ES8800243A1 - Procedimiento para preparar nuevos pirimido(2,1-b)benzotiazoles - Google Patents

Procedimiento para preparar nuevos pirimido(2,1-b)benzotiazoles

Info

Publication number
ES8800243A1
ES8800243A1 ES553574A ES553574A ES8800243A1 ES 8800243 A1 ES8800243 A1 ES 8800243A1 ES 553574 A ES553574 A ES 553574A ES 553574 A ES553574 A ES 553574A ES 8800243 A1 ES8800243 A1 ES 8800243A1
Authority
ES
Spain
Prior art keywords
group
salts
branched
straight
pyrimido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553574A
Other languages
English (en)
Other versions
ES553574A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES8800243A1 publication Critical patent/ES8800243A1/es
Publication of ES553574A0 publication Critical patent/ES553574A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Indole Compounds (AREA)
  • Polymerisation Methods In General (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS PIRIMIDO (2,1-B) BENZOTIAZOLES. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE HNR5R6, EN PRESENCIA DE 1,1-CARBONI-DIIMIDAZOL Y EN TOLUENO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R1, UN GRUPO HIDROXI, UN GRUPO ALCOXI DE C 1 A 6 Y OTROS; R2, H, ALQUILO DE C 1 A 6 LINEAL Y OTROS; R3 Y R, IGUALES O DIFERENTES, H O ALQUILO DE C 1 A 6 DE CADENA LINEAL; R5 Y R6 H O JUNTO CON UN ATOMO DE NITROGENO INTERMEDIO UN GRUPO PIPERIDINO; Y R''1 HIDROXI. SE UTILIZAN COMO ANTIALERGICOS. *FORMULA* A
ES553574A 1984-02-13 1986-04-01 Procedimiento para preparar nuevos pirimido(2,1-b)benzotiazoles Expired ES8800243A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848403739A GB8403739D0 (en) 1984-02-13 1984-02-13 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8800243A1 true ES8800243A1 (es) 1987-10-16
ES553574A0 ES553574A0 (es) 1987-10-16

Family

ID=10556508

Family Applications (2)

Application Number Title Priority Date Filing Date
ES540332A Expired ES8702421A1 (es) 1984-02-13 1985-02-12 Procedimiento para preparar nuevos pirimido (2,1-b) benzo- tiazoles
ES553574A Expired ES8800243A1 (es) 1984-02-13 1986-04-01 Procedimiento para preparar nuevos pirimido(2,1-b)benzotiazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES540332A Expired ES8702421A1 (es) 1984-02-13 1985-02-12 Procedimiento para preparar nuevos pirimido (2,1-b) benzo- tiazoles

Country Status (16)

Country Link
EP (1) EP0153230B1 (es)
JP (1) JPS60184086A (es)
KR (1) KR850005847A (es)
AT (1) ATE44745T1 (es)
AU (1) AU574131B2 (es)
CA (1) CA1257259A (es)
DE (1) DE3571621D1 (es)
DK (1) DK63385A (es)
ES (2) ES8702421A1 (es)
FI (1) FI79323C (es)
GB (2) GB8403739D0 (es)
GR (1) GR850369B (es)
HU (1) HU192318B (es)
NZ (1) NZ211104A (es)
PT (1) PT79955B (es)
ZA (1) ZA85696B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762840A (en) * 1984-02-13 1988-08-09 Roussel Uclaf Pyrimido[2,1-b]benzothiazoles having antiallergic activity
GB8519261D0 (en) * 1985-07-31 1985-09-04 Roussel Lab Ltd Chemical compounds
BR112013000043A2 (pt) 2010-07-02 2019-09-24 Gilead Sciences Inc derivados de ácido naft-2-ilacético para tratar aids
NZ604716A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
SG194512A1 (en) * 2011-04-21 2013-12-30 Gilead Sciences Inc Benzothiazole compounds and their pharmaceutical use
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
ES2571479T3 (es) 2012-04-20 2016-05-25 Gilead Sciences Inc Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919201A (en) * 1970-09-30 1975-11-11 Lilly Industries Ltd 2-({62 -Aminoacryloyl)iminobenzothiazolines
DE2810863A1 (de) * 1978-03-13 1979-09-27 Boehringer Mannheim Gmbh 1-oxo-1h-pyrimido eckige klammer auf 6,1-b eckige klammer zu benzthiazol-derivate und verfahren zu ihrer herstellung
GB8519261D0 (en) * 1985-07-31 1985-09-04 Roussel Lab Ltd Chemical compounds

Also Published As

Publication number Publication date
FI79323C (fi) 1989-12-11
NZ211104A (en) 1987-08-31
FI850582A0 (fi) 1985-02-12
AU574131B2 (en) 1988-06-30
DK63385A (da) 1985-08-14
EP0153230A2 (fr) 1985-08-28
HU192318B (en) 1987-05-28
AU3867285A (en) 1985-08-22
GB2154583A (en) 1985-09-11
GB8403739D0 (en) 1984-03-14
ATE44745T1 (de) 1989-08-15
DE3571621D1 (en) 1989-08-24
EP0153230A3 (en) 1986-10-01
FI79323B (fi) 1989-08-31
JPS60184086A (ja) 1985-09-19
HUT38649A (en) 1986-06-30
ES8702421A1 (es) 1986-12-16
DK63385D0 (da) 1985-02-12
EP0153230B1 (fr) 1989-07-19
PT79955A (en) 1985-03-01
GB2154583B (en) 1987-10-28
ZA85696B (en) 1986-03-26
GB8503541D0 (en) 1985-03-13
ES553574A0 (es) 1987-10-16
GR850369B (es) 1985-06-14
CA1257259A (en) 1989-07-11
FI850582L (fi) 1985-08-14
ES540332A0 (es) 1986-12-16
KR850005847A (ko) 1985-09-26
PT79955B (en) 1987-02-02

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506