CS409991A3 - Tetrahydrobenzothiazole derivatives, process of their preparation andpharmaceutical compositions containing them - Google Patents

Tetrahydrobenzothiazole derivatives, process of their preparation andpharmaceutical compositions containing them

Info

Publication number
CS409991A3
CS409991A3 CS914099A CS409991A CS409991A3 CS 409991 A3 CS409991 A3 CS 409991A3 CS 914099 A CS914099 A CS 914099A CS 409991 A CS409991 A CS 409991A CS 409991 A3 CS409991 A3 CS 409991A3
Authority
CS
Czechoslovakia
Prior art keywords
group
phenyl
alkyl
hydrogen atom
alkenyl
Prior art date
Application number
CS914099A
Other languages
English (en)
Inventor
Gerhard Dr Dipl Chem Griss
Claus Dr Dipl Chem Schneider
Rudolf Dr Dipl Chem Hurnaus
Walter Prof Dr Kobinger
Ludwig Dr Pichler
Rudolf Dr Bauer
Joachim Dr Mierau
Dieter Prof Dr Hinzen
Gunter Dr Schingnitz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25827684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS409991(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19843447075 external-priority patent/DE3447075A1/de
Priority claimed from DE19853508947 external-priority patent/DE3508947A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of CS409991A3 publication Critical patent/CS409991A3/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cereal-Derived Products (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS914099A 1984-12-22 1991-12-27 Tetrahydrobenzothiazole derivatives, process of their preparation andpharmaceutical compositions containing them CS409991A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843447075 DE3447075A1 (de) 1984-12-22 1984-12-22 Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE19853508947 DE3508947A1 (de) 1985-03-13 1985-03-13 Mittel zur behandlung des parkinsonismus bzw. der parkinsonschen-erkrankung

Publications (1)

Publication Number Publication Date
CS409991A3 true CS409991A3 (en) 1992-09-16

Family

ID=25827684

Family Applications (1)

Application Number Title Priority Date Filing Date
CS914099A CS409991A3 (en) 1984-12-22 1991-12-27 Tetrahydrobenzothiazole derivatives, process of their preparation andpharmaceutical compositions containing them

Country Status (25)

Country Link
US (3) US4731374A (cs)
EP (1) EP0186087B1 (cs)
KR (1) KR930009791B1 (cs)
AT (1) ATE45735T1 (cs)
AU (1) AU583874B2 (cs)
BG (1) BG62023B2 (cs)
CA (1) CA1263653A (cs)
CS (1) CS409991A3 (cs)
DE (1) DE3572485D1 (cs)
DK (1) DK168862B1 (cs)
ES (5) ES8702787A1 (cs)
FI (1) FI81787C (cs)
GR (1) GR853126B (cs)
HK (1) HK78692A (cs)
HU (1) HU193618B (cs)
IE (1) IE58863B1 (cs)
IL (1) IL77415A (cs)
LU (1) LU90208I2 (cs)
MX (1) MX9202792A (cs)
NL (1) NL980002I2 (cs)
NO (1) NO165070C (cs)
NZ (1) NZ214661A (cs)
PH (1) PH24533A (cs)
PT (1) PT81735B (cs)
SG (1) SG82492G (cs)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung
US4826860A (en) * 1987-03-16 1989-05-02 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
DE3923689A1 (de) * 1989-07-18 1991-01-24 Boehringer Ingelheim Kg Neue verwendung von tetrahydrobenzthiazolderivaten als arzneistoffe
DE3930282A1 (de) * 1989-09-11 1991-03-21 Boehringer Ingelheim Kg Verwendung von dopamin-autorezeptor-agonisten bei der behandlung von drogenabhaengigkeit
DE3937271A1 (de) * 1989-11-09 1991-05-16 Boehringer Ingelheim Kg Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol
FR2674853B1 (fr) * 1991-04-03 1995-01-20 Synthelabo Derives de piperidinylguanidine, leur preparation et leur application en therapeutique.
DE4241013A1 (de) * 1992-12-05 1994-06-09 Boehringer Ingelheim Kg Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung
US5650420A (en) * 1994-12-15 1997-07-22 Pharmacia & Upjohn Company Pramipexole as a neuroprotective agent
US6156777A (en) * 1994-12-15 2000-12-05 Pharmacia & Upjohn Company Use of pramipexole as a neuroprotective agent
DE19507752A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten Cyclohexanonen
DE19536916A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Kg Inhalative Applikation von 2-Amino-6n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol, insbesondere seines (-)-Enantiomeren, sowie deren pharmakologisch verträgliche Säureadditionssalze
KR20000016147A (ko) * 1996-05-31 2000-03-25 로렌스 티. 마이젠헬더 선택적 도파민 d3 리간드로서의 아릴 치환된 시클릭 아민
US6001861A (en) * 1998-01-16 1999-12-14 Pharmacia & Upjohn Company Use of pramipexole in the treatment of restless legs syndrome
DE19701619B4 (de) * 1997-01-17 2007-10-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Pramipexol zur Behandlung des restless legs syndroms
AU760439B2 (en) * 1998-05-15 2003-05-15 Pharmacia & Upjohn Company Cabergoline and pramipexole: new uses and combinations
SE9802360D0 (sv) 1998-07-01 1998-07-01 Wikstroem Hakan Vilhelm New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
DE19830201A1 (de) * 1998-07-07 2000-01-13 Boehringer Ingelheim Pharma Mittel mit antidepressiver Wirkung
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
PE20011074A1 (es) 2000-02-23 2001-10-04 Upjohn Co Uso de pramipexol en el tratamiento de trastornos de adiccion
AU7887501A (en) * 2000-07-06 2002-01-21 Us Gov Health & Human Serv Tetrahydrobenzothiazole analogues as neuroprotective agents
US6277875B1 (en) * 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
ES2187249B1 (es) * 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
US20020165246A1 (en) * 2001-03-05 2002-11-07 Andrew Holman Administration of sleep restorative agents
DE10137453A1 (de) * 2001-08-02 2003-02-20 Boehringer Ingelheim Pharma Pramlpexol als Antikonvulsivum
DE10138275A1 (de) * 2001-08-10 2003-02-27 Boehringer Ingelheim Pharma Verbindungen zur Beseitigung der Anhedonie
ES2351303T3 (es) 2001-12-11 2011-02-02 University Of Virginia Patent Foundation Utilización de pramipexol para el tratamiento de la esclerosis lateral amiotrófica.
US20060281797A1 (en) * 2001-12-11 2006-12-14 University Of Virginia Patent Foundation Neurorestoration with R(+) Pramipexole
US20030166696A1 (en) * 2002-01-24 2003-09-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pramipexole for the treatment of HIV dementia
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
MY136318A (en) * 2002-07-25 2008-09-30 Pharmacia Corp Sustained-release tablet composition
PE20040134A1 (es) * 2002-07-25 2004-03-06 Pharmacia Corp Forma de dosificacion de una vez al dia de pramipexol
US20050226926A1 (en) * 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
DE102004006808A1 (de) 2004-02-11 2005-09-01 Grünenthal GmbH Substituierte 4,5,6,7-Tetrahydro-benzothiazol-2-ylamin-Verbindungen
DE602005025988D1 (de) 2004-03-19 2011-03-03 Dipharma Francis Srl Zwischenprodukte für die herstellung von pramipexol
ES2245604B1 (es) 2004-06-25 2006-12-01 Ragactives, S. L. Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles.
WO2006012276A1 (en) * 2004-06-30 2006-02-02 Amr Technology, Inc. Process for preparing chirally pure 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoles by liquid chromatographic resolution
US20070123573A1 (en) * 2004-07-01 2007-05-31 Alembic Limited Process for the preparation of biologically active tetrahydrobenzthiazole derivative
EP1773793A2 (en) * 2004-07-03 2007-04-18 Merck Generics (UK) Limited Process for the preparation of pramipexole by chiral chromatography
NZ553645A (en) * 2004-08-13 2010-09-30 Boehringer Ingelheim Int Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
NZ553561A (en) 2004-08-13 2010-12-24 Boehringer Ingelheim Int Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
US7691888B2 (en) * 2004-10-07 2010-04-06 Boehringer Ingelheim International Gmbh Thiazolyl-dihydro-indazole
DE112005003227T5 (de) * 2004-12-30 2007-11-15 Chemagis Ltd. Neues Verfahren zur Herstellung von Pramipexol und dem Gemisch seiner optischen Isomeren durch Reduktion mit Natriumtriacetoxyborhydrid
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) * 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
EP1731514A1 (en) * 2005-06-02 2006-12-13 Sandoz AG Process for the preparation of Pramipexole
ES2334061T3 (es) * 2005-08-15 2010-03-04 University Of Virginia Patent Foundation Neurorrestauracion con pramipexol r(+).
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
JP2009511618A (ja) * 2005-10-18 2009-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中度から重度のむずむず脚症候群(rls)を治療するためのプラミペキソールの使用
AU2006327566A1 (en) * 2005-12-02 2007-06-28 Alembic Limited Stabilized pharmaceutical composition of pramipexole and method of preparation thereof
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
US20090041844A1 (en) * 2006-02-10 2009-02-12 Boehringer Ingelheim International Gmbh Modified Release Formulation
WO2007117431A2 (en) 2006-04-03 2007-10-18 Teva Pharmaceutical Industries, Ltd. Use of rasagiline for the treatment of restless legs syndrome
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
WO2007121188A2 (en) * 2006-04-10 2007-10-25 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
EP2497472A1 (en) 2006-05-16 2012-09-12 Knopp Neurosciences, Inc. Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of Parkinson's disease and their pharmaceutical compositions
PL2026803T3 (pl) 2006-05-16 2012-05-31 Knopp Neurosciences Inc Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania
EP2026766A1 (en) 2006-05-17 2009-02-25 Synthon B.V. Tablet composition with a prolonged release of tamsulosin
WO2008001200A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal composition having enhanced color stability
US20080254118A1 (en) * 2007-04-11 2008-10-16 Hans-Werner Wernersbach Process for preparing pramipexole dihydrochloride tablets
WO2008041240A1 (en) * 2006-10-03 2008-04-10 Cadila Healthcare Limited Process for preparing (s)-pramipexole and its intermediates
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
WO2008086353A1 (en) * 2007-01-08 2008-07-17 Zurawski Vincent R Jr Propargyl-containing derivatives of tetrahydro-benzthiazoles and methods of making and using the same
SI22446A (sl) * 2007-02-07 2008-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli
EP2137171A4 (en) * 2007-03-14 2010-05-19 Knopp Neurosciences Inc SYNTHESIS OF BENZOTHIAZOLE DIAMINES SUBSTITUTED AND PURIFIED FROM THE CHIRAL PERSPECTIVE
US20080254117A1 (en) * 2007-04-10 2008-10-16 Noel Cotton Process for preparing pramipexole dihydrochloride tablets
ES2402334T3 (es) 2007-08-02 2013-04-30 Gilead Biologics, Inc Procedimientos y composiciones para el tratamiento y el diagnóstico de la fibrosis
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
US20090247537A1 (en) * 2008-03-25 2009-10-01 William Dale Overfield Methods for preventing or treating bruxism using dopaminergic agents
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
SG178845A1 (en) 2009-08-21 2012-04-27 Gilead Biologics Inc Catalytic domains from lysyl oxidase and loxl2
CN102711820A (zh) * 2009-08-21 2012-10-03 吉联亚生物科技有限公司 治疗肺纤维化疾病的方法和组合物
WO2011022670A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
CN102711821A (zh) * 2009-08-21 2012-10-03 吉联亚生物科技有限公司 治疗方法和组合物
US20110207144A1 (en) * 2009-08-21 2011-08-25 Derek Marshall In vitro screening assays
TR200906997A1 (tr) 2009-09-11 2011-03-21 Sanovel �La� San. Ve T�C. A. �. Pramipeksol farmasötik bileşimleri.
TR200907554A1 (tr) 2009-10-06 2011-04-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Oral yolla dağılan pramıpexole bileşimleri.
EP2525786A2 (en) 2010-01-18 2012-11-28 Synthon BV Pramipexole extended release tablets
BR112012019693A2 (pt) 2010-02-04 2017-06-20 Gilead Biologics Inc anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles.
US20130079526A1 (en) 2010-03-03 2013-03-28 Knopp Neurosciences Inc. Synthesis of Chirally Purified Substituted Benzothiazole Diamines
TR201001862A1 (tr) 2010-03-11 2011-10-21 Sanovel �La� San.Ve T�C.A.�. Kontrollü salım gerçekleştiren pramipeksol formülasyonları.
AU2011256928A1 (en) 2010-05-24 2012-12-20 Lupin Limited Extended release formulation of pramipexole
EP2462925A1 (en) 2010-11-12 2012-06-13 Neuraxpharm Arzneimittel GmbH Pramipexole Dihydrochloride Granulate
TWI537274B (zh) 2011-03-14 2016-06-11 橘生藥品工業股份有限公司 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途
WO2012140604A1 (en) 2011-04-15 2012-10-18 Sandoz Ag Stable formulations of pramipexole hydrochloride
ITMI20110666A1 (it) * 2011-04-19 2012-10-20 Dipharma Francis Srl Procedimento per la preparazione di (r) ed (s) pramipexolo e suoi intermedi
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
EP2732812A1 (de) 2012-11-15 2014-05-21 Aristo Pharma GmbH Pramipexol-Retardtablettenformulierung
US9585885B2 (en) 2012-12-10 2017-03-07 Kissei Pharmaceutical Co., Ltd. Substituted pyrido[2,3-g]quinazolines as dopamine D2 receptor agonists
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
HRP20251187T1 (hr) 2013-07-12 2025-11-21 Areteia Therapeutics, Inc. Liječenje povišenih razina eozinofila i/ili bazofila
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
US9642840B2 (en) 2013-08-13 2017-05-09 Knopp Biosciences, Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
US9763918B2 (en) 2013-08-13 2017-09-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
EP2870965A1 (en) 2013-11-06 2015-05-13 Sanovel Ilac Sanayi ve Ticaret A.S. Oral liquid pharmaceutical formulations of pramipexole
EP2870961B1 (en) 2013-11-06 2018-07-18 Sanovel Ilac Sanayi ve Ticaret A.S. Effervescent formulations of pramipexole
CN103626718A (zh) * 2013-12-13 2014-03-12 山东新华制药股份有限公司 盐酸普拉克索的工业化制备方法
CN103664820B (zh) * 2013-12-30 2016-01-27 四川科伦药业股份有限公司 普拉克索类似物及其制备方法
US12472149B2 (en) * 2015-07-17 2025-11-18 BE Pharbel Manufacturing Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form
IL260290B2 (en) 2015-12-30 2023-11-01 Corium Inc Systems and methods for long-term percutaneous administration
US11541018B2 (en) 2016-06-23 2023-01-03 Corium, Llc Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
MX2019001104A (es) 2016-07-27 2019-10-02 Corium Int Inc Sistemas de suministro transdermico de memantina.
CN109789134A (zh) 2016-07-27 2019-05-21 考里安国际公司 与口服递送药代动力学生物等效的透皮递送系统
JP7153010B2 (ja) 2016-07-27 2022-10-13 コリウム, インコーポレイテッド 塩薬物のin situでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法
IL312486B2 (en) 2017-04-10 2025-05-01 Chase Therapeutics Corp NK1 antagonist combination and method for treating synucleinopathies
EP3615024B1 (en) 2017-04-24 2026-02-18 Alto Neuroscience, Inc. Compositions comprising pramipexole and a 5ht3 antagonist for use in treating depression
JP7158425B2 (ja) 2017-06-30 2022-10-21 チェイス セラピューティクス コーポレイション Nk-1アンタゴニスト組成物およびうつ病の処置における使用法
CA3086163A1 (en) 2017-12-20 2019-06-27 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
CN110734413A (zh) * 2019-12-02 2020-01-31 山东铂源药业有限公司 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN111333593B (zh) * 2020-04-22 2022-04-29 湖北可赛化工有限公司 一种合成4-甲基-2肼基苯并噻唑的方法
JP2023550235A (ja) * 2020-11-19 2023-12-01 四川科▲倫▼▲薬▼物研究院有限公司 ベンゾチアゾール系化合物の塩、その結晶形及び使用
WO2025190207A1 (zh) * 2024-03-15 2025-09-18 四川科伦药物研究院有限公司 化合物的晶体及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB812512A (en) * 1956-04-12 1959-04-29 Bayer Ag Compositions for combating nematodes
DE2136233A1 (de) * 1971-07-20 1973-02-01 Riedel De Haen Ag Tetrahydrobenzthiazolderivate enthaltende pharmazeutische praeparate
FR2406635A1 (fr) * 1977-10-24 1979-05-18 Logeais Labor Jacques Nouveaux derives du benzo(d)thiazole, leur procede de preparation et leurs applications en therapeutique
FR2459239A1 (fr) * 1979-06-20 1981-01-09 Logeais Labor Jacques Nouveaux derives amines du benzothiazole, leur procede de preparation et leur application en therapeutique
DE3027528A1 (de) * 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen Ueberbrueckte thiazolyloxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
EP0207696A1 (en) * 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotetrahydrobenzothiazoles and oxazoles

Also Published As

Publication number Publication date
NL980002I2 (nl) 1998-05-06
DE3572485D1 (en) 1989-09-28
HK78692A (en) 1992-10-23
AU5154485A (en) 1986-07-17
FI855102A7 (fi) 1986-06-23
BG62023B2 (bg) 1998-12-30
FI855102A0 (fi) 1985-12-20
PH24533A (en) 1990-08-03
DK590285A (da) 1986-06-23
NL980002I1 (nl) 1998-03-02
PT81735A (de) 1986-01-01
ES8707513A1 (es) 1987-08-01
HUT39736A (en) 1986-10-29
IE58863B1 (en) 1993-11-17
CA1263653A (en) 1989-12-05
US4843086A (en) 1989-06-27
KR860004862A (ko) 1986-07-14
NO855195L (no) 1986-06-23
ES550235A0 (es) 1987-01-16
US4886812A (en) 1989-12-12
PT81735B (pt) 1988-04-21
FI81787B (fi) 1990-08-31
NO165070B (no) 1990-09-10
FI81787C (fi) 1990-12-10
ES8707515A1 (es) 1987-08-01
ES8702787A1 (es) 1987-01-16
ES556875A0 (es) 1987-08-01
LU90208I2 (fr) 1998-04-06
HU193618B (en) 1987-11-30
EP0186087B1 (de) 1989-08-23
MX9202792A (es) 1992-06-30
US4731374A (en) 1988-03-15
IL77415A (en) 1990-03-19
NO165070C (no) 1990-12-19
NZ214661A (en) 1990-04-26
ATE45735T1 (de) 1989-09-15
IE853270L (en) 1986-06-22
ES556874A0 (es) 1987-08-01
ES8707514B9 (es) 2011-04-14
AU583874B2 (en) 1989-05-11
ES556873A0 (es) 1987-08-01
ES8707514A1 (es) 1987-08-01
SG82492G (en) 1992-12-04
EP0186087A1 (de) 1986-07-02
DK168862B1 (da) 1994-06-27
DK590285D0 (da) 1985-12-18
KR930009791B1 (ko) 1993-10-11
GR853126B (cs) 1986-04-22

Similar Documents

Publication Publication Date Title
CS409991A3 (en) Tetrahydrobenzothiazole derivatives, process of their preparation andpharmaceutical compositions containing them
IL66650A (en) Dibenzoxepines and dibenzooxazepines,their preparation and pharmaceutical compositions containing them
BG49940A3 (bg) Метод за получаване на производни на 4-/4-фенил-1-пиперазинил/- феноли
ATE208779T1 (de) Substituierte spiroheterocyclische 1h-3-aryl- pyrrolidin-2,4-dion-derivate, verfahren zu deren herstellung und deren verwendung als schädlingsbekämpfungsmittel
ATE47997T1 (de) Substituierte imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung.
ES8103744A1 (es) Un metodo para la preparacion de derivados de ftalimidina
CS603384A2 (en) Method of 4,6-substituted alpha-d-maltohexa-bis-octa-oside derivatives production
EP0161574A3 (en) New b-carboline-3-oxadiazolyl derivatives, method of preparing the same and their use
DE3778714D1 (de) Indenothiazolderivate und verfahren zu ihrer herstellung.
HUT38927A (en) Process for producing 5-alkyl-1-phenyl-2-/piperazino-alkyl/-pyrazolin-3-one derivatives
IE901314L (en) 2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
ES8801637A1 (es) Un procedimiento para la preparacion de benzimidazoles.
ATE72239T1 (de) Pyrimidinderivate und verfahren zu ihrer herstellung.
HUT39445A (en) Herbicides containing as reagent derivatives of benzodisultam and process for production of the reagents
ES8303446A1 (es) Procedimiento para la obtencion de derivados de aminoacridin (d) y (l)-n-glicosido.
ATE33138T1 (de) Verfahren zur herstellung von 5-azaindol und zwischenprodukte.

Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic