NO169493C - Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater

Info

Publication number
NO169493C
NO169493C NO860190A NO860190A NO169493C NO 169493 C NO169493 C NO 169493C NO 860190 A NO860190 A NO 860190A NO 860190 A NO860190 A NO 860190A NO 169493 C NO169493 C NO 169493C
Authority
NO
Norway
Prior art keywords
peptid
derivatives
preparation
therapeutic active
analogy procedure
Prior art date
Application number
NO860190A
Other languages
English (en)
Other versions
NO169493B (no
NO860190L (no
Inventor
Scott Haven Bergeson
Philip Duke Edwards
John Anthony Schwartz
Andrew Shaw
Mark Morris Stein
Diane Amy Trainor
Richard Alan Wildonger
Donald John Wolanin
Original Assignee
Ici America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858501522A external-priority patent/GB8501522D0/en
Priority claimed from GB858501524A external-priority patent/GB8501524D0/en
Priority claimed from GB858501523A external-priority patent/GB8501523D0/en
Application filed by Ici America Inc filed Critical Ici America Inc
Publication of NO860190L publication Critical patent/NO860190L/no
Publication of NO169493B publication Critical patent/NO169493B/no
Publication of NO169493C publication Critical patent/NO169493C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/02—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO860190A 1985-01-22 1986-01-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater NO169493C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858501522A GB8501522D0 (en) 1985-01-22 1985-01-22 Dipeptide derivatives
GB858501524A GB8501524D0 (en) 1985-01-22 1985-01-22 Tetrapeptide derivatives
GB858501523A GB8501523D0 (en) 1985-01-22 1985-01-22 Tripeptide derivatives

Publications (3)

Publication Number Publication Date
NO860190L NO860190L (no) 1986-07-23
NO169493B NO169493B (no) 1992-03-23
NO169493C true NO169493C (no) 1992-07-01

Family

ID=27262565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO860190A NO169493C (no) 1985-01-22 1986-01-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater

Country Status (25)

Country Link
US (2) US4910190A (no)
EP (1) EP0189305B1 (no)
JP (2) JPH0759591B2 (no)
KR (1) KR910002689B1 (no)
CN (1) CN1027640C (no)
AU (1) AU594658B2 (no)
CA (1) CA1341023C (no)
CZ (1) CZ278063B6 (no)
DE (1) DE3686172T2 (no)
DK (1) DK172736B1 (no)
ES (3) ES8706169A1 (no)
FI (1) FI84171C (no)
GB (1) GB8600263D0 (no)
GR (1) GR860169B (no)
HK (1) HK18097A (no)
HU (1) HU206370B (no)
IE (1) IE58957B1 (no)
IL (1) IL77680A (no)
NO (1) NO169493C (no)
PH (1) PH26575A (no)
PL (1) PL150268B1 (no)
PT (1) PT81887B (no)
SK (1) SK278095B6 (no)
UA (1) UA39093C2 (no)
ZW (1) ZW1486A1 (no)

