IL114271A - Oxophthalazinic acid derivatives Acetic acid - Google Patents

Oxophthalazinic acid derivatives Acetic acid

Info

Publication number
IL114271A
IL114271A IL114271A IL11427190A IL114271A IL 114271 A IL114271 A IL 114271A IL 114271 A IL114271 A IL 114271A IL 11427190 A IL11427190 A IL 11427190A IL 114271 A IL114271 A IL 114271A
Authority
IL
Israel
Prior art keywords
oxo
compound
oxophthalazinyl
solution
acetic acid
Prior art date
Application number
IL114271A
Other languages
English (en)
Hebrew (he)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL114271A publication Critical patent/IL114271A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30Phthalazines
    • C07D237/32Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL114271A 1989-05-11 1990-05-06 Oxophthalazinic acid derivatives Acetic acid IL114271A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/350,997 US4954629A (en) 1989-05-11 1989-05-11 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
IL9430190A IL94301A (en) 1989-05-11 1990-05-06 Process for the preparation of acetic oxophetylazinyl acids, certain new compounds and pharmaceutical preparations containing them

Publications (1)

Publication Number Publication Date
IL114271A true IL114271A (en) 1998-04-05

Family

ID=23379152

Family Applications (3)

Application Number Title Priority Date Filing Date
IL9430190A IL94301A (en) 1989-05-11 1990-05-06 Process for the preparation of acetic oxophetylazinyl acids, certain new compounds and pharmaceutical preparations containing them
IL114271A IL114271A (en) 1989-05-11 1990-05-06 Oxophthalazinic acid derivatives Acetic acid
IL11427195A IL114271A0 (en) 1989-05-11 1995-06-22 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL9430190A IL94301A (en) 1989-05-11 1990-05-06 Process for the preparation of acetic oxophetylazinyl acids, certain new compounds and pharmaceutical preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11427195A IL114271A0 (en) 1989-05-11 1995-06-22 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Country Status (30)

Country Link
US (1) US4954629A (es)
EP (1) EP0397350B1 (es)
JP (1) JPH035479A (es)
KR (1) KR920006419B1 (es)
CN (1) CN1025855C (es)
AR (1) AR246968A1 (es)
AT (1) ATE103913T1 (es)
AU (2) AU618898B2 (es)
BG (1) BG50609A3 (es)
CA (1) CA2016504C (es)
CZ (1) CZ281213B6 (es)
DD (1) DD294257A5 (es)
DE (1) DE69007846T2 (es)
DK (1) DK0397350T3 (es)
EG (1) EG19082A (es)
ES (1) ES2063265T3 (es)
FI (1) FI93959C (es)
HU (1) HU212304B (es)
IE (1) IE62591B1 (es)
IL (3) IL94301A (es)
MX (2) MX167455B (es)
NO (1) NO177708C (es)
NZ (1) NZ233597A (es)
PH (1) PH26567A (es)
PL (1) PL164427B1 (es)
PT (1) PT93985B (es)
RO (1) RO107256B1 (es)
RU (1) RU2014333C1 (es)
YU (1) YU91290A (es)
ZA (1) ZA903565B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
EP0982306A3 (en) * 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
JP5934206B2 (ja) * 2010-07-16 2016-06-15 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク アルドース還元酵素阻害剤および同使用方法
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
CN102558184B (zh) * 2011-12-30 2014-07-16 西南大学 酞嗪类衍生物的合成方法
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
BR112018076244A2 (pt) 2016-06-21 2019-03-26 The Trustees Of Columbia University In The City Of New York inibidores da aldose redutase e métodos de uso destes
PL3658142T3 (pl) 2017-07-28 2024-08-26 Applied Therapeutics, Inc. Związki i sposoby leczenia galaktozemii
JP2022519944A (ja) 2019-04-01 2022-03-25 アプライド セラピューティクス インコーポレイテッド アルドースレダクターゼの阻害剤
SG11202111822QA (en) 2019-05-07 2021-11-29 Univ Miami Treatment and detection of inherited neuropathies and associated disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3337859A1 (de) * 1983-01-21 1984-07-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von benzthiazolen
ES2032749T3 (es) * 1985-11-07 1993-03-01 Pfizer Inc. Acidos oxoftalazinil-aceticos heterociclicos.
CA1299178C (en) * 1985-11-07 1992-04-21 Banavara Lakshmana Mylari Heterocyclic oxophtalazinyl acetic acids
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0322153A3 (en) * 1987-12-21 1990-08-16 Pfizer Inc. Heterocyclic oxophtalazinyl acetic acids
WO1989006651A1 (en) * 1988-01-19 1989-07-27 Pfizer Inc. 1h-indazole-3-acetic acids as aldose reductase inhibitors
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Also Published As

Publication number Publication date
PH26567A (en) 1992-08-19
IL94301A (en) 1996-01-19
EP0397350A1 (en) 1990-11-14
FI93959B (fi) 1995-03-15
DE69007846T2 (de) 1994-07-28
IL94301A0 (en) 1991-03-10
MX9207687A (es) 1994-06-30
AU618898B2 (en) 1992-01-09
ZA903565B (en) 1991-12-24
US4954629A (en) 1990-09-04
CZ281213B6 (cs) 1996-07-17
PT93985A (pt) 1991-01-08
CA2016504C (en) 1999-07-27
CZ227890A3 (en) 1996-04-17
KR920006419B1 (ko) 1992-08-06
RU2014333C1 (ru) 1994-06-15
JPH0573753B2 (es) 1993-10-15
HU902995D0 (en) 1990-09-28
FI93959C (fi) 1995-06-26
NO902071L (no) 1990-11-12
CN1047499A (zh) 1990-12-05
ES2063265T3 (es) 1995-01-01
RO107256B1 (ro) 1993-10-30
PT93985B (pt) 1996-11-29
AU5490690A (en) 1990-11-15
DK0397350T3 (da) 1994-05-09
PL285113A1 (en) 1991-07-15
CN1025855C (zh) 1994-09-07
AU8680691A (en) 1992-01-02
ATE103913T1 (de) 1994-04-15
DD294257A5 (de) 1991-09-26
CA2016504A1 (en) 1990-11-11
KR900018114A (ko) 1990-12-20
JPH035479A (ja) 1991-01-11
NO177708B (no) 1995-07-31
IE62591B1 (en) 1995-02-08
FI902333A0 (fi) 1990-05-10
IE901626L (en) 1990-11-11
BG50609A3 (en) 1992-09-15
EG19082A (en) 1994-07-30
DE69007846D1 (de) 1994-05-11
NO902071D0 (no) 1990-05-10
NZ233597A (en) 1992-02-25
MX167455B (es) 1993-03-23
YU91290A (sh) 1992-09-07
HU212304B (en) 1996-05-28
NO177708C (no) 1995-11-08
AU626225B2 (en) 1992-07-23
IL114271A0 (en) 1995-10-31
HUT54690A (en) 1991-03-28
EP0397350B1 (en) 1994-04-06
AR246968A1 (es) 1994-10-31
PL164427B1 (pl) 1994-07-29

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Legal Events

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FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees