NO163185C - Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. - Google Patents
Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater.Info
- Publication number
- NO163185C NO163185C NO851298A NO851298A NO163185C NO 163185 C NO163185 C NO 163185C NO 851298 A NO851298 A NO 851298A NO 851298 A NO851298 A NO 851298A NO 163185 C NO163185 C NO 163185C
- Authority
- NO
- Norway
- Prior art keywords
- derivative
- benzyl
- preparation
- condensing
- addition salt
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- KUAJKNGLESWEFE-UHFFFAOYSA-N 1-benzhydryl-4-benzylpiperazine Chemical class C=1C=CC=CC=1CN(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 KUAJKNGLESWEFE-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- IQXXEPZFOOTTBA-UHFFFAOYSA-N 1-benzylpiperazine Chemical compound C=1C=CC=CC=1CN1CCNCC1 IQXXEPZFOOTTBA-UHFFFAOYSA-N 0.000 abstract 1
- 150000003935 benzaldehydes Chemical class 0.000 abstract 1
- -1 benzyl halide Chemical class 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59064464A JPS60222472A (ja) | 1984-03-30 | 1984-03-30 | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO851298L NO851298L (no) | 1985-10-01 |
| NO163185C true NO163185C (no) | 1990-04-18 |
Family
ID=13258978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO851298A NO163185C (no) | 1984-03-30 | 1985-03-29 | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4663325A (enExample) |
| EP (1) | EP0159566B1 (enExample) |
| JP (1) | JPS60222472A (enExample) |
| AT (1) | ATE31411T1 (enExample) |
| CA (1) | CA1248110A (enExample) |
| DE (1) | DE3561199D1 (enExample) |
| ES (3) | ES8702393A1 (enExample) |
| FI (1) | FI79101C (enExample) |
| GR (1) | GR850787B (enExample) |
| NO (1) | NO163185C (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61161272A (ja) * | 1985-01-11 | 1986-07-21 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
| JPS62277370A (ja) * | 1986-02-04 | 1987-12-02 | Terumo Corp | ジエン誘導体およびこれを含有する血管拡張剤 |
| FR2614021B1 (fr) * | 1987-04-14 | 1991-03-01 | Andre Buzas | Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant |
| DE4108527A1 (de) * | 1991-03-15 | 1992-09-17 | Basf Ag | Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung |
| AU646926B2 (en) * | 1991-03-20 | 1994-03-10 | Duphar International Research B.V. | Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity |
| WO1995015958A1 (en) * | 1993-12-08 | 1995-06-15 | Alcon Laboratories, Inc. | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
| JP4456269B2 (ja) * | 1998-01-29 | 2010-04-28 | ナムローゼ・フェンノートシャップ・オルガノン | 視神経乳頭循環改善剤 |
| RU2204556C2 (ru) * | 2001-06-18 | 2003-05-20 | Федеральное государственное унитарное предприятие "Новокузнецкий научно-исследовательский химико-фармацевтический институт" | Способ получения 1-(парахлорбензгидрил)-4-(2-оксиэтил)пиперазина |
| EA200500234A1 (ru) | 2002-08-19 | 2005-08-25 | Пфайзер Продактс Инк. | Комбинированная терапия гиперпролиферативных болезней |
| US7433519B2 (en) | 2003-04-04 | 2008-10-07 | Avid Technology, Inc. | Bitstream format for compressed image data |
| US7403561B2 (en) | 2003-04-04 | 2008-07-22 | Avid Technology, Inc. | Fixed bit rate, intraframe compression and decompression of video |
| US20050159403A1 (en) * | 2003-04-22 | 2005-07-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage |
| WO2004093813A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
| SG141430A1 (en) * | 2003-05-30 | 2008-04-28 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
