NO902071D0 - Fremgangsmaate og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger derav. - Google Patents

Fremgangsmaate og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger derav.

Info

Publication number
NO902071D0
NO902071D0 NO902071A NO902071A NO902071D0 NO 902071 D0 NO902071 D0 NO 902071D0 NO 902071 A NO902071 A NO 902071A NO 902071 A NO902071 A NO 902071A NO 902071 D0 NO902071 D0 NO 902071D0
Authority
NO
Norway
Prior art keywords
oxoftalazinyl
analogs
intermediates
procedure
preparation
Prior art date
Application number
NO902071A
Other languages
English (en)
Other versions
NO177708C (no
NO902071L (no
NO177708B (no
Inventor
Banavara Lakshmana Mylari
William James Zembrowski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO902071D0 publication Critical patent/NO902071D0/no
Publication of NO902071L publication Critical patent/NO902071L/no
Publication of NO177708B publication Critical patent/NO177708B/no
Publication of NO177708C publication Critical patent/NO177708C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO902071A 1989-05-11 1990-05-10 Fremgangsmåte og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger derav NO177708C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/350,997 US4954629A (en) 1989-05-11 1989-05-11 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Publications (4)

Publication Number Publication Date
NO902071D0 true NO902071D0 (no) 1990-05-10
NO902071L NO902071L (no) 1990-11-12
NO177708B NO177708B (no) 1995-07-31
NO177708C NO177708C (no) 1995-11-08

Family

ID=23379152

Family Applications (1)

Application Number Title Priority Date Filing Date
NO902071A NO177708C (no) 1989-05-11 1990-05-10 Fremgangsmåte og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger derav

Country Status (30)

Country Link
US (1) US4954629A (no)
EP (1) EP0397350B1 (no)
JP (1) JPH035479A (no)
KR (1) KR920006419B1 (no)
CN (1) CN1025855C (no)
AR (1) AR246968A1 (no)
AT (1) ATE103913T1 (no)
AU (2) AU618898B2 (no)
BG (1) BG50609A3 (no)
CA (1) CA2016504C (no)
CZ (1) CZ281213B6 (no)
DD (1) DD294257A5 (no)
DE (1) DE69007846T2 (no)
DK (1) DK0397350T3 (no)
EG (1) EG19082A (no)
ES (1) ES2063265T3 (no)
FI (1) FI93959C (no)
HU (1) HU212304B (no)
IE (1) IE62591B1 (no)
IL (3) IL114271A (no)
MX (2) MX167455B (no)
NO (1) NO177708C (no)
NZ (1) NZ233597A (no)
PH (1) PH26567A (no)
PL (1) PL164427B1 (no)
PT (1) PT93985B (no)
RO (1) RO107256B1 (no)
RU (1) RU2014333C1 (no)
YU (1) YU91290A (no)
ZA (1) ZA903565B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
EP0982306A3 (en) * 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
JP5934206B2 (ja) 2010-07-16 2016-06-15 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク アルドース還元酵素阻害剤および同使用方法
US8916563B2 (en) * 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
CN102558184B (zh) * 2011-12-30 2014-07-16 西南大学 酞嗪类衍生物的合成方法
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
DK3757107T3 (da) 2016-06-21 2023-11-27 Univ Columbia 4-oxo-3,4-dihydrothieno[3,4-d]pyridazinforbindelser som aldosereduktasehæmmere og metoder til anvendelse deraf
JP7307059B2 (ja) 2017-07-28 2023-07-11 アプライド セラピューティクス， インコーポレイテッド ガラクトース血症を処置するための組成物および方法
SG11202110590PA (en) 2019-04-01 2021-10-28 Applied Therapeutics Inc Inhibitors of aldose reductase
SG11202111822QA (en) 2019-05-07 2021-11-29 Univ Miami Treatment and detection of inherited neuropathies and associated disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3337859A1 (de) * 1983-01-21 1984-07-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von benzthiazolen
DE3684410D1 (de) * 1985-11-07 1992-04-23 Pfizer Heterocyclische oxophthalazinylessigsaeure.
CA1299178C (en) * 1985-11-07 1992-04-21 Banavara Lakshmana Mylari Heterocyclic oxophtalazinyl acetic acids
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0322153A3 (en) * 1987-12-21 1990-08-16 Pfizer Inc. Heterocyclic oxophtalazinyl acetic acids
WO1989006651A1 (en) * 1988-01-19 1989-07-27 Pfizer Inc. 1h-indazole-3-acetic acids as aldose reductase inhibitors
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Also Published As

Publication number Publication date
PT93985B (pt) 1996-11-29
ZA903565B (en) 1991-12-24
CA2016504C (en) 1999-07-27
CN1047499A (zh) 1990-12-05
FI93959B (fi) 1995-03-15
US4954629A (en) 1990-09-04
IL94301A (en) 1996-01-19
PL285113A1 (en) 1991-07-15
ATE103913T1 (de) 1994-04-15
IL114271A0 (en) 1995-10-31
IL94301A0 (en) 1991-03-10
JPH035479A (ja) 1991-01-11
CZ227890A3 (en) 1996-04-17
RU2014333C1 (ru) 1994-06-15
DE69007846D1 (de) 1994-05-11
CA2016504A1 (en) 1990-11-11
IL114271A (en) 1998-04-05
CZ281213B6 (cs) 1996-07-17
DE69007846T2 (de) 1994-07-28
FI93959C (fi) 1995-06-26
HUT54690A (en) 1991-03-28
MX9207687A (es) 1994-06-30
HU212304B (en) 1996-05-28
YU91290A (sh) 1992-09-07
AU8680691A (en) 1992-01-02
IE901626L (en) 1990-11-11
NO177708C (no) 1995-11-08
DD294257A5 (de) 1991-09-26
AU618898B2 (en) 1992-01-09
KR920006419B1 (ko) 1992-08-06
RO107256B1 (ro) 1993-10-30
AU626225B2 (en) 1992-07-23
DK0397350T3 (da) 1994-05-09
ES2063265T3 (es) 1995-01-01
EP0397350A1 (en) 1990-11-14
IE62591B1 (en) 1995-02-08
HU902995D0 (en) 1990-09-28
NO902071L (no) 1990-11-12
EP0397350B1 (en) 1994-04-06
NO177708B (no) 1995-07-31
CN1025855C (zh) 1994-09-07
EG19082A (en) 1994-07-30
MX167455B (es) 1993-03-23
NZ233597A (en) 1992-02-25
PT93985A (pt) 1991-01-08
FI902333A0 (fi) 1990-05-10
KR900018114A (ko) 1990-12-20
PL164427B1 (pl) 1994-07-29
JPH0573753B2 (no) 1993-10-15
AR246968A1 (es) 1994-10-31
AU5490690A (en) 1990-11-15
PH26567A (en) 1992-08-19
BG50609A3 (en) 1992-09-15

Similar Documents

Publication Publication Date Title
NO173498C (no) Analogifremgangsmaate for fremstilling av substituerte 9-amino-tetrahydroakridiner
NO902071L (no) Fremgangsmaate og mellomprodukter for fremstilling av oksoftalazinyl-eddiksyrer og analoger derav.
NO883046L (no) Fremgangsmaate til fremstilling av chinolonkarboksylsyrer.
NO874759D0 (no) Fremgangsmaate til fremstilling av purin-9-ylalkylenoksymetylfosfonsyrer.
NO911892L (no) Fremgangsmaate for fremstilling og anvendelse av alfa-oksopypyrrol(2,3-b)indoleddiksyrer, estere, amider og beslektede analoger.
NO873069D0 (no) Fremgangsmaate for fremstilling av hydroksimsyrer av 7-oksabicykloheptan-substituerte etere og tioetere.
NO880802D0 (no) Mellomprodukter og fremgangsmaater til fremstilling av antihyperkolesterolemiske tetrazolforbindelser.
NO885446D0 (no) Fremgangsmaate for fremstilling av kinolincarboxylsyrer.
NO901894D0 (no) Fremgangsmaate for fremstilling av substituerte bifenylkarboksylsyrer og nye mellomprodukter.
DK725788D0 (da) Fremgangsmaade til fremstilling af kanelsyreestre
NO863388L (no) Fremgangsmaate ved fremstilling av cyclohexanalkansyrer.
ES531976A0 (es) Procedimiento de preparacion de acidos aceticos sustituidos
NO885771D0 (no) Fremgangsmaate for fremstilling av heterocykliske oksoftalazinyl-eddiksyrer.
ITMI921715A0 (it) Procedimento per la preparazione di acidi alogenobenzoici
NO176760C (no) Mellomprodukter for fremstilling av imidazopyridaziner
NO870748L (no) Fremgangsmaate for fremstilling av alfa-ketosyrer.
NO905569L (no) Fremgangsmaate for fremstilling av fettsyrehalogenider.
IT8521824A0 (it) Procedimento per la preparazione dell'estere metilico di alfa-l.-aspartil-l-fenilalanina apartire da anidride n-fenacetil-l-aspartica edl-fenilalanina metil estere.
IT8224803A0 (it) Procedimento per la preparazione di esteri e acidi n-alchil-2-(pirril-2)-gliossilici e acetici.
IT1207420B (it) Acidi carbossilici. procedimento per la preparazione di
NO871680L (no) Mellomprodukter ved fremstilling av alkansyrer og estere derav.
IT9047509A0 (it) Procedimento per la preparazione di benzammidi di acidi 4 - amino - benzoici.
IT9022074A0 (it) Acidi fosfonofluorcalcansolfonici e procedimento per la loro preparazione.
NO930481D0 (no) Fremgangsmaate for fremstilling av klormetaner
NO930322L (no) Fremgangsmaate og mellomprodukt for fremstilling av 2-hydroksy-3-sulfido-3-fenylpropansyrer

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN NOVEMBER 2001