MXPA01007858A - Nueva reductasa de carbonilo, su gene y metodo para su uso. - Google Patents

Nueva reductasa de carbonilo, su gene y metodo para su uso.

Info

Publication number
MXPA01007858A
MXPA01007858A MXPA01007858A MXPA01007858A MXPA01007858A MX PA01007858 A MXPA01007858 A MX PA01007858A MX PA01007858 A MXPA01007858 A MX PA01007858A MX PA01007858 A MXPA01007858 A MX PA01007858A MX PA01007858 A MXPA01007858 A MX PA01007858A
Authority
MX
Mexico
Prior art keywords
polypeptide
gene
same
chloro
butyl
Prior art date
Application number
MXPA01007858A
Other languages
English (en)
Inventor
Kizaki Noriyuki
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of MXPA01007858A publication Critical patent/MXPA01007858A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MXPA01007858A 1999-12-03 2000-11-24 Nueva reductasa de carbonilo, su gene y metodo para su uso. MXPA01007858A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34554199 1999-12-03
PCT/JP2000/008321 WO2001040450A1 (fr) 1999-12-03 2000-11-24 Nouvelle carbonyl reductase, son gene et son procede d'utilisation

Publications (1)

Publication Number Publication Date
MXPA01007858A true MXPA01007858A (es) 2003-07-14

Family

ID=18377296

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01007858A MXPA01007858A (es) 1999-12-03 2000-11-24 Nueva reductasa de carbonilo, su gene y metodo para su uso.

Country Status (15)

Country Link
US (1) US6645746B1 (es)
EP (1) EP1152054B1 (es)
JP (1) JP4510351B2 (es)
KR (1) KR100512080B1 (es)
AT (1) ATE291616T1 (es)
AU (1) AU1551701A (es)
CA (1) CA2360376C (es)
CZ (1) CZ20012792A3 (es)
DE (1) DE60018909T2 (es)
ES (1) ES2240205T3 (es)
HU (1) HUP0105331A3 (es)
MX (1) MXPA01007858A (es)
NO (1) NO20013801L (es)
SI (1) SI20642A (es)
WO (1) WO2001040450A1 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60336324D1 (de) * 2002-08-09 2011-04-21 Codexis Inc Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate
WO2004052829A1 (ja) * 2002-12-06 2004-06-24 Kaneka Corporation 光学活性３−ヒドロキシプロピオン酸エステル誘導体の製造法
US7824898B2 (en) 2003-08-11 2010-11-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
CA2533838A1 (en) * 2003-08-11 2005-02-24 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
KR20060064620A (ko) * 2003-08-11 2006-06-13 코덱시스, 인코포레이티드 개선된 글루코스 데히드로게나제 폴리펩티드 및 관련폴리뉴클레오티드
KR20060071397A (ko) * 2003-08-11 2006-06-26 코덱시스, 인코포레이티드 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법
DE10345772A1 (de) * 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
WO2006046455A1 (ja) * 2004-10-27 2006-05-04 Kaneka Corporation 新規カルボニル還元酵素、その遺伝子、およびその利用法
DE102005044736A1 (de) * 2005-09-19 2007-03-22 Basf Ag Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen
AT503017B1 (de) * 2005-12-19 2007-07-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen
US8304216B2 (en) 2006-03-31 2012-11-06 Kaneka Corporation Method for production of erythro-or threo-2-amino-3-hydroxypropionic acid ester, novel carbonyl reductase, gene for the reductase, vector, transformant, and method for production of optically active alcohol using those
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
AT504542B1 (de) * 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
WO2008103248A1 (en) 2007-02-08 2008-08-28 Codexis, Inc. Ketoreductases and uses thereof
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
WO2009036404A2 (en) 2007-09-13 2009-03-19 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
TWI601825B (zh) * 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
KR20100061571A (ko) 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 케토리덕타제 폴리펩티드 및 이의 용도
CN101883846A (zh) 2007-10-01 2010-11-10 科德克希思公司 用于生成氮杂环丁酮的还原酶多肽
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
ES2560459T3 (es) 2008-08-27 2016-02-19 Codexis, Inc. Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
EP2329014B1 (en) 2008-08-29 2014-10-22 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
SG172231A1 (en) 2008-12-18 2011-07-28 Codexis Inc Recombinant halohydrin dehalogenase polypeptides
EP2226386A1 (de) 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
CN102482648B (zh) 2009-06-22 2014-12-10 科德克希思公司 酮还原酶介导的产生α氯代醇的立体选择性途径
EP2445890B1 (en) * 2009-06-22 2015-05-06 SK Biopharmaceuticals Co., Ltd. Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester
ES2575560T3 (es) 2009-08-19 2016-06-29 Codexis, Inc. Polipéptidos cetorreductasa para preparar fenilefrina
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
US9080192B2 (en) 2010-02-10 2015-07-14 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
EP2639216B1 (en) 2010-11-09 2018-07-11 Kaneka Corporation Halogenated indenones and method for producing optically active indanones or optically active indanols by using same
CN102676596A (zh) * 2011-03-16 2012-09-19 苏州国镝医药科技有限公司 生物酶手性合成立普妥中间体ats-7
CN104053771B (zh) 2011-11-18 2016-11-09 科德克希思公司 用于制备羟基取代的氨基甲酸酯的生物催化剂
EP2812440B1 (de) 2012-02-07 2019-06-26 Annikki GmbH Verfahren zur herstellung von furanderivaten aus glucose
TW201343623A (zh) 2012-02-07 2013-11-01 Annikki Gmbh 使氧化還原輔因子經酶催化再生之方法
WO2013117251A1 (de) 2012-02-07 2013-08-15 Annikki Gmbh Verfahren zur enzymatischen regenerierung von redoxkofaktoren
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
KR101446551B1 (ko) 2013-02-26 2014-10-06 주식회사 아미노로직스 (2rs)-아미노-(3s)-히드록시-부티르산 또는 이의 유도체의 제조방법
US10253340B2 (en) 2013-03-27 2019-04-09 Annikki Gmbh Method for the isomerisation of glucose
EP3134519B1 (en) 2014-04-22 2018-06-06 c-LEcta GmbH Ketoreductases
CN104328148A (zh) * 2014-11-04 2015-02-04 尚科生物医药（上海）有限公司 酶法制备(3r,5s)-6-氯-3,5-二羟基己酸叔丁酯
DK3256577T3 (da) 2015-02-10 2020-09-14 Codexis Inc Ketoreduktase polypeptider til syntesen af chirale forbindelser
CN104830921B (zh) * 2015-04-27 2019-07-02 上海工业生物技术研发中心 一种酶法制备他汀类化合物中间体的方法
CN105087684A (zh) * 2015-09-16 2015-11-25 连云港宏业化工有限公司 一种（3r，5s）-6-氯-3,5-二羟基己酸叔丁酯的制备方法
CN105087685A (zh) * 2015-09-16 2015-11-25 连云港宏业化工有限公司 一种合成（3r，5s）-6-氯-3,5-二羟基己酸叔丁酯的方法
CN106011092A (zh) * 2016-06-20 2016-10-12 苏州汉酶生物技术有限公司 一种工程化酮还原酶多肽及其用于制备孟鲁斯特中间体的方法
CN106011095B (zh) * 2016-07-27 2021-02-26 苏州汉酶生物技术有限公司 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法
WO2018200214A2 (en) 2017-04-27 2018-11-01 Codexis, Inc. Ketoreductase polypeptides and polynucleotides
EP3652328A1 (en) 2017-07-14 2020-05-20 c-LEcta GmbH Ketoreductases
CN108441523A (zh) * 2018-03-22 2018-08-24 南京工业大学 （3r,5s）-6-氯-3,5,-二羟基己酸叔丁酯的制备方法
CN110387359B (zh) * 2018-04-17 2021-04-20 湖州颐盛生物科技有限公司 羰基还原酶突变体及其应用
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
EP4313986A1 (en) 2021-04-02 2024-02-07 Genentech, Inc. Processes for making bicyclic ketone compounds
CN114875081A (zh) * 2022-06-07 2022-08-09 湖北迅达药业股份有限公司 一种瑞舒伐他汀关键中间体的绿色工业化生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278313A (en) 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
CA2329893A1 (en) * 1998-04-30 1999-11-11 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
JP3803551B2 (ja) 1998-08-05 2006-08-02 株式会社カネカ 光学活性２−［６−（ヒドロキシメチル）−１，３−ジオキサン−４−イル］酢酸誘導体の製造法
DE19857302C2 (de) 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester
WO2001004336A1 (de) 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern

Also Published As

Publication number Publication date
EP1152054A1 (en) 2001-11-07
CZ20012792A3 (cs) 2002-03-13
EP1152054B1 (en) 2005-03-23
WO2001040450A1 (fr) 2001-06-07
SI20642A (sl) 2002-02-28
EP1152054A4 (en) 2002-11-20
US6645746B1 (en) 2003-11-11
DE60018909T2 (de) 2006-03-30
HUP0105331A3 (en) 2005-10-28
CA2360376A1 (en) 2001-06-07
AU1551701A (en) 2001-06-12
ES2240205T3 (es) 2005-10-16
KR20020008116A (ko) 2002-01-29
NO20013801D0 (no) 2001-08-02
CA2360376C (en) 2005-04-26
HUP0105331A2 (hu) 2002-05-29
KR100512080B1 (ko) 2005-09-02
NO20013801L (no) 2001-10-03
DE60018909D1 (de) 2005-04-28
ATE291616T1 (de) 2005-04-15
JP4510351B2 (ja) 2010-07-21

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