ATE44745T1 - Pyrimido(2,1-b)benzothiazolderivate und ihre salze, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen. - Google Patents
Pyrimido(2,1-b)benzothiazolderivate und ihre salze, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen.Info
- Publication number
- ATE44745T1 ATE44745T1 AT85400219T AT85400219T ATE44745T1 AT E44745 T1 ATE44745 T1 AT E44745T1 AT 85400219 T AT85400219 T AT 85400219T AT 85400219 T AT85400219 T AT 85400219T AT E44745 T1 ATE44745 T1 AT E44745T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- salts
- products
- pyrimido
- manufacture
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- RWVLSUFUYXWYKA-UHFFFAOYSA-N 4h-pyrimido[2,1-b][1,3]benzothiazole Chemical class C1=CC=C2N3CC=CN=C3SC2=C1 RWVLSUFUYXWYKA-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Luminescent Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Polymerisation Methods In General (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848403739A GB8403739D0 (en) | 1984-02-13 | 1984-02-13 | Chemical compounds |
| EP85400219A EP0153230B1 (de) | 1984-02-13 | 1985-02-11 | Pyrimido(2,1-b)benzothiazolderivate und ihre Salze, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE44745T1 true ATE44745T1 (de) | 1989-08-15 |
Family
ID=10556508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85400219T ATE44745T1 (de) | 1984-02-13 | 1985-02-11 | Pyrimido(2,1-b)benzothiazolderivate und ihre salze, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0153230B1 (de) |
| JP (1) | JPS60184086A (de) |
| KR (1) | KR850005847A (de) |
| AT (1) | ATE44745T1 (de) |
| AU (1) | AU574131B2 (de) |
| CA (1) | CA1257259A (de) |
| DE (1) | DE3571621D1 (de) |
| DK (1) | DK63385A (de) |
| ES (2) | ES8702421A1 (de) |
| FI (1) | FI79323C (de) |
| GB (2) | GB8403739D0 (de) |
| GR (1) | GR850369B (de) |
| HU (1) | HU192318B (de) |
| NZ (1) | NZ211104A (de) |
| PT (1) | PT79955B (de) |
| ZA (1) | ZA85696B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762840A (en) * | 1984-02-13 | 1988-08-09 | Roussel Uclaf | Pyrimido[2,1-b]benzothiazoles having antiallergic activity |
| GB8519261D0 (en) * | 1985-07-31 | 1985-09-04 | Roussel Lab Ltd | Chemical compounds |
| EP2588455B1 (de) | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-essigsäure derivate als hiv antivirale verbindungen |
| CN103140474A (zh) | 2010-07-02 | 2013-06-05 | 吉里德科学公司 | 治疗aids的萘-2-基乙酸衍生物 |
| MX2013012266A (es) | 2011-04-21 | 2013-11-22 | Gilead Sciences Inc | Compuestos de benzotiazol y su uso farmaceutico. |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| ES2571479T3 (es) | 2012-04-20 | 2016-05-25 | Gilead Sciences Inc | Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919201A (en) * | 1970-09-30 | 1975-11-11 | Lilly Industries Ltd | 2-({62 -Aminoacryloyl)iminobenzothiazolines |
| DE2810863A1 (de) * | 1978-03-13 | 1979-09-27 | Boehringer Mannheim Gmbh | 1-oxo-1h-pyrimido eckige klammer auf 6,1-b eckige klammer zu benzthiazol-derivate und verfahren zu ihrer herstellung |
| GB8519261D0 (en) * | 1985-07-31 | 1985-09-04 | Roussel Lab Ltd | Chemical compounds |
-
1984
- 1984-02-13 GB GB848403739A patent/GB8403739D0/en active Pending
-
1985
- 1985-01-13 KR KR1019850000879A patent/KR850005847A/ko not_active Ceased
- 1985-01-29 ZA ZA85696A patent/ZA85696B/xx unknown
- 1985-02-11 DE DE8585400219T patent/DE3571621D1/de not_active Expired
- 1985-02-11 AT AT85400219T patent/ATE44745T1/de not_active IP Right Cessation
- 1985-02-11 EP EP85400219A patent/EP0153230B1/de not_active Expired
- 1985-02-12 GB GB08503541A patent/GB2154583B/en not_active Expired
- 1985-02-12 JP JP60023706A patent/JPS60184086A/ja active Pending
- 1985-02-12 ES ES540332A patent/ES8702421A1/es not_active Expired
- 1985-02-12 NZ NZ211104A patent/NZ211104A/en unknown
- 1985-02-12 FI FI850582A patent/FI79323C/fi not_active IP Right Cessation
- 1985-02-12 GR GR850369A patent/GR850369B/el unknown
- 1985-02-12 DK DK63385A patent/DK63385A/da not_active Application Discontinuation
- 1985-02-12 CA CA000474113A patent/CA1257259A/en not_active Expired
- 1985-02-12 HU HU85529A patent/HU192318B/hu not_active IP Right Cessation
- 1985-02-12 PT PT79955A patent/PT79955B/pt not_active IP Right Cessation
- 1985-02-13 AU AU38672/85A patent/AU574131B2/en not_active Ceased
-
1986
- 1986-04-01 ES ES553574A patent/ES8800243A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0153230A3 (en) | 1986-10-01 |
| FI79323C (fi) | 1989-12-11 |
| EP0153230B1 (de) | 1989-07-19 |
| JPS60184086A (ja) | 1985-09-19 |
| ES8800243A1 (es) | 1987-10-16 |
| NZ211104A (en) | 1987-08-31 |
| KR850005847A (ko) | 1985-09-26 |
| AU3867285A (en) | 1985-08-22 |
| FI79323B (fi) | 1989-08-31 |
| DE3571621D1 (en) | 1989-08-24 |
| GB8403739D0 (en) | 1984-03-14 |
| PT79955A (en) | 1985-03-01 |
| PT79955B (en) | 1987-02-02 |
| ES8702421A1 (es) | 1986-12-16 |
| GB2154583A (en) | 1985-09-11 |
| EP0153230A2 (de) | 1985-08-28 |
| AU574131B2 (en) | 1988-06-30 |
| DK63385D0 (da) | 1985-02-12 |
| FI850582A0 (fi) | 1985-02-12 |
| FI850582L (fi) | 1985-08-14 |
| DK63385A (da) | 1985-08-14 |
| HUT38649A (en) | 1986-06-30 |
| ES540332A0 (es) | 1986-12-16 |
| ES553574A0 (es) | 1987-10-16 |
| ZA85696B (en) | 1986-03-26 |
| GR850369B (de) | 1985-06-14 |
| GB8503541D0 (en) | 1985-03-13 |
| CA1257259A (en) | 1989-07-11 |
| HU192318B (en) | 1987-05-28 |
| GB2154583B (en) | 1987-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |