AR245704A1 - Un procedimiento de preparacion de eteres de oxima de propenona de geometria trans en relacion al doble enlace etilenico. - Google Patents

Un procedimiento de preparacion de eteres de oxima de propenona de geometria trans en relacion al doble enlace etilenico.

Info

Publication number
AR245704A1
AR245704A1 AR89315585A AR31558589A AR245704A1 AR 245704 A1 AR245704 A1 AR 245704A1 AR 89315585 A AR89315585 A AR 89315585A AR 31558589 A AR31558589 A AR 31558589A AR 245704 A1 AR245704 A1 AR 245704A1
Authority
AR
Argentina
Prior art keywords
formula
alkyl
hydrogen
preparation
mineral
Prior art date
Application number
AR89315585A
Other languages
English (en)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of AR245704A1 publication Critical patent/AR245704A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UN PROCEDIMIENTO DE PREPARACION DE ETERES DE OXIMA DE PROPENONA DE GEOMETRIA TRANS EN RELACION AL DOBLE ENLACE ETILENICO Y DE FORMULA (I), EN LA CUAL -AR Y AR'SON: A)FENILO SUSTITUIDO O NO, POR HALOGENO, ALQUILO, NITRO, HIDROXILO, ALCOXI, ACILOXI, DIMETILAMINO, CARBOXIALCOXI; O ANTRILO-9 O NAFTILO;B)PIRIDILO,TIENILO O FURILO;-R1 Y R2 SON HIDROGENO, ALQUILO O TAMBIEN R1 Y R2 JUNTOS PIRROLIDINILO-1,PIPERIDINO,MORFOLINO O PIPERAZINILO- 1;-M ES HIDROGENO,CLORO O DE BROMO,ALQUILO;-N=2 O 3; ASI COMO SUS SALES CON ACIDOS MINERALES U ORGANICOS,A) SE TRATA UNA CALCONA DE FORMULA (II), CON UNA HIDROXILAMINA DE FORMULA: H2NOZ, EN LA CUAL Z -YA SEA UNA CADENA AMINOALQUILO DE FORMULA -(CH2)N-NR1R2, EN DONDE R1 Y R2 SON H O DE FORMULA (CH2)NX, DONDE X ES UN GRUPO SALIENTE; B) SE TRATA A CONTINUACION EL PRODUCTO ASI OBTENIDO DE FORMULA (IA) Y Z ES HIDROGENO O UN GRUPO -(CH2)NX, YA SEA, CUANDO Z ES HIDROGENO, EN PRESENCIA DE UN AGENTE DE CONDENSACION BASICO, CON UNA AMINA DE FORMULA (V), EN LA CU AL X' ES UN GRUPO SALIENTE;-YA SEA CUANDO Z ES -(CH2)N-X, CON UNA AMINA DE FORMULA HNR1R2; C) SE TRANSFORMA EVENTUALMENTE EL PRODUCTO ASI OBTENIDO EN A) O B) EN UNA DE SUS SALES CON ACIDOS MINERALES U ORGANICOS.
AR89315585A 1988-12-02 1989-12-01 Un procedimiento de preparacion de eteres de oxima de propenona de geometria trans en relacion al doble enlace etilenico. AR245704A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8815860A FR2639942B1 (fr) 1988-12-02 1988-12-02 Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
AR245704A1 true AR245704A1 (es) 1994-02-28

Family

ID=9372544

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89315585A AR245704A1 (es) 1988-12-02 1989-12-01 Un procedimiento de preparacion de eteres de oxima de propenona de geometria trans en relacion al doble enlace etilenico.

Country Status (21)

Country Link
US (2) US5166416A (es)
EP (1) EP0373998B1 (es)
JP (1) JP2562503B2 (es)
KR (1) KR0156910B1 (es)
AR (1) AR245704A1 (es)
AU (2) AU623706B2 (es)
CA (1) CA2004350C (es)
CZ (1) CZ419091A3 (es)
DE (1) DE68908374T2 (es)
DK (1) DK174434B1 (es)
ES (1) ES2059804T3 (es)
FI (1) FI94752C (es)
FR (1) FR2639942B1 (es)
HK (1) HK1001557A1 (es)
HU (1) HU211463A9 (es)
IE (1) IE63400B1 (es)
IL (1) IL92519A (es)
NO (1) NO171269C (es)
NZ (2) NZ240166A (es)
PT (1) PT92446B (es)
ZA (1) ZA899201B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
FR2639942B1 (fr) * 1988-12-02 1991-03-29 Sanofi Sa Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant
IL103106A (en) * 1991-09-25 1998-06-15 Sanofi Elf Sites of tynocyclopentanone oximes, their preparation and pharmaceutical preparations containing them
HU213421B (en) * 1993-04-09 1997-06-30 Egyt Gyogyszervegyeszeti Gyar New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them
US5844000A (en) * 1997-06-12 1998-12-01 Sanofi Propenone oxime ethers and pharmaceutical compositions containing them
FR2765107B1 (fr) * 1997-06-26 2000-03-24 Sanofi Sa Utilisation d'un antagoniste specifique des recepteurs 5ht2 pour la preparation de medicaments utiles dans le traitement du syndrome d'apnee du sommeil
FR2787328A1 (fr) 1998-12-22 2000-06-23 Sanofi Sa Utilisation d'un antagoniste des recepteurs 5ht2a pour la preparation de medicaments utiles dans le traitement des ronflements et du syndrome de haute resistance ou de resistance des voies aeriennes superieures
RU2005106205A (ru) * 2002-08-05 2005-12-10 Сандоз АГ (CH) Новая соль и полиморфные модификации деслоратадина гемифумарата
US20050070577A1 (en) * 2003-07-03 2005-03-31 Pfizer Inc. Compositions containing a serotonin selective reuptake inhibitor and a 5-HT2A receptor antagonist
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
CA2551294A1 (en) * 2003-12-26 2005-07-21 Allergan, Inc. Disubstituted chalcone oximes having rary retinoid receptor antagonist activity
RU2420318C2 (ru) 2004-09-30 2011-06-10 Ф.Хоффманн-Ля Рош Аг Композиции и способы для лечения когнитивных расстройств
US20090076159A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched eplivanserin
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
EP2266554A1 (en) 2009-05-26 2010-12-29 Sanofi-Aventis Method of treating sleep disorders using eplivanserin
JP2012508792A (ja) * 2008-11-13 2012-04-12 サノフイ エプリバンセリンを使用して睡眠障害を治療する方法
EP2186511A1 (en) 2008-11-13 2010-05-19 Sanofi-Aventis Method of treating sleep disorders using eplivanserin
FR2938534B1 (fr) * 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine
CN102307850A (zh) 2009-02-10 2012-01-04 日本曹达株式会社 含氮化合物和有害生物防除剂
EP2255807A1 (en) 2009-05-26 2010-12-01 Sanofi-Aventis Method of treating sleep disorders using the combination of eplivanserin and zolpidem
EP2255726A1 (en) 2009-05-26 2010-12-01 Sanofi-Aventis Spectral profile of SWS enhancing drugs
EP2269600A1 (en) 2009-07-02 2011-01-05 Sanofi-Aventis Treatment of sleep disorders using eplivanserin in COPD patients
CN101941919B (zh) * 2009-07-07 2014-07-02 天津药物研究院 一种制备顺式肟及肟醚衍生物的方法
CN106883141B (zh) * 2017-03-15 2018-08-10 何黎琴 一种丹皮酚肟醚类化合物、其制备方法及医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094374A (en) 1963-11-21 1967-12-13 Gen Aniline & Film Corp Diazotype materials
NL7503311A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
NL7503312A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
NL7503310A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
US4279930A (en) * 1978-10-10 1981-07-21 The Upjohn Company Process for treating inflammation
AU532700B2 (en) * 1979-04-02 1983-10-13 Sumitomo Chemical Company, Limited Diphenylalkanoether
FI92189C (fi) * 1986-03-17 1994-10-10 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisen difenyylimetaanijohdannaisen valmistamiseksi
GB8617648D0 (en) * 1986-07-18 1986-08-28 Ici Plc Fungicides
KR0139296B1 (ko) * 1988-11-21 1998-05-15 가와무라 시게꾸니 칼콘 유도체 및 그 제조 방법
FR2639942B1 (fr) * 1988-12-02 1991-03-29 Sanofi Sa Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
CA2004350C (en) 1997-06-03
IL92519A (en) 1994-05-30
JPH02262552A (ja) 1990-10-25
EP0373998A1 (fr) 1990-06-20
HU211463A9 (en) 1995-11-28
NO894786D0 (no) 1989-11-30
FR2639942B1 (fr) 1991-03-29
PT92446B (pt) 1995-07-18
AU4568889A (en) 1990-06-07
JP2562503B2 (ja) 1996-12-11
DK605989A (da) 1990-06-03
DE68908374T2 (de) 1994-01-05
NZ231606A (en) 1992-02-25
NO171269C (no) 1993-02-17
FI94752B (fi) 1995-07-14
DE68908374D1 (de) 1993-09-16
IE893848L (en) 1990-06-02
IE63400B1 (en) 1995-04-19
NO171269B (no) 1992-11-09
DK174434B1 (da) 2003-03-03
AU640310B2 (en) 1993-08-19
ES2059804T3 (es) 1994-11-16
ZA899201B (en) 1990-09-26
DK605989D0 (da) 1989-11-30
NO894786L (no) 1990-06-05
CZ419091A3 (en) 1993-05-12
NZ240166A (en) 1992-02-25
CA2004350A1 (en) 1990-06-02
US5166416A (en) 1992-11-24
US5290951A (en) 1994-03-01
AU623706B2 (en) 1992-05-21
AU1218392A (en) 1992-05-28
EP0373998B1 (fr) 1993-08-11
FI94752C (fi) 1995-10-25
KR0156910B1 (ko) 1998-12-01
HK1001557A1 (en) 1998-06-26
FR2639942A1 (fr) 1990-06-08
FI895757A0 (fi) 1989-12-01
PT92446A (pt) 1990-06-29
KR900009572A (ko) 1990-07-04

Similar Documents

Publication Publication Date Title
AR245704A1 (es) Un procedimiento de preparacion de eteres de oxima de propenona de geometria trans en relacion al doble enlace etilenico.
RS20050311A (en) Selected cgrp antagonists,method for production and use thereof as medicament
AR246433A1 (es) Un procedimiento para desinfectar un substrato.
IL108507A0 (en) Substituted phenyl sulfonamides, their preparationand pharmaceutical compositions containing them
MXPA05004188A (es) Antagonistas de cgrp elegidos, procedimiento para su preparacion, asi como su empleo como medicamentos.
CO5261559A1 (es) Antagonistas de neurokinina selectivos
MX9307941A (es) Proceso para el tratamiento en el sondeo o perforacion de pozos.
ES2067466T3 (es) Dispersante.
ATE260907T1 (de) Verfahren zur herstellung von olefinischen epoxiden
ATE235959T1 (de) Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln
AR033147A1 (es) Compuestos de amida.
RU2017123537A (ru) Средство для деформирующей обработки волос
JPS6413041A (en) Agent for suppressing growth of polymer in olefin-production apparatus
IL40184A (en) 5-cinnamoyl-benzofurans,their preparation and pharmaceutical compositions containing them
AR246521A1 (es) Un procedimiento para la preparacion de derivados del cromeno.
DE60006163D1 (de) Verfahren zur herstellung von 5-cyanophthalid
LTIP704A (en) Process for the preparation of hexahydroazepines derivatives
FI97627C (fi) Koostumus ja menetelmä korroosion estämiseksi
AR025296A1 (es) MÉTODO PARA INHIBIR LA POLIMERIZACIoN PREMATURA DE MONoMEROS VINIL AROMÁTICOS Y COMPOSICIoN DE MONoMEROS VINIL AROMÁTICOS Y DEL INHIBIDOR.
PL341527A1 (en) Method of reducing aox level of water resisting resins by treating with a base
EA200500123A1 (ru) Содержащая циклесонид стерильная водная суспензия
GB925538A (en) Improvements in or relating to trifluoromethylthiaxanthene and -xanthene derivatives
AR052258A1 (es) Derivados de fenilpiperazinas con una afinidad combinada para receptores de dopamina - d2 y sitios de reabsorcion de serotonina, composiciones farmaceuticas que los contienen y su empleo como medicamentos para el tratamiento de enfermedades del sistema nervioso central.
AR007970A1 (es) Pirroles sustituidos, su utilizacion y composiciones farmaceuticas que los comprenden
AR012688A1 (es) Proceso para la preparacion de un compuesto derivado de (-)-trans-1-bencil- 3-hidroximetil-4-(4-fluorofenil)piperidina y paroxetina preparada a partirde dicho compuesto