NO175528C - Analogifremgangsmåte for fremstilling av terapeutisk aktive fenylacetamid-derivater - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive fenylacetamid-derivater

Info

Publication number
NO175528C
NO175528C NO913008A NO913008A NO175528C NO 175528 C NO175528 C NO 175528C NO 913008 A NO913008 A NO 913008A NO 913008 A NO913008 A NO 913008A NO 175528 C NO175528 C NO 175528C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
analogous process
phenylacetamide derivatives
phenylacetamide
Prior art date
Application number
NO913008A
Other languages
English (en)
Norwegian (no)
Other versions
NO913008L (no
NO175528B (no
NO913008D0 (no
Inventor
David Robert Brittain
Steven Paul Brown
Anthony Loren Cooper
Jethro Lawrence Longridge
Jeffrey James Morris
John Preston
Linda Slater
Original Assignee
Zeneca Ltd
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10680064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO175528(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeneca Ltd, Ici Plc filed Critical Zeneca Ltd
Publication of NO913008D0 publication Critical patent/NO913008D0/no
Publication of NO913008L publication Critical patent/NO913008L/no
Publication of NO175528B publication Critical patent/NO175528B/no
Publication of NO175528C publication Critical patent/NO175528C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO913008A 1990-08-02 1991-08-01 Analogifremgangsmåte for fremstilling av terapeutisk aktive fenylacetamid-derivater NO175528C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909016978A GB9016978D0 (en) 1990-08-02 1990-08-02 Acetamide derivatives

Publications (4)

Publication Number Publication Date
NO913008D0 NO913008D0 (no) 1991-08-01
NO913008L NO913008L (no) 1992-02-03
NO175528B NO175528B (no) 1994-07-18
NO175528C true NO175528C (no) 1994-10-26

Family

ID=10680064

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913008A NO175528C (no) 1990-08-02 1991-08-01 Analogifremgangsmåte for fremstilling av terapeutisk aktive fenylacetamid-derivater

Country Status (33)

Country Link
US (2) US5270342A (ro)
EP (1) EP0469887B1 (ro)
JP (1) JP2930452B2 (ro)
KR (1) KR920004342A (ro)
CN (1) CN1036389C (ro)
AP (1) AP261A (ro)
AT (1) ATE115560T1 (ro)
AU (1) AU646273B2 (ro)
BG (1) BG60316B2 (ro)
CA (1) CA2048325A1 (ro)
CZ (1) CZ280642B6 (ro)
DE (1) DE69105856T2 (ro)
DK (1) DK0469887T3 (ro)
ES (1) ES2067874T3 (ro)
FI (1) FI913706A (ro)
GB (2) GB9016978D0 (ro)
HK (1) HK1000965A1 (ro)
HR (1) HRP931326B1 (ro)
HU (2) HU210057B (ro)
IE (1) IE65870B1 (ro)
IL (1) IL98908A (ro)
JO (1) JO1696B1 (ro)
MY (1) MY109594A (ro)
NO (1) NO175528C (ro)
NZ (1) NZ239124A (ro)
PH (1) PH31572A (ro)
PL (2) PL168026B1 (ro)
PT (1) PT98529B (ro)
RO (1) RO109645B1 (ro)
RU (1) RU2068409C1 (ro)
SI (1) SI9111318A (ro)
YU (1) YU131891A (ro)
ZA (1) ZA915783B (ro)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9016978D0 (en) * 1990-08-02 1990-09-19 Ici Plc Acetamide derivatives
GB9016984D0 (en) * 1990-08-02 1990-09-19 Ici Plc Aniline derivatives
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
FR2757509B1 (fr) 1996-12-23 1999-03-26 Lipha Nouveaux derives de sulfonamides et sulfonylurees, leurs preparations et medicaments les contenant
ATE344046T1 (de) * 1997-04-15 2006-11-15 Csir Pflanzenextrakte mit appetitunterdrückender aktivität
GB9714274D0 (en) 1997-07-08 1997-09-10 Zeneca Ltd Pharmaceutical composition
EP2823812A1 (en) * 1998-02-02 2015-01-14 Trustees Of Tufts College Dipeptidylpeptidase IV inhibitors for use in the treatment of Type II diabetes
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
EE200300249A (et) 2000-11-30 2003-10-15 Pfizer Products Inc. GABA agonistide ja aldoosreduktaasi inhibiitoritekombinatsioon
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
PL1877370T3 (pl) * 2005-04-28 2009-07-31 Shiratori Pharmaceutical Co Ltd Sposób wytwarzania pochodnych hydrazonu
EP2016065B1 (en) * 2005-12-28 2012-09-19 Vertex Pharmaceuticals Incorporated 1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US8877717B2 (en) 2007-03-12 2014-11-04 Zadec Aps Anti-diabetic extract of rooibos
EP2139330B1 (en) 2007-03-23 2014-09-24 The Board of Regents of The University of Texas System Methods involving aldose reductase inhibitors
FR2914188B1 (fr) * 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
CA2822672C (en) 2010-12-23 2018-06-05 The Board Of Regents Of The University Of Texas System Methods for treating copd
US12090142B2 (en) 2018-02-22 2024-09-17 Board Of Regents, The University Of Texas System Combination therapy for the treatment of cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229653A (ro) * 1968-03-14 1971-04-28
US3882247A (en) * 1972-04-21 1975-05-06 Du Pont Fungicidal nitro organic sulfur compounds
SU479761A1 (ru) * 1973-07-18 1975-08-05 Институт Органической Химии Им. Н.Д.Зелинского Ан Ссср Способ получени -динитроалкилсульфонов
US4053633A (en) * 1976-06-24 1977-10-11 The Dow Chemical Company Aryl dibromonitromethyl sulfones
US4058633A (en) * 1976-09-15 1977-11-15 Fairmont Foods Company Meat product, and process for preparing same
FR2432316A1 (fr) * 1978-08-02 1980-02-29 Choay Sa Nouveaux medicaments contenant, a titre de substance active, des composes de type benzenesulfone, nouveaux composes de ce type et procede pour leur preparation
US4670470A (en) * 1979-08-15 1987-06-02 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US4309554A (en) * 1980-04-28 1982-01-05 The Dow Chemical Company 3-(2-Thiophenesulfonyl)-2-halopropanenitriles
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
DE3326635A1 (de) * 1983-07-23 1985-01-31 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von monomethylsubstituierten methylen-verbindungen
EP0169887B1 (en) * 1984-02-01 1990-06-27 BAXTER INTERNATIONAL INC. (a Delaware corporation) Clinical analysis systems and methods
DE3768352D1 (de) * 1986-06-30 1991-04-11 Merck & Co Inc Alkansulfonamide als antiglaucoma-mittel.
GB8718619D0 (en) * 1987-08-06 1987-09-09 Ici Plc Pharmaceutical compositions
GB8810203D0 (en) * 1988-04-29 1988-06-02 Ici Plc Heterocyclic compounds
IE63463B1 (en) * 1989-02-06 1995-04-19 Zeneca Ltd Phenylsulphone derivatives
GB9016978D0 (en) * 1990-08-02 1990-09-19 Ici Plc Acetamide derivatives

Also Published As

Publication number Publication date
FI913706A0 (fi) 1991-08-02
GB9016978D0 (en) 1990-09-19
PL168026B1 (pl) 1995-12-30
PL291312A1 (en) 1992-09-21
IL98908A (en) 1995-03-30
HK1000965A1 (en) 1998-05-15
CN1036389C (zh) 1997-11-12
MY109594A (en) 1997-03-31
DE69105856T2 (de) 1995-05-11
ES2067874T3 (es) 1995-04-01
JPH04234356A (ja) 1992-08-24
CS232791A3 (en) 1992-03-18
ZA915783B (en) 1992-05-27
IE65870B1 (en) 1995-11-29
HU912482D0 (en) 1991-12-30
AU646273B2 (en) 1994-02-17
US5270342A (en) 1993-12-14
JO1696B1 (en) 1992-12-15
NO913008L (no) 1992-02-03
HRP931326A2 (en) 1996-04-30
GB9115254D0 (en) 1991-08-28
BG60316B2 (bg) 1994-07-25
CA2048325A1 (en) 1992-02-03
HRP931326B1 (en) 1998-06-30
HU210057B (en) 1995-01-30
NO175528B (no) 1994-07-18
PL166392B1 (pl) 1995-05-31
IL98908A0 (en) 1992-07-15
JP2930452B2 (ja) 1999-08-03
SI9111318A (en) 1997-10-31
PH31572A (en) 1998-11-03
DK0469887T3 (da) 1995-04-03
NZ239124A (en) 1994-04-27
DE69105856D1 (de) 1995-01-26
CN1059517A (zh) 1992-03-18
PT98529B (pt) 1999-01-29
HU210883A9 (en) 1995-09-28
GB2247678A (en) 1992-03-11
NO913008D0 (no) 1991-08-01
AU8123391A (en) 1992-02-06
HUT59088A (en) 1992-04-28
US5430060A (en) 1995-07-04
YU131891A (sh) 1994-06-10
IE912529A1 (en) 1992-02-12
ATE115560T1 (de) 1994-12-15
RO109645B1 (ro) 1995-04-28
EP0469887B1 (en) 1994-12-14
KR920004342A (ko) 1992-03-27
PT98529A (pt) 1992-06-30
RU2068409C1 (ru) 1996-10-27
AP9100306A0 (en) 1991-07-31
EP0469887A1 (en) 1992-02-05
GB2247678B (en) 1994-07-27
AP261A (en) 1993-06-03
FI913706A (fi) 1992-02-03
CZ280642B6 (cs) 1996-03-13

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