DE69803178D1 - Verfahren zur reduktion von 1-substituierte-3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridine - Google Patents
Verfahren zur reduktion von 1-substituierte-3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridineInfo
- Publication number
- DE69803178D1 DE69803178D1 DE69803178T DE69803178T DE69803178D1 DE 69803178 D1 DE69803178 D1 DE 69803178D1 DE 69803178 T DE69803178 T DE 69803178T DE 69803178 T DE69803178 T DE 69803178T DE 69803178 D1 DE69803178 D1 DE 69803178D1
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydropyridine
- fluorophenyl
- hydroxymethyl
- substituted
- reducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9710004.4A GB9710004D0 (en) | 1997-05-17 | 1997-05-17 | Chemical process |
PCT/EP1998/002826 WO1998052920A1 (en) | 1997-05-17 | 1998-05-13 | Chemical process for the reduction of 1-substituted -3-hydroxymethyl-4- (4-fluorophenyl)tetrahydropyridines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69803178D1 true DE69803178D1 (de) | 2002-02-21 |
DE69803178T2 DE69803178T2 (de) | 2002-10-31 |
Family
ID=10812456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69803178T Expired - Lifetime DE69803178T2 (de) | 1997-05-17 | 1998-05-13 | Verfahren zur reduktion von 1-substituierte-3-hydroxymethyl-4-(4-fluorophenyl) tetrahydropyridine |
Country Status (28)
Country | Link |
---|---|
US (1) | US6326496B1 (de) |
EP (1) | EP0983237B1 (de) |
JP (1) | JP4463883B2 (de) |
KR (1) | KR100515852B1 (de) |
CN (1) | CN1121386C (de) |
AR (1) | AR012688A1 (de) |
AT (1) | ATE212013T1 (de) |
AU (1) | AU748902B2 (de) |
BG (1) | BG63847B1 (de) |
BR (1) | BR9809809B1 (de) |
CA (1) | CA2289013C (de) |
CZ (1) | CZ292282B6 (de) |
DE (1) | DE69803178T2 (de) |
DK (1) | DK0983237T3 (de) |
ES (1) | ES2171299T3 (de) |
GB (1) | GB9710004D0 (de) |
HU (1) | HUP0002709A3 (de) |
ID (1) | ID24181A (de) |
IL (1) | IL132360A (de) |
NO (1) | NO313326B1 (de) |
NZ (1) | NZ501692A (de) |
PL (1) | PL189464B1 (de) |
PT (1) | PT983237E (de) |
RU (1) | RU2205178C2 (de) |
SK (1) | SK149599A3 (de) |
TR (1) | TR199902823T2 (de) |
UA (1) | UA61952C2 (de) |
WO (1) | WO1998052920A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001085688A1 (en) * | 2000-05-12 | 2001-11-15 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
GB0021147D0 (en) | 2000-08-30 | 2000-10-11 | Knoll Ag | Chemical process |
US6777554B2 (en) | 2001-02-05 | 2004-08-17 | Teva Pharmaceutical Industries Ltd. | Preparation of N-methylparoxetine and related intermediate compounds |
JP2006512278A (ja) | 2001-06-13 | 2006-04-13 | テバ ファーマシューティカル インダストリーズ リミティド | アルコキシ不純物を実質的に含有しないパロキセチンの製造方法 |
US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
EP1948646A2 (de) * | 2005-11-14 | 2008-07-30 | Auspex Pharmaceuticals Inc. | Substituierte phenylpiperidine mit serotoninerger aktivität und verbesserten therapeutischen eigenschaften |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3849542A (en) | 1966-05-09 | 1974-11-19 | Dow Chemical Co | Lithium magnesium aluminum hydride |
GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
DE3680184D1 (de) * | 1985-08-10 | 1991-08-14 | Beecham Group Plc | Verfahren zur herstellung von arylpiperidincarbinol. |
EP0299549A3 (de) * | 1987-07-09 | 1989-02-08 | Duphar International Research B.V | Tertiäre 2,5-Dialkyl-3-phenyl-piperidin-Derivate mit Opiatantagonistischer Wirkung |
GB9100505D0 (en) * | 1991-01-10 | 1991-02-20 | Shell Int Research | Piperidine derivatives |
US5258517A (en) * | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
GB9305175D0 (en) * | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
NZ307479A (en) | 1995-05-17 | 1999-08-30 | Novo Nordisk As | A process for preparing 4-(4-halo substituted phenyl)-3-(3,4-methylenedioxy phenoxy methyl)piperidine derivatives |
EP1384711A1 (de) * | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Optische Trennung eines Piperidin-Derivates |
HU221921B1 (hu) | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
GB9623359D0 (en) * | 1996-11-09 | 1997-01-08 | Smithkline Beecham Plc | Novel process |
-
1997
- 1997-05-17 GB GBGB9710004.4A patent/GB9710004D0/en active Pending
-
1998
- 1998-05-12 AR ARP980102206A patent/AR012688A1/es unknown
- 1998-05-13 PL PL98336796A patent/PL189464B1/pl not_active IP Right Cessation
- 1998-05-13 WO PCT/EP1998/002826 patent/WO1998052920A1/en active IP Right Grant
- 1998-05-13 UA UA99126877A patent/UA61952C2/uk unknown
- 1998-05-13 PT PT98929307T patent/PT983237E/pt unknown
- 1998-05-13 AT AT98929307T patent/ATE212013T1/de not_active IP Right Cessation
- 1998-05-13 DE DE69803178T patent/DE69803178T2/de not_active Expired - Lifetime
- 1998-05-13 US US09/423,749 patent/US6326496B1/en not_active Expired - Fee Related
- 1998-05-13 CZ CZ19994081A patent/CZ292282B6/cs not_active IP Right Cessation
- 1998-05-13 NZ NZ501692A patent/NZ501692A/en unknown
- 1998-05-13 EP EP98929307A patent/EP0983237B1/de not_active Expired - Lifetime
- 1998-05-13 CA CA002289013A patent/CA2289013C/en not_active Expired - Fee Related
- 1998-05-13 ES ES98929307T patent/ES2171299T3/es not_active Expired - Lifetime
- 1998-05-13 IL IL13236098A patent/IL132360A/xx not_active IP Right Cessation
- 1998-05-13 BR BRPI9809809-8A patent/BR9809809B1/pt not_active IP Right Cessation
- 1998-05-13 CN CN98805113A patent/CN1121386C/zh not_active Expired - Fee Related
- 1998-05-13 SK SK1495-99A patent/SK149599A3/sk unknown
- 1998-05-13 JP JP54990898A patent/JP4463883B2/ja not_active Expired - Fee Related
- 1998-05-13 ID IDW991271A patent/ID24181A/id unknown
- 1998-05-13 DK DK98929307T patent/DK0983237T3/da active
- 1998-05-13 KR KR10-1999-7010581A patent/KR100515852B1/ko not_active IP Right Cessation
- 1998-05-13 HU HU0002709A patent/HUP0002709A3/hu unknown
- 1998-05-13 TR TR1999/02823T patent/TR199902823T2/xx unknown
- 1998-05-13 RU RU99127285/04A patent/RU2205178C2/ru not_active IP Right Cessation
- 1998-05-13 AU AU79121/98A patent/AU748902B2/en not_active Ceased
-
1999
- 1999-10-26 BG BG103834A patent/BG63847B1/bg unknown
- 1999-11-16 NO NO19995619A patent/NO313326B1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: AESICA PHARMACEUTICALS LTD., CRAMLINGTON, NORTHUMB |