IT1246777B
(it)
*
|
1991-04-12 |
1994-11-26 |
Boehringer Mannheim Italia |
Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
|
IT1246778B
(it)
*
|
1991-04-12 |
1994-11-26 |
Boehringer Mannheim Italia |
Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
|
US5270365A
(en)
*
|
1991-12-17 |
1993-12-14 |
Merck & Co., Inc. |
Prevention and treatment of periodontal disease with alendronate
|
US6399592B1
(en)
|
1992-12-23 |
2002-06-04 |
Merck & Co., Inc. |
Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
|
US5510517A
(en)
*
|
1993-08-25 |
1996-04-23 |
Merck & Co., Inc. |
Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
|
TW257765B
(xx)
*
|
1993-08-25 |
1995-09-21 |
Merck & Co Inc |
|
US5462932A
(en)
*
|
1994-05-17 |
1995-10-31 |
Merck & Co., Inc. |
Oral liquid alendronate formulations
|
US5449819A
(en)
*
|
1994-06-06 |
1995-09-12 |
Merck & Co., Inc. |
Process for removing waste pox, alendronate and its by products
|
US5589691A
(en)
*
|
1994-06-06 |
1996-12-31 |
Merck & Co., Inc. |
Process for recovery and recycle of methanesulfonic acid and phosphorous acid
|
US5780455A
(en)
*
|
1994-08-24 |
1998-07-14 |
Merck & Co., Inc. |
Intravenous alendronate formulations
|
KR19980702210A
(ko)
*
|
1995-02-17 |
1998-07-15 |
폴락 돈나 엘 |
비척추골 골절의 위험률을 감소시키는 방법
|
TW393488B
(en)
*
|
1995-04-20 |
2000-06-11 |
Merck & Co Inc |
Process for making 1-hydrox-ybisphosphonates
|
WO1996035407A1
(en)
*
|
1995-05-12 |
1996-11-14 |
Merck & Co., Inc. |
Prevention of tooth loss by the administration of alendronate or its salts
|
ES2236737T3
(es)
*
|
1995-06-06 |
2005-07-16 |
MERCK & CO., INC. |
Formulaciones de sal de alendronato monosodico anhidro y su uso en el tratamiento de enfermedades oseas.
|
CA2223450A1
(en)
|
1995-06-06 |
1996-12-12 |
Merck & Co., Inc. |
Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
|
KR100192215B1
(ko)
*
|
1996-09-03 |
1999-06-15 |
강재헌 |
3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
|
EE03669B1
(et)
*
|
1996-10-04 |
2002-04-15 |
Merck & Co., Inc. |
Vedelad alendronaatpreparaadid ja nende valmistamismeetod
|
CA2197267C
(en)
*
|
1997-02-11 |
2000-02-08 |
Yong Tao |
Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
|
JP4549531B2
(ja)
|
1998-04-29 |
2010-09-22 |
ザ プロクター アンド ギャンブル カンパニー |
1,3−二置換−4−オキソ環式尿素の製造方法
|
KR100400051B1
(ko)
|
1998-04-29 |
2003-09-29 |
더 프록터 앤드 갬블 캄파니 |
1,3-이치환-4-옥소환식 요소의 제조 방법
|
WO1999067809A1
(en)
|
1998-06-24 |
1999-12-29 |
Merck & Co., Inc. |
Compositions and methods for inhibiting bone resorption
|
US20030078211A1
(en)
*
|
1998-06-24 |
2003-04-24 |
Merck & Co., Inc. |
Compositions and methods for inhibiting bone resorption
|
US6008207A
(en)
*
|
1998-08-13 |
1999-12-28 |
Merck & Co., Inc. |
Anhydrous alendronate monosodium salt formulations
|
EP1702924A3
(en)
*
|
1998-08-27 |
2007-07-18 |
Teva Pharmaceutical Industries Ltd |
Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
|
WO2000012517A1
(en)
|
1998-08-27 |
2000-03-09 |
Teva Pharmaceutical Industries Ltd. |
Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
|
US6331533B1
(en)
|
1998-11-16 |
2001-12-18 |
Merck & Co., Inc. |
Method for inhibiting dental resorptive lesions
|
KR100327786B1
(ko)
*
|
1999-03-25 |
2002-03-14 |
유승필 |
4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법
|
US6143919A
(en)
*
|
1999-05-18 |
2000-11-07 |
3M Innovative Properties Company |
Polymerizable acidic compounds and methods of preparation
|
US6315566B1
(en)
|
1999-05-18 |
2001-11-13 |
3M Innovative Properties Company |
Dental materials
|
US6963008B2
(en)
*
|
1999-07-19 |
2005-11-08 |
Teva Pharmaceutical Industries Ltd. |
Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
|
ES2153794B1
(es)
|
1999-08-06 |
2001-10-16 |
Medichem Sa |
Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
|
US6677320B2
(en)
|
2000-01-20 |
2004-01-13 |
Hoffmann-La Roches Inc. |
Parenteral bisphosphonate composition with improved local tolerance
|
US6476006B2
(en)
|
2000-06-23 |
2002-11-05 |
Teva Pharmaceutical Industries, Ltd. |
Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
|
KR100327787B1
(ko)
*
|
2001-02-27 |
2002-03-15 |
유승필 |
4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법
|
US20060269602A1
(en)
*
|
2001-04-13 |
2006-11-30 |
Dasch James R |
Method of modifying the release profile of sustained release compositions
|
US6558702B2
(en)
*
|
2001-04-13 |
2003-05-06 |
Alkermes Controlled Therapeutics, Inc. |
Method of modifying the release profile of sustained release compositions
|
TR200101250A2
(tr)
*
|
2001-05-10 |
2003-04-21 |
E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. |
4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
|
GB0115824D0
(en)
*
|
2001-06-28 |
2001-08-22 |
Rhodia Cons Spec Ltd |
Improved solvent systems
|
MXPA04006027A
(es)
*
|
2001-12-21 |
2004-09-27 |
Procter & Gamble |
Metodo para el tratamiento de trastornos de los huesos.
