GB2154583B - Pyrimidobenzthiazoles - Google Patents
PyrimidobenzthiazolesInfo
- Publication number
- GB2154583B GB2154583B GB08503541A GB8503541A GB2154583B GB 2154583 B GB2154583 B GB 2154583B GB 08503541 A GB08503541 A GB 08503541A GB 8503541 A GB8503541 A GB 8503541A GB 2154583 B GB2154583 B GB 2154583B
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- branched
- straight
- hydrogen atom
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Saccharide Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Indole Compounds (AREA)
- Polymerisation Methods In General (AREA)
Abstract
Compounds of formula I <IMAGE> [wherein R and R3,which may be the same or different, each represents a hydrogen atom or a straight or branched C1-6 alkyl group or together with the intervening carbon atom represent a C3-6 cycloalkyl group; R1 represents a hydroxy group, a straight or branched C1-6 alkoxy group or a group of formula <IMAGE> (wherein R5 and R6, which may be the same or different, each represents a hydrogen atom or a C1-6 alkyl group or together with the intervening nitrogen atom represent a piperidino or morpholino group); and R2 represents a hydrogen atom, a straight or branched C1-16 alkyl group, a C2-7 alkoxycarbonyl group, a C3-6 cycloalkyl group, an aralkyl group, an aryl group (unsubstituted or substituted by one or more halogen atoms or C1-6 alkyl, C1-6 alkoxy or nitro groups), or a heteroaryl group] and salts thereof are antiallergic agents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848403739A GB8403739D0 (en) | 1984-02-13 | 1984-02-13 | Chemical compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8503541D0 GB8503541D0 (en) | 1985-03-13 |
GB2154583A GB2154583A (en) | 1985-09-11 |
GB2154583B true GB2154583B (en) | 1987-10-28 |
Family
ID=10556508
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB848403739A Pending GB8403739D0 (en) | 1984-02-13 | 1984-02-13 | Chemical compounds |
GB08503541A Expired GB2154583B (en) | 1984-02-13 | 1985-02-12 | Pyrimidobenzthiazoles |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB848403739A Pending GB8403739D0 (en) | 1984-02-13 | 1984-02-13 | Chemical compounds |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0153230B1 (en) |
JP (1) | JPS60184086A (en) |
KR (1) | KR850005847A (en) |
AT (1) | ATE44745T1 (en) |
AU (1) | AU574131B2 (en) |
CA (1) | CA1257259A (en) |
DE (1) | DE3571621D1 (en) |
DK (1) | DK63385A (en) |
ES (2) | ES8702421A1 (en) |
FI (1) | FI79323C (en) |
GB (2) | GB8403739D0 (en) |
GR (1) | GR850369B (en) |
HU (1) | HU192318B (en) |
NZ (1) | NZ211104A (en) |
PT (1) | PT79955B (en) |
ZA (1) | ZA85696B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4762840A (en) * | 1984-02-13 | 1988-08-09 | Roussel Uclaf | Pyrimido[2,1-b]benzothiazoles having antiallergic activity |
GB8519261D0 (en) * | 1985-07-31 | 1985-09-04 | Roussel Lab Ltd | Chemical compounds |
US9296758B2 (en) | 2010-07-02 | 2016-03-29 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as HIV antiviral compounds |
US9102614B2 (en) | 2010-07-02 | 2015-08-11 | Gilead Sciences, Inc. | Naphth-2-ylacetic acid derivatives to treat AIDS |
CN103797001B (en) * | 2011-04-21 | 2016-04-20 | 吉利德科学公司 | Benzothiazole compound and application pharmaceutically thereof |
US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
CA2850881C (en) | 2012-04-20 | 2021-02-16 | Gilead Sciences, Inc. | Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3919201A (en) * | 1970-09-30 | 1975-11-11 | Lilly Industries Ltd | 2-({62 -Aminoacryloyl)iminobenzothiazolines |
DE2810863A1 (en) * | 1978-03-13 | 1979-09-27 | Boehringer Mannheim Gmbh | 1-OXO-1H-PYRIMIDO ANGLE CLAMP ON 6.1-B ANGLE CLAMP ON BENZTHIAZOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
GB8519261D0 (en) * | 1985-07-31 | 1985-09-04 | Roussel Lab Ltd | Chemical compounds |
-
1984
- 1984-02-13 GB GB848403739A patent/GB8403739D0/en active Pending
-
1985
- 1985-01-13 KR KR1019850000879A patent/KR850005847A/en not_active Application Discontinuation
- 1985-01-29 ZA ZA85696A patent/ZA85696B/en unknown
- 1985-02-11 EP EP85400219A patent/EP0153230B1/en not_active Expired
- 1985-02-11 DE DE8585400219T patent/DE3571621D1/en not_active Expired
- 1985-02-11 AT AT85400219T patent/ATE44745T1/en not_active IP Right Cessation
- 1985-02-12 HU HU85529A patent/HU192318B/en not_active IP Right Cessation
- 1985-02-12 ES ES540332A patent/ES8702421A1/en not_active Expired
- 1985-02-12 CA CA000474113A patent/CA1257259A/en not_active Expired
- 1985-02-12 NZ NZ211104A patent/NZ211104A/en unknown
- 1985-02-12 DK DK63385A patent/DK63385A/en not_active Application Discontinuation
- 1985-02-12 GB GB08503541A patent/GB2154583B/en not_active Expired
- 1985-02-12 JP JP60023706A patent/JPS60184086A/en active Pending
- 1985-02-12 FI FI850582A patent/FI79323C/en not_active IP Right Cessation
- 1985-02-12 GR GR850369A patent/GR850369B/el unknown
- 1985-02-12 PT PT79955A patent/PT79955B/en not_active IP Right Cessation
- 1985-02-13 AU AU38672/85A patent/AU574131B2/en not_active Ceased
-
1986
- 1986-04-01 ES ES553574A patent/ES8800243A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ATE44745T1 (en) | 1989-08-15 |
DK63385A (en) | 1985-08-14 |
EP0153230A3 (en) | 1986-10-01 |
EP0153230B1 (en) | 1989-07-19 |
AU3867285A (en) | 1985-08-22 |
PT79955A (en) | 1985-03-01 |
NZ211104A (en) | 1987-08-31 |
HU192318B (en) | 1987-05-28 |
PT79955B (en) | 1987-02-02 |
ES553574A0 (en) | 1987-10-16 |
AU574131B2 (en) | 1988-06-30 |
GB8403739D0 (en) | 1984-03-14 |
HUT38649A (en) | 1986-06-30 |
KR850005847A (en) | 1985-09-26 |
EP0153230A2 (en) | 1985-08-28 |
ES8800243A1 (en) | 1987-10-16 |
DE3571621D1 (en) | 1989-08-24 |
FI850582A0 (en) | 1985-02-12 |
CA1257259A (en) | 1989-07-11 |
ZA85696B (en) | 1986-03-26 |
JPS60184086A (en) | 1985-09-19 |
FI79323C (en) | 1989-12-11 |
DK63385D0 (en) | 1985-02-12 |
GR850369B (en) | 1985-06-14 |
FI79323B (en) | 1989-08-31 |
ES540332A0 (en) | 1986-12-16 |
ES8702421A1 (en) | 1986-12-16 |
GB2154583A (en) | 1985-09-11 |
GB8503541D0 (en) | 1985-03-13 |
FI850582L (en) | 1985-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19950212 |