| US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
| US20060205727A1 (en) * | 2005-03-11 | 2006-09-14 | Wayne Kaesemeyer | Combination therapy for endothelial dysfunction, angina and diabetes |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| WO2007050783A2 (en) | 2005-10-26 | 2007-05-03 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| BRPI0618379A2 (pt) * | 2005-11-08 | 2011-08-30 | Ranbaxy Lab Ltd | processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| AR059838A1 (es) * | 2006-03-14 | 2008-04-30 | Ranbaxy Lab Ltd | Formulaciones para dosis estabilizantes de estatina |
| AU2007274724B2 (en) * | 2006-07-14 | 2012-07-26 | Ranbaxy Laboratories Limited | Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof |
| ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
| CA2679263A1 (en) | 2007-02-28 | 2008-09-04 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| CN102936233B (zh) * | 2012-11-16 | 2016-01-20 | 葛长乐 | 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型 |
| CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN107636792B (zh) * | 2015-10-20 | 2019-05-14 | 韩国标准科学研究院 | 易于位置调节的电子显微镜用电子枪及包括其的电子显微镜 |
| CN109666008A (zh) * | 2018-12-31 | 2019-04-23 | 辰欣药业股份有限公司 | 一种盐酸洛美利嗪的合成方法 |
| WO2020150473A2 (en) | 2019-01-18 | 2020-07-23 | Dogma Therapeutics, Inc. | Pcsk9 inhibitors and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB705979A (en) * | 1951-03-22 | 1954-03-24 | Henri Morren | 1.4-aralkyl piperazines and process for the preparation thereof |
| FR1312427A (fr) * | 1961-04-12 | 1962-12-21 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
| FR1303080A (fr) * | 1961-07-25 | 1962-09-07 | Science Union Et Compagnie Soc | Pipérazines disubstituées |
| NL7306771A (enExample) * | 1972-06-02 | 1973-12-04 | ||
| DE2900810A1 (de) * | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
| GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
-
1984
- 1984-03-30 JP JP59064464A patent/JPS60222472A/ja active Granted
-
1985
- 1985-03-25 US US06/715,813 patent/US4663325A/en not_active Expired - Lifetime
- 1985-03-26 FI FI851217A patent/FI79101C/fi not_active IP Right Cessation
- 1985-03-26 CA CA000477468A patent/CA1248110A/en not_active Expired
- 1985-03-27 AT AT85103707T patent/ATE31411T1/de not_active IP Right Cessation
- 1985-03-27 EP EP85103707A patent/EP0159566B1/en not_active Expired
- 1985-03-27 DE DE8585103707T patent/DE3561199D1/de not_active Expired
- 1985-03-28 GR GR850787A patent/GR850787B/el unknown
- 1985-03-29 ES ES541728A patent/ES8702393A1/es not_active Expired
- 1985-03-29 NO NO851298A patent/NO163185C/no not_active IP Right Cessation
-
1986
- 1986-07-29 ES ES556980A patent/ES8801236A1/es not_active Expired
- 1986-07-29 ES ES556981A patent/ES8801237A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0159566B1 (en) | 1987-12-16 |
| ES556980A0 (es) | 1988-01-01 |
| ES556981A0 (es) | 1988-01-01 |
| ES8801237A1 (es) | 1988-01-01 |
| ES8801236A1 (es) | 1988-01-01 |
| FI851217A0 (fi) | 1985-03-26 |
| NO851298L (no) | 1985-10-01 |
| ES8702393A1 (es) | 1987-01-01 |
| JPH0313232B2 (enExample) | 1991-02-22 |
| FI79101C (fi) | 1989-11-10 |
| DE3561199D1 (en) | 1988-01-28 |
| EP0159566A1 (en) | 1985-10-30 |
| JPS60222472A (ja) | 1985-11-07 |
| FI79101B (fi) | 1989-07-31 |
| GR850787B (enExample) | 1985-11-25 |
| FI851217L (fi) | 1985-10-01 |
| US4663325A (en) | 1987-05-05 |
| CA1248110A (en) | 1989-01-03 |
| ES541728A0 (es) | 1987-01-01 |
| ATE31411T1 (de) | 1988-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |