DE602004031341D1 - MULTIFUNCTIONAL CYTOKINE - Google Patents

MULTIFUNCTIONAL CYTOKINE

Info

Publication number
DE602004031341D1
DE602004031341D1 DE602004031341T DE602004031341T DE602004031341D1 DE 602004031341 D1 DE602004031341 D1 DE 602004031341D1 DE 602004031341 T DE602004031341 T DE 602004031341T DE 602004031341 T DE602004031341 T DE 602004031341T DE 602004031341 D1 DE602004031341 D1 DE 602004031341D1
Authority
DE
Germany
Prior art keywords
multifunctional cytokine
cytokine
multifunctional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004031341T
Other languages
German (de)
Inventor
Stephane Paul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Priority claimed from PCT/EP2004/008114 external-priority patent/WO2005014642A2/en
Publication of DE602004031341D1 publication Critical patent/DE602004031341D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
DE602004031341T 2003-07-21 2004-07-20 MULTIFUNCTIONAL CYTOKINE Active DE602004031341D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03360086 2003-07-21
US53932004P 2004-01-28 2004-01-28
PCT/EP2004/008114 WO2005014642A2 (en) 2003-07-21 2004-07-20 Novel multifunctional cytokines

Publications (1)

Publication Number Publication Date
DE602004031341D1 true DE602004031341D1 (en) 2011-03-24

Family

ID=34137606

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031341T Active DE602004031341D1 (en) 2003-07-21 2004-07-20 MULTIFUNCTIONAL CYTOKINE

Country Status (4)

Country Link
US (2) US7608267B2 (en)
JP (1) JP4880060B2 (en)
AU (2) AU2009222623B2 (en)
DE (1) DE602004031341D1 (en)

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RU2444528C2 (en) * 2005-05-06 2012-03-10 Займоджинетикс, Инк. Il-31 monoclonal antibodies and methods of using
KR102025502B1 (en) 2008-09-26 2019-09-25 토카겐 인크. Gene therapy vectors and cytosine deaminases
CN103582699B (en) * 2011-04-08 2017-03-22 贝勒医学院 Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
CN104884627A (en) 2012-10-25 2015-09-02 托卡根公司 Retroviral vector with mini-promoter cassette
US9642921B2 (en) 2012-12-20 2017-05-09 Tocagen Inc. Cancer combination therapy and recombinant vectors
CA2904506A1 (en) 2013-03-15 2014-09-18 Bioven 3 Limited Self-assembling synthetic proteins
WO2015007536A2 (en) * 2013-07-18 2015-01-22 Vib Vzw Fusokines involving cytokines with strongly reduced receptor binding affinities
WO2015042521A1 (en) * 2013-09-20 2015-03-26 University Of Virginia Patent Foundation Compositions and methods for treatment of autoimmune and inflammatory diseases and disorders
JP6073417B2 (en) * 2015-06-26 2017-02-01 チャ バイオテック カンパニー リミテッド Spontaneous killing cell proliferation method and composition for spontaneous killing cell proliferation
EP3490583B1 (en) * 2016-08-01 2023-11-29 Virogin Biotech Canada Ltd Oncolytic herpes simplex virus vectors expressing immune system-stimulatory molecules
PT3548053T (en) * 2016-12-05 2022-05-04 Tecnifar Ind Tecnica Farmaceutica S A Bacteriophage compositions comprising respiratory antibacterial phages and methods of use thereof
WO2018165208A1 (en) * 2017-03-06 2018-09-13 Altor Bioscience Corporation Il-15-based fusions to il-12 and il-18
CN110520436A (en) 2017-03-15 2019-11-29 潘迪恩治疗公司 Target immunological tolerance
CA3061864A1 (en) * 2017-05-01 2018-11-08 Rutgers, The State University Of New Jersey Type i and type iii interferon fusion molecules and methods for use thereof
AU2018273914A1 (en) 2017-05-24 2019-11-14 Pandion Operations, Inc. Targeted immunotolerance
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US11433139B2 (en) 2018-03-16 2022-09-06 Zoetis Services Llc Peptide vaccines against interleukin-31
KR20220035333A (en) 2019-05-20 2022-03-22 팬디온 오퍼레이션스, 인코포레이티드 MADCAM Targeted Immune Tolerance
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
KR20230038496A (en) * 2020-07-13 2023-03-20 트랜스진 treatment of immunosuppression
CN113603791A (en) * 2021-08-11 2021-11-05 厦门目青股权投资合伙企业(有限合伙) Fusion protein and application thereof

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
EP0158198A1 (en) 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
DE3712985A1 (en) 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
US5662896A (en) 1988-03-21 1997-09-02 Chiron Viagene, Inc. Compositions and methods for cancer immunotherapy
US5229109A (en) 1992-04-14 1993-07-20 Board Of Regents, The University Of Texas System Low toxicity interleukin-2 analogues for use in immunotherapy
WO1998008947A1 (en) 1995-12-19 1998-03-05 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Enhancement of dna immunization through the use of cytokines
EP0816510A4 (en) 1995-12-22 2001-04-11 Toray Industries Process for producing biologically active fused proteins
US5998598A (en) 1997-03-10 1999-12-07 The United States Of America, As Represented By The Department Of Health And Human Services Immunoadhesins and methods of production and use thereof
DE19823351A1 (en) 1997-05-16 1998-12-10 Krause Hans Agent for inhibiting apoptosis
GB9800927D0 (en) 1998-01-16 1998-03-11 Univ Bristol Recombinant adenoviral delivery of antibody fusion proteins
DZ2788A1 (en) 1998-05-15 2003-12-01 Bayer Ag Selective IL-2 agonists and antagonists.
US6552005B1 (en) * 1998-09-29 2003-04-22 Uab Research Foundation Molecular chemotherapy enhancement of radiotherapy
KR100743640B1 (en) 1999-03-09 2007-07-27 지모제넥틱스, 인코포레이티드 Novel cytokine zalpha11 ligand
CN1235911C (en) 1999-08-09 2006-01-11 利思进药品公司 Multiple cytokine-antibody complexes
US20010044418A1 (en) 2000-03-10 2001-11-22 Shoshana Levy Treatment of allergies
IL153201A0 (en) 2000-06-02 2003-07-06 Smithkline Beecham Corp Methods of treating viral diseases with il-18 and il-18 combinations
EP2123672A1 (en) 2000-09-14 2009-11-25 Beth Israel Deaconess Medical Center, Inc. Modulation of IL-2- and IL-15- mediated T cell responses
CN100503829C (en) 2001-03-08 2009-06-24 阿雷斯贸易股份有限公司 Interleukin-18 mutants, their production and use
WO2002102404A1 (en) 2001-06-18 2002-12-27 Institut National De La Recherche Agronomique Uses of cytokines
AU2002335973A1 (en) 2001-10-23 2003-05-06 Centre For Translational Research In Cancer A synthetic chimeric fusion protein with immuno-therapeutic uses
ES2381025T3 (en) 2001-12-04 2012-05-22 Merck Patent Gmbh Immunocytokines with modulated selectivity

Also Published As

Publication number Publication date
US20100074869A1 (en) 2010-03-25
US7608267B2 (en) 2009-10-27
AU2009222623B2 (en) 2011-10-06
US20050063945A1 (en) 2005-03-24
JP2011045375A (en) 2011-03-10
AU2009222623A1 (en) 2009-10-29
JP4880060B2 (en) 2012-02-22
AU2010200422A1 (en) 2010-02-25

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