YU41198A - Derivati pirolopirolona kao inhibitori neutrofilne elastaze - Google Patents

Derivati pirolopirolona kao inhibitori neutrofilne elastaze

Info

Publication number
YU41198A
YU41198A YU41198A YU41198A YU41198A YU 41198 A YU41198 A YU 41198A YU 41198 A YU41198 A YU 41198A YU 41198 A YU41198 A YU 41198A YU 41198 A YU41198 A YU 41198A
Authority
YU
Yugoslavia
Prior art keywords
inhibitors
neutrophil elastase
pyrrolopyrrolone
derivatives
pyrrolopyrrolone derivatives
Prior art date
Application number
YU41198A
Other languages
English (en)
Inventor
Dennis Dowle Michael
Finch Harry
Andrew Harrison Lee
George Adam Inglis Graham
Redpath Johnson Martin
Shah Pritom
Andrew Smith Robin
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9606508.1A external-priority patent/GB9606508D0/en
Priority claimed from GBGB9623001.6A external-priority patent/GB9623001D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of YU41198A publication Critical patent/YU41198A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

U skladu sa ovim pronalaskom opisana su jedinjenja formule (I) (ukazano je na njihovu relativnu stereohemiju), gde su R1, R2, R3 i X definisani u prijavi, zajedno sa postupcima njihovog dobijanja, preparatima koji ih sadrže i njihova upotreba kao farmaceutskih sredstava. Jedinjenja formule (I) su se, izmedju ostalog, pokazala upotrebljivim za lečenje hroničnog bronhitisa.
YU41198A 1996-03-28 1998-09-23 Derivati pirolopirolona kao inhibitori neutrofilne elastaze YU41198A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9606508.1A GB9606508D0 (en) 1996-03-28 1996-03-28 Chemical componds
GBGB9623001.6A GB9623001D0 (en) 1996-11-05 1996-11-05 Chemical compounds

Publications (1)

Publication Number Publication Date
YU41198A true YU41198A (sh) 1999-09-27

Family

ID=26309008

Family Applications (1)

Application Number Title Priority Date Filing Date
YU41198A YU41198A (sh) 1996-03-28 1998-09-23 Derivati pirolopirolona kao inhibitori neutrofilne elastaze

Country Status (30)

Country Link
US (3) US5994344A (sh)
EP (1) EP0891362B1 (sh)
JP (1) JP4118337B2 (sh)
KR (1) KR20000005039A (sh)
CN (1) CN1067075C (sh)
AP (1) AP823A (sh)
AR (1) AR006401A1 (sh)
AT (1) ATE261969T1 (sh)
AU (1) AU726649B2 (sh)
BR (1) BR9708449A (sh)
CA (1) CA2250209A1 (sh)
CO (1) CO4790152A1 (sh)
CZ (1) CZ309798A3 (sh)
DE (1) DE69728139T2 (sh)
DK (1) DK0891362T3 (sh)
EA (1) EA001437B1 (sh)
EE (1) EE9800335A (sh)
ES (1) ES2217404T3 (sh)
HU (1) HUP9900567A3 (sh)
IL (1) IL125859A0 (sh)
IS (1) IS4837A (sh)
NO (1) NO984470L (sh)
NZ (1) NZ331490A (sh)
PE (1) PE55298A1 (sh)
PL (1) PL329153A1 (sh)
PT (1) PT891362E (sh)
SK (1) SK132498A3 (sh)
TR (1) TR199801935T2 (sh)
WO (1) WO1997036903A1 (sh)
YU (1) YU41198A (sh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9719189D0 (en) * 1997-09-09 1997-11-12 Glaxo Group Ltd New therapeutic method
PE107899A1 (es) * 1997-09-09 1999-11-17 Glaxo Group Ltd Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
GB9719187D0 (en) * 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
GB9719172D0 (en) * 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
GB9821199D0 (en) * 1998-09-30 1998-11-25 Glaxo Group Ltd Chemical compounds
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
MXPA05009771A (es) 2003-03-14 2005-10-26 Ono Pharmaceutical Co Derivados heterociclicos que contienen nitrogeno y medicamentos que los contienen como el ingrediente activo.
US8530509B2 (en) 2003-06-20 2013-09-10 Siga Technologies, Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
US7692037B2 (en) * 2004-09-02 2010-04-06 Eastman Chemical Company Optimized liquid-phase oxidation
AU2005283326B2 (en) 2004-09-13 2011-07-21 Ono Pharmaceutical Co., Ltd. Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
GB0512238D0 (en) * 2005-06-15 2005-07-27 Univ Cambridge Tech Anti-inflammatory agents
BRPI0708731A2 (pt) 2006-03-10 2011-06-07 Ono Pharmaceutical Co derivado heterocìclico nitrogenado, e agente farmacêutico compreendendo o derivado como ingrediente ativo
MX348481B (es) * 2007-04-23 2017-06-15 Siga Tech Inc Productos quimicos, composiciones y metodos para tratamiento y prevencion de infecciones de virus orthopox y enfermedades asociadas.
CA2705947C (en) 2007-11-16 2016-08-09 Rigel Pharmaceuticals, Inc. Carboxamide, sulfonamide and amine compounds for metabolic disorders
ES2553340T3 (es) 2007-12-12 2015-12-07 Rigel Pharmaceuticals, Inc. Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos
CN102099357B (zh) 2008-04-23 2014-07-02 里格尔药品股份有限公司 用于治疗代谢障碍的甲酰胺化合物
KR102197721B1 (ko) * 2012-12-18 2021-01-05 키에시 파르마슈티시 엣스. 피. 에이. 신규 화합물
JP2023500182A (ja) 2019-09-17 2023-01-05 メレオ バイオファーマ ４ リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
EP4106757B1 (en) 2020-04-16 2023-08-23 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
TW202325294A (zh) 2021-10-20 2023-07-01 英商梅瑞奧生物製藥４有限公司 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2932650A (en) * 1957-11-19 1960-04-12 Arthur C Cope 2-6-diazabicyclo (3. 3. 0) octanes
US4997950A (en) * 1989-04-20 1991-03-05 Richard Finbar Murphy Novel C-terminal gastrin antagonists
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
US5610296A (en) * 1994-12-05 1997-03-11 G. D. Searle & Co. Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs

Also Published As

Publication number Publication date
US6215002B1 (en) 2001-04-10
HUP9900567A2 (hu) 1999-06-28
CA2250209A1 (en) 1997-10-09
AP823A (en) 2000-04-25
JP2000507950A (ja) 2000-06-27
AP9801351A0 (en) 1998-09-30
IS4837A (is) 1998-08-28
DE69728139D1 (de) 2004-04-22
EA199800773A1 (ru) 1999-06-24
CN1067075C (zh) 2001-06-13
EP0891362A1 (en) 1999-01-20
NZ331490A (en) 2000-06-23
CO4790152A1 (es) 1999-05-31
NO984470L (no) 1998-11-25
WO1997036903A1 (en) 1997-10-09
DE69728139T2 (de) 2004-10-21
SK132498A3 (en) 1999-08-06
TR199801935T2 (xx) 1999-03-22
AU2291797A (en) 1997-10-22
JP4118337B2 (ja) 2008-07-16
EA001437B1 (ru) 2001-02-26
PE55298A1 (es) 1998-09-19
PL329153A1 (en) 1999-03-15
CN1219935A (zh) 1999-06-16
NO984470D0 (no) 1998-09-25
PT891362E (pt) 2004-08-31
AR006401A1 (es) 1999-08-25
US6057457A (en) 2000-05-02
US5994344A (en) 1999-11-30
HUP9900567A3 (en) 2001-02-28
KR20000005039A (ko) 2000-01-25
BR9708449A (pt) 1999-08-03
ATE261969T1 (de) 2004-04-15
DK0891362T3 (da) 2004-07-12
EE9800335A (et) 1999-04-15
EP0891362B1 (en) 2004-03-17
CZ309798A3 (cs) 1999-02-17
IL125859A0 (en) 1999-04-11
AU726649B2 (en) 2000-11-16
ES2217404T3 (es) 2004-11-01

Similar Documents

Publication Publication Date Title
YU41198A (sh) Derivati pirolopirolona kao inhibitori neutrofilne elastaze
MEP24608A (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
ZA988158B (en) Sulfinic acid derivatives and their preparation and use
TR200402157T2 (tr) Heteroaril süksinamidler ve metalloproteinaz inhibitörü olarak kullanımları
EA199800611A1 (ru) Производные фенилтиазола с противогерпетическими свойствами
YU34896A (sh) Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
MX9604020A (es) Arilalquildiazinonas.
ATE306261T1 (de) Antithrombosemittel
PT97888A (pt) Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
ES2132415T3 (es) Nuevos derivados de 5-pirrolil-2-piridilmetilsulfinilbencimidazol.
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
DE69232929D1 (de) Saccharinderivate als proteolytische Enzyminhibitoren
RU94038064A (ru) Производные пиперазина и пиперидина, их применение в качестве противопсихотических средств, способ их получения фармацевтическая композиция
MX9503529A (es) Derivados de glicinamida, procedimiento para su preparacion y medicamentos que los contienen.
RU94046018A (ru) 3-арилпиразольные производные, способ их получения и фунгицидная композиция на их основе
FI954898A (fi) Vesiliukoiset kamptotesiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö kasvaintenvastaisina aineina
YU33401A (sh) 13-točlani azalidi i njihova primena kao antibiotičkih sredstava
ATE181731T1 (de) Isothioharnstoff-derivate als no synthase hemmer
AU6319480A (en) 2-hydroxyalkyl-3,4,5-trihydroxypiperidines
CA2218663A1 (en) Benzisoxazole and indazole derivatives as antipsychotic agents
YU65899A (sh) Stabilizovani karbapenem intermedijari i sintetska upotreba
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
CA2107485A1 (fr) Nouveaux derives d'ellipticine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MY128261A (en) New substituted azetidinones as anti-inflammatory and antidegenerative agents
DE69512208D1 (de) Aminosäurederivate und ihre verwendung als phospholipase-a2-inhibitoren