AR007970A1 - Pirroles sustituidos, su utilizacion y composiciones farmaceuticas que los comprenden - Google Patents

Pirroles sustituidos, su utilizacion y composiciones farmaceuticas que los comprenden

Info

Publication number
AR007970A1
AR007970A1 ARP970103310A ARP970103310A AR007970A1 AR 007970 A1 AR007970 A1 AR 007970A1 AR P970103310 A ARP970103310 A AR P970103310A AR P970103310 A ARP970103310 A AR P970103310A AR 007970 A1 AR007970 A1 AR 007970A1
Authority
AR
Argentina
Prior art keywords
substituted pyrroles
pharmaceutical compositions
formula
substituted
hydroxy
Prior art date
Application number
ARP970103310A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR007970A1 publication Critical patent/AR007970A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Se refiere a pirroles substituidos de la fórmula (I), en la que R es alquilo, alquiltio o hidroxi, donde el grupo alquilo puede estar sustituido ono por uno o varios sustituyentes, elegidos del conjunto formado por hidroxi, alcoxi, aminohal ógeno, ciano, tioalquilo, carboxi, derivados de ácidocarboxílico o alquilsulfinilo o R es un producto previo de síntesis de los pirroles sustituidos de fórmula (I) farmacéuticamente aceptables y a lassales farmacéuticamente aceptables delos com puestos de la fórmula (I) que son agentes antiproliferativos idóneos para el tratamiento del cáncer. Serefiere además a la utilización de dichos pirroles sustituidos y a composiciones farmacéuticas que los comprenden.
ARP970103310A 1996-07-29 1997-07-22 Pirroles sustituidos, su utilizacion y composiciones farmaceuticas que los comprenden AR007970A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2208096P 1996-07-29 1996-07-29

Publications (1)

Publication Number Publication Date
AR007970A1 true AR007970A1 (es) 1999-11-24

Family

ID=21807715

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103310A AR007970A1 (es) 1996-07-29 1997-07-22 Pirroles sustituidos, su utilizacion y composiciones farmaceuticas que los comprenden

Country Status (18)

Country Link
US (1) US5891901A (es)
EP (1) EP0915871B1 (es)
JP (1) JP2000516590A (es)
KR (1) KR20000029627A (es)
CN (1) CN1077572C (es)
AR (1) AR007970A1 (es)
AT (1) ATE347551T1 (es)
AU (1) AU739704B2 (es)
BR (1) BR9710902A (es)
CA (1) CA2262088A1 (es)
CO (1) CO4890846A1 (es)
DE (1) DE69737060D1 (es)
HR (1) HRP970417A2 (es)
MA (1) MA24288A1 (es)
PE (1) PE91498A1 (es)
TR (1) TR199900153T2 (es)
WO (1) WO1998004553A1 (es)
ZA (1) ZA976487B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1064279B1 (en) * 1998-03-17 2003-06-25 F.Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation
US6521658B1 (en) * 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
TW201041580A (en) * 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20050123975A1 (en) * 2003-11-19 2005-06-09 Applera Corporation Methods for determining the degradation state or concentration of nucleic acids
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) * 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
CN1226249A (zh) 1999-08-18
JP2000516590A (ja) 2000-12-12
US5891901A (en) 1999-04-06
EP0915871A1 (en) 1999-05-19
WO1998004553A1 (en) 1998-02-05
BR9710902A (pt) 1999-08-17
KR20000029627A (ko) 2000-05-25
EP0915871B1 (en) 2006-12-06
CN1077572C (zh) 2002-01-09
ZA976487B (en) 1998-01-29
AU4296497A (en) 1998-02-20
CA2262088A1 (en) 1998-02-05
CO4890846A1 (es) 2000-02-28
PE91498A1 (es) 1998-12-22
MA24288A1 (fr) 1998-04-01
ATE347551T1 (de) 2006-12-15
HRP970417A2 (en) 1998-08-31
TR199900153T2 (xx) 1999-04-21
AU739704B2 (en) 2001-10-18
DE69737060D1 (de) 2007-01-18

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal