C(I)C1 PQCVXAHYKDZYKO-ZGAQRXBASA-N 0.000 claims description 2
• BULQZLBWTLQKOJ-PFHJWNERSA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(I)C=CC=C(I)C1 BULQZLBWTLQKOJ-PFHJWNERSA-N 0.000 claims description 2
• FCIRRFADSYETTD-HPGPFDCKSA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxybutanoic acid Chemical compound ClC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 FCIRRFADSYETTD-HPGPFDCKSA-N 0.000 claims description 2
• FJQFFECPKVVJSY-VDGVVHNXSA-N (2s)-3-[3-chloro-4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 FJQFFECPKVVJSY-VDGVVHNXSA-N 0.000 claims description 2
• JWKQLCDLVCMRBK-BODNZJIQSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(Br)=CC(Br)=C1 JWKQLCDLVCMRBK-BODNZJIQSA-N 0.000 claims description 2
• YUHOORODLHSWBJ-GUWAZMKPSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-dibromophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(Br)=CC(Br)=C1 YUHOORODLHSWBJ-GUWAZMKPSA-N 0.000 claims description 2
• HYZVBXLDPKGWCM-CTSWPSOHSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC)=CC(OCC)=C1 HYZVBXLDPKGWCM-CTSWPSOHSA-N 0.000 claims description 2
• QBMMCBFAACTXEV-PMDNVAFQSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-diethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC)=CC(OCC)=C1 QBMMCBFAACTXEV-PMDNVAFQSA-N 0.000 claims description 2
• WVPSTHODYORKAR-BODNZJIQSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-difluorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(F)=CC(F)=C1 WVPSTHODYORKAR-BODNZJIQSA-N 0.000 claims description 2
• JHFJTHMSUFFPRJ-GUWAZMKPSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(F)=CC(F)=C1 JHFJTHMSUFFPRJ-GUWAZMKPSA-N 0.000 claims description 2
• UNNGWUAZSJFQLP-BODNZJIQSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-diiodophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(I)=CC(I)=C1 UNNGWUAZSJFQLP-BODNZJIQSA-N 0.000 claims description 2
• AZHIJKZFTLJRAS-GUWAZMKPSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-diiodophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(I)=CC(I)=C1 AZHIJKZFTLJRAS-GUWAZMKPSA-N 0.000 claims description 2
• PPAWROQXKROQNO-GOOYREHVSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OC)=CC(OC)=C1 PPAWROQXKROQNO-GOOYREHVSA-N 0.000 claims description 2
• VBJJQXYTHAHWFY-BVBLWJPBSA-N (2s)-3-[3-chloro-4-[(e)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OC)=CC(OC)=C1 VBJJQXYTHAHWFY-BVBLWJPBSA-N 0.000 claims description 2
• CGIUMSLPDNNCQT-KGSFJYNRSA-N (2s)-3-[3-chloro-4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC)C=CC=C(OCC)C1 CGIUMSLPDNNCQT-KGSFJYNRSA-N 0.000 claims description 2
• SQVQSWJKCDCBPU-YLRTXIDLSA-N (2s)-3-[3-chloro-4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC)C=CC=C(OCC)C1 SQVQSWJKCDCBPU-YLRTXIDLSA-N 0.000 claims description 2
• UUTLGJVQZBTOTD-SYMXCSSMSA-N (2s)-3-[3-chloro-4-[(z)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(F)C=CC=C(F)C1 UUTLGJVQZBTOTD-SYMXCSSMSA-N 0.000 claims description 2
• BULQZLBWTLQKOJ-OPQGSUJVSA-N (2s)-3-[3-chloro-4-[(z)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(I)C=CC=C(I)C1 BULQZLBWTLQKOJ-OPQGSUJVSA-N 0.000 claims description 2
• FJQFFECPKVVJSY-RENKASEKSA-N (2s)-3-[3-chloro-4-[(z)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 FJQFFECPKVVJSY-RENKASEKSA-N 0.000 claims description 2
• JWKQLCDLVCMRBK-YDBYVANFSA-N (2s)-3-[3-chloro-4-[(z)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(Br)=CC(Br)=C1 JWKQLCDLVCMRBK-YDBYVANFSA-N 0.000 claims description 2
