NO20016071L - Fremgangsmåte for stabilisering av proteiner i komplekse blandinger i löpet av deres lagring i vandige opplösningsmidler - Google Patents
Fremgangsmåte for stabilisering av proteiner i komplekse blandinger i löpet av deres lagring i vandige opplösningsmidlerInfo
- Publication number
- NO20016071L NO20016071L NO20016071A NO20016071A NO20016071L NO 20016071 L NO20016071 L NO 20016071L NO 20016071 A NO20016071 A NO 20016071A NO 20016071 A NO20016071 A NO 20016071A NO 20016071 L NO20016071 L NO 20016071L
- Authority
- NO
- Norway
- Prior art keywords
- course
- storage
- aqueous solvents
- complex mixtures
- stabilizing proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Foreliggende oppfinnelse angår en fremgangsmåte for lagring av proteiner i et vandig oppløsningsmiddel. Tilsats av cystein forsinker reduksjon av den virksomme konsentrasjonen av proteinet. Fremgangsmåten egner seg for anvendelse ved produksjon av proteiner i mikroorganismer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19930676A DE19930676B4 (de) | 1999-07-02 | 1999-07-02 | Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln |
PCT/EP2000/005666 WO2001002435A1 (de) | 1999-07-02 | 2000-06-20 | Verfahren zur stabilisierung von proteinen in komplexen mischungen bei deren lagerung in wässrigen lösungsmitteln |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20016071L true NO20016071L (no) | 2001-12-12 |
NO20016071D0 NO20016071D0 (no) | 2001-12-12 |
NO329429B1 NO329429B1 (no) | 2010-10-18 |
Family
ID=7913515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20016071A NO329429B1 (no) | 1999-07-02 | 2001-12-12 | Fremgangsmate for lagring av insulin i et vandig opplosningsmiddel. |
Country Status (25)
Country | Link |
---|---|
US (3) | US6339061B1 (no) |
EP (1) | EP1196447B1 (no) |
JP (1) | JP4555525B2 (no) |
KR (1) | KR100754235B1 (no) |
CN (1) | CN1220703C (no) |
AR (1) | AR024621A1 (no) |
AT (1) | ATE423137T1 (no) |
AU (1) | AU768443B2 (no) |
BR (1) | BRPI0012150B8 (no) |
CA (1) | CA2377794C (no) |
CY (1) | CY1109050T1 (no) |
DE (2) | DE19930676B4 (no) |
DK (1) | DK1196447T3 (no) |
ES (1) | ES2321373T3 (no) |
HK (1) | HK1047115B (no) |
HU (1) | HU228936B1 (no) |
IL (2) | IL147250A0 (no) |
MX (1) | MXPA01012836A (no) |
NO (1) | NO329429B1 (no) |
NZ (1) | NZ516372A (no) |
PL (1) | PL200145B1 (no) |
PT (1) | PT1196447E (no) |
SI (1) | SI1196447T1 (no) |
WO (1) | WO2001002435A1 (no) |
ZA (1) | ZA200110507B (no) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10224111A1 (de) * | 2002-05-29 | 2003-12-18 | November Ag Molekulare Medizin | Verfahren zum Assemblieren von Untereinheiten zu Kapsoiden |
US20060201877A1 (en) * | 2005-03-10 | 2006-09-14 | Baldridge John W | Septic system cleaning |
US8116073B2 (en) * | 2010-01-26 | 2012-02-14 | Amtek System Co., Ltd. | Display structure of slip-cover-hinge electronic device |
CN108404194A (zh) * | 2018-04-20 | 2018-08-17 | 朱清 | 一种快速止血纱布的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4371523A (en) * | 1980-12-29 | 1983-02-01 | The Regents Of The University Of California | Reducing the aggregation of insulin in solution |
FI78616C (fi) * | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
DE3583880D1 (de) * | 1984-04-09 | 1991-10-02 | Takeda Chemical Industries Ltd | Stabile interleukin-2-zusammensetzung. |
DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
US4937085A (en) * | 1986-08-15 | 1990-06-26 | Agra-Research, Inc. | Discoloration preventing food preservative and method |
GB8806893D0 (en) * | 1988-03-23 | 1988-04-27 | Unilever Plc | Cosmetic composition |
KR900003362A (ko) * | 1988-08-24 | 1990-03-26 | 전학제 | 유전공학기법을 이용한 인체 인슈린 유사체의 제조방법 |
JPH0341033A (ja) * | 1989-07-07 | 1991-02-21 | Kyowa Hakko Kogyo Co Ltd | 安定なモチリン類含有製剤 |
US5227293A (en) | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
GR1005153B (el) | 1989-08-29 | 2006-03-13 | The General Hospital Corporation | Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους. |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
IL139335A (en) * | 1994-01-03 | 2005-08-31 | Genentech Inc | Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia |
DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
US6165981A (en) * | 1995-03-07 | 2000-12-26 | Dade Behring Inc. | Stabilizing solutions for proteins and peptides |
US5780431A (en) * | 1996-09-20 | 1998-07-14 | Neurobiological Technologies, Inc. | Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form |
DE19735711C2 (de) * | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
-
1999
- 1999-07-02 DE DE19930676A patent/DE19930676B4/de not_active Expired - Lifetime
-
2000
- 2000-06-20 CN CNB008091773A patent/CN1220703C/zh not_active Expired - Lifetime
- 2000-06-20 HU HU0202264A patent/HU228936B1/hu unknown
- 2000-06-20 EP EP00943838A patent/EP1196447B1/de not_active Expired - Lifetime
- 2000-06-20 PL PL353160A patent/PL200145B1/pl unknown
- 2000-06-20 DK DK00943838T patent/DK1196447T3/da active
- 2000-06-20 DE DE50015562T patent/DE50015562D1/de not_active Expired - Lifetime
- 2000-06-20 WO PCT/EP2000/005666 patent/WO2001002435A1/de active Application Filing
- 2000-06-20 AT AT00943838T patent/ATE423137T1/de active
- 2000-06-20 AU AU58164/00A patent/AU768443B2/en not_active Expired
- 2000-06-20 SI SI200031027T patent/SI1196447T1/sl unknown
- 2000-06-20 NZ NZ516372A patent/NZ516372A/xx not_active IP Right Cessation
- 2000-06-20 IL IL14725000A patent/IL147250A0/xx unknown
- 2000-06-20 JP JP2001508222A patent/JP4555525B2/ja not_active Expired - Lifetime
- 2000-06-20 CA CA2377794A patent/CA2377794C/en not_active Expired - Lifetime
- 2000-06-20 PT PT00943838T patent/PT1196447E/pt unknown
- 2000-06-20 KR KR1020027000032A patent/KR100754235B1/ko active IP Right Grant
- 2000-06-20 ES ES00943838T patent/ES2321373T3/es not_active Expired - Lifetime
- 2000-06-20 BR BRPI0012150A patent/BRPI0012150B8/pt not_active IP Right Cessation
- 2000-06-20 MX MXPA01012836A patent/MXPA01012836A/es active IP Right Grant
- 2000-06-29 AR ARP000103312A patent/AR024621A1/es active IP Right Grant
- 2000-06-30 US US09/608,297 patent/US6339061B1/en not_active Expired - Lifetime
-
2001
- 2001-11-26 US US09/991,964 patent/US6734164B2/en not_active Expired - Lifetime
- 2001-12-12 NO NO20016071A patent/NO329429B1/no not_active IP Right Cessation
- 2001-12-21 ZA ZA200110507A patent/ZA200110507B/xx unknown
- 2001-12-23 IL IL147250A patent/IL147250A/en active IP Right Grant
-
2002
- 2002-11-29 HK HK02108639.8A patent/HK1047115B/zh not_active IP Right Cessation
-
2004
- 2004-03-10 US US10/796,160 patent/US7514403B2/en not_active Expired - Fee Related
-
2009
- 2009-05-11 CY CY20091100502T patent/CY1109050T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |