AU574131B2 - Pyrimido (2,1-b)benzothiazoles - Google Patents

Pyrimido (2,1-b)benzothiazoles

Info

Publication number
AU574131B2
AU574131B2 AU38672/85A AU3867285A AU574131B2 AU 574131 B2 AU574131 B2 AU 574131B2 AU 38672/85 A AU38672/85 A AU 38672/85A AU 3867285 A AU3867285 A AU 3867285A AU 574131 B2 AU574131 B2 AU 574131B2
Authority
AU
Australia
Prior art keywords
group
branched
straight
hydrogen atom
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU38672/85A
Other versions
AU3867285A (en
Inventor
Julian Marian Charles Golec
David Alun Rowlands
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU3867285A publication Critical patent/AU3867285A/en
Application granted granted Critical
Publication of AU574131B2 publication Critical patent/AU574131B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Luminescent Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Indole Compounds (AREA)
  • Polymerisation Methods In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Compounds of formula I <IMAGE> [wherein R and R3,which may be the same or different, each represents a hydrogen atom or a straight or branched C1-6 alkyl group or together with the intervening carbon atom represent a C3-6 cycloalkyl group; R1 represents a hydroxy group, a straight or branched C1-6 alkoxy group or a group of formula <IMAGE> (wherein R5 and R6, which may be the same or different, each represents a hydrogen atom or a C1-6 alkyl group or together with the intervening nitrogen atom represent a piperidino or morpholino group); and R2 represents a hydrogen atom, a straight or branched C1-16 alkyl group, a C2-7 alkoxycarbonyl group, a C3-6 cycloalkyl group, an aralkyl group, an aryl group (unsubstituted or substituted by one or more halogen atoms or C1-6 alkyl, C1-6 alkoxy or nitro groups), or a heteroaryl group] and salts thereof are antiallergic agents.
AU38672/85A 1984-02-13 1985-02-13 Pyrimido (2,1-b)benzothiazoles Ceased AU574131B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848403739A GB8403739D0 (en) 1984-02-13 1984-02-13 Chemical compounds
GB8403739 1984-02-13

Publications (2)

Publication Number Publication Date
AU3867285A AU3867285A (en) 1985-08-22
AU574131B2 true AU574131B2 (en) 1988-06-30

Family

ID=10556508

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38672/85A Ceased AU574131B2 (en) 1984-02-13 1985-02-13 Pyrimido (2,1-b)benzothiazoles

Country Status (16)

Country Link
EP (1) EP0153230B1 (en)
JP (1) JPS60184086A (en)
KR (1) KR850005847A (en)
AT (1) ATE44745T1 (en)
AU (1) AU574131B2 (en)
CA (1) CA1257259A (en)
DE (1) DE3571621D1 (en)
DK (1) DK63385A (en)
ES (2) ES8702421A1 (en)
FI (1) FI79323C (en)
GB (2) GB8403739D0 (en)
GR (1) GR850369B (en)
HU (1) HU192318B (en)
NZ (1) NZ211104A (en)
PT (1) PT79955B (en)
ZA (1) ZA85696B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU586010B2 (en) * 1985-07-31 1989-06-29 Roussel-Uclaf Pyrimido``2,1-b`` benzothiazole derivatives

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762840A (en) * 1984-02-13 1988-08-09 Roussel Uclaf Pyrimido[2,1-b]benzothiazoles having antiallergic activity
EP2588455B1 (en) 2010-07-02 2018-04-04 Gilead Sciences, Inc. 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
MA34397B1 (en) 2010-07-02 2013-07-03 Gilead Sciences Inc NAPHTH-2-YLACETIC ACID DERIVATIVES IN AIDS TREATMENT
UA111841C2 (en) * 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. BENZOTHIAZOL COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
PE20141558A1 (en) 2012-04-20 2014-11-06 Gilead Sciences Inc DERIVATIVES OF BENZOTHIAZOLE-6-IL ACETIC ACID AND THEIR USE TO TREAT HIV INFECTION

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6068786A (en) * 1985-07-31 1987-02-05 Roussel-Uclaf Pyrimido``2,1-b`` benzothiazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919201A (en) * 1970-09-30 1975-11-11 Lilly Industries Ltd 2-({62 -Aminoacryloyl)iminobenzothiazolines
DE2810863A1 (en) * 1978-03-13 1979-09-27 Boehringer Mannheim Gmbh 1-OXO-1H-PYRIMIDO ANGLE CLAMP ON 6.1-B ANGLE CLAMP ON BENZTHIAZOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6068786A (en) * 1985-07-31 1987-02-05 Roussel-Uclaf Pyrimido``2,1-b`` benzothiazole derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU586010B2 (en) * 1985-07-31 1989-06-29 Roussel-Uclaf Pyrimido``2,1-b`` benzothiazole derivatives

Also Published As

Publication number Publication date
KR850005847A (en) 1985-09-26
EP0153230A3 (en) 1986-10-01
ES8702421A1 (en) 1986-12-16
ES553574A0 (en) 1987-10-16
HU192318B (en) 1987-05-28
ES8800243A1 (en) 1987-10-16
GB8403739D0 (en) 1984-03-14
GR850369B (en) 1985-06-14
GB8503541D0 (en) 1985-03-13
EP0153230B1 (en) 1989-07-19
ES540332A0 (en) 1986-12-16
NZ211104A (en) 1987-08-31
FI79323C (en) 1989-12-11
ATE44745T1 (en) 1989-08-15
DK63385D0 (en) 1985-02-12
FI850582L (en) 1985-08-14
CA1257259A (en) 1989-07-11
DK63385A (en) 1985-08-14
AU3867285A (en) 1985-08-22
HUT38649A (en) 1986-06-30
JPS60184086A (en) 1985-09-19
GB2154583B (en) 1987-10-28
DE3571621D1 (en) 1989-08-24
GB2154583A (en) 1985-09-11
PT79955A (en) 1985-03-01
FI850582A0 (en) 1985-02-12
PT79955B (en) 1987-02-02
FI79323B (en) 1989-08-31
EP0153230A2 (en) 1985-08-28
ZA85696B (en) 1986-03-26

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