NO176922C - Fremgangsmåte for fremstilling av bifunksjonelle proteiner - Google Patents

Fremgangsmåte for fremstilling av bifunksjonelle proteiner

Info

Publication number
NO176922C
NO176922C NO881658A NO881658A NO176922C NO 176922 C NO176922 C NO 176922C NO 881658 A NO881658 A NO 881658A NO 881658 A NO881658 A NO 881658A NO 176922 C NO176922 C NO 176922C
Authority
NO
Norway
Prior art keywords
preparation
bifunctional proteins
bifunctional
proteins
Prior art date
Application number
NO881658A
Other languages
English (en)
Norwegian (no)
Other versions
NO881658L (no
NO176922B (no
NO881658D0 (no
Inventor
Paul Habermann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO881658D0 publication Critical patent/NO881658D0/no
Publication of NO881658L publication Critical patent/NO881658L/no
Publication of NO176922B publication Critical patent/NO176922B/no
Publication of NO176922C publication Critical patent/NO176922C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO881658A 1987-04-16 1988-04-15 Fremgangsmåte for fremstilling av bifunksjonelle proteiner NO176922C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873712985 DE3712985A1 (de) 1987-04-16 1987-04-16 Bifunktionelle proteine

Publications (4)

Publication Number Publication Date
NO881658D0 NO881658D0 (no) 1988-04-15
NO881658L NO881658L (no) 1988-10-17
NO176922B NO176922B (no) 1995-03-13
NO176922C true NO176922C (no) 1995-06-21

Family

ID=6325799

Family Applications (1)

Application Number Title Priority Date Filing Date
NO881658A NO176922C (no) 1987-04-16 1988-04-15 Fremgangsmåte for fremstilling av bifunksjonelle proteiner

Country Status (20)

Country Link
EP (1) EP0288809B1 (enrdf_load_html_response)
JP (1) JP2667193B2 (enrdf_load_html_response)
KR (1) KR970000187B1 (enrdf_load_html_response)
AR (1) AR242991A1 (enrdf_load_html_response)
AT (1) ATE79135T1 (enrdf_load_html_response)
AU (1) AU613022B2 (enrdf_load_html_response)
CA (1) CA1322157C (enrdf_load_html_response)
DE (2) DE3712985A1 (enrdf_load_html_response)
DK (1) DK170741B1 (enrdf_load_html_response)
ES (1) ES2033981T3 (enrdf_load_html_response)
FI (1) FI98830C (enrdf_load_html_response)
GR (1) GR3006141T3 (enrdf_load_html_response)
HU (1) HU204303B (enrdf_load_html_response)
IE (1) IE61574B1 (enrdf_load_html_response)
IL (1) IL86086A (enrdf_load_html_response)
NO (1) NO176922C (enrdf_load_html_response)
NZ (1) NZ224247A (enrdf_load_html_response)
PH (1) PH25327A (enrdf_load_html_response)
PT (1) PT87237B (enrdf_load_html_response)
ZA (1) ZA882659B (enrdf_load_html_response)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662896A (en) * 1988-03-21 1997-09-02 Chiron Viagene, Inc. Compositions and methods for cancer immunotherapy
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
ES2055445T3 (es) * 1989-08-22 1994-08-16 Immunex Corp Proteinas de fusion que comprenden gm-csf e il-3.
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
CA2693296C (en) 1997-12-08 2013-09-10 Merck Patent Gmbh Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
ES2256027T3 (es) 1999-08-09 2006-07-16 Emd Lexigen Research Center Corp. Complejos de anticuerpos que contienen multiples citoquinas.
AU2154401A (en) 1999-11-12 2001-05-30 Merck Patent Gmbh Erythropoietin forms with improved properties
JP4553290B2 (ja) * 1999-11-30 2010-09-29 塩野義製薬株式会社 ケモカインｓｌｃ−ｉｌ２融合タンパク質とその遺伝子
MXPA02007733A (es) 2000-02-11 2004-09-10 Merck Patent Gmbh Mejoramiento de la vida media circulante de proteinas de fusion basadas en anticuerpos.
PL358582A1 (en) 2000-06-29 2004-08-09 Merck Patent Gmbh Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents
AU2002248571B2 (en) 2001-03-07 2007-01-18 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
MXPA03009924A (es) 2001-05-03 2004-01-29 Merck Patent Gmbh Anticuerpo recombinante especifico de tumor y uso del mismo.
HK1080090B (zh) 2001-10-10 2012-12-14 诺和诺德公司 肽的重构和糖缀合的方法
US7186804B2 (en) 2001-12-04 2007-03-06 Emd Lexigen Research Center Corp. IL-2 fusion proteins with modulated selectivity
DE60333121D1 (de) 2002-12-17 2010-08-05 Merck Patent Gmbh Pers 14.18, der gd2 bindet und seine fusion mit il-2
CA2678736A1 (en) * 2003-07-21 2005-02-17 Transgene S.A. Novel multifunctional il-2 - il-18 fusion proteins
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
WO2010001414A1 (en) * 2008-07-03 2010-01-07 Lupin Limited Expression of heterologous proteins in bacterial system using a gm-csf fusion tag

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
EP0158198A1 (en) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
WO1985004673A1 (en) * 1984-04-10 1985-10-24 Takeda Chemical Industries, Ltd. Novel dna and its use
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
JPS61128889A (ja) * 1984-11-27 1986-06-16 Green Cross Corp:The 組換えｄｎａ及び該ｄｎａによる形質転換体
JPH0646957B2 (ja) * 1985-03-11 1994-06-22 武田薬品工業株式会社 インタ−ロイキン−２の製造方法
WO1987002060A1 (en) * 1985-10-03 1987-04-09 Biogen N.V. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3541856A1 (de) * 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung

Also Published As

Publication number Publication date
PH25327A (en) 1991-04-30
DK170741B1 (da) 1996-01-08
EP0288809B1 (de) 1992-08-05
PT87237A (pt) 1988-05-01
FI881743L (fi) 1988-10-17
PT87237B (pt) 1992-07-31
FI881743A0 (fi) 1988-04-14
HUT47319A (en) 1989-02-28
FI98830C (fi) 1997-08-25
IE61574B1 (en) 1994-11-16
IL86086A0 (en) 1988-09-30
IE881146L (en) 1988-10-16
DE3712985A1 (de) 1988-11-03
ZA882659B (en) 1988-10-14
CA1322157C (en) 1993-09-14
AU613022B2 (en) 1991-07-25
DE3873397D1 (de) 1992-09-10
JP2667193B2 (ja) 1997-10-27
DK209188A (da) 1988-10-17
AR242991A1 (es) 1993-06-30
IL86086A (en) 1995-01-24
NO881658L (no) 1988-10-17
NO176922B (no) 1995-03-13
KR970000187B1 (ko) 1997-01-06
DK209188D0 (da) 1988-04-15
NZ224247A (en) 1990-04-26
ES2033981T3 (es) 1993-04-01
EP0288809A1 (de) 1988-11-02
HU204303B (en) 1991-12-30
FI98830B (fi) 1997-05-15
JPS63301898A (ja) 1988-12-08
NO881658D0 (no) 1988-04-15
ATE79135T1 (de) 1992-08-15
AU1466188A (en) 1988-10-20
KR880012760A (ko) 1988-11-29
GR3006141T3 (enrdf_load_html_response) 1993-06-21

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