EP1194582A1 - Procede de reduction d'acides cetocarboxyliques et de leurs esters - Google Patents

Procede de reduction d'acides cetocarboxyliques et de leurs esters

Info

Publication number
EP1194582A1
EP1194582A1 EP00953007A EP00953007A EP1194582A1 EP 1194582 A1 EP1194582 A1 EP 1194582A1 EP 00953007 A EP00953007 A EP 00953007A EP 00953007 A EP00953007 A EP 00953007A EP 1194582 A1 EP1194582 A1 EP 1194582A1
Authority
EP
European Patent Office
Prior art keywords
sep
formula
compounds
esters
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00953007A
Other languages
German (de)
English (en)
Inventor
Michael Müller
Michael Wolberg
Werner Hummel
Christian Wandrey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Forschungszentrum Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19937825A external-priority patent/DE19937825B4/de
Application filed by Forschungszentrum Juelich GmbH filed Critical Forschungszentrum Juelich GmbH
Publication of EP1194582A1 publication Critical patent/EP1194582A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé de réduction d'acides dicétocarboxyliques ou d'acides hydroxycétocarboxyliques ou de leurs esters, dans lequel au moins un groupe céto est converti en groupe hydroxy en présence d'espèces de Lactobacillus.
EP00953007A 1999-07-09 2000-07-05 Procede de reduction d'acides cetocarboxyliques et de leurs esters Withdrawn EP1194582A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19932038 1999-07-09
DE19932038 1999-07-09
DE19937825 1999-08-11
DE19937825A DE19937825B4 (de) 1999-07-09 1999-08-11 Verfahren zur Reduktion von Hydroxyketo-Carbonsäuren und deren Estern
PCT/EP2000/006287 WO2001004336A1 (fr) 1999-07-09 2000-07-05 Procede de reduction d'acides cetocarboxyliques et de leurs esters

Publications (1)

Publication Number Publication Date
EP1194582A1 true EP1194582A1 (fr) 2002-04-10

Family

ID=26054116

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00953007A Withdrawn EP1194582A1 (fr) 1999-07-09 2000-07-05 Procede de reduction d'acides cetocarboxyliques et de leurs esters

Country Status (4)

Country Link
US (1) US6689591B2 (fr)
EP (1) EP1194582A1 (fr)
JP (1) JP2003504070A (fr)
WO (1) WO2001004336A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001040450A1 (fr) 1999-12-03 2001-06-07 Kaneka Corporation Nouvelle carbonyl reductase, son gene et son procede d'utilisation
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
PL366831A1 (en) 2001-07-13 2005-02-07 Astrazeneca Uk Limited Preparation of aminopyrimidine compounds
JP4578240B2 (ja) * 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
US7629157B2 (en) * 2003-08-11 2009-12-08 Codexis, Inc. Ketoreductase polypeptides and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
WO2005017141A1 (fr) 2003-08-11 2005-02-24 Codexis, Inc. Deshalogenases d'halohydrine ameliorees et polynucleotides correspondants
WO2005045016A2 (fr) * 2003-08-11 2005-05-19 Codexis, Inc. Polypeptides de glucose deshydrogenase et polynucleotides apparentes
KR20060071397A (ko) 2003-08-11 2006-06-26 코덱시스, 인코포레이티드 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
DE10345772A1 (de) * 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
CN101784669B (zh) 2007-08-24 2015-02-18 科德克希思公司 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽
ATE547513T1 (de) * 2007-09-28 2012-03-15 Codexis Inc Ketoreduktase-polypeptide und verwendungen davon
SG172231A1 (en) * 2008-12-18 2011-07-28 Codexis Inc Recombinant halohydrin dehalogenase polypeptides
CN102212082B (zh) * 2010-04-05 2015-03-04 重庆博腾制药科技股份有限公司 瑞舒伐他汀钙中间体及制备方法
AU2014230120B2 (en) * 2013-03-14 2018-06-21 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Process for producing (R)-3hydroxybutyl (R)-3hydroxybutyrate
WO2014203045A1 (fr) 2013-06-20 2014-12-24 Lupin Limited Nouveau procédé écologique et économique pour la synthèse de tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidène-hexanoate
CN104372039A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 双酶法制备瑞舒伐他汀侧链中间体的方法
CN105713884A (zh) * 2014-12-02 2016-06-29 安琪酵母股份有限公司 生物催化氢化组合物及其合成罗素伐他汀手性中间体方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3840751A1 (de) * 1988-12-03 1990-07-05 Forschungszentrum Juelich Gmbh Mikrobiologisch hergestellte diacetyl-reduktase, verfahren zu ihrer gewinnung und ihre verwendung
DE4014573C1 (fr) * 1990-05-07 1991-10-10 Forschungszentrum Juelich Gmbh, 5170 Juelich, De
US5225339A (en) * 1992-02-26 1993-07-06 The Scripps Research Institute Lactobacillus kefir alcohol dehydrogenase
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
DE19610984A1 (de) * 1996-03-21 1997-09-25 Boehringer Mannheim Gmbh Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen
DE19812004A1 (de) * 1998-03-19 1999-09-30 Forschungszentrum Juelich Gmbh Dehydrogenasen mit verbesserter NAD-Abhängigkeit, deren Herstellung und Verwendung
DE19857302C2 (de) * 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0104336A1 *

Also Published As

Publication number Publication date
WO2001004336A1 (fr) 2001-01-18
JP2003504070A (ja) 2003-02-04
US6689591B2 (en) 2004-02-10
US20020098557A1 (en) 2002-07-25

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