NO20002835L - 2-aryl-oksodihydropurinderivater, fremgangsmÕte for fremstilling av disse medisinske preparater inneholdende disse, og mellomprodukter derfor - Google Patents
2-aryl-oksodihydropurinderivater, fremgangsmÕte for fremstilling av disse medisinske preparater inneholdende disse, og mellomprodukter derforInfo
- Publication number
- NO20002835L NO20002835L NO20002835A NO20002835A NO20002835L NO 20002835 L NO20002835 L NO 20002835L NO 20002835 A NO20002835 A NO 20002835A NO 20002835 A NO20002835 A NO 20002835A NO 20002835 L NO20002835 L NO 20002835L
- Authority
- NO
- Norway
- Prior art keywords
- aryl
- preparation
- preparations containing
- medicinal preparations
- intermediates therefor
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 2
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35000097 | 1997-12-03 | ||
| PCT/JP1998/005320 WO1999028320A1 (fr) | 1997-12-03 | 1998-11-26 | Derives de 2-aryl-8-oxodihydropurine, procede de production de ces derives, compositions medicales contenant ces derives, et intermediaires de ces derives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20002835D0 NO20002835D0 (no) | 2000-06-02 |
| NO20002835L true NO20002835L (no) | 2000-07-24 |
Family
ID=18407561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002835A NO20002835L (no) | 1997-12-03 | 2000-06-02 | 2-aryl-oksodihydropurinderivater, fremgangsmÕte for fremstilling av disse medisinske preparater inneholdende disse, og mellomprodukter derfor |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6372740B1 (pl) |
| EP (1) | EP1036794B1 (pl) |
| JP (1) | JP3815966B2 (pl) |
| KR (1) | KR100494347B1 (pl) |
| CN (1) | CN1146566C (pl) |
| AR (1) | AR017796A1 (pl) |
| AT (1) | ATE248169T1 (pl) |
| AU (1) | AU744014B2 (pl) |
| BR (1) | BR9815140A (pl) |
| CA (1) | CA2312885C (pl) |
| DE (1) | DE69817611T2 (pl) |
| DK (1) | DK1036794T3 (pl) |
| ES (1) | ES2205574T3 (pl) |
| HK (1) | HK1028769A1 (pl) |
| HU (1) | HUP0004422A3 (pl) |
| ID (1) | ID24929A (pl) |
| IL (1) | IL135920A0 (pl) |
| NO (1) | NO20002835L (pl) |
| NZ (1) | NZ504457A (pl) |
| PL (1) | PL191489B1 (pl) |
| PT (1) | PT1036794E (pl) |
| RU (1) | RU2223272C2 (pl) |
| SK (1) | SK285703B6 (pl) |
| TR (1) | TR200001600T2 (pl) |
| TW (1) | TW502034B (pl) |
| WO (1) | WO1999028320A1 (pl) |
| ZA (1) | ZA9810490B (pl) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003146987A (ja) * | 1999-05-31 | 2003-05-21 | Dainippon Pharmaceut Co Ltd | ２−アリールプリン−９−アセトアミド誘導体 |
| GB9913932D0 (en) * | 1999-06-15 | 1999-08-18 | Pfizer Ltd | Purine derivatives |
| WO2001023361A1 (fr) * | 1999-09-27 | 2001-04-05 | Ono Pharmaceutical Co., Ltd. | Derives de la pyrimidine, leur procede de preparation, et medicaments les contenant comme principe actif |
| CN1247578C (zh) * | 2000-07-31 | 2006-03-29 | 大日本住友制药株式会社 | 含有2－芳基－8－氧化二氢嘌呤衍生物作为活性成分的痴呆症治疗剂 |
| JP4808156B2 (ja) * | 2003-08-05 | 2011-11-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | 電位依存型イオンチャネルの阻害剤としての縮合ピリミジン化合物 |
| KR20060129023A (ko) * | 2004-02-23 | 2006-12-14 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 헤테로환 화합물 |
| US20080015196A1 (en) * | 2004-04-16 | 2008-01-17 | Neurogen Corporation | Imidazopyrazines, Imidazopyridines, and Imidazopyrimidines as Crf1 Receptor Ligands |
| FR2870239B1 (fr) | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique. |
| US7884109B2 (en) * | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
| EP1874772A1 (en) * | 2005-04-05 | 2008-01-09 | Pharmacopeia, Inc. | Purine and imidazopyridine derivatives for immunosuppression |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US20070225304A1 (en) * | 2005-09-06 | 2007-09-27 | Pharmacopeia Drug Discovery, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
| US7989459B2 (en) * | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
| US20090281075A1 (en) * | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
| CA2646429A1 (en) * | 2006-03-09 | 2007-09-13 | Pharmacopeia, Inc. | 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders |
| TW200831104A (en) * | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| US7902187B2 (en) * | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| WO2008043019A1 (en) * | 2006-10-04 | 2008-04-10 | Pharmacopeia, Inc | 8-substituted 2-(benzimidazolyl) purine derivatives for immunosuppression |
| ATE543819T1 (de) | 2006-10-19 | 2012-02-15 | Signal Pharm Llc | Heteroarylverbindungen, zusammensetzungen daraus und behandlungsverfahren damit |
| US20080119496A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
| JP2009007273A (ja) | 2007-06-27 | 2009-01-15 | Ajinomoto Co Inc | ジアミノピリミジン化合物の製造方法 |
| US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| US8473571B2 (en) | 2009-01-08 | 2013-06-25 | Microsoft Corporation | Synchronizing presentation states between multiple applications |
| EP2476682B1 (en) * | 2009-09-09 | 2017-04-26 | Sumitomo Dainippon Pharma Co., Ltd. | 8-oxodihydropurine derivative |
| NZ618135A (en) | 2009-10-26 | 2015-05-29 | Signal Pharm Llc | Methods of synthesis and purification of heteroaryl compounds |
| JP2014076947A (ja) * | 2011-02-03 | 2014-05-01 | Dainippon Sumitomo Pharma Co Ltd | ２−オキシ置換８−オキソジヒドロプリン誘導体 |
| US20140301947A1 (en) | 2011-06-06 | 2014-10-09 | Imperial Innovations Limited | Methods to predict binding affinity of tspo imaging agents to tspo |
| EA030664B1 (ru) | 2011-10-19 | 2018-09-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Лечение злокачественной опухоли ингибиторами tor-киназы |
| ES2694413T3 (es) | 2011-12-02 | 2018-12-20 | Signal Pharmaceuticals, Llc | Composiciones farmacéuticas de 7-(6-(2-hidroxipropan-2-il)piridin-3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino [2,3-b]pirazin-2(1H)-ona, una forma sólida de la misma y métodos para su uso |
| KR102064626B1 (ko) | 2012-02-24 | 2020-01-09 | 시그날 파마소티칼 엘엘씨 | Tor 키나제 억제자 복합 치료법을 사용한 비소세포 폐암의 치료 방법 |
| CN102675315B (zh) * | 2012-02-28 | 2015-04-01 | 中国人民解放军第四军医大学 | 含取代苯烷基的嘌呤类化合物和制备方法及应用 |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| ES2638179T3 (es) | 2013-01-16 | 2017-10-19 | Signal Pharmaceuticals, Llc | Compuestos de pirrolopirimidina sustituidos, composiciones de los mismos, y métodos de tratamiento con los mismos |
| TWI656875B (zh) | 2013-04-17 | 2019-04-21 | 美商標誌製藥公司 | 藉二氫吡并吡治療癌症 |
| TW201527300A (zh) | 2013-04-17 | 2015-07-16 | Signal Pharm Llc | 關於１－乙基－７－（２－甲基－６－（１Ｈ－１，２，４－三唑－３－基）吡啶－３－基）－３，４－二氫吡并［２，３－ｂ］吡－２（１Ｈ）－酮之醫藥調配物、方法、固態型式及使用方法 |
| UA119538C2 (uk) | 2013-04-17 | 2019-07-10 | Сігнал Фармасьютікалз, Елелсі | Лікування злоякісної пухлини дигідропіразинопіразинами |
| CA2908742C (en) | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| WO2014172431A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
| CA2909579A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer |
| JP6382949B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ，エルエルシー | 癌を治療するためのｔｏｒキナーゼ阻害剤及び５−置換キナゾリノン化合物を含む組合せ療法 |
| CN113831345A (zh) | 2013-05-29 | 2021-12-24 | 西格诺药品有限公司 | 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 |
| US9737535B2 (en) | 2014-04-16 | 2017-08-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines |
| US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2016010886A1 (en) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| IL300788A (en) | 2015-11-20 | 2023-04-01 | Forma Therapeutics Inc | Furinones as ubiquitin-specific protease 1 inhibitors |
| EP3641772B1 (en) | 2017-06-22 | 2023-08-02 | Celgene Corporation | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| WO2019155042A1 (en) | 2018-02-12 | 2019-08-15 | F. Hoffmann-La Roche Ag | Novel sulfone compounds and derivatives for the treatment and prophylaxis of virus infection |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2525595A1 (fr) | 1982-04-27 | 1983-10-28 | Pharmuka Lab | Nouveaux derives d'arene et d'heteroarenecarboxamides et leur utilisation comme medicaments |
| FR2582514B1 (fr) | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| DK273689A (da) | 1988-06-06 | 1989-12-07 | Sanofi Sa | 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler |
| FR2632639B1 (fr) | 1988-06-09 | 1990-10-05 | Sanofi Sa | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent |
| US5856481A (en) | 1994-07-28 | 1999-01-05 | Syntex (U.S.A.) Inc. | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
| IL117659A (en) | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
| WO1998001448A1 (fr) | 1996-07-03 | 1998-01-15 | Japan Energy Corporation | Nouveaux derives de purine |
| JP2002501493A (ja) * | 1997-04-22 | 2002-01-15 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｃｒｆアンタゴニストのチオフェノピリジン類 |
| JP3814125B2 (ja) * | 1999-06-02 | 2006-08-23 | 大日本住友製薬株式会社 | ２−アリール−８−オキソジヒドロプリン誘導体からなる医薬 |
-
1998
- 1998-11-17 ZA ZA9810490A patent/ZA9810490B/xx unknown
- 1998-11-25 TW TW087119571A patent/TW502034B/zh not_active IP Right Cessation
- 1998-11-26 HU HU0004422A patent/HUP0004422A3/hu unknown
- 1998-11-26 PT PT98955937T patent/PT1036794E/pt unknown
- 1998-11-26 NZ NZ504457A patent/NZ504457A/en unknown
- 1998-11-26 EP EP98955937A patent/EP1036794B1/en not_active Expired - Lifetime
- 1998-11-26 ID IDW20000990A patent/ID24929A/id unknown
- 1998-11-26 ES ES98955937T patent/ES2205574T3/es not_active Expired - Lifetime
- 1998-11-26 RU RU2000117278/04A patent/RU2223272C2/ru not_active IP Right Cessation
- 1998-11-26 JP JP2000523212A patent/JP3815966B2/ja not_active Expired - Fee Related
- 1998-11-26 BR BR9815140-1A patent/BR9815140A/pt not_active Application Discontinuation
- 1998-11-26 WO PCT/JP1998/005320 patent/WO1999028320A1/ja active IP Right Grant
- 1998-11-26 CA CA002312885A patent/CA2312885C/en not_active Expired - Fee Related
- 1998-11-26 CN CNB988134519A patent/CN1146566C/zh not_active Expired - Fee Related
- 1998-11-26 AU AU12604/99A patent/AU744014B2/en not_active Ceased
- 1998-11-26 US US09/555,490 patent/US6372740B1/en not_active Expired - Fee Related
- 1998-11-26 DE DE69817611T patent/DE69817611T2/de not_active Expired - Fee Related
- 1998-11-26 DK DK98955937T patent/DK1036794T3/da active
- 1998-11-26 IL IL13592098A patent/IL135920A0/xx not_active IP Right Cessation
- 1998-11-26 PL PL340925A patent/PL191489B1/pl unknown
- 1998-11-26 SK SK797-2000A patent/SK285703B6/sk unknown
- 1998-11-26 TR TR2000/01600T patent/TR200001600T2/xx unknown
- 1998-11-26 KR KR10-2000-7005968A patent/KR100494347B1/ko not_active IP Right Cessation
- 1998-11-26 AT AT98955937T patent/ATE248169T1/de not_active IP Right Cessation
- 1998-12-03 AR ARP980106147A patent/AR017796A1/es active IP Right Grant
-
2000
- 2000-06-02 NO NO20002835A patent/NO20002835L/no unknown
- 2000-12-15 HK HK00108107A patent/HK1028769A1/xx not_active IP Right Cessation
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