|
CA2472578A1
(en)
*
|
2002-01-24 |
2003-07-31 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Anti-cancer combination and use thereof
|
ITMI20020908A1
(it)
*
|
2002-04-29 |
2003-10-29 |
Chemi Spa |
Processo di preparazione di sodio alendronato
|
KR20140021045A
(ko)
*
|
2002-05-10 |
2014-02-19 |
에프. 호프만-라 로슈 아게 |
골다공증 치료 및 예방용 비스포스폰산
|
ATE461205T1
(de)
*
|
2002-05-17 |
2010-04-15 |
Teva Pharma |
Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
|
WO2003103664A1
(en)
*
|
2002-06-06 |
2003-12-18 |
Merck Frosst Canada & Co. |
1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
|
JP4485117B2
(ja)
*
|
2002-06-27 |
2010-06-16 |
日東電工株式会社 |
保護剥離用フィルム
|
CA2495917A1
(en)
*
|
2002-08-28 |
2004-03-11 |
Merck Frosst Canada & Co. |
Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
|
US20040138180A1
(en)
*
|
2002-10-03 |
2004-07-15 |
Barr Laboratories, Inc. |
Bisphosphonate composition and process for the preparation thereof
|
JP4427453B2
(ja)
*
|
2002-12-20 |
2010-03-10 |
エフ.ホフマン−ラ ロシュ アーゲー |
高用量イバンドロネート製剤
|
US20040206932A1
(en)
*
|
2002-12-30 |
2004-10-21 |
Abuelyaman Ahmed S. |
Compositions including polymerizable bisphosphonic acids and methods
|
HUP0300227A2
(hu)
*
|
2003-01-28 |
2004-09-28 |
Richter Gedeon Vegyészeti Gyár Rt. |
Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
|
JP5001006B2
(ja)
*
|
2003-08-12 |
2012-08-15 |
スリーエム イノベイティブ プロパティズ カンパニー |
自己エッチング性歯科用組成物および方法
|
AU2004266740B2
(en)
|
2003-08-21 |
2010-08-26 |
Merck Frosst Canada Ltd |
Cathepsin cysteine protease inhibitors
|
US7411087B2
(en)
*
|
2003-08-21 |
2008-08-12 |
Sun Pharmaceutical Industries Limited |
Process for preparation of bisphosphonic acid compounds
|
AU2004273672A1
(en)
*
|
2003-09-19 |
2005-03-31 |
Wisconsin Alumni Research Foundation |
Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and a bisphosphonate
|
US20050113343A1
(en)
*
|
2003-10-14 |
2005-05-26 |
Pliva - Research And Development Ltd. |
Solid-state form of alendronate sodium and preparation thereof
|
US20050181043A1
(en)
*
|
2004-02-12 |
2005-08-18 |
Indranil Nandi |
Alendronate salt tablet compositions
|
KR101388777B1
(ko)
|
2004-05-24 |
2014-04-23 |
워너 칠콧 컴퍼니 엘엘씨 |
킬레이팅제를 함유하는 비스포스포네이트의 고형의 장용 경구 투여 형태
|
UA87854C2
(xx)
|
2004-06-07 |
2009-08-25 |
Мерк Энд Ко., Инк. |
N-(2-бензил)-2-фенілбутанаміди як модулятори рецептора андрогену$n-(2-бензил)-2-фенилбутанамиды как модуляторы рецептора андрогена
|
CN101018534B
(zh)
*
|
2004-07-08 |
2012-07-04 |
3M创新有限公司 |
牙科的方法,组合物,和包括酸敏感染料的试剂盒
|
EP1784155B1
(en)
*
|
2004-08-11 |
2011-09-28 |
3M Innovative Properties Company |
Self-adhesive compositions including a plurality of acidic compounds
|
US7361761B2
(en)
*
|
2004-09-28 |
2008-04-22 |
Orchid Chemicals & Pharmaceuticals Ltd. |
Process for the preparation of bisphosphonic acid
|
JP2008531691A
(ja)
|
2005-03-02 |
2008-08-14 |
メルク エンド カムパニー インコーポレーテッド |
カテプシンk阻害組成物
|
EA200701997A1
(ru)
*
|
2005-03-17 |
2008-02-28 |
Элан Фарма Интернэшнл Лтд. |
Композиция из наночастиц бисфосфоната
|
EP1891081B1
(en)
*
|
2005-06-13 |
2014-08-20 |
Jubilant Organosys Limited |
Process for producing bisphosphonic acids and forms thereof
|
AR054673A1
(es)
|
2005-07-28 |
2007-07-11 |
Gador Sa |
Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
|
US8003820B2
(en)
*
|
2005-10-20 |
2011-08-23 |
Dr. Reddy's Laboratories Limited |
Process for preparing bisphosphonic acids
|
PT1803727E
(pt)
*
|
2005-12-27 |
2009-06-15 |
Ipca Lab Ltd |
Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
|
WO2007083240A2
(en)
|
2006-01-20 |
2007-07-26 |
Aurobindo Pharma Limited |
An improved process for the preparation of bisphosphonic acids
|
EP1987046A1
(en)
*
|
2006-02-20 |
2008-11-05 |
Alembic Limited |
An improved process for the preparation of biphosphonic derivatives
|
US8076483B2
(en)
*
|
2006-05-11 |
2011-12-13 |
M/S. Ind Swift Laboratories Limited |
Process for the preparation of pure risedronic acid or salts
|
CA2570949A1
(en)
*
|
2006-12-12 |
2008-06-12 |
Apotex Pharmachem Inc. |
Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
|
US9943465B2
(en)
*
|
2006-12-13 |
2018-04-17 |
3M Innovative Properties Company |
Methods of using a dental composition having an acidic component and a photobleachable dye
|
US20090170815A1
(en)
*
|
2007-12-28 |
2009-07-02 |
Roxane Laboratories Incorporated. |
Alendronate oral liquid formulations
|
EP2310398A2
(en)
*
|
2008-07-11 |
2011-04-20 |
Synthon B.V. |
Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
|
US20100130746A1
(en)
*
|
2008-11-26 |
2010-05-27 |
Martin Kas |
Process for Making Zoledronic Acid
|
WO2010143193A1
(en)
|
2009-06-11 |
2010-12-16 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Targeted liposomes comprising n-containing bisphosphonates and uses thereof
|
WO2011023280A1
(en)
|
2009-08-28 |
2011-03-03 |
Synthon B.V. |
Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
|
MX2012003914A
(es)
|
2009-10-02 |
2012-05-08 |
|
Metodo para la fabricacion de acidos aminohidroxi difosfonicos.
|
CA2738045C
(en)
|
2010-05-28 |
2019-02-19 |
Simon Fraser University |
Conjugate compounds, methods of making same, and uses thereof
|
CA2820019A1
(en)
|
2010-12-06 |
2012-06-14 |
Effrx Pharmaceuticals Sa |
Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
|
US8791162B2
(en)
|
2011-02-14 |
2014-07-29 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
SI2731591T1
(sl)
|
2011-07-13 |
2021-02-26 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Liposomi ko-inkapsulirajoči bifosfonat in amfipatično sredstvo
|
WO2015054089A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
WO2015051479A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
WO2015120580A1
(en)
|
2014-02-11 |
2015-08-20 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
PL407922A1
(pl)
|
2014-04-16 |
2015-10-26 |
Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością |
Nowe bisfosfoniany i ich zastosowanie
|
WO2015181676A1
(en)
|
2014-05-30 |
2015-12-03 |
Pfizer Inc. |
Carbonitrile derivatives as selective androgen receptor modulators
|
US9650414B1
(en)
|
2014-05-30 |
2017-05-16 |
Simon Fraser University |
Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
|
CA2988523A1
(en)
|
2015-06-12 |
2016-12-15 |
Simon Fraser University |
Amide-linked ep4 agonist-bisphosphonate compounds and uses thereof
|
EP3827010A4
(en)
|
2018-07-23 |
2022-03-16 |
Brise Pharmaceuticals Co., Ltd. |
BISPHOSPHONATE-DRUG CONJUGATES
|
WO2023275715A1
(en)
|
2021-06-30 |
2023-01-05 |
Pfizer Inc. |
Metabolites of selective androgen receptor modulators
|