IL86086A0 - Bifunctional proteins and pharmaceutical compositions containing them - Google Patents
Bifunctional proteins and pharmaceutical compositions containing themInfo
- Publication number
- IL86086A0 IL86086A0 IL86086A IL8608688A IL86086A0 IL 86086 A0 IL86086 A0 IL 86086A0 IL 86086 A IL86086 A IL 86086A IL 8608688 A IL8608688 A IL 8608688A IL 86086 A0 IL86086 A0 IL 86086A0
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- bifunctional proteins
- bifunctional
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873712985 DE3712985A1 (en) | 1987-04-16 | 1987-04-16 | BIFUNCTIONAL PROTEINS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL86086A0 true IL86086A0 (en) | 1988-09-30 |
| IL86086A IL86086A (en) | 1995-01-24 |
Family
ID=6325799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8608688A IL86086A (en) | 1987-04-16 | 1988-04-15 | Fusion protein with activities of interleukin-2 and gm-csf and pharmaceutical compositions containing said protein |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0288809B1 (en) |
| JP (1) | JP2667193B2 (en) |
| KR (1) | KR970000187B1 (en) |
| AR (1) | AR242991A1 (en) |
| AT (1) | ATE79135T1 (en) |
| AU (1) | AU613022B2 (en) |
| CA (1) | CA1322157C (en) |
| DE (2) | DE3712985A1 (en) |
| DK (1) | DK170741B1 (en) |
| ES (1) | ES2033981T3 (en) |
| FI (1) | FI98830C (en) |
| GR (1) | GR3006141T3 (en) |
| HU (1) | HU204303B (en) |
| IE (1) | IE61574B1 (en) |
| IL (1) | IL86086A (en) |
| NO (1) | NO176922C (en) |
| NZ (1) | NZ224247A (en) |
| PH (1) | PH25327A (en) |
| PT (1) | PT87237B (en) |
| ZA (1) | ZA882659B (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5662896A (en) * | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
| US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
| DE69007975T2 (en) * | 1989-08-22 | 1994-07-21 | Immunex Corp | FUSION PROTEIN CONSISTING OF GM-CSF AND IL-3. |
| US5073627A (en) * | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| US5108910A (en) * | 1989-08-22 | 1992-04-28 | Immunex Corporation | DNA sequences encoding fusion proteins comprising GM-CSF and IL-3 |
| US5376367A (en) * | 1991-11-22 | 1994-12-27 | Immunex Corporation | Fusion proteins comprising MGF and IL-3 |
| US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| ES2221717T3 (en) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | USEFUL HETERODIMERAS FUSION PROTEINS FOR DIRECTED IMMUNOTHERAPY AND GENERAL IMMUNOSTIMULATION. |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| KR100827757B1 (en) | 1999-08-09 | 2008-05-07 | 메르크 파텐트 게엠베하 | Multiple cytokine-antibody complexes |
| WO2001040311A1 (en) * | 1999-11-30 | 2001-06-07 | Shionogi & Co., Ltd. | Chemokine slc-il2 fused protein and gene thereof |
| ATE336514T1 (en) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | INCREASE THE CIRCULATION HALF-LIFE OF ANTIBODIES-BASED FUSION PROTEINS |
| EP1366067B1 (en) | 2001-03-07 | 2012-09-26 | Merck Patent GmbH | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| AU2002308562B2 (en) | 2001-05-03 | 2008-01-24 | Merck Patent Gmbh | Recombinant tumor specific antibody and use thereof |
| CN102180944A (en) | 2001-10-10 | 2011-09-14 | 诺和诺德公司 | Remodeling and glycoconjugation of peptides |
| EP1454138B1 (en) | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
| PL211180B1 (en) | 2002-12-17 | 2012-04-30 | Merck Patent Gmbh | Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2 |
| DE602004031341D1 (en) | 2003-07-21 | 2011-03-24 | Transgene Sa | MULTIFUNCTIONAL CYTOKINE |
| AU2004263274B2 (en) * | 2003-07-21 | 2009-11-05 | Transgene S.A. | Novel multifunctional cytokines |
| WO2010001414A1 (en) * | 2008-07-03 | 2010-01-07 | Lupin Limited | Expression of heterologous proteins in bacterial system using a gm-csf fusion tag |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
| GB8327880D0 (en) * | 1983-10-18 | 1983-11-16 | Ajinomoto Kk | Saccharomyces cerevisiae |
| EP0158198A1 (en) * | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
| WO1985004673A1 (en) * | 1984-04-10 | 1985-10-24 | Takeda Chemical Industries, Ltd. | Novel dna and its use |
| DE3419995A1 (en) * | 1984-05-29 | 1985-12-05 | Hoechst Ag, 6230 Frankfurt | GENE TECHNOLOGICAL METHOD FOR PRODUCING HUMAN INTERLEUKIN-2 AND MEANS FOR CARRYING OUT THIS METHOD |
| AU588819B2 (en) * | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
| JPS61128889A (en) * | 1984-11-27 | 1986-06-16 | Green Cross Corp:The | Recombinant dna and transformant by same |
| JPH0646957B2 (en) * | 1985-03-11 | 1994-06-22 | 武田薬品工業株式会社 | Method for producing interleukin-2 |
| JPS63502795A (en) * | 1985-10-03 | 1988-10-20 | バイオジェン インコーポレイテッド | Granulocyte-macrophage colony-stimulating factor-like polypeptides, DNA sequences, recombinant DNA molecules and methods for producing high yields of human granulocyte-macrophage colony-stimulating factor-like polypeptides in microbial cells. |
| DE3541856A1 (en) * | 1985-11-27 | 1987-06-04 | Hoechst Ag | EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS |
| DE3545568A1 (en) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE |
-
1987
- 1987-04-16 DE DE19873712985 patent/DE3712985A1/en not_active Withdrawn
-
1988
- 1988-04-09 DE DE8888105693T patent/DE3873397D1/en not_active Expired - Fee Related
- 1988-04-09 AT AT88105693T patent/ATE79135T1/en not_active IP Right Cessation
- 1988-04-09 ES ES198888105693T patent/ES2033981T3/en not_active Expired - Lifetime
- 1988-04-09 EP EP88105693A patent/EP0288809B1/en not_active Expired - Lifetime
- 1988-04-14 PT PT87237A patent/PT87237B/en active IP Right Grant
- 1988-04-14 NZ NZ224247A patent/NZ224247A/en unknown
- 1988-04-14 FI FI881743A patent/FI98830C/en not_active IP Right Cessation
- 1988-04-15 ZA ZA882659A patent/ZA882659B/en unknown
- 1988-04-15 NO NO881658A patent/NO176922C/en not_active IP Right Cessation
- 1988-04-15 DK DK209188A patent/DK170741B1/en not_active IP Right Cessation
- 1988-04-15 JP JP63093321A patent/JP2667193B2/en not_active Expired - Fee Related
- 1988-04-15 IL IL8608688A patent/IL86086A/en not_active IP Right Cessation
- 1988-04-15 IE IE114688A patent/IE61574B1/en not_active IP Right Cessation
- 1988-04-15 AU AU14661/88A patent/AU613022B2/en not_active Ceased
- 1988-04-15 AR AR88310585A patent/AR242991A1/en active
- 1988-04-15 CA CA000564322A patent/CA1322157C/en not_active Expired - Fee Related
- 1988-04-15 HU HU881966A patent/HU204303B/en not_active IP Right Cessation
- 1988-04-16 KR KR1019880004345A patent/KR970000187B1/en not_active IP Right Cessation
-
1989
- 1989-04-14 PH PH36799A patent/PH25327A/en unknown
-
1992
- 1992-11-04 GR GR920402185T patent/GR3006141T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU204303B (en) | 1991-12-30 |
| PT87237A (en) | 1988-05-01 |
| FI98830B (en) | 1997-05-15 |
| JP2667193B2 (en) | 1997-10-27 |
| NO881658L (en) | 1988-10-17 |
| IL86086A (en) | 1995-01-24 |
| NO881658D0 (en) | 1988-04-15 |
| FI98830C (en) | 1997-08-25 |
| ES2033981T3 (en) | 1993-04-01 |
| GR3006141T3 (en) | 1993-06-21 |
| CA1322157C (en) | 1993-09-14 |
| JPS63301898A (en) | 1988-12-08 |
| IE881146L (en) | 1988-10-16 |
| NZ224247A (en) | 1990-04-26 |
| AR242991A1 (en) | 1993-06-30 |
| NO176922B (en) | 1995-03-13 |
| DE3712985A1 (en) | 1988-11-03 |
| DK170741B1 (en) | 1996-01-08 |
| NO176922C (en) | 1995-06-21 |
| DE3873397D1 (en) | 1992-09-10 |
| ZA882659B (en) | 1988-10-14 |
| HUT47319A (en) | 1989-02-28 |
| PT87237B (en) | 1992-07-31 |
| EP0288809A1 (en) | 1988-11-02 |
| EP0288809B1 (en) | 1992-08-05 |
| PH25327A (en) | 1991-04-30 |
| IE61574B1 (en) | 1994-11-16 |
| FI881743A (en) | 1988-10-17 |
| FI881743A0 (en) | 1988-04-14 |
| AU1466188A (en) | 1988-10-20 |
| KR970000187B1 (en) | 1997-01-06 |
| DK209188A (en) | 1988-10-17 |
| KR880012760A (en) | 1988-11-29 |
| ATE79135T1 (en) | 1992-08-15 |
| AU613022B2 (en) | 1991-07-25 |
| DK209188D0 (en) | 1988-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |