IL132360A - Chemical process for the reduction of 1-substituted 3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridines - Google Patents

Chemical process for the reduction of 1-substituted 3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridines

Info

Publication number
IL132360A
IL132360A IL13236098A IL13236098A IL132360A IL 132360 A IL132360 A IL 132360A IL 13236098 A IL13236098 A IL 13236098A IL 13236098 A IL13236098 A IL 13236098A IL 132360 A IL132360 A IL 132360A
Authority
IL
Israel
Prior art keywords
tetrahydropyridines
fluorophenyl
hydroxymethyl
substituted
reduction
Prior art date
Application number
IL13236098A
Other languages
English (en)
Other versions
IL132360A0 (en
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of IL132360A0 publication Critical patent/IL132360A0/xx
Publication of IL132360A publication Critical patent/IL132360A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL13236098A 1997-05-17 1998-05-13 Chemical process for the reduction of 1-substituted 3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridines IL132360A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710004.4A GB9710004D0 (en) 1997-05-17 1997-05-17 Chemical process
PCT/EP1998/002826 WO1998052920A1 (en) 1997-05-17 1998-05-13 Chemical process for the reduction of 1-substituted -3-hydroxymethyl-4- (4-fluorophenyl)tetrahydropyridines

Publications (2)

Publication Number Publication Date
IL132360A0 IL132360A0 (en) 2001-03-19
IL132360A true IL132360A (en) 2003-02-12

Family

ID=10812456

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13236098A IL132360A (en) 1997-05-17 1998-05-13 Chemical process for the reduction of 1-substituted 3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridines

Country Status (28)

Country Link
US (1) US6326496B1 (xx)
EP (1) EP0983237B1 (xx)
JP (1) JP4463883B2 (xx)
KR (1) KR100515852B1 (xx)
CN (1) CN1121386C (xx)
AR (1) AR012688A1 (xx)
AT (1) ATE212013T1 (xx)
AU (1) AU748902B2 (xx)
BG (1) BG63847B1 (xx)
BR (1) BR9809809B1 (xx)
CA (1) CA2289013C (xx)
CZ (1) CZ292282B6 (xx)
DE (1) DE69803178T2 (xx)
DK (1) DK0983237T3 (xx)
ES (1) ES2171299T3 (xx)
GB (1) GB9710004D0 (xx)
HU (1) HUP0002709A3 (xx)
ID (1) ID24181A (xx)
IL (1) IL132360A (xx)
NO (1) NO313326B1 (xx)
NZ (1) NZ501692A (xx)
PL (1) PL189464B1 (xx)
PT (1) PT983237E (xx)
RU (1) RU2205178C2 (xx)
SK (1) SK149599A3 (xx)
TR (1) TR199902823T2 (xx)
UA (1) UA61952C2 (xx)
WO (1) WO1998052920A1 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000246280A1 (en) * 2000-05-12 2001-11-20 Synthon B.V. Tosylate salts of 4-(p-fluorophenyl)-piperidine-3-carbinols
GB0021147D0 (en) 2000-08-30 2000-10-11 Knoll Ag Chemical process
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
JP2006512278A (ja) * 2001-06-13 2006-04-13 テバ ファーマシューティカル インダストリーズ リミティド アルコキシ不純物を実質的に含有しないパロキセチンの製造方法
US20050266082A1 (en) * 2004-05-26 2005-12-01 Patel Satishkumar A Preparation of stable paroxetine HC1 ER tablets using a melt granulation process
US20070112031A1 (en) * 2005-11-14 2007-05-17 Gant Thomas G Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
US20080033050A1 (en) 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3849542A (en) * 1966-05-09 1974-11-19 Dow Chemical Co Lithium magnesium aluminum hydride
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0223334B1 (en) * 1985-08-10 1991-07-10 Beecham Group Plc Process for the preparation of aryl-piperidine carbinols
EP0299549A3 (en) * 1987-07-09 1989-02-08 Duphar International Research B.V Tertiary 2,5-dialkyl-3-phenyl-piperidine derivatives having opiate-antagonistic activity
GB9100505D0 (en) * 1991-01-10 1991-02-20 Shell Int Research Piperidine derivatives
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9305175D0 (en) * 1993-03-13 1993-04-28 Smithkline Beecham Plc Novel process
JPH11505229A (ja) * 1995-05-17 1999-05-18 ノボ ノルディスク アクティーゼルスカブ ４−アリール−ピペリジン誘導体を製造する方法
DE69739561D1 (de) * 1996-06-13 2009-10-15 Sumitomo Chemical Co Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung
HU221921B1 (hu) 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process

Also Published As

Publication number Publication date
AR012688A1 (es) 2000-11-08
CN1255916A (zh) 2000-06-07
BG63847B1 (bg) 2003-03-31
CA2289013A1 (en) 1998-11-26
KR100515852B1 (ko) 2005-09-21
ATE212013T1 (de) 2002-02-15
RU2205178C2 (ru) 2003-05-27
KR20010012620A (ko) 2001-02-26
PT983237E (pt) 2002-05-31
CA2289013C (en) 2007-11-13
AU748902B2 (en) 2002-06-13
UA61952C2 (en) 2003-12-15
WO1998052920A1 (en) 1998-11-26
BR9809809B1 (pt) 2009-05-05
DE69803178D1 (de) 2002-02-21
PL189464B1 (pl) 2005-08-31
ES2171299T3 (es) 2002-09-01
CZ408199A3 (cs) 2000-04-12
GB9710004D0 (en) 1997-07-09
EP0983237A1 (en) 2000-03-08
EP0983237B1 (en) 2002-01-16
ID24181A (id) 2000-07-13
PL336796A1 (en) 2000-07-17
NZ501692A (en) 2001-05-25
BG103834A (en) 2000-07-31
NO313326B1 (no) 2002-09-16
JP4463883B2 (ja) 2010-05-19
CN1121386C (zh) 2003-09-17
AU7912198A (en) 1998-12-11
DK0983237T3 (da) 2002-03-25
US6326496B1 (en) 2001-12-04
NO995619L (no) 1999-11-16
NO995619D0 (no) 1999-11-16
TR199902823T2 (xx) 2000-05-22
HUP0002709A1 (hu) 2001-01-29
HUP0002709A3 (en) 2002-01-28
SK149599A3 (en) 2000-05-16
DE69803178T2 (de) 2002-10-31
BR9809809A (pt) 2000-06-27
JP2001525838A (ja) 2001-12-11
IL132360A0 (en) 2001-03-19
CZ292282B6 (cs) 2003-08-13

Similar Documents

Publication Publication Date Title
HUP0104314A3 (en) Catalytic dewaxing process
ZA974351B (en) Decontamination of metal.
HUP0003737A3 (en) New process for the preparation of omeprazole
HUP0101779A3 (en) Process for de-chlorinating and de-fouling waste-oil
GB9725898D0 (en) Process for treating metal surfaces
IL132360A (en) Chemical process for the reduction of 1-substituted 3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridines
GB9610320D0 (en) Chemical process
AU6569898A (en) Leukotriene antagonists useful for treating iritis
HUP0104482A3 (en) Method for preparing 4-hidroxyquinolines and/or tautomeric compounds
GB9717928D0 (en) Process for the enatioselective hydrolysis of n-derivatised lactams
ZA982449B (en) Process for preparing 1-Alkyl-4-(2-chloro-3-alkoxy-4-alkylsulfonylbenzoyl)-5-hydroxypyrazole and related compounds.
GB9709810D0 (en) Chemical process
SI0983237T1 (en) Chemical process for the reduction of 1-substituted -3-hydroxymethyl-4- (4-fluorophenyl)tetrahydropyridines
ZA991576B (en) Process for the preparation of substituted pyridines.
GB9608095D0 (en) Chemical process
HK1038738A1 (en) Process for the preparation of 1-(2-fluorophenyl)-substituted triazolinones.
GB9718837D0 (en) Chemical Process
GB9608094D0 (en) Chemical process
GB9926102D0 (en) An improved metalworking process
HK1025323A1 (en) Process for preparing 6-o-monoesters of castanospermine.
HU9801092D0 (en) Process for coating salamirod and couted salamirod
GB9718010D0 (en) Chemical process
GB9702554D0 (en) Chemical process
GB9715846D0 (en) Chemical process
ZA9811167B (en) Chemical process

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees