NO169839C - Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa, alfa -(iminobis(metylen))bis(3,4-dihydro-2h-1-benzopyran-2-metanol)derivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa, alfa -(iminobis(metylen))bis(3,4-dihydro-2h-1-benzopyran-2-metanol)derivater

Info

Publication number
NO169839C
NO169839C NO844845A NO844845A NO169839C NO 169839 C NO169839 C NO 169839C NO 844845 A NO844845 A NO 844845A NO 844845 A NO844845 A NO 844845A NO 169839 C NO169839 C NO 169839C
Authority
NO
Norway
Prior art keywords
alfa
benzopyrane
iminobis
analogy
dihydro
Prior art date
Application number
NO844845A
Other languages
English (en)
Norwegian (no)
Other versions
NO169839B (no
NO844845L (no
Inventor
Guy Rosalia Eugene Van Lommen
Marcel Frans Leopold De Bruyn
Marc Francis Josephin Schroven
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO844845L publication Critical patent/NO844845L/no
Publication of NO169839B publication Critical patent/NO169839B/no
Publication of NO169839C publication Critical patent/NO169839C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO844845A 1983-12-05 1984-12-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa, alfa -(iminobis(metylen))bis(3,4-dihydro-2h-1-benzopyran-2-metanol)derivater NO169839C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55808183A 1983-12-05 1983-12-05

Publications (3)

Publication Number Publication Date
NO844845L NO844845L (no) 1985-06-06
NO169839B NO169839B (no) 1992-05-04
NO169839C true NO169839C (no) 1992-08-12

Family

ID=24228139

Family Applications (2)

Application Number Title Priority Date Filing Date
NO844845A NO169839C (no) 1983-12-05 1984-12-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa, alfa -(iminobis(metylen))bis(3,4-dihydro-2h-1-benzopyran-2-metanol)derivater
NO2004007C NO2004007I2 (no) 1983-12-05 2004-11-26 Nebivolol-hydroklorid er det genriske oaviibttit denfolgenderacemiske blanding:(+)Ä(SRRR)+(RSSS)Ü-of,9E'Äiminobis(metylen)ÜbisÄ6-fttO-3,4-dihydro-2H-1-benzopyran-2-metanolÜhydroklorid, som har den felgende struktur:

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2004007C NO2004007I2 (no) 1983-12-05 2004-11-26 Nebivolol-hydroklorid er det genriske oaviibttit denfolgenderacemiske blanding:(+)Ä(SRRR)+(RSSS)Ü-of,9E'Äiminobis(metylen)ÜbisÄ6-fttO-3,4-dihydro-2H-1-benzopyran-2-metanolÜhydroklorid, som har den felgende struktur:

Country Status (32)

Country Link
EP (1) EP0145067B1 (fi)
JP (1) JPS60132977A (fi)
KR (1) KR870000923B1 (fi)
AR (1) AR241414A1 (fi)
AT (1) ATE40361T1 (fi)
AU (1) AU573658B2 (fi)
BG (1) BG43866A3 (fi)
CA (1) CA1337429C (fi)
CS (1) CS250242B2 (fi)
CY (1) CY1609A (fi)
DD (1) DD235453A5 (fi)
DE (1) DE3476388D1 (fi)
DK (2) DK165112C (fi)
DZ (1) DZ712A1 (fi)
ES (1) ES8603870A1 (fi)
FI (1) FI82460C (fi)
GR (1) GR81098B (fi)
HK (1) HK52791A (fi)
HU (1) HU202219B (fi)
IE (1) IE57831B1 (fi)
IL (1) IL73706A (fi)
MA (1) MA20292A1 (fi)
NO (2) NO169839C (fi)
NZ (1) NZ210388A (fi)
PH (1) PH22432A (fi)
PL (1) PL146342B1 (fi)
PT (1) PT79609B (fi)
RO (1) RO91184B (fi)
SG (1) SG47091G (fi)
SU (1) SU1428199A3 (fi)
ZA (1) ZA849445B (fi)
ZW (1) ZW19784A1 (fi)

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JPH02103116U (fi) * 1989-02-01 1990-08-16
JPH02218675A (ja) * 1989-02-21 1990-08-31 Nippon Kayaku Co Ltd ６―フルオロクロモン―２―カルボン酸及びその製造法
IE68675B1 (en) * 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
SK9362000A3 (en) * 1997-12-19 2001-09-11 Bayer Ag Carboxyl substituted chroman derivatives useful as beta-3-adrenoreceptor agonists
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6593497B1 (en) 1999-06-02 2003-07-15 Theravance, Inc. β2-adrenergic receptor agonists
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UA73965C2 (en) 1999-12-08 2005-10-17 Theravance Inc b2 ADRENERGIC RECEPTOR ANTAGONISTS
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JP2004528337A (ja) 2001-05-02 2004-09-16 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法
CN1292749C (zh) 2001-07-26 2007-01-03 默克专利股份有限公司 2－[5－(4－氟苯基)－3－吡啶基甲氨基甲基]苯并二氢吡喃及其生理学上可接受的盐的新用途
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
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RU2378272C2 (ru) 2004-07-30 2010-01-10 Торрент Фармасьютикалз Лимитед Небиволол и его фармацевтически приемлемые соли, способ их получения и фармацевтические композиции небиволола
ES2341250T3 (es) * 2004-08-11 2010-06-17 Hetero Drugs Limited Procedimiento novedoso de preparacion de intermediarios de nebivolol.
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
JP2008528626A (ja) 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
WO2006084684A1 (de) * 2005-02-11 2006-08-17 Stada Arzneimittel Ag Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer
AT502220A1 (de) * 2005-07-19 2007-02-15 Pharmacon Forschung & Beratung Verfahren zur herstellung von nebivolol
US7560575B2 (en) 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7858812B2 (en) 2006-01-18 2010-12-28 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
CN101553485B (zh) 2006-11-27 2013-02-06 Zach系统股份公司 制备奈必洛尔的方法
AU2008209264B2 (en) 2007-01-22 2014-11-27 Mylan Pharmaceuticals Ulc Pharmaceutical compositions comprising nebivolol or a nebivolol analogue
CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1392067B1 (it) * 2008-10-31 2012-02-09 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
PT2907809T (pt) 2014-02-14 2019-01-16 Corden Pharma Int Gmbh Processo sem base para a preparação de intermediários de cetona utilizáveis para fabrico de nebivolol
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
KR102529680B1 (ko) 2015-05-19 2023-05-09 저장 아우선 파마슈티칼 씨오., 엘티디. 네비볼롤 합성방법 및 그의 중간 화합물
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Also Published As

Publication number Publication date
PT79609B (en) 1986-12-12
CA1337429C (en) 1995-10-24
IE57831B1 (en) 1993-04-21
DE3476388D1 (en) 1989-03-02
JPS60132977A (ja) 1985-07-16
EP0145067B1 (en) 1989-01-25
DK165321C (da) 1993-03-29
ZA849445B (en) 1986-07-30
CS250242B2 (en) 1987-04-16
PH22432A (en) 1988-09-12
SU1428199A3 (ru) 1988-09-30
NZ210388A (en) 1987-07-31
GR81098B (en) 1984-12-17
HK52791A (en) 1991-07-19
NO169839B (no) 1992-05-04
KR870000923B1 (ko) 1987-05-07
DK11892D0 (da) 1992-01-31
SG47091G (en) 1991-07-26
DK165321B (da) 1992-11-09
DK577084D0 (da) 1984-12-04
FI844777L (fi) 1985-06-06
ZW19784A1 (en) 1986-07-02
JPH0250114B2 (fi) 1990-11-01
FI844777A0 (fi) 1984-12-04
HUT37418A (en) 1985-12-28
DK11892A (da) 1992-01-31
AU573658B2 (en) 1988-06-16
FI82460C (fi) 1991-03-11
HU202219B (en) 1991-02-28
PL250524A1 (en) 1986-02-25
ES538256A0 (es) 1986-01-01
FI82460B (fi) 1990-11-30
IL73706A (en) 1988-07-31
IE843103L (en) 1985-06-05
DK165112B (da) 1992-10-12
BG43866A3 (en) 1988-08-15
DZ712A1 (fr) 2004-09-13
NO844845L (no) 1985-06-06
NO2004007I1 (no) 2004-12-20
EP0145067A3 (en) 1986-03-26
KR850004485A (ko) 1985-07-15
ATE40361T1 (de) 1989-02-15
AU3632684A (en) 1985-06-13
AR241414A1 (es) 1992-07-31
DK577084A (da) 1985-06-06
PL146342B1 (en) 1989-01-31
DD235453A5 (de) 1986-05-07
MA20292A1 (fr) 1985-07-01
ES8603870A1 (es) 1986-01-01
RO91184A (ro) 1987-07-30
EP0145067A2 (en) 1985-06-19
IL73706A0 (en) 1985-03-31
CY1609A (en) 1992-04-03
NO2004007I2 (no) 2005-05-09
PT79609A (en) 1985-01-01
DK165112C (da) 1993-03-01
RO91184B (ro) 1987-07-31

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