AR012688A1 - Proceso para la preparacion de un compuesto derivado de (-)-trans-1-bencil- 3-hidroximetil-4-(4-fluorofenil)piperidina y paroxetina preparada a partirde dicho compuesto - Google Patents
Proceso para la preparacion de un compuesto derivado de (-)-trans-1-bencil- 3-hidroximetil-4-(4-fluorofenil)piperidina y paroxetina preparada a partirde dicho compuestoInfo
- Publication number
- AR012688A1 AR012688A1 ARP980102206A ARP980102206A AR012688A1 AR 012688 A1 AR012688 A1 AR 012688A1 AR P980102206 A ARP980102206 A AR P980102206A AR P980102206 A ARP980102206 A AR P980102206A AR 012688 A1 AR012688 A1 AR 012688A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- preparation
- hydroximethyl
- bencil
- fluorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Un proceso para la preparacion de un compuesto de formula (I) en el cual R1 representa un grupo protector de amina donde un compuesto de formula(II), en la cual R1 es como se definion anteriormente, es reducido por un hidruro de metal en presencia de una sal inorgánica, en presencia tambiénde un diluyente. Paroxetina preparada a partir del compuesto de formula (I) obtenido mediante el proceso descripto como intermediario. La paroxetina es uncompuesto que posee actividad antidepresiva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9710004.4A GB9710004D0 (en) | 1997-05-17 | 1997-05-17 | Chemical process |
Publications (1)
Publication Number | Publication Date |
---|---|
AR012688A1 true AR012688A1 (es) | 2000-11-08 |
Family
ID=10812456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980102206A AR012688A1 (es) | 1997-05-17 | 1998-05-12 | Proceso para la preparacion de un compuesto derivado de (-)-trans-1-bencil- 3-hidroximetil-4-(4-fluorofenil)piperidina y paroxetina preparada a partirde dicho compuesto |
Country Status (28)
Country | Link |
---|---|
US (1) | US6326496B1 (es) |
EP (1) | EP0983237B1 (es) |
JP (1) | JP4463883B2 (es) |
KR (1) | KR100515852B1 (es) |
CN (1) | CN1121386C (es) |
AR (1) | AR012688A1 (es) |
AT (1) | ATE212013T1 (es) |
AU (1) | AU748902B2 (es) |
BG (1) | BG63847B1 (es) |
BR (1) | BR9809809B1 (es) |
CA (1) | CA2289013C (es) |
CZ (1) | CZ292282B6 (es) |
DE (1) | DE69803178T2 (es) |
DK (1) | DK0983237T3 (es) |
ES (1) | ES2171299T3 (es) |
GB (1) | GB9710004D0 (es) |
HU (1) | HUP0002709A3 (es) |
ID (1) | ID24181A (es) |
IL (1) | IL132360A (es) |
NO (1) | NO313326B1 (es) |
NZ (1) | NZ501692A (es) |
PL (1) | PL189464B1 (es) |
PT (1) | PT983237E (es) |
RU (1) | RU2205178C2 (es) |
SK (1) | SK149599A3 (es) |
TR (1) | TR199902823T2 (es) |
UA (1) | UA61952C2 (es) |
WO (1) | WO1998052920A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1280775A1 (en) * | 2000-05-12 | 2003-02-05 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
GB0021147D0 (en) | 2000-08-30 | 2000-10-11 | Knoll Ag | Chemical process |
US6777554B2 (en) | 2001-02-05 | 2004-08-17 | Teva Pharmaceutical Industries Ltd. | Preparation of N-methylparoxetine and related intermediate compounds |
JP2006512278A (ja) * | 2001-06-13 | 2006-04-13 | テバ ファーマシューティカル インダストリーズ リミティド | アルコキシ不純物を実質的に含有しないパロキセチンの製造方法 |
US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
