NO177708C - Fremgangsmåte og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger derav - Google Patents
Fremgangsmåte og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger deravInfo
- Publication number
- NO177708C NO177708C NO902071A NO902071A NO177708C NO 177708 C NO177708 C NO 177708C NO 902071 A NO902071 A NO 902071A NO 902071 A NO902071 A NO 902071A NO 177708 C NO177708 C NO 177708C
- Authority
- NO
- Norway
- Prior art keywords
- analogs
- intermediates
- preparation
- acetic acids
- oxophthalazinyl acetic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/350,997 US4954629A (en) | 1989-05-11 | 1989-05-11 | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO902071D0 NO902071D0 (no) | 1990-05-10 |
| NO902071L NO902071L (no) | 1990-11-12 |
| NO177708B NO177708B (no) | 1995-07-31 |
| NO177708C true NO177708C (no) | 1995-11-08 |
Family
ID=23379152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902071A NO177708C (no) | 1989-05-11 | 1990-05-10 | Fremgangsmåte og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger derav |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4954629A (pt) |
| EP (1) | EP0397350B1 (pt) |
| JP (1) | JPH035479A (pt) |
| KR (1) | KR920006419B1 (pt) |
| CN (1) | CN1025855C (pt) |
| AR (1) | AR246968A1 (pt) |
| AT (1) | ATE103913T1 (pt) |
| AU (2) | AU618898B2 (pt) |
| BG (1) | BG50609A3 (pt) |
| CA (1) | CA2016504C (pt) |
| CZ (1) | CZ281213B6 (pt) |
| DD (1) | DD294257A5 (pt) |
| DE (1) | DE69007846T2 (pt) |
| DK (1) | DK0397350T3 (pt) |
| EG (1) | EG19082A (pt) |
| ES (1) | ES2063265T3 (pt) |
| FI (1) | FI93959C (pt) |
| HU (1) | HU212304B (pt) |
| IE (1) | IE62591B1 (pt) |
| IL (3) | IL94301A (pt) |
| MX (2) | MX167455B (pt) |
| NO (1) | NO177708C (pt) |
| NZ (1) | NZ233597A (pt) |
| PH (1) | PH26567A (pt) |
| PL (1) | PL164427B1 (pt) |
| PT (1) | PT93985B (pt) |
| RO (1) | RO107256B1 (pt) |
| RU (1) | RU2014333C1 (pt) |
| YU (1) | YU91290A (pt) |
| ZA (1) | ZA903565B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4996204A (en) * | 1989-05-11 | 1991-02-26 | Pfizer Inc. | Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors |
| IL124236A (en) * | 1997-05-05 | 2003-01-12 | Pfizer | Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor |
| EP0982306A3 (en) * | 1998-08-21 | 2000-07-05 | Pfizer Products Inc. | Polymorph of zopolrestat monohydrate |
| PT3597650T (pt) | 2010-07-16 | 2022-12-16 | Univ Columbia | Inibidores da aldose redutase e utilizações dos mesmos |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| CN102558184B (zh) * | 2011-12-30 | 2014-07-16 | 西南大学 | 酞嗪类衍生物的合成方法 |
| CN102702108A (zh) * | 2012-06-27 | 2012-10-03 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| CN102863393A (zh) * | 2012-09-26 | 2013-01-09 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| IL283809B2 (en) | 2016-06-21 | 2024-01-01 | Univ Columbia | Compounds for use in a method for treating neuropathy, retinopathy, nephropathy or cardiomyopathy |
| AU2018307964B2 (en) | 2017-07-28 | 2023-11-16 | Applied Therapeutics Inc. | Compositions and methods for treating galactosemia |
| BR112021019596A2 (pt) | 2019-04-01 | 2021-11-30 | Applied Therapeutics Inc | Inibidores de aldose redutase |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE47592B1 (en) * | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| DE3337859A1 (de) * | 1983-01-21 | 1984-07-26 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von benzthiazolen |
| CA1299178C (en) * | 1985-11-07 | 1992-04-21 | Banavara Lakshmana Mylari | Heterocyclic oxophtalazinyl acetic acids |
| IL80475A (en) * | 1985-11-07 | 1993-01-31 | Pfizer | Heterocyclic-substituted 4-oxo (or thio)-3h- phthalazinyl-acetic acid derivatives and pharmaceutical compositions containing them |
| JPH0676391B2 (ja) * | 1987-06-09 | 1994-09-28 | フアイザー・インコーポレイテツド | ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法 |
| EP0322153A3 (en) * | 1987-12-21 | 1990-08-16 | Pfizer Inc. | Heterocyclic oxophtalazinyl acetic acids |
| WO1989006651A1 (en) * | 1988-01-19 | 1989-07-27 | Pfizer Inc. | 1h-indazole-3-acetic acids as aldose reductase inhibitors |
| US4996204A (en) * | 1989-05-11 | 1991-02-26 | Pfizer Inc. | Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors |
-
1989
- 1989-05-11 US US07/350,997 patent/US4954629A/en not_active Expired - Lifetime
-
1990
- 1990-04-25 EP EP90304441A patent/EP0397350B1/en not_active Expired - Lifetime
- 1990-04-25 DK DK90304441.0T patent/DK0397350T3/da active
- 1990-04-25 ES ES90304441T patent/ES2063265T3/es not_active Expired - Lifetime
- 1990-04-25 AT AT90304441T patent/ATE103913T1/de not_active IP Right Cessation
- 1990-04-25 DE DE69007846T patent/DE69007846T2/de not_active Expired - Fee Related
- 1990-05-02 RO RO144965A patent/RO107256B1/ro unknown
- 1990-05-04 IE IE162690A patent/IE62591B1/en not_active IP Right Cessation
- 1990-05-06 IL IL9430190A patent/IL94301A/en not_active IP Right Cessation
- 1990-05-06 IL IL114271A patent/IL114271A/en not_active IP Right Cessation
- 1990-05-08 CZ CS902278A patent/CZ281213B6/cs not_active IP Right Cessation
- 1990-05-08 NZ NZ233597A patent/NZ233597A/en unknown
- 1990-05-09 PT PT93985A patent/PT93985B/pt not_active IP Right Cessation
- 1990-05-09 PL PL90285113A patent/PL164427B1/pl unknown
- 1990-05-10 FI FI902333A patent/FI93959C/fi not_active IP Right Cessation
- 1990-05-10 AU AU54906/90A patent/AU618898B2/en not_active Ceased
- 1990-05-10 EG EG27690A patent/EG19082A/xx active
- 1990-05-10 CN CN90102797A patent/CN1025855C/zh not_active Expired - Fee Related
- 1990-05-10 KR KR1019900006579A patent/KR920006419B1/ko not_active IP Right Cessation
- 1990-05-10 AR AR90316824A patent/AR246968A1/es active
- 1990-05-10 DD DD90340590A patent/DD294257A5/de not_active IP Right Cessation
- 1990-05-10 RU SU904743977A patent/RU2014333C1/ru active
- 1990-05-10 ZA ZA903565A patent/ZA903565B/xx unknown
- 1990-05-10 HU HU902995A patent/HU212304B/hu not_active IP Right Cessation
- 1990-05-10 NO NO902071A patent/NO177708C/no not_active IP Right Cessation
- 1990-05-10 BG BG091982A patent/BG50609A3/xx unknown
- 1990-05-10 YU YU91290A patent/YU91290A/sh unknown
- 1990-05-10 CA CA002016504A patent/CA2016504C/en not_active Expired - Fee Related
- 1990-05-11 JP JP2122862A patent/JPH035479A/ja active Granted
- 1990-05-11 PH PH40512A patent/PH26567A/en unknown
- 1990-05-11 MX MX020672A patent/MX167455B/es unknown
-
1991
- 1991-10-28 AU AU86806/91A patent/AU626225B2/en not_active Ceased
-
1992
- 1992-12-31 MX MX9207687A patent/MX9207687A/es not_active IP Right Cessation
-
1995
- 1995-06-22 IL IL11427195A patent/IL114271A0/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN NOVEMBER 2001 |