JP2003520839A - 新規化合物、それらの製造及び使用 - Google Patents

新規化合物、それらの製造及び使用

Info

Publication number
JP2003520839A
JP2003520839A JP2001555029A JP2001555029A JP2003520839A JP 2003520839 A JP2003520839 A JP 2003520839A JP 2001555029 A JP2001555029 A JP 2001555029A JP 2001555029 A JP2001555029 A JP 2001555029A JP 2003520839 A JP2003520839 A JP 2003520839A
Authority
JP
Japan
Prior art keywords
phenyl
ethoxy
ynyloxy
propionic acid
pent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001555029A
Other languages
English (en)
Japanese (ja)
Inventor
モーゲンセン、ジョン・パトリック
ザウアーベルグ、ペール
バリー、ポール・スタンリー
イェッペセン、ローネ
ペッターソン、イングリッド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of JP2003520839A publication Critical patent/JP2003520839A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001555029A 2000-01-28 2001-01-26 新規化合物、それらの製造及び使用 Pending JP2003520839A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DK200000137 2000-01-28
DKPA200000137 2000-01-28
DK200001065 2000-07-07
DKPA200001065 2000-07-07
DK200001593 2000-10-25
DKPA200001593 2000-10-25
PCT/DK2001/000057 WO2001055086A1 (en) 2000-01-28 2001-01-26 Alkynylsubstituted propionic acid derivatives and their use against diabetes and obesity

Publications (1)

Publication Number Publication Date
JP2003520839A true JP2003520839A (ja) 2003-07-08

Family

ID=27222337

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001555029A Pending JP2003520839A (ja) 2000-01-28 2001-01-26 新規化合物、それらの製造及び使用

Country Status (13)

Country Link
EP (1) EP1254102A1 (es)
JP (1) JP2003520839A (es)
KR (1) KR20020090211A (es)
CN (1) CN1396904A (es)
AU (1) AU2831801A (es)
BR (1) BR0107902A (es)
CA (1) CA2396372A1 (es)
HU (1) HUP0204247A3 (es)
IL (1) IL150259A0 (es)
MX (1) MXPA02007295A (es)
NO (1) NO20023567L (es)
PL (1) PL357017A1 (es)
WO (1) WO2001055086A1 (es)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514456A (ja) * 2002-01-15 2005-05-19 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体
JP2008504249A (ja) * 2004-06-28 2008-02-14 ノボ　ノルディスク　アクティーゼルスカブ 糖尿病を治療するための方法
JP2020514295A (ja) * 2017-01-06 2020-05-21 スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． ミオスタチン活性化の阻害により代謝疾患を処置するための方法
US11439704B2 (en) 2015-09-15 2022-09-13 Scholar Rock, Inc. Methods for using anti-myostatin antibodies
US11925683B2 (en) 2014-11-06 2024-03-12 Scholar Rock, Inc. Compositions for making and using anti-Myostatin antibodies
US12006359B2 (en) 2020-10-29 2024-06-11 Scholar Rock, Inc. Methods for altering body composition by administering anti-pro/latent myostatin antibodies

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
JPWO2003016265A1 (ja) 2001-08-17 2004-12-02 エーザイ株式会社 環状化合物およびｐｐａｒアゴニスト
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
EP1438283A1 (en) * 2001-10-17 2004-07-21 Novo Nordisk A/S Dicarboxylic acid derivatives, their preparation and therapeutic use
CN1688540A (zh) * 2002-09-05 2005-10-26 诺沃挪第克公司 新颖的乙烯基羧酸衍生物以及它们的治疗用途
WO2005105736A1 (en) 2004-05-05 2005-11-10 Novo Nordisk A/S Novel compounds, their preparation and use
EA201101085A1 (ru) 2005-12-22 2012-05-30 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Феноксиуксусные кислоты в качестве активаторов ppar дельта
JP2023534835A (ja) 2020-07-22 2023-08-14 レネオ ファーマシューティカルズ，インク． 結晶性ｐｐａｒデルタアゴニスト
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL176885B1 (pl) * 1992-07-03 1999-08-31 Smithkline Beecham Plc Kompozycja farmaceutyczna
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
BR9508468A (pt) * 1994-07-29 1997-11-25 Smithkline Beecham Plc Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário
GB9600464D0 (en) * 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
GB9606805D0 (en) * 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514456A (ja) * 2002-01-15 2005-05-19 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体
JP2008504249A (ja) * 2004-06-28 2008-02-14 ノボ　ノルディスク　アクティーゼルスカブ 糖尿病を治療するための方法
US11925683B2 (en) 2014-11-06 2024-03-12 Scholar Rock, Inc. Compositions for making and using anti-Myostatin antibodies
US11439704B2 (en) 2015-09-15 2022-09-13 Scholar Rock, Inc. Methods for using anti-myostatin antibodies
JP2020514295A (ja) * 2017-01-06 2020-05-21 スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． ミオスタチン活性化の阻害により代謝疾患を処置するための方法
JP7198757B2 (ja) 2017-01-06 2023-01-04 スカラー ロック インコーポレイテッド ミオスタチン活性化の阻害により代謝疾患を処置するための方法
US12006359B2 (en) 2020-10-29 2024-06-11 Scholar Rock, Inc. Methods for altering body composition by administering anti-pro/latent myostatin antibodies

Also Published As

Publication number Publication date
NO20023567D0 (no) 2002-07-26
WO2001055086A1 (en) 2001-08-02
HUP0204247A3 (en) 2003-10-28
MXPA02007295A (es) 2002-11-29
HUP0204247A2 (hu) 2003-04-28
BR0107902A (pt) 2002-11-05
KR20020090211A (ko) 2002-11-30
EP1254102A1 (en) 2002-11-06
NO20023567L (no) 2002-09-25
AU2831801A (en) 2001-08-07
IL150259A0 (en) 2002-12-01
PL357017A1 (en) 2004-07-12
CN1396904A (zh) 2003-02-12
CA2396372A1 (en) 2001-08-02

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