EP1948646A2 (en) * | 2005-11-14 | 2008-07-30 | Auspex Pharmaceuticals Inc. | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3849542A (en) | 1966-05-09 | 1974-11-19 | Dow Chemical Co | Lithium magnesium aluminum hydride |
GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
DE3680184D1 (de) * | 1985-08-10 | 1991-08-14 | Beecham Group Plc | Verfahren zur herstellung von arylpiperidincarbinol. |
EP0299549A3 (en) * | 1987-07-09 | 1989-02-08 | Duphar International Research B.V | Tertiary 2,5-dialkyl-3-phenyl-piperidine derivatives having opiate-antagonistic activity |
GB9100505D0 (en) * | 1991-01-10 | 1991-02-20 | Shell Int Research | Piperidine derivatives |
US5258517A (en) * | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
GB9305175D0 (en) * | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
HUP9900318A3 (en) * | 1995-05-17 | 2001-09-28 | Novo Nordisk As | Process for preparing 4-aryl-piperidine derivatives |
EP0812827B1 (en) * | 1996-06-13 | 2009-09-02 | Sumitomo Chemical Company, Limited | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation |
HU221921B1 (hu) | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
GB9623359D0 (en) * | 1996-11-09 | 1997-01-08 | Smithkline Beecham Plc | Novel process |
-
1997
- 1997-05-17 GB GBGB9710004.4A patent/GB9710004D0/en active Pending
-
1998
- 1998-05-12 AR ARP980102206A patent/AR012688A1/es unknown
- 1998-05-13 DK DK98929307T patent/DK0983237T3/da active
- 1998-05-13 ES ES98929307T patent/ES2171299T3/es not_active Expired - Lifetime
- 1998-05-13 WO PCT/EP1998/002826 patent/WO1998052920A1/en active IP Right Grant
- 1998-05-13 CN CN98805113A patent/CN1121386C/zh not_active Expired - Fee Related
- 1998-05-13 SK SK1495-99A patent/SK149599A3/sk unknown
- 1998-05-13 IL IL13236098A patent/IL132360A/xx not_active IP Right Cessation
- 1998-05-13 TR TR1999/02823T patent/TR199902823T2/xx unknown
- 1998-05-13 DE DE69803178T patent/DE69803178T2/de not_active Expired - Lifetime
- 1998-05-13 KR KR10-1999-7010581A patent/KR100515852B1/ko not_active IP Right Cessation
- 1998-05-13 EP EP98929307A patent/EP0983237B1/en not_active Expired - Lifetime
- 1998-05-13 JP JP54990898A patent/JP4463883B2/ja not_active Expired - Fee Related
- 1998-05-13 BR BRPI9809809-8A patent/BR9809809B1/pt not_active IP Right Cessation
- 1998-05-13 ID IDW991271A patent/ID24181A/id unknown
- 1998-05-13 HU HU0002709A patent/HUP0002709A3/hu unknown
- 1998-05-13 AU AU79121/98A patent/AU748902B2/en not_active Ceased
- 1998-05-13 NZ NZ501692A patent/NZ501692A/en unknown
- 1998-05-13 CZ CZ19994081A patent/CZ292282B6/cs not_active IP Right Cessation
- 1998-05-13 US US09/423,749 patent/US6326496B1/en not_active Expired - Fee Related
- 1998-05-13 AT AT98929307T patent/ATE212013T1/de not_active IP Right Cessation
- 1998-05-13 PT PT98929307T patent/PT983237E/pt unknown
- 1998-05-13 UA UA99126877A patent/UA61952C2/uk unknown
- 1998-05-13 PL PL98336796A patent/PL189464B1/pl not_active IP Right Cessation
- 1998-05-13 CA CA002289013A patent/CA2289013C/en not_active Expired - Fee Related
- 1998-05-13 RU RU99127285/04A patent/RU2205178C2/ru not_active IP Right Cessation
-
1999
- 1999-10-26 BG BG103834A patent/BG63847B1/bg unknown
- 1999-11-16 NO NO19995619A patent/NO313326B1/no unknown
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