• HYZVBXLDPKGWCM-WLYOPYGYSA-N (2s)-3-[3-chloro-4-[(z)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC)=CC(OCC)=C1 HYZVBXLDPKGWCM-WLYOPYGYSA-N 0.000 claims description 2
• QBMMCBFAACTXEV-NAFJXCGOSA-N (2s)-3-[3-chloro-4-[(z)-5-(3,5-diethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OCC)=CC(OCC)=C1 QBMMCBFAACTXEV-NAFJXCGOSA-N 0.000 claims description 2
• JHFJTHMSUFFPRJ-OMUFJYGLSA-N (2s)-3-[3-chloro-4-[(z)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(F)=CC(F)=C1 JHFJTHMSUFFPRJ-OMUFJYGLSA-N 0.000 claims description 2
• UNNGWUAZSJFQLP-YDBYVANFSA-N (2s)-3-[3-chloro-4-[(z)-5-(3,5-diiodophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(I)=CC(I)=C1 UNNGWUAZSJFQLP-YDBYVANFSA-N 0.000 claims description 2
• PPAWROQXKROQNO-VVVJUMKJSA-N (2s)-3-[3-chloro-4-[(z)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OC)=CC(OC)=C1 PPAWROQXKROQNO-VVVJUMKJSA-N 0.000 claims description 2
• VBJJQXYTHAHWFY-DADDIACRSA-N (2s)-3-[3-chloro-4-[(z)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OC)=CC(OC)=C1 VBJJQXYTHAHWFY-DADDIACRSA-N 0.000 claims description 2
• QGPMNFGQRRDNSS-ZGAQRXBASA-N (2s)-3-[4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(Br)C=CC=C(Br)C1 QGPMNFGQRRDNSS-ZGAQRXBASA-N 0.000 claims description 2
• UVFBJDARYDNVPA-UICFQJRISA-N (2s)-3-[4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(Br)C=CC=C(Br)C1 UVFBJDARYDNVPA-UICFQJRISA-N 0.000 claims description 2
• MQFQTKSSXLCWAT-PFHJWNERSA-N (2s)-3-[4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(Br)C=CC=C(Br)C1 MQFQTKSSXLCWAT-PFHJWNERSA-N 0.000 claims description 2
• PUAGHGLFWZPMGN-PFHJWNERSA-N (2s)-3-[4-[(e)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(Br)C=CC=C(Br)C1 PUAGHGLFWZPMGN-PFHJWNERSA-N 0.000 claims description 2
• VQNSUAANTRKDPV-RBKRILAMSA-N (2s)-3-[4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC)C=CC=C(OCC)C1 VQNSUAANTRKDPV-RBKRILAMSA-N 0.000 claims description 2
• BCOYPYVOXBCBLB-UUWYDYNASA-N (2s)-3-[4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC)C=CC=C(OCC)C1 BCOYPYVOXBCBLB-UUWYDYNASA-N 0.000 claims description 2
• OCYBWRBQJVVWLW-VNBDLNNKSA-N (2s)-3-[4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OCC)C=CC=C(OCC)C1 OCYBWRBQJVVWLW-VNBDLNNKSA-N 0.000 claims description 2
• MVFPHBNUHKYGMB-VNBDLNNKSA-N (2s)-3-[4-[(e)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OCC)C=CC=C(OCC)C1 MVFPHBNUHKYGMB-VNBDLNNKSA-N 0.000 claims description 2
• ZOFMXTDNELZNIF-ZGAQRXBASA-N (2s)-3-[4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(F)C=CC=C(F)C1 ZOFMXTDNELZNIF-ZGAQRXBASA-N 0.000 claims description 2
• QSXPIVXJOKEOGW-UICFQJRISA-N (2s)-3-[4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(F)C=CC=C(F)C1 QSXPIVXJOKEOGW-UICFQJRISA-N 0.000 claims description 2
• MLLJSRRQAPUEAL-PFHJWNERSA-N (2s)-3-[4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(F)C=CC=C(F)C1 MLLJSRRQAPUEAL-PFHJWNERSA-N 0.000 claims description 2
• RXLPNZDIZBRITD-PFHJWNERSA-N (2s)-3-[4-[(e)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(F)C=CC=C(F)C1 RXLPNZDIZBRITD-PFHJWNERSA-N 0.000 claims description 2
• NYYWIDKREGZEHA-ZGAQRXBASA-N (2s)-3-[4-[(e)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(I)C=CC=C(I)C1 NYYWIDKREGZEHA-ZGAQRXBASA-N 0.000 claims description 2
• FIIHVFYNMSIQEC-PFHJWNERSA-N (2s)-3-[4-[(e)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(I)C=CC=C(I)C1 FIIHVFYNMSIQEC-PFHJWNERSA-N 0.000 claims description 2
• FHRVOSGTWGSIJT-HPGPFDCKSA-N (2s)-3-[4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxybutanoic acid Chemical compound IC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 FHRVOSGTWGSIJT-HPGPFDCKSA-N 0.000 claims description 2
• YSWLVUVQFPLBDN-VDGVVHNXSA-N (2s)-3-[4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 YSWLVUVQFPLBDN-VDGVVHNXSA-N 0.000 claims description 2
• JTOPUSNCDKUGJU-BBCNVBMOSA-N (2s)-3-[4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxybutanoic acid Chemical compound C1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 JTOPUSNCDKUGJU-BBCNVBMOSA-N 0.000 claims description 2
• SGGVFGHJWQLNGO-VDGVVHNXSA-N (2s)-3-[4-[(e)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OC)C=CC=C(OC)C1 SGGVFGHJWQLNGO-VDGVVHNXSA-N 0.000 claims description 2
• KIYHZFNQHUNAOR-BODNZJIQSA-N (2s)-3-[4-[(e)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(Br)=CC(Br)=C1 KIYHZFNQHUNAOR-BODNZJIQSA-N 0.000 claims description 2
• OMTRLJDOHJSIHS-VROYLXGSSA-N (2s)-3-[4-[(e)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(Br)=CC(Br)=C1 OMTRLJDOHJSIHS-VROYLXGSSA-N 0.000 claims description 2
• XOXGCGNCVDBTEV-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-(3,5-dibromophenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(Br)=CC(Br)=C1 XOXGCGNCVDBTEV-GUWAZMKPSA-N 0.000 claims description 2
• IHEZLGTVVLEANZ-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-(3,5-dibromophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(Br)=CC(Br)=C1 IHEZLGTVVLEANZ-GUWAZMKPSA-N 0.000 claims description 2
• LDMAWMWSTCNZPV-VROYLXGSSA-N (2s)-3-[4-[(e)-5-(3,5-dichlorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(Cl)=CC(Cl)=C1 LDMAWMWSTCNZPV-VROYLXGSSA-N 0.000 claims description 2
• IMMBCQQONYQDPO-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-(3,5-dichlorophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(Cl)=CC(Cl)=C1 IMMBCQQONYQDPO-GUWAZMKPSA-N 0.000 claims description 2
• NEESGZNRRTXXII-CTSWPSOHSA-N (2s)-3-[4-[(e)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC)=CC(OCC)=C1 NEESGZNRRTXXII-CTSWPSOHSA-N 0.000 claims description 2
• QGRMTWQVDPPDKR-KPLKGUCASA-N (2s)-3-[4-[(e)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC)=CC(OCC)=C1 QGRMTWQVDPPDKR-KPLKGUCASA-N 0.000 claims description 2
• OPDVAUIRCABEDK-PMDNVAFQSA-N (2s)-3-[4-[(e)-5-(3,5-diethoxyphenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC)=CC(OCC)=C1 OPDVAUIRCABEDK-PMDNVAFQSA-N 0.000 claims description 2
• XWWBLXVMCWCFDO-PMDNVAFQSA-N (2s)-3-[4-[(e)-5-(3,5-diethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC)=CC(OCC)=C1 XWWBLXVMCWCFDO-PMDNVAFQSA-N 0.000 claims description 2
• ZMENIYPJLAYTIQ-BODNZJIQSA-N (2s)-3-[4-[(e)-5-(3,5-difluorophenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(F)=CC(F)=C1 ZMENIYPJLAYTIQ-BODNZJIQSA-N 0.000 claims description 2
• ZCCSCSRAFZBLLL-VROYLXGSSA-N (2s)-3-[4-[(e)-5-(3,5-difluorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(F)=CC(F)=C1 ZCCSCSRAFZBLLL-VROYLXGSSA-N 0.000 claims description 2
• UZGAQWVNWYQYEW-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(F)=CC(F)=C1 UZGAQWVNWYQYEW-GUWAZMKPSA-N 0.000 claims description 2
• OAKUOYFRLBHGAM-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(F)=CC(F)=C1 OAKUOYFRLBHGAM-GUWAZMKPSA-N 0.000 claims description 2
• MENRMNPLRKIAOA-BODNZJIQSA-N (2s)-3-[4-[(e)-5-(3,5-diiodophenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(I)=CC(I)=C1 MENRMNPLRKIAOA-BODNZJIQSA-N 0.000 claims description 2
• SSNJBKMEAXPTCV-VROYLXGSSA-N (2s)-3-[4-[(e)-5-(3,5-diiodophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(I)=CC(I)=C1 SSNJBKMEAXPTCV-VROYLXGSSA-N 0.000 claims description 2
• VFQQVRPSWXWLDE-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-(3,5-diiodophenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(I)=CC(I)=C1 VFQQVRPSWXWLDE-GUWAZMKPSA-N 0.000 claims description 2
• KWERIBDIKKAQTO-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-(3,5-diiodophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(I)=CC(I)=C1 KWERIBDIKKAQTO-GUWAZMKPSA-N 0.000 claims description 2
• KKKQIBLHMFKFEC-GOOYREHVSA-N (2s)-3-[4-[(e)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OC)=CC(OC)=C1 KKKQIBLHMFKFEC-GOOYREHVSA-N 0.000 claims description 2
• KTNTXXGMMZJANZ-VHFIJRQBSA-N (2s)-3-[4-[(e)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OC)=CC(OC)=C1 KTNTXXGMMZJANZ-VHFIJRQBSA-N 0.000 claims description 2
• IJPNTHKIMYXNHC-BVBLWJPBSA-N (2s)-3-[4-[(e)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OC)=CC(OC)=C1 IJPNTHKIMYXNHC-BVBLWJPBSA-N 0.000 claims description 2
• AIXJVDVWFQIOSD-BVBLWJPBSA-N (2s)-3-[4-[(e)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OC)=CC(OC)=C1 AIXJVDVWFQIOSD-BVBLWJPBSA-N 0.000 claims description 2
• PAGYMNAMVMIZGC-HUILLMRYSA-N (2s)-3-[4-[(e)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 PAGYMNAMVMIZGC-HUILLMRYSA-N 0.000 claims description 2
• FTTHJJJRPZQXHM-HUILLMRYSA-N (2s)-3-[4-[(e)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 FTTHJJJRPZQXHM-HUILLMRYSA-N 0.000 claims description 2
• IUDXGHANOWXIBO-HUILLMRYSA-N (2s)-3-[4-[(e)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 IUDXGHANOWXIBO-HUILLMRYSA-N 0.000 claims description 2
• BMJGFIKOPQZNPQ-MUSPHSLOSA-N (2s)-3-[4-[(e)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 BMJGFIKOPQZNPQ-MUSPHSLOSA-N 0.000 claims description 2
• YSCGJEJYGJIFQO-XXQPFPDHSA-N (2s)-3-[4-[(e)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]pent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 YSCGJEJYGJIFQO-XXQPFPDHSA-N 0.000 claims description 2
• CAQZGKQEISXDLZ-XXQPFPDHSA-N (2s)-3-[4-[(e)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 CAQZGKQEISXDLZ-XXQPFPDHSA-N 0.000 claims description 2
• FPNFGQFNVXWDCZ-XXQPFPDHSA-N (2s)-3-[4-[(e)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 FPNFGQFNVXWDCZ-XXQPFPDHSA-N 0.000 claims description 2
• JYJWQLXMZBHJJL-FZRLKEFVSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 JYJWQLXMZBHJJL-FZRLKEFVSA-N 0.000 claims description 2
• KUUWNQVFBPYJGN-FZRLKEFVSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 KUUWNQVFBPYJGN-FZRLKEFVSA-N 0.000 claims description 2
• KWSGNLFOICWEQW-FZRLKEFVSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 KWSGNLFOICWEQW-FZRLKEFVSA-N 0.000 claims description 2
• UAUNYERAGADNGR-FBGPZHRUSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 UAUNYERAGADNGR-FBGPZHRUSA-N 0.000 claims description 2
• NNLWGHPNVHTDTB-OJZQOFKYSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]pent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 NNLWGHPNVHTDTB-OJZQOFKYSA-N 0.000 claims description 2
• OMBNCAISCHLFPV-OJZQOFKYSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]pent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 OMBNCAISCHLFPV-OJZQOFKYSA-N 0.000 claims description 2
• JHGSQBWPCPJESY-OJZQOFKYSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 JHGSQBWPCPJESY-OJZQOFKYSA-N 0.000 claims description 2
• ZIMSBVKNMLVTEU-OJZQOFKYSA-N (2s)-3-[4-[(e)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 ZIMSBVKNMLVTEU-OJZQOFKYSA-N 0.000 claims description 2
• RRTYHUQNONZZIR-BODNZJIQSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 RRTYHUQNONZZIR-BODNZJIQSA-N 0.000 claims description 2
• VDTAAXWORUHPQJ-BODNZJIQSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 VDTAAXWORUHPQJ-BODNZJIQSA-N 0.000 claims description 2
• GJPBQAYKKUFVDC-BODNZJIQSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 GJPBQAYKKUFVDC-BODNZJIQSA-N 0.000 claims description 2
• ZMOQRERCLICEKZ-VROYLXGSSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 ZMOQRERCLICEKZ-VROYLXGSSA-N 0.000 claims description 2
• HMXPQWQIPLHGIJ-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 HMXPQWQIPLHGIJ-GUWAZMKPSA-N 0.000 claims description 2
• HXEVWPFPZQLMHK-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 HXEVWPFPZQLMHK-GUWAZMKPSA-N 0.000 claims description 2
• DSJSZDJPUKFECB-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 DSJSZDJPUKFECB-GUWAZMKPSA-N 0.000 claims description 2
• QNWVDQWEMGLGOE-GUWAZMKPSA-N (2s)-3-[4-[(e)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 QNWVDQWEMGLGOE-GUWAZMKPSA-N 0.000 claims description 2
• QGPMNFGQRRDNSS-SYMXCSSMSA-N (2s)-3-[4-[(z)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(Br)C=CC=C(Br)C1 QGPMNFGQRRDNSS-SYMXCSSMSA-N 0.000 claims description 2
• UVFBJDARYDNVPA-UXZAGDMNSA-N (2s)-3-[4-[(z)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(Br)C=CC=C(Br)C1 UVFBJDARYDNVPA-UXZAGDMNSA-N 0.000 claims description 2
• MQFQTKSSXLCWAT-OPQGSUJVSA-N (2s)-3-[4-[(z)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(Br)C=CC=C(Br)C1 MQFQTKSSXLCWAT-OPQGSUJVSA-N 0.000 claims description 2
• PUAGHGLFWZPMGN-OPQGSUJVSA-N (2s)-3-[4-[(z)-5-(1,5-dibromocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(Br)C=CC=C(Br)C1 PUAGHGLFWZPMGN-OPQGSUJVSA-N 0.000 claims description 2
• VQNSUAANTRKDPV-KGSFJYNRSA-N (2s)-3-[4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC)C=CC=C(OCC)C1 VQNSUAANTRKDPV-KGSFJYNRSA-N 0.000 claims description 2
• BCOYPYVOXBCBLB-OJEOETSSSA-N (2s)-3-[4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC)C=CC=C(OCC)C1 BCOYPYVOXBCBLB-OJEOETSSSA-N 0.000 claims description 2
• OCYBWRBQJVVWLW-YLRTXIDLSA-N (2s)-3-[4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC)C=CC=C(OCC)C1 OCYBWRBQJVVWLW-YLRTXIDLSA-N 0.000 claims description 2
• MVFPHBNUHKYGMB-YLRTXIDLSA-N (2s)-3-[4-[(z)-5-(1,5-diethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC)C=CC=C(OCC)C1 MVFPHBNUHKYGMB-YLRTXIDLSA-N 0.000 claims description 2
• ZOFMXTDNELZNIF-SYMXCSSMSA-N (2s)-3-[4-[(z)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(F)C=CC=C(F)C1 ZOFMXTDNELZNIF-SYMXCSSMSA-N 0.000 claims description 2
• RXLPNZDIZBRITD-OPQGSUJVSA-N (2s)-3-[4-[(z)-5-(1,5-difluorocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(F)C=CC=C(F)C1 RXLPNZDIZBRITD-OPQGSUJVSA-N 0.000 claims description 2
• NYYWIDKREGZEHA-SYMXCSSMSA-N (2s)-3-[4-[(z)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(I)C=CC=C(I)C1 NYYWIDKREGZEHA-SYMXCSSMSA-N 0.000 claims description 2
• IHGMAKVTPIGYMW-UXZAGDMNSA-N (2s)-3-[4-[(z)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(I)C=CC=C(I)C1 IHGMAKVTPIGYMW-UXZAGDMNSA-N 0.000 claims description 2
• OMJWTTLAONLNSI-OPQGSUJVSA-N (2s)-3-[4-[(z)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(I)C=CC=C(I)C1 OMJWTTLAONLNSI-OPQGSUJVSA-N 0.000 claims description 2
• FIIHVFYNMSIQEC-OPQGSUJVSA-N (2s)-3-[4-[(z)-5-(1,5-diiodocyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(I)C=CC=C(I)C1 FIIHVFYNMSIQEC-OPQGSUJVSA-N 0.000 claims description 2
• YSWLVUVQFPLBDN-RENKASEKSA-N (2s)-3-[4-[(z)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 YSWLVUVQFPLBDN-RENKASEKSA-N 0.000 claims description 2
• SGGVFGHJWQLNGO-RENKASEKSA-N (2s)-3-[4-[(z)-5-(1,5-dimethoxycyclohexa-2,4-dien-1-yl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 SGGVFGHJWQLNGO-RENKASEKSA-N 0.000 claims description 2
• KIYHZFNQHUNAOR-YDBYVANFSA-N (2s)-3-[4-[(z)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(Br)=CC(Br)=C1 KIYHZFNQHUNAOR-YDBYVANFSA-N 0.000 claims description 2
• OMTRLJDOHJSIHS-RSAMLISRSA-N (2s)-3-[4-[(z)-5-(3,5-dibromophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(Br)=CC(Br)=C1 OMTRLJDOHJSIHS-RSAMLISRSA-N 0.000 claims description 2
• IHEZLGTVVLEANZ-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-(3,5-dibromophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(Br)=CC(Br)=C1 IHEZLGTVVLEANZ-OMUFJYGLSA-N 0.000 claims description 2
• NEESGZNRRTXXII-WLYOPYGYSA-N (2s)-3-[4-[(z)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC)=CC(OCC)=C1 NEESGZNRRTXXII-WLYOPYGYSA-N 0.000 claims description 2
• QGRMTWQVDPPDKR-BHIHAWCJSA-N (2s)-3-[4-[(z)-5-(3,5-diethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC)=CC(OCC)=C1 QGRMTWQVDPPDKR-BHIHAWCJSA-N 0.000 claims description 2
• XWWBLXVMCWCFDO-NAFJXCGOSA-N (2s)-3-[4-[(z)-5-(3,5-diethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OCC)=CC(OCC)=C1 XWWBLXVMCWCFDO-NAFJXCGOSA-N 0.000 claims description 2
• ZMENIYPJLAYTIQ-YDBYVANFSA-N (2s)-3-[4-[(z)-5-(3,5-difluorophenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(F)=CC(F)=C1 ZMENIYPJLAYTIQ-YDBYVANFSA-N 0.000 claims description 2
• ZCCSCSRAFZBLLL-RSAMLISRSA-N (2s)-3-[4-[(z)-5-(3,5-difluorophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(F)=CC(F)=C1 ZCCSCSRAFZBLLL-RSAMLISRSA-N 0.000 claims description 2
• UZGAQWVNWYQYEW-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(F)=CC(F)=C1 UZGAQWVNWYQYEW-OMUFJYGLSA-N 0.000 claims description 2
• OAKUOYFRLBHGAM-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-(3,5-difluorophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(F)=CC(F)=C1 OAKUOYFRLBHGAM-OMUFJYGLSA-N 0.000 claims description 2
• SSNJBKMEAXPTCV-RSAMLISRSA-N (2s)-3-[4-[(z)-5-(3,5-diiodophenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(I)=CC(I)=C1 SSNJBKMEAXPTCV-RSAMLISRSA-N 0.000 claims description 2
• VFQQVRPSWXWLDE-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-(3,5-diiodophenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(I)=CC(I)=C1 VFQQVRPSWXWLDE-OMUFJYGLSA-N 0.000 claims description 2
• KWERIBDIKKAQTO-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-(3,5-diiodophenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(I)=CC(I)=C1 KWERIBDIKKAQTO-OMUFJYGLSA-N 0.000 claims description 2
• KKKQIBLHMFKFEC-VVVJUMKJSA-N (2s)-3-[4-[(z)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OC)=CC(OC)=C1 KKKQIBLHMFKFEC-VVVJUMKJSA-N 0.000 claims description 2
• KTNTXXGMMZJANZ-RKMMBKDRSA-N (2s)-3-[4-[(z)-5-(3,5-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OC)=CC(OC)=C1 KTNTXXGMMZJANZ-RKMMBKDRSA-N 0.000 claims description 2
• IJPNTHKIMYXNHC-DADDIACRSA-N (2s)-3-[4-[(z)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OC)=CC(OC)=C1 IJPNTHKIMYXNHC-DADDIACRSA-N 0.000 claims description 2
• AIXJVDVWFQIOSD-DADDIACRSA-N (2s)-3-[4-[(z)-5-(3,5-dimethoxyphenyl)pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OC)=CC(OC)=C1 AIXJVDVWFQIOSD-DADDIACRSA-N 0.000 claims description 2
• PAGYMNAMVMIZGC-FIAGSFMPSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 PAGYMNAMVMIZGC-FIAGSFMPSA-N 0.000 claims description 2
• FTTHJJJRPZQXHM-FIAGSFMPSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 FTTHJJJRPZQXHM-FIAGSFMPSA-N 0.000 claims description 2
• IUDXGHANOWXIBO-FIAGSFMPSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 IUDXGHANOWXIBO-FIAGSFMPSA-N 0.000 claims description 2
• BMJGFIKOPQZNPQ-ZNNUSVSRSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 BMJGFIKOPQZNPQ-ZNNUSVSRSA-N 0.000 claims description 2
• YSCGJEJYGJIFQO-IZDJXGPRSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]pent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 YSCGJEJYGJIFQO-IZDJXGPRSA-N 0.000 claims description 2
• ZAUPYNRCFZQULG-IZDJXGPRSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]pent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 ZAUPYNRCFZQULG-IZDJXGPRSA-N 0.000 claims description 2
• CAQZGKQEISXDLZ-IZDJXGPRSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 CAQZGKQEISXDLZ-IZDJXGPRSA-N 0.000 claims description 2
• FPNFGQFNVXWDCZ-IZDJXGPRSA-N (2s)-3-[4-[(z)-5-[1,5-bis(2,2,2-trifluoroethoxy)cyclohexa-2,4-dien-1-yl]pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OCC(F)(F)F)C=CC=C(OCC(F)(F)F)C1 FPNFGQFNVXWDCZ-IZDJXGPRSA-N 0.000 claims description 2
• JYJWQLXMZBHJJL-KJAUIJNUSA-N (2s)-3-[4-[(z)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 JYJWQLXMZBHJJL-KJAUIJNUSA-N 0.000 claims description 2
• KUUWNQVFBPYJGN-KJAUIJNUSA-N (2s)-3-[4-[(z)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 KUUWNQVFBPYJGN-KJAUIJNUSA-N 0.000 claims description 2
• KWSGNLFOICWEQW-KJAUIJNUSA-N (2s)-3-[4-[(z)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 KWSGNLFOICWEQW-KJAUIJNUSA-N 0.000 claims description 2
• UAUNYERAGADNGR-BVJONSBASA-N (2s)-3-[4-[(z)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 UAUNYERAGADNGR-BVJONSBASA-N 0.000 claims description 2
• NNLWGHPNVHTDTB-CCZWLNLGSA-N (2s)-3-[4-[(z)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]pent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 NNLWGHPNVHTDTB-CCZWLNLGSA-N 0.000 claims description 2
• OMBNCAISCHLFPV-CCZWLNLGSA-N (2s)-3-[4-[(z)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]pent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 OMBNCAISCHLFPV-CCZWLNLGSA-N 0.000 claims description 2
• JHGSQBWPCPJESY-CCZWLNLGSA-N (2s)-3-[4-[(z)-5-[3,5-bis(2,2,2-trifluoroethoxy)phenyl]pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(OCC(F)(F)F)=CC(OCC(F)(F)F)=C1 JHGSQBWPCPJESY-CCZWLNLGSA-N 0.000 claims description 2
• RRTYHUQNONZZIR-YDBYVANFSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 RRTYHUQNONZZIR-YDBYVANFSA-N 0.000 claims description 2
• VDTAAXWORUHPQJ-YDBYVANFSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 VDTAAXWORUHPQJ-YDBYVANFSA-N 0.000 claims description 2
• GJPBQAYKKUFVDC-YDBYVANFSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 GJPBQAYKKUFVDC-YDBYVANFSA-N 0.000 claims description 2
• ZMOQRERCLICEKZ-RSAMLISRSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]-3-methylpent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 ZMOQRERCLICEKZ-RSAMLISRSA-N 0.000 claims description 2
• HMXPQWQIPLHGIJ-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]-3-bromophenyl]-2-ethoxypropanoic acid Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 HMXPQWQIPLHGIJ-OMUFJYGLSA-N 0.000 claims description 2
• HXEVWPFPZQLMHK-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]-3-chlorophenyl]-2-ethoxypropanoic acid Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 HXEVWPFPZQLMHK-OMUFJYGLSA-N 0.000 claims description 2
• DSJSZDJPUKFECB-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]-3-iodophenyl]-2-ethoxypropanoic acid Chemical compound IC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 DSJSZDJPUKFECB-OMUFJYGLSA-N 0.000 claims description 2
• QNWVDQWEMGLGOE-OMUFJYGLSA-N (2s)-3-[4-[(z)-5-[3,5-bis(trifluoromethyl)phenyl]pent-2-en-4-ynoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 QNWVDQWEMGLGOE-OMUFJYGLSA-N 0.000 claims description 2
• IOWUICTWJLJBCA-BLQOUQKLSA-N BrC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 Chemical compound BrC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 IOWUICTWJLJBCA-BLQOUQKLSA-N 0.000 claims description 2
• ZUMIFJOQQCSMPY-ZGAQRXBASA-N BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 ZUMIFJOQQCSMPY-ZGAQRXBASA-N 0.000 claims description 2
• ZUMIFJOQQCSMPY-SYMXCSSMSA-N BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 ZUMIFJOQQCSMPY-SYMXCSSMSA-N 0.000 claims description 2
• MQKCGAWFBHLBBV-OPQGSUJVSA-N BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 MQKCGAWFBHLBBV-OPQGSUJVSA-N 0.000 claims description 2
• MQKCGAWFBHLBBV-PFHJWNERSA-N BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound BrC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 MQKCGAWFBHLBBV-PFHJWNERSA-N 0.000 claims description 2
• JTOPUSNCDKUGJU-FHWZBTPRSA-N C1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 Chemical compound C1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 JTOPUSNCDKUGJU-FHWZBTPRSA-N 0.000 claims description 2
• GXBVRHRUODRNJN-WTPZTIPBSA-N C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(\C)C#CC1=CC=CC(C(F)(F)F)=C1 Chemical compound C1=CC(C[C@H](OCC)C(=O)OCC)=CC=C1OC\C=C(\C)C#CC1=CC=CC(C(F)(F)F)=C1 GXBVRHRUODRNJN-WTPZTIPBSA-N 0.000 claims description 2
• GIISGNCOZVZNBL-UICFQJRISA-N C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 GIISGNCOZVZNBL-UICFQJRISA-N 0.000 claims description 2
• GIISGNCOZVZNBL-UXZAGDMNSA-N C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 GIISGNCOZVZNBL-UXZAGDMNSA-N 0.000 claims description 2
• GMVWXHZTKCTITI-OPQGSUJVSA-N C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 GMVWXHZTKCTITI-OPQGSUJVSA-N 0.000 claims description 2
• GMVWXHZTKCTITI-PFHJWNERSA-N C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 GMVWXHZTKCTITI-PFHJWNERSA-N 0.000 claims description 2
• FCIRRFADSYETTD-BLQOUQKLSA-N ClC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 Chemical compound ClC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 FCIRRFADSYETTD-BLQOUQKLSA-N 0.000 claims description 2
• YJQZAXUFEPRNRL-ZGAQRXBASA-N ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(/C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 YJQZAXUFEPRNRL-ZGAQRXBASA-N 0.000 claims description 2
• YJQZAXUFEPRNRL-SYMXCSSMSA-N ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C(\C)C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 YJQZAXUFEPRNRL-SYMXCSSMSA-N 0.000 claims description 2
• QMHUZAZGQWRCAW-OPQGSUJVSA-N ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 QMHUZAZGQWRCAW-OPQGSUJVSA-N 0.000 claims description 2
• QMHUZAZGQWRCAW-PFHJWNERSA-N ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 Chemical compound ClC1=CC(C[C@H](OCC)C(O)=O)=CC=C1OC\C=C\C#CC1(C(F)(F)F)C=CC=C(C(F)(F)F)C1 QMHUZAZGQWRCAW-PFHJWNERSA-N 0.000 claims description 2
• FHRVOSGTWGSIJT-BLQOUQKLSA-N IC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 Chemical compound IC1=CC(C(C)[C@H](OCC)C(O)=O)=CC=C1OC\C=C/C#CC1(OC)C=CC=C(OC)C1 FHRVOSGTWGSIJT-BLQOUQKLSA-N 0.000 claims description 2
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