MX9207687A - Compuestos intermedios para la preparacion de acidos oxoftalazinil aceticos. - Google Patents

Compuestos intermedios para la preparacion de acidos oxoftalazinil aceticos.

Info

Publication number
MX9207687A
MX9207687A MX9207687A MX9207687A MX9207687A MX 9207687 A MX9207687 A MX 9207687A MX 9207687 A MX9207687 A MX 9207687A MX 9207687 A MX9207687 A MX 9207687A MX 9207687 A MX9207687 A MX 9207687A
Authority
MX
Mexico
Prior art keywords
preparation
acids
acetic acids
oxoftalazinyl
intermediate compounds
Prior art date
Application number
MX9207687A
Other languages
English (en)
Inventor
Banavara Lakshmana Mylari
William James Zembrowski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9207687A publication Critical patent/MX9207687A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a compuestos intermedios para la preparación de ácidos oxoftalazinil acético con cadenas laterales de benzotiazol por reacción de un acetato de oxoftalaziniltioacetamida con sulfuro de hidrógeno y un compuesto nitrofenílico que contiene un grupo reactivo de manera que pueda formarse la cadena lateral de benzotiazol por ciclación en la que interviene el grupo tioacetamido. La oxoftalaziniltioacetamida puede ser preparada por reacción del correspondiente acetato de cianometiloxoftalazinilo con sulfuro de hidrógeno en presencia de aminas terciarias. Loa ácidos imizadol y oxopirido-pirida-zinonacéticos análogos pueden ser preparados de forma similar, así como los ácidos oxoftalazinil-, indazol- y oxopiridopiridazinon-acéticos con cadenas laterales de tiazolopiridinilo.
MX9207687A 1989-05-11 1992-12-31 Compuestos intermedios para la preparacion de acidos oxoftalazinil aceticos. MX9207687A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/350,997 US4954629A (en) 1989-05-11 1989-05-11 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Publications (1)

Publication Number Publication Date
MX9207687A true MX9207687A (es) 1994-06-30

Family

ID=23379152

Family Applications (2)

Application Number Title Priority Date Filing Date
MX020672A MX167455B (es) 1989-05-11 1990-05-11 Procedimiento para la preparacion de acidos oxoftalazinil aceticos
MX9207687A MX9207687A (es) 1989-05-11 1992-12-31 Compuestos intermedios para la preparacion de acidos oxoftalazinil aceticos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX020672A MX167455B (es) 1989-05-11 1990-05-11 Procedimiento para la preparacion de acidos oxoftalazinil aceticos

Country Status (30)

Country Link
US (1) US4954629A (es)
EP (1) EP0397350B1 (es)
JP (1) JPH035479A (es)
KR (1) KR920006419B1 (es)
CN (1) CN1025855C (es)
AR (1) AR246968A1 (es)
AT (1) ATE103913T1 (es)
AU (2) AU618898B2 (es)
BG (1) BG50609A3 (es)
CA (1) CA2016504C (es)
CZ (1) CZ281213B6 (es)
DD (1) DD294257A5 (es)
DE (1) DE69007846T2 (es)
DK (1) DK0397350T3 (es)
EG (1) EG19082A (es)
ES (1) ES2063265T3 (es)
FI (1) FI93959C (es)
HU (1) HU212304B (es)
IE (1) IE62591B1 (es)
IL (3) IL114271A (es)
MX (2) MX167455B (es)
NO (1) NO177708C (es)
NZ (1) NZ233597A (es)
PH (1) PH26567A (es)
PL (1) PL164427B1 (es)
PT (1) PT93985B (es)
RO (1) RO107256B1 (es)
RU (1) RU2014333C1 (es)
YU (1) YU91290A (es)
ZA (1) ZA903565B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
EP0982306A3 (en) * 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
JP5934206B2 (ja) 2010-07-16 2016-06-15 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク アルドース還元酵素阻害剤および同使用方法
US8916563B2 (en) * 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
CN102558184B (zh) * 2011-12-30 2014-07-16 西南大学 酞嗪类衍生物的合成方法
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
DK3757107T3 (da) 2016-06-21 2023-11-27 Univ Columbia 4-oxo-3,4-dihydrothieno[3,4-d]pyridazinforbindelser som aldosereduktasehæmmere og metoder til anvendelse deraf
JP7307059B2 (ja) 2017-07-28 2023-07-11 アプライド セラピューティクス， インコーポレイテッド ガラクトース血症を処置するための組成物および方法
SG11202110590PA (en) 2019-04-01 2021-10-28 Applied Therapeutics Inc Inhibitors of aldose reductase
SG11202111822QA (en) 2019-05-07 2021-11-29 Univ Miami Treatment and detection of inherited neuropathies and associated disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3337859A1 (de) * 1983-01-21 1984-07-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von benzthiazolen
DE3684410D1 (de) * 1985-11-07 1992-04-23 Pfizer Heterocyclische oxophthalazinylessigsaeure.
CA1299178C (en) * 1985-11-07 1992-04-21 Banavara Lakshmana Mylari Heterocyclic oxophtalazinyl acetic acids
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0322153A3 (en) * 1987-12-21 1990-08-16 Pfizer Inc. Heterocyclic oxophtalazinyl acetic acids
WO1989006651A1 (en) * 1988-01-19 1989-07-27 Pfizer Inc. 1h-indazole-3-acetic acids as aldose reductase inhibitors
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Also Published As

Publication number Publication date
PT93985B (pt) 1996-11-29
ZA903565B (en) 1991-12-24
CA2016504C (en) 1999-07-27
CN1047499A (zh) 1990-12-05
FI93959B (fi) 1995-03-15
US4954629A (en) 1990-09-04
IL94301A (en) 1996-01-19
PL285113A1 (en) 1991-07-15
ATE103913T1 (de) 1994-04-15
NO902071D0 (no) 1990-05-10
IL114271A0 (en) 1995-10-31
IL94301A0 (en) 1991-03-10
JPH035479A (ja) 1991-01-11
CZ227890A3 (en) 1996-04-17
RU2014333C1 (ru) 1994-06-15
DE69007846D1 (de) 1994-05-11
CA2016504A1 (en) 1990-11-11
IL114271A (en) 1998-04-05
CZ281213B6 (cs) 1996-07-17
DE69007846T2 (de) 1994-07-28
FI93959C (fi) 1995-06-26
HUT54690A (en) 1991-03-28
HU212304B (en) 1996-05-28
YU91290A (sh) 1992-09-07
AU8680691A (en) 1992-01-02
IE901626L (en) 1990-11-11
NO177708C (no) 1995-11-08
DD294257A5 (de) 1991-09-26
AU618898B2 (en) 1992-01-09
KR920006419B1 (ko) 1992-08-06
RO107256B1 (ro) 1993-10-30
AU626225B2 (en) 1992-07-23
DK0397350T3 (da) 1994-05-09
ES2063265T3 (es) 1995-01-01
EP0397350A1 (en) 1990-11-14
IE62591B1 (en) 1995-02-08
HU902995D0 (en) 1990-09-28
NO902071L (no) 1990-11-12
EP0397350B1 (en) 1994-04-06
NO177708B (no) 1995-07-31
CN1025855C (zh) 1994-09-07
EG19082A (en) 1994-07-30
MX167455B (es) 1993-03-23
NZ233597A (en) 1992-02-25
PT93985A (pt) 1991-01-08
FI902333A0 (fi) 1990-05-10
KR900018114A (ko) 1990-12-20
PL164427B1 (pl) 1994-07-29
JPH0573753B2 (es) 1993-10-15
AR246968A1 (es) 1994-10-31
AU5490690A (en) 1990-11-15
PH26567A (en) 1992-08-19
BG50609A3 (en) 1992-09-15

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees