|
DE3620813A1
(de)
*
|
1986-06-21 |
1987-12-23 |
Boehringer Ingelheim Kg |
Neue tetrahydro-benzothiazole, ihre herstellung und verwendung
|
|
US4826860A
(en)
*
|
1987-03-16 |
1989-05-02 |
Warner-Lambert Company |
Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
|
|
US4988699A
(en)
*
|
1989-03-14 |
1991-01-29 |
Warner-Lambert Company |
Substituted tetrahydrobenzothiazoles as dopaminergic agents
|
|
DE3923689A1
(de)
*
|
1989-07-18 |
1991-01-24 |
Boehringer Ingelheim Kg |
Neue verwendung von tetrahydrobenzthiazolderivaten als arzneistoffe
|
|
DE3930282A1
(de)
*
|
1989-09-11 |
1991-03-21 |
Boehringer Ingelheim Kg |
Verwendung von dopamin-autorezeptor-agonisten bei der behandlung von drogenabhaengigkeit
|
|
DE3937271A1
(de)
*
|
1989-11-09 |
1991-05-16 |
Boehringer Ingelheim Kg |
Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol
|
|
FR2674853B1
(fr)
*
|
1991-04-03 |
1995-01-20 |
Synthelabo |
Derives de piperidinylguanidine, leur preparation et leur application en therapeutique.
|
|
DE4241013A1
(de)
*
|
1992-12-05 |
1994-06-09 |
Boehringer Ingelheim Kg |
Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung
|
|
US6156777A
(en)
|
1994-12-15 |
2000-12-05 |
Pharmacia & Upjohn Company |
Use of pramipexole as a neuroprotective agent
|
|
US5650420A
(en)
*
|
1994-12-15 |
1997-07-22 |
Pharmacia & Upjohn Company |
Pramipexole as a neuroprotective agent
|
|
DE19507752A1
(de)
*
|
1995-03-06 |
1996-09-12 |
Bayer Ag |
Verfahren zur Herstellung von substituierten Cyclohexanonen
|
|
DE19536916A1
(de)
*
|
1995-10-04 |
1997-04-10 |
Boehringer Ingelheim Kg |
Inhalative Applikation von 2-Amino-6n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol, insbesondere seines (-)-Enantiomeren, sowie deren pharmakologisch verträgliche Säureadditionssalze
|
|
CN1159292C
(zh)
*
|
1996-05-31 |
2004-07-28 |
法玛西雅厄普约翰美国公司 |
用作选择性多巴胺d3配体的芳基取代的环胺类化合物
|
|
DE19701619B4
(de)
*
|
1997-01-17 |
2007-10-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verwendung von Pramipexol zur Behandlung des restless legs syndroms
|
|
US6001861A
(en)
*
|
1998-01-16 |
1999-12-14 |
Pharmacia & Upjohn Company |
Use of pramipexole in the treatment of restless legs syndrome
|
|
AU760439B2
(en)
*
|
1998-05-15 |
2003-05-15 |
Pharmacia & Upjohn Company |
Cabergoline and pramipexole: new uses and combinations
|
|
SE9802360D0
(sv)
|
1998-07-01 |
1998-07-01 |
Wikstroem Hakan Vilhelm |
New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
|
|
DE19830201A1
(de)
*
|
1998-07-07 |
2000-01-13 |
Boehringer Ingelheim Pharma |
Mittel mit antidepressiver Wirkung
|
|
US6232326B1
(en)
|
1998-07-14 |
2001-05-15 |
Jodi A. Nelson |
Treatment for schizophrenia and other dopamine system dysfunctions
|
|
PE20011074A1
(es)
|
2000-02-23 |
2001-10-04 |
Upjohn Co |
Uso de pramipexol en el tratamiento de trastornos de adiccion
|
|
AU2001278875B2
(en)
*
|
2000-07-06 |
2007-06-07 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Tetrahydrobenzothiazole analogues as neuroprotective agents
|
|
US6277875B1
(en)
|
2000-07-17 |
2001-08-21 |
Andrew J. Holman |
Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
|
|
US20030114410A1
(en)
|
2000-08-08 |
2003-06-19 |
Technion Research And Development Foundation Ltd. |
Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
|
|
DE10041478A1
(de)
*
|
2000-08-24 |
2002-03-14 |
Sanol Arznei Schwarz Gmbh |
Neue pharmazeutische Zusammensetzung
|
|
ES2187249B1
(es)
*
|
2000-09-18 |
2004-09-16 |
Synthon Bv |
Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
|
|
US20020165246A1
(en)
*
|
2001-03-05 |
2002-11-07 |
Andrew Holman |
Administration of sleep restorative agents
|
|
DE10137453A1
(de)
*
|
2001-08-02 |
2003-02-20 |
Boehringer Ingelheim Pharma |
Pramlpexol als Antikonvulsivum
|
|
DE10138275A1
(de)
*
|
2001-08-10 |
2003-02-27 |
Boehringer Ingelheim Pharma |
Verbindungen zur Beseitigung der Anhedonie
|
|
US20060281797A1
(en)
*
|
2001-12-11 |
2006-12-14 |
University Of Virginia Patent Foundation |
Neurorestoration with R(+) Pramipexole
|
|
EP2246053B1
(en)
|
2001-12-11 |
2013-09-18 |
University Of Virginia Patent Foundation |
Use of pramipexole to treat amyotrophic lateral sclerosis
|
|
US20030166696A1
(en)
*
|
2002-01-24 |
2003-09-04 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pramipexole for the treatment of HIV dementia
|
|
EP1490090A4
(en)
|
2002-02-22 |
2006-09-20 |
New River Pharmaceuticals Inc |
SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS
|
|
US20050226926A1
(en)
|
2002-07-25 |
2005-10-13 |
Pfizer Inc |
Sustained-release tablet composition of pramipexole
|
|
MY142204A
(en)
*
|
2002-07-25 |
2010-10-29 |
Pharmacia Corp |
Pramipexole once-daily dosage form
|
|
MY136318A
(en)
*
|
2002-07-25 |
2008-09-30 |
Pharmacia Corp |
Sustained-release tablet composition
|
|
GB0221513D0
(en)
*
|
2002-09-17 |
2002-10-23 |
Generics Uk Ltd |
Novel compounds and processes
|
|
GB2394951A
(en)
*
|
2002-11-04 |
2004-05-12 |
Cipla Ltd |
One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
|
|
US7365086B2
(en)
*
|
2003-07-25 |
2008-04-29 |
Synthon Ip Inc. |
Pramipexole acid addition salts
|
|
DE102004006808A1
(de)
*
|
2004-02-11 |
2005-09-01 |
Grünenthal GmbH |
Substituierte 4,5,6,7-Tetrahydro-benzothiazol-2-ylamin-Verbindungen
|
|
EP2289885A1
(en)
|
2004-03-19 |
2011-03-02 |
Dipharma Francis S.r.l. |
Intermediates for the preparation of pramipexole
|
|
ES2245604B1
(es)
|
2004-06-25 |
2006-12-01 |
Ragactives, S. L. |
Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles.
|
|
WO2006012276A1
(en)
*
|
2004-06-30 |
2006-02-02 |
Amr Technology, Inc. |
Process for preparing chirally pure 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoles by liquid chromatographic resolution
|
|
EP1773793A2
(en)
*
|
2004-07-03 |
2007-04-18 |
Merck Generics (UK) Limited |
Process for the preparation of pramipexole by chiral chromatography
|
|
PH12012501282A1
(en)
*
|
2004-08-13 |
2019-03-22 |
Boehringer Ingelheim Int |
Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
|
|
BRPI0513848A
(pt)
*
|
2004-08-13 |
2008-05-20 |
Boehringer Ingelheim Int |
formulação de pélete de liberação prolongada contendo pramipexol ou um sal farmaceuticamente aceitável deste, método para fabricação da mesma e uso desta
|
|
AU2005293607A1
(en)
*
|
2004-10-07 |
2006-04-20 |
Boehringer Ingelheim International Gmbh |
PI3 kinases
|
|
EP1761511A1
(en)
*
|
2004-12-06 |
2007-03-14 |
Alembic Limited |
Improved process for the preparation of biologically active tetrahydrobenzthiazole derivative
|
|
JP2008526728A
(ja)
*
|
2004-12-30 |
2008-07-24 |
ケマジス・リミテッド |
ナトリウムトリアセトキシボロヒドリドを用いた還元による、プラミペキソール及びその光学異性体混合物の新規製造方法
|
|
CN1834092B
(zh)
*
|
2005-03-15 |
2010-04-28 |
姜能桥 |
盐酸普拉克索的制备方法
|
|
WO2006117614A1
(en)
*
|
2005-05-03 |
2006-11-09 |
Ranbaxy Laboratories Limited |
Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
|
|
ES2264378B1
(es)
|
2005-05-09 |
2007-11-01 |
Ragactives, S.L. |
Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
|
|
EP1731514A1
(en)
|
2005-06-02 |
2006-12-13 |
Sandoz AG |
Process for the preparation of Pramipexole
|
|
DE602006009670D1
(de)
*
|
2005-08-15 |
2009-11-19 |
Univ Virginia |
Neurorestauration mit r(+) pramipexol
|
|
US7994220B2
(en)
|
2005-09-28 |
2011-08-09 |
Cypress Bioscience, Inc. |
Milnacipran for the long-term treatment of fibromyalgia syndrome
|
|
EP1940398A1
(de)
*
|
2005-10-18 |
2008-07-09 |
Boehringer Ingelheim International GmbH |
Verwendung von pramipexol zur behandlung des moderaten bis schweren restless legs syndroms (rls)
|
|
US20070129329A1
(en)
*
|
2005-12-02 |
2007-06-07 |
Alembic Limited |
Stabilized pharmaceutical composition of pramipexole and method of preparation thereof
|
|
PL378587A1
(pl)
*
|
2005-12-29 |
2007-07-09 |
Instytut Farmaceutyczny |
Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
|
|
ITMI20060044A1
(it)
*
|
2006-01-13 |
2007-07-14 |
Dipharma Spa |
Sintesi di intermedi pr la preparazione di pramipexolo
|
|
WO2007090883A1
(en)
*
|
2006-02-10 |
2007-08-16 |
Boehringer Ingelheim International Gmbh |
Extended release formulation
|
|
WO2007090881A2
(en)
*
|
2006-02-10 |
2007-08-16 |
Boehringer Ingelheim International Gmbh |
Modified release formulation
|
|
JP5769923B2
(ja)
|
2006-04-03 |
2015-08-26 |
テバ ファーマシューティカル インダストリーズ リミティド |
レストレスレッグス症候群の治療のためのラサギリンの使用
|
|
US20070259930A1
(en)
*
|
2006-04-10 |
2007-11-08 |
Knopp Neurosciences, Inc. |
Compositions and methods of using r(+) pramipexole
|
|
US8518926B2
(en)
|
2006-04-10 |
2013-08-27 |
Knopp Neurosciences, Inc. |
Compositions and methods of using (R)-pramipexole
|
|
ES2379117T3
(es)
|
2006-05-16 |
2012-04-20 |
Knopp Neurosciences, Inc. |
Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas
|
|
EP2497472A1
(en)
|
2006-05-16 |
2012-09-12 |
Knopp Neurosciences, Inc. |
Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of Parkinson's disease and their pharmaceutical compositions
|
|
EP2026766A1
(en)
|
2006-05-17 |
2009-02-25 |
Synthon B.V. |
Tablet composition with a prolonged release of tamsulosin
|
|
WO2008001200A2
(en)
*
|
2006-06-29 |
2008-01-03 |
Antares Pharma Ipl Ag |
Transdermal composition having enhanced color stability
|
|
US20080254118A1
(en)
*
|
2007-04-11 |
2008-10-16 |
Hans-Werner Wernersbach |
Process for preparing pramipexole dihydrochloride tablets
|
|
WO2008041240A1
(en)
*
|
2006-10-03 |
2008-04-10 |
Cadila Healthcare Limited |
Process for preparing (s)-pramipexole and its intermediates
|
|
US8524695B2
(en)
|
2006-12-14 |
2013-09-03 |
Knopp Neurosciences, Inc. |
Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
|
|
WO2008086353A1
(en)
*
|
2007-01-08 |
2008-07-17 |
Zurawski Vincent R Jr |
Propargyl-containing derivatives of tetrahydro-benzthiazoles and methods of making and using the same
|
|
SI22446A
(sl)
*
|
2007-02-07 |
2008-08-31 |
Krka, Tovarna Zdravil, D.D., Novo Mesto |
Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli
|
|
JP2010521496A
(ja)
*
|
2007-03-14 |
2010-06-24 |
ノップ ニューロサイエンシーズ、インク. |
キラル精製置換ベンゾチアゾールジアミンの合成
|
|
US20080254117A1
(en)
*
|
2007-04-10 |
2008-10-16 |
Noel Cotton |
Process for preparing pramipexole dihydrochloride tablets
|
|
US8679485B2
(en)
|
2007-08-02 |
2014-03-25 |
Gilead Biologics, Inc. |
Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
|
|
GB0721333D0
(en)
*
|
2007-10-31 |
2007-12-12 |
Motac Neuroscience Ltd |
Medicaments
|
|
US20090247537A1
(en)
*
|
2008-03-25 |
2009-10-01 |
William Dale Overfield |
Methods for preventing or treating bruxism using dopaminergic agents
|
|
CA2734491A1
(en)
|
2008-08-19 |
2010-02-25 |
Knopp Neurosciences, Inc. |
Compositions and methods of using (r)-pramipexole
|
|
WO2010080769A2
(en)
|
2009-01-06 |
2010-07-15 |
Arresto Biosciences, Inc. |
Chemotherapeutic methods and compositions
|
|
AU2010262970A1
(en)
*
|
2009-06-19 |
2012-01-12 |
Knopp Neurosciences, Inc. |
Compositions and methods for treating amyotrophic lateral sclerosis
|
|
EP2467396A4
(en)
|
2009-08-21 |
2012-12-26 |
Gilead Biologics Inc |
CATALYTIC DOMAINS FROM LYSYL OXIDASE AND LOXL2
|
|
US20110044907A1
(en)
*
|
2009-08-21 |
2011-02-24 |
Derek Marshall |
In vivo screening assays
|
|
CN102711821A
(zh)
*
|
2009-08-21 |
2012-10-03 |
吉联亚生物科技有限公司 |
治疗方法和组合物
|
|
AU2010284000A1
(en)
*
|
2009-08-21 |
2012-03-22 |
Gilead Biologics, Inc. |
In vitro screening assays
|
|
CN102711839A
(zh)
*
|
2009-08-21 |
2012-10-03 |
吉联亚生物科技有限公司 |
体内筛选试验
|
|
TR200906997A1
(tr)
|
2009-09-11 |
2011-03-21 |
Sanovel �La� San. Ve T�C. A. �. |
Pramipeksol farmasötik bileşimleri.
|
|
TR200907554A1
(tr)
|
2009-10-06 |
2011-04-21 |
Sanovel İlaç San.Ve Ti̇c.A.Ş. |
Oral yolla dağılan pramıpexole bileşimleri.
|
|
WO2011086182A2
(en)
|
2010-01-18 |
2011-07-21 |
Synthon Bv |
Pramipexole extended release tablets
|
|
CN105622757A
(zh)
|
2010-02-04 |
2016-06-01 |
吉联亚生物科技有限公司 |
结合赖氨酰氧化酶样2(loxl2)的抗体和其使用方法
|
|
US20130079526A1
(en)
|
2010-03-03 |
2013-03-28 |
Knopp Neurosciences Inc. |
Synthesis of Chirally Purified Substituted Benzothiazole Diamines
|
|
TR201001862A1
(tr)
*
|
2010-03-11 |
2011-10-21 |
Sanovel �La� San.Ve T�C.A.�. |
Kontrollü salım gerçekleştiren pramipeksol formülasyonları.
|
|
WO2011148243A1
(en)
|
2010-05-24 |
2011-12-01 |
Lupin Limited |
Extended release formulation of pramipexole
|
|
EP2462925A1
(en)
|
2010-11-12 |
2012-06-13 |
Neuraxpharm Arzneimittel GmbH |
Pramipexole Dihydrochloride Granulate
|
|
TWI537274B
(zh)
|
2011-03-14 |
2016-06-11 |
橘生藥品工業股份有限公司 |
新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途
|
|
WO2012140604A1
(en)
|
2011-04-15 |
2012-10-18 |
Sandoz Ag |
Stable formulations of pramipexole hydrochloride
|
|
ITMI20110666A1
(it)
*
|
2011-04-19 |
2012-10-20 |
Dipharma Francis Srl |
Procedimento per la preparazione di (r) ed (s) pramipexolo e suoi intermedi
|
|
WO2013096816A1
(en)
|
2011-12-22 |
2013-06-27 |
Biogen Idec Ma Inc. |
Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
|
|
EP2732812A1
(de)
|
2012-11-15 |
2014-05-21 |
Aristo Pharma GmbH |
Pramipexol-Retardtablettenformulierung
|
|
US9585885B2
(en)
|
2012-12-10 |
2017-03-07 |
Kissei Pharmaceutical Co., Ltd. |
Substituted pyrido[2,3-g]quinazolines as dopamine D2 receptor agonists
|
|
US9662313B2
(en)
|
2013-02-28 |
2017-05-30 |
Knopp Biosciences Llc |
Compositions and methods for treating amyotrophic lateral sclerosis in responders
|
|
CN105764507B
(zh)
|
2013-07-12 |
2019-07-19 |
诺普生物科学有限责任公司 |
治疗升高的嗜酸性粒细胞和/或嗜碱性粒细胞的水平
|
|
US9468630B2
(en)
|
2013-07-12 |
2016-10-18 |
Knopp Biosciences Llc |
Compositions and methods for treating conditions related to increased eosinophils
|
|
WO2015023786A1
(en)
|
2013-08-13 |
2015-02-19 |
Knopp Biosciences Llc |
Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
|
|
EP3033081B1
(en)
|
2013-08-13 |
2021-05-12 |
Knopp Biosciences LLC |
Compositions and methods for treating chronic urticaria
|
|
EP2870961B1
(en)
|
2013-11-06 |
2018-07-18 |
Sanovel Ilac Sanayi ve Ticaret A.S. |
Effervescent formulations of pramipexole
|
|
EP2870965A1
(en)
|
2013-11-06 |
2015-05-13 |
Sanovel Ilac Sanayi ve Ticaret A.S. |
Oral liquid pharmaceutical formulations of pramipexole
|
|
CN103626718A
(zh)
*
|
2013-12-13 |
2014-03-12 |
山东新华制药股份有限公司 |
盐酸普拉克索的工业化制备方法
|
|
CN103664820B
(zh)
*
|
2013-12-30 |
2016-01-27 |
四川科伦药业股份有限公司 |
普拉克索类似物及其制备方法
|
|
US12472149B2
(en)
*
|
2015-07-17 |
2025-11-18 |
BE Pharbel Manufacturing |
Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form
|
|
CN108697655B
(zh)
|
2015-12-30 |
2021-12-10 |
考里安公司 |
用于长期透皮施药的系统和方法
|
|
KR102419767B1
(ko)
|
2016-06-23 |
2022-07-12 |
코리움, 인크. |
친수성 및 소수성 도메인 및 치료제가 포함된 접착성 매트릭스
|
|
KR102545649B1
(ko)
|
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|
|
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(en)
|
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|
|
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(ja)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(ko)
|
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|
|
WO2019126531A1
(en)
|
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|
|
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(zh)
*
|
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|
|
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(zh)
*
|
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|
|
US20230365518A1
(en)
*
|
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|
|
WO2025190207A1
(zh)
*
|
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|