NO20013801L - Ny karbonyl reduktase, gen derav og metoder for anvendelse av det samme - Google Patents

Ny karbonyl reduktase, gen derav og metoder for anvendelse av det samme

Info

Publication number
NO20013801L
NO20013801L NO20013801A NO20013801A NO20013801L NO 20013801 L NO20013801 L NO 20013801L NO 20013801 A NO20013801 A NO 20013801A NO 20013801 A NO20013801 A NO 20013801A NO 20013801 L NO20013801 L NO 20013801L
Authority
NO
Norway
Prior art keywords
polypeptide
gene
methods
same
chloro
Prior art date
Application number
NO20013801A
Other languages
English (en)
Norwegian (no)
Other versions
NO20013801D0 (no
Inventor
Noriyuki Kizaka
Yukio Yamada
Yoshihiko Yasohara
Junzo Hasegawa
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of NO20013801D0 publication Critical patent/NO20013801D0/no
Publication of NO20013801L publication Critical patent/NO20013801L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20013801A 1999-12-03 2001-08-02 Ny karbonyl reduktase, gen derav og metoder for anvendelse av det samme NO20013801L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34554199 1999-12-03
PCT/JP2000/008321 WO2001040450A1 (fr) 1999-12-03 2000-11-24 Nouvelle carbonyl reductase, son gene et son procede d'utilisation

Publications (2)

Publication Number Publication Date
NO20013801D0 NO20013801D0 (no) 2001-08-02
NO20013801L true NO20013801L (no) 2001-10-03

Family

ID=18377296

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013801A NO20013801L (no) 1999-12-03 2001-08-02 Ny karbonyl reduktase, gen derav og metoder for anvendelse av det samme

Country Status (15)

Country Link
US (1) US6645746B1 (fr)
EP (1) EP1152054B1 (fr)
JP (1) JP4510351B2 (fr)
KR (1) KR100512080B1 (fr)
AT (1) ATE291616T1 (fr)
AU (1) AU1551701A (fr)
CA (1) CA2360376C (fr)
CZ (1) CZ20012792A3 (fr)
DE (1) DE60018909T2 (fr)
ES (1) ES2240205T3 (fr)
HU (1) HUP0105331A3 (fr)
MX (1) MXPA01007858A (fr)
NO (1) NO20013801L (fr)
SI (1) SI20642A (fr)
WO (1) WO2001040450A1 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0305767A (pt) * 2002-08-09 2005-05-24 Codexis Inc Métodos e composições para a preparação de derivados de ácido 4-substituìdo 3-hidroxibutìrico
EP1568679A4 (fr) * 2002-12-06 2012-08-29 Kaneka Corp Procede de production d'un derive ester 3-hydroxypropionique optiquement actif
EP1654356A1 (fr) * 2003-08-11 2006-05-10 Codexis, Inc. Deshalogenases d'halohydrine ameliorees et polynucleotides correspondants
AU2004266100A1 (en) 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7629157B2 (en) * 2003-08-11 2009-12-08 Codexis, Inc. Ketoreductase polypeptides and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
BRPI0413492A (pt) * 2003-08-11 2006-10-17 Codexis Inc polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição
DE10345772A1 (de) * 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
JP4757804B2 (ja) * 2004-10-27 2011-08-24 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
DE102005044736A1 (de) * 2005-09-19 2007-03-22 Basf Ag Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen
AT503017B1 (de) 2005-12-19 2007-07-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen
ATE529507T1 (de) 2006-03-31 2011-11-15 Kaneka Corp Verfahren zur produktion von erythro- oder threo- 2-amino-3-hydroxypropionsäureester, neuartige carbonylreduktase, gen für die reduktase, vektor, transformante und verfahren zur produktion von optisch aktivem alkohol unter verwendung dieser
CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
AT504542B1 (de) * 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
JP2010517574A (ja) 2007-02-08 2010-05-27 コデクシス， インコーポレイテッド ケトレダクターゼおよびその使用
US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
US8748143B2 (en) 2007-09-13 2014-06-10 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
TWI601825B (zh) * 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
CN101889081B (zh) * 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
JP5646328B2 (ja) * 2007-10-01 2014-12-24 コデクシス， インコーポレイテッド アゼチジノンの生産のためのケトレダクターゼポリペプチド
WO2010027710A2 (fr) 2008-08-27 2010-03-11 Codexis, Inc. Polypeptides de cétoréductase et leurs utilisations
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025238A2 (fr) 2008-08-27 2010-03-04 Codexis, Inc. Polypeptides de kétoréductase servant à préparer une 3-aryl-3-hydroxypropanamine à partir d'une 3-aryl-3-kétopropanamine
CN102186972B (zh) 2008-08-29 2014-08-20 科德克希思公司 用于立体选择性生产(4s)-3-[(5s)-5-(4-氟苯基)-5-羟基戊酰基]-4-苯基-1，3-噁唑烷-2-酮的酮还原酶多肽
EP2379713A4 (fr) * 2008-12-18 2013-07-10 Codexis Inc Polypeptides de halohydrine déshalogénase recombinants
EP2226386A1 (fr) 2009-03-05 2010-09-08 IEP GmbH Procédé de réduction stéréosélective enzymatique de composés cétoniques
DK3409765T3 (da) 2009-06-22 2021-09-27 Codexis Inc Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer
AU2009348523B2 (en) * 2009-06-22 2015-02-26 Sk Biopharmaceuticals Co., Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
ES2575560T3 (es) 2009-08-19 2016-06-29 Codexis, Inc. Polipéptidos cetorreductasa para preparar fenilefrina
US8404461B2 (en) * 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
WO2011100265A2 (fr) 2010-02-10 2011-08-18 Codexis, Inc. Procédés utilisant des acide aminé déshydrogénases et un système de régénération de cofacteur à base de cétoréductase
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
DK2639216T3 (en) 2010-11-09 2018-09-24 Kaneka Corp Halogenated Indones and Methods for Preparation of Optically Active Indanones or Optically Active Indanols Using These
CN102676596A (zh) * 2011-03-16 2012-09-19 苏州国镝医药科技有限公司 生物酶手性合成立普妥中间体ats-7
HUE046089T2 (hu) 2011-11-18 2020-01-28 Codexis Inc Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához
TW201343623A (zh) 2012-02-07 2013-11-01 Annikki Gmbh 使氧化還原輔因子經酶催化再生之方法
ES2746698T3 (es) 2012-02-07 2020-03-06 Annikki Gmbh Procedimiento para la preparación de derivados de furano a partir de glucosa
WO2013117251A1 (fr) 2012-02-07 2013-08-15 Annikki Gmbh Procédé de régénération enzymatique de cofacteurs redox
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
KR101446551B1 (ko) 2013-02-26 2014-10-06 주식회사 아미노로직스 (2rs)-아미노-(3s)-히드록시-부티르산 또는 이의 유도체의 제조방법
JP6480416B2 (ja) 2013-03-27 2019-03-13 アニッキ ゲーエムベーハーＡｎｎｉｋｋｉ Ｇｍｂｈ グルコースの異性化のための方法
US10093905B2 (en) 2014-04-22 2018-10-09 C-Lecta Gmbh Ketoreductases
CN104328148A (zh) * 2014-11-04 2015-02-04 尚科生物医药（上海）有限公司 酶法制备(3r,5s)-6-氯-3,5-二羟基己酸叔丁酯
EP3256577B1 (fr) 2015-02-10 2020-08-26 Codexis, Inc. Polypeptides de cétoréductase pour la synthèse de composés chiraux
CN104830921B (zh) * 2015-04-27 2019-07-02 上海工业生物技术研发中心 一种酶法制备他汀类化合物中间体的方法
CN105087685A (zh) * 2015-09-16 2015-11-25 连云港宏业化工有限公司 一种合成（3r，5s）-6-氯-3,5-二羟基己酸叔丁酯的方法
CN105087684A (zh) * 2015-09-16 2015-11-25 连云港宏业化工有限公司 一种（3r，5s）-6-氯-3,5-二羟基己酸叔丁酯的制备方法
CN106011092A (zh) * 2016-06-20 2016-10-12 苏州汉酶生物技术有限公司 一种工程化酮还原酶多肽及其用于制备孟鲁斯特中间体的方法
CN106011095B (zh) * 2016-07-27 2021-02-26 苏州汉酶生物技术有限公司 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法
CA3061133A1 (fr) 2017-04-27 2018-11-01 Codexis, Inc. Polypeptides de cetoreductases et polynucleotides
EP3652328A1 (fr) 2017-07-14 2020-05-20 c-LEcta GmbH Céto-réductases
CN108441523A (zh) * 2018-03-22 2018-08-24 南京工业大学 （3r,5s）-6-氯-3,5,-二羟基己酸叔丁酯的制备方法
CN110387359B (zh) * 2018-04-17 2021-04-20 湖州颐盛生物科技有限公司 羰基还原酶突变体及其应用
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
CA3214802A1 (fr) 2021-04-02 2022-10-06 Genentech, Inc. Procedes de fabrication de composes cetoniques bicycliques
CN114875081A (zh) * 2022-06-07 2022-08-09 湖北迅达药业股份有限公司 一种瑞舒伐他汀关键中间体的绿色工业化生产方法
WO2024150146A1 (fr) 2023-01-12 2024-07-18 Novartis Ag Polypeptides cétoréductases modifiés

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
EP1077212B1 (fr) * 1998-04-30 2003-08-20 Kaneka Corporation Procede de production de derives d'acide acetique 6-cyanomethyl-1,3-dioxane-4
DK1619191T3 (da) * 1998-08-05 2011-01-31 Kaneka Corp Fremgangsmåde til fremstilling af optisk aktive 2-[6-hydroxymethyl)-1,3-dioxan-4-yl]-eddikesyre-derivater
DE19857302C2 (de) 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester
EP1194582A1 (fr) 1999-07-09 2002-04-10 Forschungszentrum Jülich Gmbh Procede de reduction d'acides cetocarboxyliques et de leurs esters

Also Published As

Publication number Publication date
KR100512080B1 (ko) 2005-09-02
CZ20012792A3 (cs) 2002-03-13
HUP0105331A2 (hu) 2002-05-29
KR20020008116A (ko) 2002-01-29
CA2360376C (fr) 2005-04-26
DE60018909T2 (de) 2006-03-30
DE60018909D1 (de) 2005-04-28
HUP0105331A3 (en) 2005-10-28
EP1152054A1 (fr) 2001-11-07
US6645746B1 (en) 2003-11-11
EP1152054B1 (fr) 2005-03-23
AU1551701A (en) 2001-06-12
MXPA01007858A (es) 2003-07-14
EP1152054A4 (fr) 2002-11-20
JP4510351B2 (ja) 2010-07-21
WO2001040450A1 (fr) 2001-06-07
ES2240205T3 (es) 2005-10-16
CA2360376A1 (fr) 2001-06-07
SI20642A (sl) 2002-02-28
NO20013801D0 (no) 2001-08-02
ATE291616T1 (de) 2005-04-15

Similar Documents

Publication Publication Date Title
NO20013801L (no) Ny karbonyl reduktase, gen derav og metoder for anvendelse av det samme
EP1801206A4 (fr) Methode de synthese de la l-arginine, de la l-ornithine, ou de la l-citrulline
ATE293696T1 (de) Mutierte alpha-amylase enzyme mit erhöhter stabilität
NZ595502A (en) Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
WO2003089457B1 (fr) Inhibiteurs peptidiques de la proteine kinase c$g(g) pour la gestion de la douleur
WO2002061076A1 (fr) Proteine associee a l'adiponectine
AU7154096A (en) Blue copper oxidase mutants with enhanced activity
AU7617796A (en) Variants of human recombinant interferon-gamma (rhu-ifn-gamma) having increased heat-stability
EP0857789A3 (fr) Acide férulique décarboxylase
AU2099301A (en) Method for obtaining proteins having improved functional characteristics
AU1941597A (en) Protein having cellulase activities and process for producing the same
DE60141633D1 (de) Neuartige glukose-6-phosphat dehydrogenase
TATE Purification and Properties of a Bovine Brain Thyrotropin‐Releasing‐Factor Deamidase: A Post‐Proline Cleaving Enzyme of Limited Specificity
WO2004091475A3 (fr) Medicaments pour la maladie de gaucher et procedes d'identification de ces medicaments
EP1197555A4 (fr) Adn codant une enzyme ii de pts de sucrose
WO2023086520A3 (fr) Enzymes modifiées et procédé de synthèse de divers analogues de tyrosine
AU4944996A (en) Dna fragment encoding d-amino acid oxidase
JPH03219880A (ja) 細菌コラゲナーゼ遺伝子
Hatsuzawa et al. Purification of mouse Ren 2 prorenin produced in Chinese hamster ovary cells
ATE281522T1 (de) Sentrin-spezifische menschliche protease senp1
AU2001278683A1 (en) Novel carbonyl reductase, gene thereof and method of using the same
EP1584628A3 (fr) Protéine virale
Shafqat et al. Liver Class‐I Alcohol Dehydrogenase Isozyme Relationships and Constant Patterns in a Variable Basic Structure: Distinctions from Characterization of an Ethanol Dehydrogenase in Cobra, Naja Naja
MX2023013222A (es) Variantes de enzimas y usos de las mismas.
ATE301199T1 (de) Beta-primeverosidase gen

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application