NO171269C - Analogifremgangsmaate for fremstilling av terapeutisk aktive propenonoksimetere og mellomprodukter - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive propenonoksimetere og mellomprodukterInfo
- Publication number
- NO171269C NO171269C NO894786A NO894786A NO171269C NO 171269 C NO171269 C NO 171269C NO 894786 A NO894786 A NO 894786A NO 894786 A NO894786 A NO 894786A NO 171269 C NO171269 C NO 171269C
- Authority
- NO
- Norway
- Prior art keywords
- propenonoximers
- intermediates
- preparation
- therapeutic active
- analogy procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8815860A FR2639942B1 (fr) | 1988-12-02 | 1988-12-02 | Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant |
Publications (4)
Publication Number | Publication Date |
---|---|
NO894786D0 NO894786D0 (no) | 1989-11-30 |
NO894786L NO894786L (no) | 1990-06-05 |
NO171269B NO171269B (no) | 1992-11-09 |
NO171269C true NO171269C (no) | 1993-02-17 |
Family
ID=9372544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO894786A NO171269C (no) | 1988-12-02 | 1989-11-30 | Analogifremgangsmaate for fremstilling av terapeutisk aktive propenonoksimetere og mellomprodukter |
Country Status (21)
Country | Link |
---|---|
US (2) | US5166416A (xx) |
EP (1) | EP0373998B1 (xx) |
JP (1) | JP2562503B2 (xx) |
KR (1) | KR0156910B1 (xx) |
AR (1) | AR245704A1 (xx) |
AU (2) | AU623706B2 (xx) |
CA (1) | CA2004350C (xx) |
CZ (1) | CZ419091A3 (xx) |
DE (1) | DE68908374T2 (xx) |
DK (1) | DK174434B1 (xx) |
ES (1) | ES2059804T3 (xx) |
FI (1) | FI94752C (xx) |
FR (1) | FR2639942B1 (xx) |
HK (1) | HK1001557A1 (xx) |
HU (1) | HU211463A9 (xx) |
IE (1) | IE63400B1 (xx) |
IL (1) | IL92519A (xx) |
NO (1) | NO171269C (xx) |
NZ (2) | NZ240166A (xx) |
PT (1) | PT92446B (xx) |
ZA (1) | ZA899201B (xx) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
FR2639942B1 (fr) * | 1988-12-02 | 1991-03-29 | Sanofi Sa | Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant |
IL103106A (en) * | 1991-09-25 | 1998-06-15 | Sanofi Elf | Sites of tynocyclopentanone oximes, their preparation and pharmaceutical preparations containing them |
HU213421B (en) * | 1993-04-09 | 1997-06-30 | Egyt Gyogyszervegyeszeti Gyar | New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them |
US5844000A (en) * | 1997-06-12 | 1998-12-01 | Sanofi | Propenone oxime ethers and pharmaceutical compositions containing them |
FR2765107B1 (fr) * | 1997-06-26 | 2000-03-24 | Sanofi Sa | Utilisation d'un antagoniste specifique des recepteurs 5ht2 pour la preparation de medicaments utiles dans le traitement du syndrome d'apnee du sommeil |
FR2787328A1 (fr) | 1998-12-22 | 2000-06-23 | Sanofi Sa | Utilisation d'un antagoniste des recepteurs 5ht2a pour la preparation de medicaments utiles dans le traitement des ronflements et du syndrome de haute resistance ou de resistance des voies aeriennes superieures |
RU2005106205A (ru) * | 2002-08-05 | 2005-12-10 | Сандоз АГ (CH) | Новая соль и полиморфные модификации деслоратадина гемифумарата |
US20050070577A1 (en) * | 2003-07-03 | 2005-03-31 | Pfizer Inc. | Compositions containing a serotonin selective reuptake inhibitor and a 5-HT2A receptor antagonist |
PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
CA2551294A1 (en) * | 2003-12-26 | 2005-07-21 | Allergan, Inc. | Disubstituted chalcone oximes having rary retinoid receptor antagonist activity |
RU2420318C2 (ru) | 2004-09-30 | 2011-06-10 | Ф.Хоффманн-Ля Рош Аг | Композиции и способы для лечения когнитивных расстройств |
US20090076159A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched eplivanserin |
WO2009082268A2 (ru) | 2007-12-21 | 2009-07-02 | Alla Chem, Llc | ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ |
EP2266554A1 (en) | 2009-05-26 | 2010-12-29 | Sanofi-Aventis | Method of treating sleep disorders using eplivanserin |
JP2012508792A (ja) * | 2008-11-13 | 2012-04-12 | サノフイ | エプリバンセリンを使用して睡眠障害を治療する方法 |
EP2186511A1 (en) | 2008-11-13 | 2010-05-19 | Sanofi-Aventis | Method of treating sleep disorders using eplivanserin |
FR2938534B1 (fr) * | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Procede de preparation de l'hemifumarate d'eplivanserine |
CN102307850A (zh) | 2009-02-10 | 2012-01-04 | 日本曹达株式会社 | 含氮化合物和有害生物防除剂 |
EP2255807A1 (en) | 2009-05-26 | 2010-12-01 | Sanofi-Aventis | Method of treating sleep disorders using the combination of eplivanserin and zolpidem |
EP2255726A1 (en) | 2009-05-26 | 2010-12-01 | Sanofi-Aventis | Spectral profile of SWS enhancing drugs |
EP2269600A1 (en) | 2009-07-02 | 2011-01-05 | Sanofi-Aventis | Treatment of sleep disorders using eplivanserin in COPD patients |
CN101941919B (zh) * | 2009-07-07 | 2014-07-02 | 天津药物研究院 | 一种制备顺式肟及肟醚衍生物的方法 |
CN106883141B (zh) * | 2017-03-15 | 2018-08-10 | 何黎琴 | 一种丹皮酚肟醚类化合物、其制备方法及医药用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1094374A (en) | 1963-11-21 | 1967-12-13 | Gen Aniline & Film Corp | Diazotype materials |
NL7503311A (nl) * | 1975-03-20 | 1976-09-22 | Philips Nv | Verbindingen met antidepressieve werking. |
NL7503312A (nl) * | 1975-03-20 | 1976-09-22 | Philips Nv | Verbindingen met antidepressieve werking. |
NL7503310A (nl) * | 1975-03-20 | 1976-09-22 | Philips Nv | Verbindingen met antidepressieve werking. |
US4279930A (en) * | 1978-10-10 | 1981-07-21 | The Upjohn Company | Process for treating inflammation |
AU532700B2 (en) * | 1979-04-02 | 1983-10-13 | Sumitomo Chemical Company, Limited | Diphenylalkanoether |
FI92189C (fi) * | 1986-03-17 | 1994-10-10 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisen difenyylimetaanijohdannaisen valmistamiseksi |
GB8617648D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Fungicides |
KR0139296B1 (ko) * | 1988-11-21 | 1998-05-15 | 가와무라 시게꾸니 | 칼콘 유도체 및 그 제조 방법 |
FR2639942B1 (fr) * | 1988-12-02 | 1991-03-29 | Sanofi Sa | Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
1988
- 1988-12-02 FR FR8815860A patent/FR2639942B1/fr not_active Expired - Fee Related
-
1989
- 1989-11-29 AU AU45688/89A patent/AU623706B2/en not_active Expired
- 1989-11-29 PT PT92446A patent/PT92446B/pt not_active IP Right Cessation
- 1989-11-30 DK DK198906059A patent/DK174434B1/da not_active IP Right Cessation
- 1989-11-30 NO NO894786A patent/NO171269C/no not_active IP Right Cessation
- 1989-12-01 CA CA002004350A patent/CA2004350C/en not_active Expired - Lifetime
- 1989-12-01 IL IL9251989A patent/IL92519A/en not_active IP Right Cessation
- 1989-12-01 NZ NZ240166A patent/NZ240166A/en not_active IP Right Cessation
- 1989-12-01 NZ NZ231606A patent/NZ231606A/en unknown
- 1989-12-01 AR AR89315585A patent/AR245704A1/es active
- 1989-12-01 IE IE384889A patent/IE63400B1/en not_active IP Right Cessation
- 1989-12-01 US US07/444,823 patent/US5166416A/en not_active Expired - Lifetime
- 1989-12-01 ZA ZA899201A patent/ZA899201B/xx unknown
- 1989-12-01 JP JP1313121A patent/JP2562503B2/ja not_active Expired - Lifetime
- 1989-12-01 DE DE89403339T patent/DE68908374T2/de not_active Expired - Lifetime
- 1989-12-01 EP EP89403339A patent/EP0373998B1/fr not_active Expired - Lifetime
- 1989-12-01 FI FI895757A patent/FI94752C/fi active IP Right Grant
- 1989-12-01 ES ES89403339T patent/ES2059804T3/es not_active Expired - Lifetime
- 1989-12-02 KR KR1019890017809A patent/KR0156910B1/ko not_active IP Right Cessation
-
1991
- 1991-12-31 CZ CS914190A patent/CZ419091A3/cs unknown
-
1992
- 1992-03-10 AU AU12183/92A patent/AU640310B2/en not_active Expired
- 1992-07-10 US US07/911,736 patent/US5290951A/en not_active Expired - Lifetime
-
1995
- 1995-06-28 HU HU95P/P00484P patent/HU211463A9/hu unknown
-
1997
- 1997-11-26 HK HK97102253A patent/HK1001557A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |