BG63847B1 - Метод за редуциране на 1-заместени-3-хидроксиметил 4-(4-флуорфенил)тетрахидропиридини - Google Patents
Метод за редуциране на 1-заместени-3-хидроксиметил 4-(4-флуорфенил)тетрахидропиридини Download PDFInfo
- Publication number
- BG63847B1 BG63847B1 BG103834A BG10383499A BG63847B1 BG 63847 B1 BG63847 B1 BG 63847B1 BG 103834 A BG103834 A BG 103834A BG 10383499 A BG10383499 A BG 10383499A BG 63847 B1 BG63847 B1 BG 63847B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- hydride
- sodium
- lithium
- aluminum hydride
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9710004.4A GB9710004D0 (en) | 1997-05-17 | 1997-05-17 | Chemical process |
| PCT/EP1998/002826 WO1998052920A1 (en) | 1997-05-17 | 1998-05-13 | Chemical process for the reduction of 1-substituted -3-hydroxymethyl-4- (4-fluorophenyl)tetrahydropyridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG103834A BG103834A (en) | 2000-07-31 |
| BG63847B1 true BG63847B1 (bg) | 2003-03-31 |
Family
ID=10812456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103834A BG63847B1 (bg) | 1997-05-17 | 1999-10-26 | Метод за редуциране на 1-заместени-3-хидроксиметил 4-(4-флуорфенил)тетрахидропиридини |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6326496B1 (de) |
| EP (1) | EP0983237B1 (de) |
| JP (1) | JP4463883B2 (de) |
| KR (1) | KR100515852B1 (de) |
| CN (1) | CN1121386C (de) |
| AR (1) | AR012688A1 (de) |
| AT (1) | ATE212013T1 (de) |
| AU (1) | AU748902B2 (de) |
| BG (1) | BG63847B1 (de) |
| BR (1) | BR9809809B1 (de) |
| CA (1) | CA2289013C (de) |
| CZ (1) | CZ292282B6 (de) |
| DE (1) | DE69803178T2 (de) |
| DK (1) | DK0983237T3 (de) |
| ES (1) | ES2171299T3 (de) |
| GB (1) | GB9710004D0 (de) |
| HU (1) | HUP0002709A3 (de) |
| ID (1) | ID24181A (de) |
| IL (1) | IL132360A (de) |
| NO (1) | NO313326B1 (de) |
| NZ (1) | NZ501692A (de) |
| PL (1) | PL189464B1 (de) |
| PT (1) | PT983237E (de) |
| RU (1) | RU2205178C2 (de) |
| SK (1) | SK149599A3 (de) |
| TR (1) | TR199902823T2 (de) |
| UA (1) | UA61952C2 (de) |
| WO (1) | WO1998052920A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001085688A1 (en) * | 2000-05-12 | 2001-11-15 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
| GB0021147D0 (en) | 2000-08-30 | 2000-10-11 | Knoll Ag | Chemical process |
| US6777554B2 (en) | 2001-02-05 | 2004-08-17 | Teva Pharmaceutical Industries Ltd. | Preparation of N-methylparoxetine and related intermediate compounds |
| AU2002318185A1 (en) * | 2001-06-13 | 2002-12-23 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of paroxetine substantially free of alkoxy impurities |
| US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
| EP1948646A2 (de) * | 2005-11-14 | 2008-07-30 | Auspex Pharmaceuticals Inc. | Substituierte phenylpiperidine mit serotoninerger aktivität und verbesserten therapeutischen eigenschaften |
| US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
| US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849542A (en) | 1966-05-09 | 1974-11-19 | Dow Chemical Co | Lithium magnesium aluminum hydride |
| GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| EP0223334B1 (de) * | 1985-08-10 | 1991-07-10 | Beecham Group Plc | Verfahren zur Herstellung von Arylpiperidincarbinol |
| EP0299549A3 (de) * | 1987-07-09 | 1989-02-08 | Duphar International Research B.V | Tertiäre 2,5-Dialkyl-3-phenyl-piperidin-Derivate mit Opiatantagonistischer Wirkung |
| GB9100505D0 (en) * | 1991-01-10 | 1991-02-20 | Shell Int Research | Piperidine derivatives |
| US5258517A (en) * | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
| GB9305175D0 (en) * | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
| JPH11505229A (ja) * | 1995-05-17 | 1999-05-18 | ノボ ノルディスク アクティーゼルスカブ | ４−アリール−ピペリジン誘導体を製造する方法 |
| EP0812827B1 (de) * | 1996-06-13 | 2009-09-02 | Sumitomo Chemical Company, Limited | Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung |
| HU221921B1 (hu) | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| GB9623359D0 (en) * | 1996-11-09 | 1997-01-08 | Smithkline Beecham Plc | Novel process |
-
1997
- 1997-05-17 GB GBGB9710004.4A patent/GB9710004D0/en active Pending
-
1998
- 1998-05-12 AR ARP980102206A patent/AR012688A1/es unknown
- 1998-05-13 PT PT98929307T patent/PT983237E/pt unknown
- 1998-05-13 CA CA002289013A patent/CA2289013C/en not_active Expired - Fee Related
- 1998-05-13 ES ES98929307T patent/ES2171299T3/es not_active Expired - Lifetime
- 1998-05-13 SK SK1495-99A patent/SK149599A3/sk unknown
- 1998-05-13 DE DE69803178T patent/DE69803178T2/de not_active Expired - Lifetime
- 1998-05-13 CN CN98805113A patent/CN1121386C/zh not_active Expired - Fee Related
- 1998-05-13 IL IL13236098A patent/IL132360A/xx not_active IP Right Cessation
- 1998-05-13 NZ NZ501692A patent/NZ501692A/en unknown
- 1998-05-13 UA UA99126877A patent/UA61952C2/uk unknown
- 1998-05-13 CZ CZ19994081A patent/CZ292282B6/cs not_active IP Right Cessation
- 1998-05-13 AT AT98929307T patent/ATE212013T1/de not_active IP Right Cessation
- 1998-05-13 US US09/423,749 patent/US6326496B1/en not_active Expired - Fee Related
- 1998-05-13 AU AU79121/98A patent/AU748902B2/en not_active Ceased
- 1998-05-13 JP JP54990898A patent/JP4463883B2/ja not_active Expired - Fee Related
- 1998-05-13 EP EP98929307A patent/EP0983237B1/de not_active Expired - Lifetime
- 1998-05-13 KR KR10-1999-7010581A patent/KR100515852B1/ko not_active IP Right Cessation
- 1998-05-13 HU HU0002709A patent/HUP0002709A3/hu unknown
- 1998-05-13 PL PL98336796A patent/PL189464B1/pl not_active IP Right Cessation
- 1998-05-13 ID IDW991271A patent/ID24181A/id unknown
- 1998-05-13 BR BRPI9809809-8A patent/BR9809809B1/pt not_active IP Right Cessation
- 1998-05-13 DK DK98929307T patent/DK0983237T3/da active
- 1998-05-13 WO PCT/EP1998/002826 patent/WO1998052920A1/en active IP Right Grant
- 1998-05-13 TR TR1999/02823T patent/TR199902823T2/xx unknown
- 1998-05-13 RU RU99127285/04A patent/RU2205178C2/ru not_active IP Right Cessation
-
1999
- 1999-10-26 BG BG103834A patent/BG63847B1/bg unknown
- 1999-11-16 NO NO19995619A patent/NO313326B1/no unknown
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