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US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
EP0276101A3 (en) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituted peptide derivatives
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
US5296608A (en) * 1988-04-25 1994-03-22 Hoffman-La Roche Inc. Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides
US5182263A (en) * 1988-04-25 1993-01-26 Hoffmann-La Roche Inc. Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
GB8910550D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted amides
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
DK0458537T3 (da) * 1990-05-24 1999-10-18 Zeneca Ltd Anvendelse af en terapeutisk forbindelse til behandling af bronkitis
DK0458536T3 (da) * 1990-05-24 1998-10-19 Zeneca Ltd Terapeutisk middel til behandling og forebyggelse af åndedrætsbesværsyndrom hos voksne
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
GB9014132D0 (en) * 1990-06-25 1990-08-15 Ici Plc Agent for therapy
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
US5521179A (en) * 1991-04-18 1996-05-28 Zeneca Limited Heterocyclic amides
US5340801A (en) * 1991-05-08 1994-08-23 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having cholecystokinin and gastrin antagonistic properties
DK0587799T3 (da) * 1991-05-23 1999-11-22 Merrell Pharma Inc Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning
GB9113164D0 (en) * 1991-06-18 1991-08-07 Ici Plc Pharmaceutical agent
AU2390892A (en) * 1991-08-08 1993-03-02 Yamanouchi Pharmaceutical Co., Ltd. Urea derivative
AU658426B2 (en) * 1991-08-15 1995-04-13 Zeneca Limited Substituted heterocycles
GB9216272D0 (en) * 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5486529A (en) * 1992-04-16 1996-01-23 Zeneca Limited Certain pyridyl ketones for treating diseases involving leukocyte elastase
WO1993021214A1 (en) * 1992-04-16 1993-10-28 Zeneca Limited Alpha-aminoboronic acid peptides and their use as elastase inhibitors
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9214053D0 (en) * 1992-07-02 1992-08-12 Ici Plc Heterocyclic amides
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP0804465B1 (en) * 1994-06-02 2003-08-06 Aventis Pharmaceuticals Inc. Novel elastase inhibitors
ATE186305T1 (de) * 1994-06-02 1999-11-15 Merrell Pharma Inc Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung
AU696292B2 (en) * 1994-06-02 1998-09-03 Merrell Pharmaceuticals Inc. Acylated enol derivatives as prodrugs of elastase inhibitors
US6693072B2 (en) * 1994-06-02 2004-02-17 Aventis Pharmaceuticals Inc. Elastase inhibitors
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6423688B1 (en) 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en) * 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) * 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6682554B2 (en) * 1998-09-05 2004-01-27 Jomed Gmbh Methods and apparatus for a stent having an expandable web structure
JP2000256396A (ja) 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
GB9928882D0 (en) * 1999-12-08 2000-02-02 Zeneca Ltd Assay method
US6403612B2 (en) * 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
US20040006093A1 (en) * 2000-10-17 2004-01-08 Thorsett Eugene D. Compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1476573B1 (en) 2002-01-28 2010-01-06 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
BR0307424A (pt) 2002-02-05 2004-12-28 Dainippon Pharmaceutical Co Compostos heterocìclicos com atividade inibidora de elastase e seus intermediários
US7964350B1 (en) 2007-05-18 2011-06-21 Applied Biosystems, Llc Sample preparation for in situ nucleic acid analysis
US8211637B2 (en) * 2008-12-19 2012-07-03 Life Technologies Corporation Proteinase K inhibitors, methods and compositions therefor
US10710957B2 (en) 2017-01-09 2020-07-14 University Of Central Florida Research Foundation, Inc. Motuporamine derivatives as antimicrobial agents and antibiotic enhancers against resistant gram-negative bacteria
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GB195212A (en) * 1922-01-30 1923-03-29 Edward Crawshaw Improvements in expansion joints between steam boilers and their settings or flue walls
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
EP0124317B1 (en) * 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
CH672792A5 (no) * 1985-02-19 1989-12-29 Sandoz Ag
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
EP0249349B1 (en) * 1986-06-05 1992-10-14 Ici Americas Inc. Difluoroketo compounds

Also Published As

Publication number Publication date
AU594658B2 (en) 1990-03-15
CS39586A3 (en) 1992-01-15
NO169493B (no) 1992-03-23
ES557363A0 (es) 1988-07-01
KR860005835A (ko) 1986-08-13
FI84171C (fi) 1991-10-25
CA1341023C (en) 2000-06-13
ES8802526A1 (es) 1988-07-01
JPH0680039B2 (ja) 1994-10-12
IL77680A (en) 1990-12-23
DE3686172D1 (de) 1992-09-03
DK30886D0 (da) 1986-01-21
ES557048A0 (es) 1987-08-01
ES8706169A1 (es) 1987-05-16
JPS61218518A (ja) 1986-09-29
PT81887B (pt) 1988-05-27
JPH0759591B2 (ja) 1995-06-28
HK18097A (en) 1997-02-13
ES551113A0 (es) 1987-05-16
DE3686172T2 (de) 1993-01-14
GB8600263D0 (en) 1986-02-12
AU5262386A (en) 1986-07-31
FI84171B (fi) 1991-07-15
UA39093C2 (uk) 2001-06-15
DK30886A (da) 1986-07-23
ES8707551A1 (es) 1987-08-01
EP0189305B1 (en) 1992-07-29
CN86101066A (zh) 1986-11-05
JPH05246984A (ja) 1993-09-24
US5726158A (en) 1998-03-10
PT81887A (en) 1986-02-01
HU206370B (en) 1992-10-28
GR860169B (en) 1986-05-15
EP0189305A3 (en) 1988-10-05
ZW1486A1 (en) 1987-09-30
EP0189305A2 (en) 1986-07-30
PL150268B1 (en) 1990-05-31
FI860281A (fi) 1986-07-23
FI860281A0 (fi) 1986-01-21
HUT39464A (en) 1986-09-29
CN1027640C (zh) 1995-02-15
CZ278063B6 (en) 1993-08-11
SK278095B6 (en) 1995-12-06
IE860180L (en) 1986-07-22
PH26575A (en) 1992-08-19
IE58957B1 (en) 1993-12-01
NO860190L (no) 1986-07-23
PL257573A1 (en) 1987-03-23
US4910190A (en) 1990-03-20
DK172736B1 (da) 1999-06-21
KR910002689B1 (ko) 1991-05-03

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