FI98830B - Process for the preparation of bifunctional proteins - Google Patents

Process for the preparation of bifunctional proteins

Info

Publication number
FI98830B
FI98830B FI881743A FI881743A FI98830B FI 98830 B FI98830 B FI 98830B FI 881743 A FI881743 A FI 881743A FI 881743 A FI881743 A FI 881743A FI 98830 B FI98830 B FI 98830B
Authority
FI
Finland
Prior art keywords
preparation
bifunctional proteins
bifunctional
proteins
Prior art date
Application number
FI881743A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI98830C (en
FI881743A (en
FI881743A0 (en
Inventor
Paul Habermann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI881743A0 publication Critical patent/FI881743A0/en
Publication of FI881743A publication Critical patent/FI881743A/en
Publication of FI98830B publication Critical patent/FI98830B/en
Application granted granted Critical
Publication of FI98830C publication Critical patent/FI98830C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI881743A 1987-04-16 1988-04-14 Process for the preparation of bifunctional proteins FI98830C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3712985 1987-04-16
DE19873712985 DE3712985A1 (en) 1987-04-16 1987-04-16 BIFUNCTIONAL PROTEINS

Publications (4)

Publication Number Publication Date
FI881743A0 FI881743A0 (en) 1988-04-14
FI881743A FI881743A (en) 1988-10-17
FI98830B true FI98830B (en) 1997-05-15
FI98830C FI98830C (en) 1997-08-25

Family

ID=6325799

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881743A FI98830C (en) 1987-04-16 1988-04-14 Process for the preparation of bifunctional proteins

Country Status (20)

Country Link
EP (1) EP0288809B1 (en)
JP (1) JP2667193B2 (en)
KR (1) KR970000187B1 (en)
AR (1) AR242991A1 (en)
AT (1) ATE79135T1 (en)
AU (1) AU613022B2 (en)
CA (1) CA1322157C (en)
DE (2) DE3712985A1 (en)
DK (1) DK170741B1 (en)
ES (1) ES2033981T3 (en)
FI (1) FI98830C (en)
GR (1) GR3006141T3 (en)
HU (1) HU204303B (en)
IE (1) IE61574B1 (en)
IL (1) IL86086A (en)
NO (1) NO176922C (en)
NZ (1) NZ224247A (en)
PH (1) PH25327A (en)
PT (1) PT87237B (en)
ZA (1) ZA882659B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662896A (en) * 1988-03-21 1997-09-02 Chiron Viagene, Inc. Compositions and methods for cancer immunotherapy
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
DE69007975T2 (en) * 1989-08-22 1994-07-21 Immunex Corp FUSION PROTEIN CONSISTING OF GM-CSF AND IL-3.
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
ES2221717T3 (en) 1997-12-08 2005-01-01 Emd Lexigen Research Center Corp. USEFUL HETERODIMERAS FUSION PROTEINS FOR DIRECTED IMMUNOTHERAPY AND GENERAL IMMUNOSTIMULATION.
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
KR100827757B1 (en) 1999-08-09 2008-05-07 메르크 파텐트 게엠베하 Multiple cytokine-antibody complexes
WO2001040311A1 (en) * 1999-11-30 2001-06-07 Shionogi & Co., Ltd. Chemokine slc-il2 fused protein and gene thereof
ATE336514T1 (en) 2000-02-11 2006-09-15 Merck Patent Gmbh INCREASE THE CIRCULATION HALF-LIFE OF ANTIBODIES-BASED FUSION PROTEINS
EP1366067B1 (en) 2001-03-07 2012-09-26 Merck Patent GmbH Expression technology for proteins containing a hybrid isotype antibody moiety
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
AU2002308562B2 (en) 2001-05-03 2008-01-24 Merck Patent Gmbh Recombinant tumor specific antibody and use thereof
CN102180944A (en) 2001-10-10 2011-09-14 诺和诺德公司 Remodeling and glycoconjugation of peptides
EP1454138B1 (en) 2001-12-04 2012-01-18 Merck Patent GmbH Immunocytokines with modulated selectivity
PL211180B1 (en) 2002-12-17 2012-04-30 Merck Patent Gmbh Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
DE602004031341D1 (en) 2003-07-21 2011-03-24 Transgene Sa MULTIFUNCTIONAL CYTOKINE
AU2004263274B2 (en) * 2003-07-21 2009-11-05 Transgene S.A. Novel multifunctional cytokines
WO2010001414A1 (en) * 2008-07-03 2010-01-07 Lupin Limited Expression of heterologous proteins in bacterial system using a gm-csf fusion tag

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
EP0158198A1 (en) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
WO1985004673A1 (en) * 1984-04-10 1985-10-24 Takeda Chemical Industries, Ltd. Novel dna and its use
DE3419995A1 (en) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt GENE TECHNOLOGICAL METHOD FOR PRODUCING HUMAN INTERLEUKIN-2 AND MEANS FOR CARRYING OUT THIS METHOD
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
JPS61128889A (en) * 1984-11-27 1986-06-16 Green Cross Corp:The Recombinant dna and transformant by same
JPH0646957B2 (en) * 1985-03-11 1994-06-22 武田薬品工業株式会社 Method for producing interleukin-2
JPS63502795A (en) * 1985-10-03 1988-10-20 バイオジェン インコーポレイテッド Granulocyte-macrophage colony-stimulating factor-like polypeptides, DNA sequences, recombinant DNA molecules and methods for producing high yields of human granulocyte-macrophage colony-stimulating factor-like polypeptides in microbial cells.
DE3541856A1 (en) * 1985-11-27 1987-06-04 Hoechst Ag EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS
DE3545568A1 (en) * 1985-12-21 1987-07-16 Hoechst Ag GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE

Also Published As

Publication number Publication date
HU204303B (en) 1991-12-30
PT87237A (en) 1988-05-01
JP2667193B2 (en) 1997-10-27
NO881658L (en) 1988-10-17
IL86086A (en) 1995-01-24
NO881658D0 (en) 1988-04-15
FI98830C (en) 1997-08-25
ES2033981T3 (en) 1993-04-01
GR3006141T3 (en) 1993-06-21
CA1322157C (en) 1993-09-14
IL86086A0 (en) 1988-09-30
JPS63301898A (en) 1988-12-08
IE881146L (en) 1988-10-16
NZ224247A (en) 1990-04-26
AR242991A1 (en) 1993-06-30
NO176922B (en) 1995-03-13
DE3712985A1 (en) 1988-11-03
DK170741B1 (en) 1996-01-08
NO176922C (en) 1995-06-21
DE3873397D1 (en) 1992-09-10
ZA882659B (en) 1988-10-14
HUT47319A (en) 1989-02-28
PT87237B (en) 1992-07-31
EP0288809A1 (en) 1988-11-02
EP0288809B1 (en) 1992-08-05
PH25327A (en) 1991-04-30
IE61574B1 (en) 1994-11-16
FI881743A (en) 1988-10-17
FI881743A0 (en) 1988-04-14
AU1466188A (en) 1988-10-20
KR970000187B1 (en) 1997-01-06
DK209188A (en) 1988-10-17
KR880012760A (en) 1988-11-29
ATE79135T1 (en) 1992-08-15
AU613022B2 (en) 1991-07-25
DK209188D0 (en) 1988-04-15

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: HOECHST AKTIENGESELLSCHAFT

BB Publication of examined application
MM Patent lapsed

Owner name: HOECHST AKTIENGESELLSCHAFT