FI881743A - Process for the preparation of bifunctional proteins - Google Patents

Process for the preparation of bifunctional proteins Download PDF

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Publication number
FI881743A
FI881743A FI881743A FI881743A FI881743A FI 881743 A FI881743 A FI 881743A FI 881743 A FI881743 A FI 881743A FI 881743 A FI881743 A FI 881743A FI 881743 A FI881743 A FI 881743A
Authority
FI
Finland
Prior art keywords
preparation
bifunctional proteins
bifunctional
proteins
Prior art date
Application number
FI881743A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI98830C (en
FI881743A0 (en
FI98830B (en
Inventor
Paul Habermann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI881743A0 publication Critical patent/FI881743A0/en
Publication of FI881743A publication Critical patent/FI881743A/en
Application granted granted Critical
Publication of FI98830B publication Critical patent/FI98830B/en
Publication of FI98830C publication Critical patent/FI98830C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
FI881743A 1987-04-16 1988-04-14 Process for the preparation of bifunctional proteins FI98830C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3712985 1987-04-16
DE19873712985 DE3712985A1 (en) 1987-04-16 1987-04-16 BIFUNCTIONAL PROTEINS

Publications (4)

Publication Number Publication Date
FI881743A0 FI881743A0 (en) 1988-04-14
FI881743A true FI881743A (en) 1988-10-17
FI98830B FI98830B (en) 1997-05-15
FI98830C FI98830C (en) 1997-08-25

Family

ID=6325799

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881743A FI98830C (en) 1987-04-16 1988-04-14 Process for the preparation of bifunctional proteins

Country Status (20)

Country Link
EP (1) EP0288809B1 (en)
JP (1) JP2667193B2 (en)
KR (1) KR970000187B1 (en)
AR (1) AR242991A1 (en)
AT (1) ATE79135T1 (en)
AU (1) AU613022B2 (en)
CA (1) CA1322157C (en)
DE (2) DE3712985A1 (en)
DK (1) DK170741B1 (en)
ES (1) ES2033981T3 (en)
FI (1) FI98830C (en)
GR (1) GR3006141T3 (en)
HU (1) HU204303B (en)
IE (1) IE61574B1 (en)
IL (1) IL86086A (en)
NO (1) NO176922C (en)
NZ (1) NZ224247A (en)
PH (1) PH25327A (en)
PT (1) PT87237B (en)
ZA (1) ZA882659B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662896A (en) * 1988-03-21 1997-09-02 Chiron Viagene, Inc. Compositions and methods for cancer immunotherapy
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
ES2055445T3 (en) * 1989-08-22 1994-08-16 Immunex Corp FUSION PROTEINS INCLUDING GM-CSF AND IL-3.
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
DE69824039T2 (en) 1997-12-08 2005-08-18 Lexigen Pharmaceuticals Corp., Lexington HETERODIMARY FUSION PROTEINS FOR THE USE OF TARGETED IMMUNOTHERAPY AND GENERAL IMMUNE REGION
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
BR0013231A (en) 1999-08-09 2002-07-23 Lexigen Pharm Corp Multiple cytokine-antibody complexes
WO2001040311A1 (en) * 1999-11-30 2001-06-07 Shionogi & Co., Ltd. Chemokine slc-il2 fused protein and gene thereof
ES2269366T3 (en) 2000-02-11 2007-04-01 Merck Patent Gmbh IMPROVEMENT OF AVERAGE LIFE IN CIRCULATION OF FUSION PROTEINS BASED ON ANTIBODIES.
BR0207854A (en) 2001-03-07 2004-08-24 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
DE60239454D1 (en) 2001-05-03 2011-04-28 Merck Patent Gmbh RECOMBINANT, TUMOR-SPECIFIC ANTIBODY AND ITS USE
NZ532027A (en) 2001-10-10 2008-09-26 Neose Technologies Inc Remodeling and glycoconjugation of peptides
ES2381025T3 (en) 2001-12-04 2012-05-22 Merck Patent Gmbh Immunocytokines with modulated selectivity
JP4494977B2 (en) 2002-12-17 2010-06-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Humanized antibody (H14.18) of mouse 14.18 antibody that binds to GD2 and its IL-2 fusion protein
EP1648931B1 (en) * 2003-07-21 2011-02-09 Transgene S.A. Multifunctional cytokines
DE602004031341D1 (en) 2003-07-21 2011-03-24 Transgene Sa MULTIFUNCTIONAL CYTOKINE
WO2010001414A1 (en) * 2008-07-03 2010-01-07 Lupin Limited Expression of heterologous proteins in bacterial system using a gm-csf fusion tag

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
EP0158198A1 (en) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
WO1985004673A1 (en) * 1984-04-10 1985-10-24 Takeda Chemical Industries, Ltd. Novel dna and its use
DE3419995A1 (en) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt GENE TECHNOLOGICAL METHOD FOR PRODUCING HUMAN INTERLEUKIN-2 AND MEANS FOR CARRYING OUT THIS METHOD
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
JPS61128889A (en) * 1984-11-27 1986-06-16 Green Cross Corp:The Recombinant dna and transformant by same
JPH0646957B2 (en) * 1985-03-11 1994-06-22 武田薬品工業株式会社 Method for producing interleukin-2
EP0238655A4 (en) * 1985-10-03 1989-09-11 Biogen Nv Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells.
DE3541856A1 (en) * 1985-11-27 1987-06-04 Hoechst Ag EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS
DE3545568A1 (en) * 1985-12-21 1987-07-16 Hoechst Ag GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE

Also Published As

Publication number Publication date
ES2033981T3 (en) 1993-04-01
NO881658D0 (en) 1988-04-15
PT87237A (en) 1988-05-01
FI98830C (en) 1997-08-25
AR242991A1 (en) 1993-06-30
JPS63301898A (en) 1988-12-08
DE3873397D1 (en) 1992-09-10
NO881658L (en) 1988-10-17
IL86086A (en) 1995-01-24
NZ224247A (en) 1990-04-26
KR970000187B1 (en) 1997-01-06
DK170741B1 (en) 1996-01-08
FI881743A0 (en) 1988-04-14
IE881146L (en) 1988-10-16
DK209188D0 (en) 1988-04-15
HU204303B (en) 1991-12-30
NO176922C (en) 1995-06-21
AU1466188A (en) 1988-10-20
PH25327A (en) 1991-04-30
ZA882659B (en) 1988-10-14
DK209188A (en) 1988-10-17
EP0288809A1 (en) 1988-11-02
FI98830B (en) 1997-05-15
ATE79135T1 (en) 1992-08-15
CA1322157C (en) 1993-09-14
GR3006141T3 (en) 1993-06-21
KR880012760A (en) 1988-11-29
NO176922B (en) 1995-03-13
AU613022B2 (en) 1991-07-25
HUT47319A (en) 1989-02-28
DE3712985A1 (en) 1988-11-03
IE61574B1 (en) 1994-11-16
IL86086A0 (en) 1988-09-30
PT87237B (en) 1992-07-31
EP0288809B1 (en) 1992-08-05
JP2667193B2 (en) 1997-10-27

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Date Code Title Description
FG Patent granted

Owner name: HOECHST AKTIENGESELLSCHAFT

BB Publication of examined application
MM Patent lapsed

Owner name: HOECHST AKTIENGESELLSCHAFT