NO171209C - Analogifremgangsmaate for fremstilling av terapeutisk aktive morfinanestere - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive morfinanestere

Info

Publication number
NO171209C
NO171209C NO852699A NO852699A NO171209C NO 171209 C NO171209 C NO 171209C NO 852699 A NO852699 A NO 852699A NO 852699 A NO852699 A NO 852699A NO 171209 C NO171209 C NO 171209C
Authority
NO
Norway
Prior art keywords
morphinan
esters
preparation
therapeutic active
analogue procedure
Prior art date
Application number
NO852699A
Other languages
English (en)
Norwegian (no)
Other versions
NO171209B (no
NO852699L (no
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of NO852699L publication Critical patent/NO852699L/no
Publication of NO171209B publication Critical patent/NO171209B/no
Publication of NO171209C publication Critical patent/NO171209C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO852699A 1984-07-05 1985-07-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive morfinanestere NO171209C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (3)

Publication Number Publication Date
NO852699L NO852699L (no) 1986-01-06
NO171209B NO171209B (no) 1992-11-02
NO171209C true NO171209C (no) 1993-02-10

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
NO852699A NO171209C (no) 1984-07-05 1985-07-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive morfinanestere

Country Status (18)

Country Link
US (1) US4668685A (ru)
EP (1) EP0170090B1 (ru)
AU (1) AU578391B2 (ru)
CA (1) CA1301150C (ru)
DE (1) DE3573251D1 (ru)
DK (1) DK160501C (ru)
ES (1) ES8704443A1 (ru)
FI (1) FI83215C (ru)
GR (1) GR851653B (ru)
HK (1) HK39790A (ru)
HU (1) HU193995B (ru)
IE (1) IE58136B1 (ru)
IL (1) IL75721A (ru)
MX (1) MX160445A (ru)
NO (1) NO171209C (ru)
NZ (1) NZ212641A (ru)
PT (1) PT80773B (ru)
SU (2) SU1450742A3 (ru)

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DK107688D0 (da) * 1988-03-01 1988-03-01 Novo Industri As Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner
US6702705B1 (en) 1988-05-04 2004-03-09 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
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US6258360B1 (en) * 1989-05-04 2001-07-10 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
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TW372972B (en) * 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds
DE69427551T2 (de) * 1993-03-15 2002-05-16 Nat Science Council Taipeh T A Nalbuphinester und diese enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe
NZ268969A (en) * 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
US5376662A (en) * 1993-12-08 1994-12-27 Ockert; David M. Method of attenuating nerve injury induced pain
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
HU1500214D0 (hu) 1997-12-22 2002-03-28 Euro Celtique Sa Opioid agonista és antagonista hatóanyagot tartalmazó gyógyszerkészítmény
DE60001487T2 (de) * 2000-04-27 2003-12-24 Hu Oliver Yoa Pu Polynalbuphinderivat
US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
ES2361148T3 (es) 2001-05-11 2011-06-14 Endo Pharmaceuticals Inc. Forma de dosificación de opioides de liberación controlada resistente al abuso.
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
EP2425823A1 (en) 2002-04-05 2012-03-07 Euro-Celtique S.A. Pharmaceutical preparation containing oxycodone and naloxone
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
JP5704789B2 (ja) * 2005-01-28 2015-04-22 ユーロ−セルティーク エス．エイ． 耐アルコール性剤形
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
US8163701B2 (en) 2005-08-19 2012-04-24 Signature Therapeutics, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
KR101112110B1 (ko) * 2007-03-09 2012-04-12 주식회사 녹십자 파킨슨병 예방 또는 치료용의 (+)-3-하이드록시모르피난의 경구적으로 생체이용가능한 전구약물
EP2317991B1 (en) * 2008-07-07 2017-05-03 Euro-Celtique S.A. Use of opioid antagonists for treating urinary retention
MX347106B (es) 2009-03-10 2017-04-12 Euro-Celtique S A * Coposiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona.
UA102916C2 (ru) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиция на основе коньюгата гидрокодона с бензольной кислотой, производными бензойной кислот или гетероарилкарбоновой кислотой, пролекарства, способ лечения от злоупотреблений
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
CN105131003B (zh) 2010-11-12 2017-09-26 盐野义制药株式会社 6,7‑不饱和‑7‑氨基甲酰基吗啡喃衍生物的晶体及其制备方法
EP2771002A4 (en) 2011-10-26 2015-08-12 Kempharm Inc BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATE FROM HYDROMORPHONE, PRODRUGS AND METHOD FOR THE PRODUCTION AND USE THEREOF
CN105517551A (zh) 2013-07-23 2016-04-20 欧洲凯尔特公司 用于在患有疼痛和导致肠生态失调和/或提高肠细菌移位风险之疾病的患者中治疗疼痛的羟考酮与纳洛酮的组合
SG11201704178UA (en) 2014-11-25 2017-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
NZ731586A (en) 2014-12-02 2018-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
WO2021029914A1 (en) 2019-08-11 2021-02-18 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
DE224197C (ru) *
US3254088A (en) * 1961-03-14 1966-05-31 Lewenstein Morphine derivative
FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1097167A (en) * 1966-05-31 1967-12-29 Shionogi & Co 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production
CH543514A (de) * 1967-08-25 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Morphinanderivaten
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
JPS59186987A (ja) * 1983-04-06 1984-10-23 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン

Also Published As

Publication number Publication date
SU1508960A3 (ru) 1989-09-15
DK160501C (da) 1991-08-26
HU193995B (en) 1987-12-28
HK39790A (en) 1990-06-01
ES544852A0 (es) 1987-04-01
NZ212641A (en) 1988-10-28
FI83215B (fi) 1991-02-28
DE3573251D1 (en) 1989-11-02
SU1450742A3 (ru) 1989-01-07
DK160501B (da) 1991-03-18
FI83215C (fi) 1991-06-10
IE58136B1 (en) 1993-07-14
US4668685A (en) 1987-05-26
IL75721A (en) 1990-04-29
FI852659A0 (fi) 1985-07-04
GR851653B (ru) 1985-11-26
AU4451685A (en) 1986-01-09
HUT40132A (en) 1986-11-28
DK306885A (da) 1986-01-06
ES8704443A1 (es) 1987-04-01
MX160445A (es) 1990-03-02
IL75721A0 (en) 1985-11-29
EP0170090A1 (en) 1986-02-05
AU578391B2 (en) 1988-10-20
NO171209B (no) 1992-11-02
EP0170090B1 (en) 1989-09-27
NO852699L (no) 1986-01-06
IE851683L (en) 1986-01-05
CA1301150C (en) 1992-05-19
FI852659L (fi) 1986-01-06
PT80773B (pt) 1987-10-20
PT80773A (en) 1985-08-01
DK306885D0 (da) 1985-07-04

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